Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0608 | 0.1625 |
Brugia malayi | Lectin C-type domain containing protein | 0.0028 | 0.0608 | 0.3223 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | serine peptidase, clan SB, family S8-like protein | 0.0028 | 0.0608 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0608 | 0.1625 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0608 | 0.1625 |
Plasmodium vivax | LCCL domain-containing protein | 0.0048 | 0.1888 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0443 | 0.7278 |
Brugia malayi | Zinc metalloproteinase toh-2 precursor | 0.0028 | 0.0608 | 0.3223 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0608 | 0.0608 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0608 | 0.1625 |
Echinococcus multilocularis | discoidin domain containing receptor 2 | 0.0048 | 0.1888 | 0.1888 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1888 | 1 |
Brugia malayi | Kelch motif family protein | 0.0028 | 0.0608 | 0.3223 |
Loa Loa (eye worm) | lectin C-type domain-containing protein | 0.0028 | 0.0608 | 0.1625 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0048 | 0.1888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1888 | 0.5041 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1888 | 0.5041 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1888 | 1 |
Schistosoma mansoni | neuropilin (nrp) and tolloid (tll)-like | 0.0028 | 0.0608 | 0.0608 |
Echinococcus granulosus | discoidin domain containing receptor 2 | 0.0048 | 0.1888 | 0.1888 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0608 | 0.0608 |
Trichomonas vaginalis | hypothetical protein | 0.0048 | 0.1888 | 1 |
Schistosoma mansoni | dock | 0.0048 | 0.1888 | 0.1888 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0028 | 0.0608 | 0.1625 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0443 | 0.2346 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0048 | 0.1888 | 1 |
Schistosoma mansoni | septate junction protein | 0.0048 | 0.1888 | 0.1888 |
Toxoplasma gondii | PA14 domain-containing protein | 0.0048 | 0.1888 | 1 |
Schistosoma mansoni | discoidin domain receptor | 0.0048 | 0.1888 | 0.1888 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0443 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0048 | 0.1888 | 1 |
Echinococcus granulosus | CUB | 0.0028 | 0.0608 | 0.0608 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0443 | 0.2346 |
Onchocerca volvulus | 0.0048 | 0.1888 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0608 | 0.0608 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0608 | 0.1625 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0443 | 0.7278 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0028 | 0.0608 | 0.0608 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1888 | 1 |
Brugia malayi | CUB domain containing protein | 0.0028 | 0.0608 | 0.3223 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.1888 | 0.1888 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1888 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1888 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0028 | 0.0608 | 0.0608 |
Mycobacterium tuberculosis | Possible arabinofuranosyltransferase AftD | 0.0048 | 0.1888 | 1 |
Echinococcus multilocularis | neuropilin (nrp) and tolloid (tll) | 0.0028 | 0.0608 | 0.0608 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0608 | 0.0608 |
Brugia malayi | zinc metalloproteinase toh-2 precursor | 0.0028 | 0.0608 | 0.3223 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0608 | 0.1625 |
Brugia malayi | CUB domain containing protein | 0.0028 | 0.0608 | 0.3223 |
Echinococcus multilocularis | cubilin | 0.0028 | 0.0608 | 0.0608 |
Brugia malayi | CUB domain containing protein | 0.0028 | 0.0608 | 0.3223 |
Loa Loa (eye worm) | DPY-31 protein | 0.0028 | 0.0608 | 0.1625 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0443 | 0.2346 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | discoidin domain containing receptor 2 | 0.0048 | 0.1888 | 0.1888 |
Mycobacterium leprae | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN | 0.0048 | 0.1888 | 0.5 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0028 | 0.0608 | 0.3223 |
Loa Loa (eye worm) | CUB domain-containing protein | 0.0028 | 0.0608 | 0.1625 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1888 | 1 |
Echinococcus granulosus | cubilin | 0.0028 | 0.0608 | 0.0608 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0443 | 0.2346 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0608 | 0.1625 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | Coagulation factor 5 8 type, C terminal | 0.0048 | 0.1888 | 0.1888 |
Echinococcus multilocularis | discoidin domain containing receptor 2 | 0.0048 | 0.1888 | 0.1888 |
Plasmodium vivax | LCCL domain-containing protein | 0.0048 | 0.1888 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1888 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1888 | 1 |
Echinococcus multilocularis | cubilin | 0.0028 | 0.0608 | 0.0608 |
Brugia malayi | CUB domain containing protein | 0.0028 | 0.0608 | 0.3223 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0048 | 0.1888 | 1 |
Echinococcus multilocularis | nuclear receptor 2C2 associated protein | 0.0048 | 0.1888 | 0.1888 |
Schistosoma mansoni | neuropilin (nrp) and tolloid (tll)-like | 0.0028 | 0.0608 | 0.0608 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0028 | 0.0608 | 0.0608 |
Echinococcus multilocularis | discoidin domain containing receptor 2 | 0.0048 | 0.1888 | 0.1888 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0028 | 0.0608 | 0.1625 |
Brugia malayi | CUB domain containing protein | 0.0028 | 0.0608 | 0.3223 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0608 | 0.1625 |
Echinococcus granulosus | Coagulation factor 5 8 type C terminal | 0.0048 | 0.1888 | 0.1888 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0443 | 0.1182 |
Brugia malayi | Protein kinase domain containing protein | 0.0048 | 0.1888 | 1 |
Loa Loa (eye worm) | CUB domain-containing protein | 0.0028 | 0.0608 | 0.1625 |
Echinococcus granulosus | cubilin | 0.0028 | 0.0608 | 0.0608 |
Trypanosoma cruzi | subtilisin-like serine peptidase, putative | 0.0028 | 0.0608 | 1 |
Toxoplasma gondii | F5/8 type C domain-containing protein | 0.0048 | 0.1888 | 1 |
Brugia malayi | astacin protease protein 30 | 0.0028 | 0.0608 | 0.3223 |
Schistosoma mansoni | btb and poz domain-containing protein | 0.0048 | 0.1888 | 0.1888 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1888 | 1 |
Echinococcus multilocularis | CUB | 0.0028 | 0.0608 | 0.0608 |
Echinococcus granulosus | neuropilin nrp and tolloid tll | 0.0028 | 0.0608 | 0.0608 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0608 | 0.0608 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0028 | 0.0608 | 0.3223 |
Toxoplasma gondii | F5/8 type C domain-containing protein | 0.0048 | 0.1888 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0608 | 0.3223 |
Echinococcus granulosus | discoidin domain containing receptor 2 | 0.0048 | 0.1888 | 0.1888 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.0048 | 0.1888 | 1 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0028 | 0.0608 | 0.3223 |
Brugia malayi | Suppressor of lurcher protein 1 precursor | 0.0028 | 0.0608 | 0.3223 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0028 | 0.0608 | 0.0608 |
Echinococcus multilocularis | discoidin domain receptor | 0.0048 | 0.1888 | 0.1888 |
Toxoplasma gondii | F5/8 type C domain-containing protein | 0.0048 | 0.1888 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0608 | 0.1625 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0443 | 0.7278 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3744 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0028 | 0.0608 | 0.0608 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1888 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1888 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1888 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 1 | 1 |
Loa Loa (eye worm) | zinc metalloproteinase toh-2 | 0.0028 | 0.0608 | 0.1625 |
Trypanosoma cruzi | subtilisin-like serine peptidase, putative | 0.0028 | 0.0608 | 1 |
Echinococcus multilocularis | geminin | 0.0171 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0608 | 0.1625 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0608 | 0.3223 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | discoidin domain receptor | 0.0048 | 0.1888 | 0.1888 |
Onchocerca volvulus | 0.0048 | 0.1888 | 1 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0443 | 0.2346 |
Schistosoma mansoni | discoidin domain receptor | 0.0048 | 0.1888 | 0.1888 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Displacement of [3H]MK801 from NMDA receptor in Sprague-Dawley rat cerebral cortex membrane at 50 umol by liquid scintillation counting | ChEMBL. | 25462263 | |
Activity (binding) | = 55.6 % | Displacement of [3H]EBOB from GABAA receptor in Sprague-Dawley rat frontoparietal cortex membrane at 50 umol by liquid scintillation counting | ChEMBL. | 25462263 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.