Detailed information for compound 951740

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 385.798 | Formula: C20H16ClNO5
  • H donors: 0 H acceptors: 3 LogP: 3.45 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)OCc1ccc2c(c1)cc(c(=O)o2)C(=O)N(c1ccccc1Cl)C
  • InChi: 1S/C20H16ClNO5/c1-12(23)26-11-13-7-8-18-14(9-13)10-15(20(25)27-18)19(24)22(2)17-6-4-3-5-16(17)21/h3-10H,11H2,1-2H3
  • InChiKey: JSIUCFUJKFTXPS-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0006 0.0032 0.0064
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0008 0.011 0.022
Mycobacterium leprae Probable exported protease 0.0009 0.0125 0.0033
Plasmodium falciparum alpha/beta hydrolase, putative 0.0009 0.0125 0.0138
Treponema pallidum fructose-bisphosphate aldolase 0.0325 1 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0019 0.0441 0.3393
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0212 0.0312
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0125 0.074
Plasmodium falciparum histone deacetylase 2 0.0045 0.1245 1
Mycobacterium tuberculosis Possible peroxidase BpoB (non-haem peroxidase) 0.0009 0.0125 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0125 0.074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0078 0.00000000014943
Echinococcus multilocularis histone deacetylase 6 0.0045 0.1245 0.2498
Toxoplasma gondii histone deacetylase HDAC1 0.0045 0.1245 0.6941
Loa Loa (eye worm) histone deacetylase 0.0045 0.1245 0.1831
Echinococcus granulosus histone deacetylase 6 0.0045 0.1245 0.2498
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.31 0.6219
Echinococcus multilocularis abhydrolase domain containing 3 0.0009 0.0125 0.0251
Mycobacterium ulcerans bromoperoxidase BpoC 0.0009 0.0125 0.0016
Mycobacterium tuberculosis Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) 0.0009 0.0125 0.0016
Brugia malayi hydrolase, alpha/beta fold family protein 0.0009 0.0125 0.0184
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Mycobacterium tuberculosis Probable exported protease 0.0009 0.0125 0.0016
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0535 0.046
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0125 0.0047
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0009 0.0125 0.0016
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0008 0.011 0.0081
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.011 0.0161
Mycobacterium ulcerans epoxide hydrolase EphE 0.0009 0.0125 0.0016
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0009 0.0125 0.002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0535 0.3745
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0194 0.0285
Loa Loa (eye worm) hypothetical protein 0.0045 0.1245 0.1831
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0009 0.0125 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.011 0.0031
Entamoeba histolytica hypothetical protein 0.0078 0.2299 0.2277
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0868 0.1741
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.011 0.0161
Mycobacterium ulcerans non-heme haloperoxidase Hpx 0.0009 0.0125 0.0016
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0212 0.1012
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0318 0.029
Echinococcus granulosus histone deacetylase 6 0.0045 0.1245 0.2498
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0104 0.31 0.4558
Schistosoma mansoni blooms syndrome DNA helicase 0.0022 0.054 0.1084
Trichomonas vaginalis DNA helicase recq, putative 0.0028 0.0724 0.065
Brugia malayi hydrolase, alpha/beta fold family protein 0.0009 0.0125 0.0184
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0125 0.0047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.31 0.6219
Loa Loa (eye worm) ab-hydrolase associated lipase region family protein 0.0009 0.0125 0.0184
Trypanosoma cruzi glycosyl hydrolase, putative 0.0008 0.011 0.061
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0535 0.0786
Mycobacterium ulcerans hypothetical protein 0.0009 0.0125 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0125 0.074
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0212 0.0425
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0198 0.029
Giardia lamblia Fructose-bisphosphate aldolase 0.0325 1 1
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0009 0.0125 0.0033
Plasmodium vivax histone deacetylase, putative 0.0045 0.1245 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0137 0.0274
Mycobacterium leprae POSSIBLE SECRETED PROTEASE 0.0009 0.0125 0.0033
Plasmodium vivax alpha/beta hydrolase, putative 0.0009 0.0125 0.0793
Schistosoma mansoni cpg binding protein 0.0032 0.085 0.1704
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0198 0.0396
Brugia malayi Histone deacetylase family protein 0.0045 0.1245 0.1831
Brugia malayi CXXC zinc finger family protein 0.0032 0.085 0.1249
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0008 0.011 0.0161
Brugia malayi Alpha/beta hydrolase 0.0009 0.0125 0.0184
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0212 0.0425
Leishmania major histone deacetylase, putative 0.0045 0.1245 1
Entamoeba histolytica hypothetical protein 0.0008 0.011 0.0081
Loa Loa (eye worm) histone deacetylase 7A 0.0045 0.1245 0.1831
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0159 0.481 0.4857
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0008 0.011 0.0081
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0868 0.1741
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.011 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0078 0.00000000014943
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0008 0.011 0.0161
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Schistosoma mansoni cpg binding protein 0.0034 0.0906 0.1818
Mycobacterium ulcerans haloalkane dehalogenase 0.0009 0.0125 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.31 0.6219
Mycobacterium ulcerans hypothetical protein 0.0009 0.0125 0.0016
Mycobacterium leprae Probable homoserine o-acetyltransferase MetA 0.0009 0.0125 0.0033
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0535 0.044
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0137 0.0274
Loa Loa (eye worm) hypothetical protein 0.014 0.4237 0.6229
Echinococcus multilocularis abhydrolase domain containing protein 16A 0.0009 0.0125 0.0251
Onchocerca volvulus Lipase homolog 0.0009 0.0125 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 1 1
Mycobacterium ulcerans haloalkane dehalogenase 0.0009 0.0125 0.0016
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0008 0.011 0.0081
Echinococcus multilocularis bloom syndrome protein 0.0028 0.0724 0.1451
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0535 0.1073
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0104 0.31 0.4558
Mycobacterium ulcerans hydrolase 0.0009 0.0125 0.0016
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0125 0.0793
Schistosoma mansoni hypothetical protein 0.0164 0.4985 1
Schistosoma mansoni histone deacetylase 4 5 0.0045 0.1245 0.2498
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0318 0.172
Plasmodium vivax SET domain protein, putative 0.0032 0.0868 0.6898
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0125 0.0047
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0212 0.0425
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0868 0.1741
Mycobacterium leprae Probable exported protease 0.0009 0.0125 0.0033
Trypanosoma cruzi histone deacetylase, putative 0.0045 0.1245 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0212 0.1012
Echinococcus multilocularis geminin 0.0164 0.4985 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0078 0.00000000014943
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0212 0.0312
Entamoeba histolytica alpha/beta hydrolase domain protein, putative 0.0009 0.0125 0.0097
Loa Loa (eye worm) hypothetical protein 0.0012 0.0212 0.0312
Echinococcus granulosus abhydrolase domain containing protein 3 0.0009 0.0125 0.0251
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0009 0.0125 0.0016
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0535 0.1073
Loa Loa (eye worm) hypothetical protein 0.0045 0.1245 0.1831
Mycobacterium ulcerans epoxide hydrolase EphA 0.0318 0.9787 1
Echinococcus multilocularis histone deacetylase 7 0.0045 0.1245 0.2498
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.011 0.0161
Mycobacterium ulcerans exported protease 0.0009 0.0125 0.0016
Echinococcus multilocularis abhydrolase domain containing protein 11 0.0009 0.0125 0.0251
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0318 0.9787 1
Schistosoma mansoni DNA helicase recq1 0.0012 0.0212 0.0425
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0868 0.4776
Entamoeba histolytica recQ family DNA helicase 0.0006 0.0036 0.0007
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0318 0.1834
Brugia malayi Pre-SET motif family protein 0.0222 0.6802 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0535 0.044
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0008 0.011 0.0081
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0078 0.00000000014943
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0008 0.011 0.022
Brugia malayi Histone deacetylase family protein 0.0045 0.1245 0.1831
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0535 0.0786
Echinococcus granulosus abhydrolase domain containing protein 11 0.0009 0.0125 0.0251
Loa Loa (eye worm) hypothetical protein 0.0009 0.0125 0.0184
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0125 0.0047
Loa Loa (eye worm) RecQ helicase 0.0028 0.0724 0.1064
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0009 0.0125 0.0251
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0137 0.0274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.31 0.6219
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.011 0.0031
Mycobacterium ulcerans oxidoreductase 0.0009 0.0125 0.0016
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0198 0.0396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.2299 0.4612
Mycobacterium ulcerans lipase/esterase 0.0009 0.0125 0.0016
Plasmodium falciparum histone deacetylase, putative 0.0045 0.1245 1
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.0009 0.0125 0.0016
Loa Loa (eye worm) hypothetical protein 0.0032 0.0868 0.1276
Schistosoma mansoni hypothetical protein 0.0078 0.2299 0.4612
Trypanosoma cruzi histone deacetylase, putative 0.0045 0.1245 1
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Schistosoma mansoni histone deacetylase hda2 0.0045 0.1245 0.2498
Loa Loa (eye worm) hypothetical protein 0.0006 0.0036 0.0053
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0009 0.0125 0.0016
Trichomonas vaginalis hydrolase, putative 0.0009 0.0125 0.0047
Trypanosoma brucei histone deacetylase 4 0.0045 0.1245 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 1 1
Treponema pallidum phosphoglycolate phosphatase 0.0008 0.011 0.0074
Loa Loa (eye worm) hypothetical protein 0.0008 0.011 0.0161
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Echinococcus multilocularis histone deacetylase 0.0045 0.1245 0.2498
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0868 0.1741
Plasmodium vivax haloacid dehalogenase-like hydrolase, putative 0.0008 0.011 0.0664
Loa Loa (eye worm) hydrolase 0.0009 0.0125 0.0184
Schistosoma mansoni choline dehydrogenase 0.0008 0.011 0.022
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0137 0.0274
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0008 0.011 0.0161
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.011 0.0161
Entamoeba histolytica alpha/beta hydrolase fold protein, putative 0.0009 0.0125 0.0097
Plasmodium falciparum acid cluster protein 33 homologue, putative 0.0009 0.0125 0.0138
Echinococcus granulosus geminin 0.0164 0.4985 1
Trichomonas vaginalis set domain proteins, putative 0.0253 0.7759 0.7741
Schistosoma mansoni cpg binding protein 0.0034 0.0906 0.1818
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.011 0.0031
Entamoeba histolytica hypothetical protein 0.0009 0.0125 0.0097
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0009 0.0125 0.074
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 1 1
Mycobacterium ulcerans epoxide hydrolase EphB 0.0009 0.0125 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.011 0.0031
Plasmodium falciparum epoxide hydrolase 1 0.0009 0.0125 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.011 0.0031
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0535 0.3745
Schistosoma mansoni histone deacetylase 4 5 0.0045 0.1245 0.2498
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0535 0.4161
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0008 0.011 0.0081
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0125 0.0793
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0868 0.1741
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0008 0.011 0.022
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0078 0.00000000014943
Trypanosoma cruzi hydrolase-like protein, putative 0.0009 0.0125 0.074
Onchocerca volvulus 0.0032 0.085 0.0968
Trypanosoma cruzi histone deacetylase, putative 0.0045 0.1245 1
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Mycobacterium ulcerans proline iminopeptidase PIP 0.0009 0.0125 0.0016
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0009 0.0125 0.0016
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 1 containing protein 0.0008 0.011 0.0161
Schistosoma mansoni ap endonuclease 0.0022 0.0535 0.1073
Echinococcus granulosus histone deacetylase 0.0045 0.1245 0.2498
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.31 0.6219
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0535 0.3658
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0009 0.0125 0.0138
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 1 1
Loa Loa (eye worm) abhydrolase domain-containing protein 2 0.0009 0.0125 0.0184
Schistosoma mansoni family S33 non-peptidase homologue (S33 family) 0.0009 0.0125 0.0251
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.081 0.1624
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0009 0.0125 0.0047
Onchocerca volvulus 0.0253 0.7759 1
Toxoplasma gondii exonuclease III APE 0.0022 0.0535 0.2865
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.2299 0.4612
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0125 0.0016
Trypanosoma brucei histone deacetylase 3 0.0045 0.1245 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0618 0.4475
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0125 0.0047
Brugia malayi UPF0017 protein CG3488 0.0009 0.0125 0.0184
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0125 0.0047
Toxoplasma gondii homoserine O-acetyltransferase, putative 0.0009 0.0125 0.0513
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0159 0.481 0.4857
Echinococcus granulosus lysosomal acid lipase:cholesteryl ester 0.0009 0.0125 0.0251
Entamoeba histolytica hypothetical protein 0.0078 0.2299 0.2277
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Brugia malayi Hypothetical 54.7 kDa protein F37A4.1 in chromosome III 0.0009 0.0125 0.0184
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.31 0.6219
Echinococcus multilocularis histone deacetylase 6 0.0045 0.1245 0.2498
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.2004 0.402
Schistosoma mansoni hydrolase 0.0009 0.0125 0.0251
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0008 0.011 0.0081
Onchocerca volvulus Lipase homolog 0.0009 0.0125 0.002
Brugia malayi Pre-SET motif family protein 0.0032 0.0868 0.1276
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0078 0.00000000014943
Mycobacterium ulcerans hypothetical protein 0.0009 0.0125 0.0016
Echinococcus multilocularis abhydrolase domain containing protein 3 0.0009 0.0125 0.0251
Trypanosoma brucei histone deacetylase, putative 0.0045 0.1245 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0078 0.00000000014943
Mycobacterium tuberculosis Conserved protein 0.0009 0.0125 0.0016
Schistosoma mansoni ap endonuclease 0.0022 0.0535 0.1073
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0535 1
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.2299 0.4612
Entamoeba histolytica hypothetical protein 0.0078 0.2299 0.2277
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0868 0.1741
Schistosoma mansoni DNA helicase recq5 0.0012 0.0212 0.0425
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 3 containing protein 0.0008 0.011 0.0161
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.1778 1
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0008 0.011 0.0081
Schistosoma mansoni 2-deoxyglucose-6-phosphate phosphatase 0.0008 0.011 0.022
Mycobacterium ulcerans hydrolase 0.0009 0.0125 0.0016
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0318 0.0241
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0008 0.011 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.011 0.0031
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0535 0.0508
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0212 0.0312
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0008 0.011 0.0081
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0008 0.011 0.0161
Chlamydia trachomatis phosphoglycolate phosphatase 0.0008 0.011 0.5
Mycobacterium ulcerans peroxidase BpoB 0.0009 0.0125 0.0016
Leishmania major histone deacetylase, putative 0.0045 0.1245 1
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0125 0.0016
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Echinococcus granulosus abhydrolase domain containing protein 0.0009 0.0125 0.0251
Entamoeba histolytica hypothetical protein 0.0078 0.2299 0.2277
Echinococcus multilocularis cpg binding protein 0.0034 0.0906 0.1818
Echinococcus granulosus cpg binding protein 0.0034 0.0906 0.1818
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.31 0.6219
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0008 0.011 0.0081
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0535 0.043
Onchocerca volvulus 0.0032 0.0868 0.0991
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0868 0.1741
Toxoplasma gondii alpha/beta hydrolase, putative 0.0009 0.0125 0.0513
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0212 0.0903
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0008 0.011 0.0161
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0434 0.2288
Mycobacterium ulcerans epoxide hydrolase EphF 0.0009 0.0125 0.0016
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.085 0.1249
Echinococcus granulosus histone deacetylase 6 0.0045 0.1245 0.2498
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Mycobacterium ulcerans lignin peroxidase LipJ 0.0009 0.0125 0.0016
Brugia malayi Bloom's syndrome protein homolog 0.0028 0.0724 0.1064
Mycobacterium tuberculosis Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) 0.0009 0.0125 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0535 0.4127
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.6802 1
Brugia malayi hypothetical protein 0.0078 0.2299 0.338
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Trypanosoma cruzi hydrolase-like protein, putative 0.0009 0.0125 0.074
Echinococcus granulosus bloom syndrome protein 0.0028 0.0724 0.1451
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 1 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0028 0.0724 0.065
Giardia lamblia ENC6 protein 0.0009 0.0125 0.0016
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0212 0.0104
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0009 0.0125 0.0251
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0535 0.046
Mycobacterium ulcerans lipase/esterase 0.0009 0.0125 0.0016
Brugia malayi alpha/beta hydrolase 0.0009 0.0125 0.0184
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0078 0.00000000014943
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0535 0.4127
Schistosoma mansoni blooms syndrome DNA helicase 0.0006 0.0036 0.0072
Loa Loa (eye worm) hypothetical protein 0.0009 0.0125 0.0184
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Schistosoma mansoni hypothetical protein 0.0164 0.4985 1
Mycobacterium ulcerans exported protease 0.0009 0.0125 0.0016
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Treponema pallidum phosphoglycolate phosphatase 0.0008 0.011 0.0074
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0535 0.0501
Mycobacterium tuberculosis Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) 0.0009 0.0125 0.0016
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0318 0.2332
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.0125 0.0016
Echinococcus granulosus histone deacetylase 7 0.0045 0.1245 0.2498
Mycobacterium ulcerans homoserine O-acetyltransferase 0.0009 0.0125 0.0016
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0008 0.011 0.0161
Mycobacterium leprae POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) 0.0009 0.0125 0.0033
Mycobacterium tuberculosis Probable carboxylesterase CaeA 0.0009 0.0125 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0125 0.0793
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 1 1
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.011 0.0031
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0159 0.481 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0137 0.0274
Trypanosoma cruzi hydrolase-like protein 0.0009 0.0125 0.074
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0212 0.0425
Entamoeba histolytica hypothetical protein 0.0008 0.011 0.0081
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0325 1 1
Echinococcus multilocularis abhydrolase domain containing protein 0.0009 0.0125 0.0251
Plasmodium vivax histone deacetylase 2, putative 0.0045 0.1245 1
Echinococcus multilocularis histone deacetylase 6 0.0045 0.1245 0.2498
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.011 0.0031
Mycobacterium ulcerans hypothetical protein 0.0009 0.0125 0.0016

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 62.78 % Antiinvasive activity in human HT1080 cells assessed as number of cells migrated at 1 uM after 24 hrs by Boyden chamber invasion assay ChEMBL. 18329754

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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