Detailed information for compound 952651

Basic information

Technical information
  • TDR Targets ID: 952651
  • Name: (3R,6E,8S,9S,10R)-3,8,9-trihydroxy-10-propyl- 3,4,5,8,9,10-hexahydrooxecin-2-one
  • MW: 244.284 | Formula: C12H20O5
  • H donors: 3 H acceptors: 4 LogP: 0.6 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC[C@H]1OC(=O)[C@H](O)CC/C=C/[C@@H]([C@@H]1O)O
  • InChi: 1S/C12H20O5/c1-2-5-10-11(15)8(13)6-3-4-7-9(14)12(16)17-10/h3,6,8-11,13-15H,2,4-5,7H2,1H3/b6-3+/t8-,9+,10+,11-/m0/s1
  • InChiKey: KQJGPGHQDDZVHJ-ZFOCBLLKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0214 0.2511 0.25
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0112 0.0595
Schistosoma mansoni hypothetical protein 0.0038 0.0281 0.0379
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.029 0.1681
Loa Loa (eye worm) amidase 0.0026 0.0123 0.0146
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0049 0.0419 0.0405
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.057 0.7036 0.7032
Entamoeba histolytica vacuolar protein sorting 26 0.0049 0.0419 0.1851
Toxoplasma gondii hypothetical protein 0.0049 0.0419 0.9758
Plasmodium falciparum T-complex protein 1 subunit beta 0.0027 0.0139 0.0755
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0429 0.059
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0026 0.0123 0.0659
Brugia malayi Amidase family protein 0.0026 0.0123 0.0175
Leishmania major hypothetical protein, conserved 0.0026 0.0123 0.0659
Loa Loa (eye worm) MBOAT family protein 0.057 0.7036 1
Mycobacterium ulcerans lysophospholipase 0.0146 0.1654 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.002 0.0005
Brugia malayi MBOAT family protein 0.0049 0.0419 0.0596
Brugia malayi MBOAT family protein 0.057 0.7036 1
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.057 0.7036 1
Brugia malayi Hhat protein 0.0049 0.0419 0.0596
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0239 0.0756
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0419 0.2467
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0146 0.1654 1
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0049 0.0419 0.0576
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0146 0.1654 1
Plasmodium vivax PST-A protein 0.0146 0.1654 1
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0049 0.0419 0.2467
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0049 0.0419 0.0405
Leishmania major hypothetical protein, conserved 0.0049 0.0419 0.2467
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.029 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.002 0.0007
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0049 0.0419 0.0569
Echinococcus multilocularis muscleblind protein 0.0148 0.1675 0.1663
Plasmodium falciparum esterase, putative 0.0146 0.1654 1
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0049 0.0419 0.0576
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0049 0.0419 0.9758
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0027 0.0139 0.0755
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0139 0.0176
Loa Loa (eye worm) hypothetical protein 0.0056 0.0506 0.0693
Leishmania major glycerol uptake protein, putative 0.0049 0.0419 0.2467
Giardia lamblia TCP-1 chaperonin subunit beta 0.0027 0.0139 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0422 0.058
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0049 0.0419 0.9758
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0049 0.0419 0.0576
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0049 0.0419 0.0405
Echinococcus multilocularis muscleblind protein 1 0.0148 0.1675 0.1663
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.1241 0.7483
Loa Loa (eye worm) hypothetical protein 0.0049 0.0419 0.0569
Loa Loa (eye worm) glutathione reductase 0.005 0.0429 0.0583
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0049 0.0419 0.0576
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0026 0.0123 0.0659
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.002 0.0005
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.029 0.1681
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0146 0.1654 1
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0049 0.0419 0.0576
Loa Loa (eye worm) inositol-1 0.0039 0.029 0.0385
Mycobacterium ulcerans amidase 0.0026 0.0123 0.0659
Plasmodium falciparum lysophospholipase, putative 0.0146 0.1654 1
Mycobacterium ulcerans hypothetical protein 0.0146 0.1654 1
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0281 0.04
Mycobacterium ulcerans amidase 0.0026 0.0123 0.0659
Mycobacterium ulcerans amidase 0.0026 0.0123 0.0659
Leishmania major monoglyceride lipase, putative 0.0146 0.1654 1
Trichomonas vaginalis porcupine, putative 0.0049 0.0419 0.2467
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0429 0.2528
Echinococcus granulosus GPCR family 2 0.0018 0.002 0.0007
Trypanosoma cruzi amidase, putative 0.0026 0.0123 0.0659
Plasmodium falciparum thioredoxin reductase 0.005 0.0429 0.2528
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0132
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0112 0.0595
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.0419 0.1851
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0146 0.1654 1
Leishmania major hypothetical protein, conserved 0.0025 0.0112 0.0595
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0026 0.0123 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0422 0.0408
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0049 0.0419 0.0405
Trypanosoma brucei trypanothione reductase 0.005 0.0429 0.2528
Loa Loa (eye worm) hypothetical protein 0.0049 0.0419 0.0569
Brugia malayi MBOAT family protein 0.0049 0.0419 0.0596
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0026 0.0123 0.0659
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0026 0.0123 0.0659
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0506 0.0719
Echinococcus granulosus sterol O acyltransferase 1 0.0049 0.0419 0.0576
Toxoplasma gondii thioredoxin reductase 0.005 0.0429 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0049 0.0419 0.0576
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0146 0.1654 1
Brugia malayi MBOAT family protein 0.0049 0.0419 0.0596
Loa Loa (eye worm) T-complex protein 1 0.0027 0.0139 0.0169
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0146 0.1654 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.1403 0.8468
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0146 0.1654 1
Leishmania major T-complex protein 1, beta subunit, putative 0.0027 0.0139 0.0755
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0422 0.058
Schistosoma mansoni fatty-acid amide hydrolase 0.0026 0.0123 0.0154
Brugia malayi Amidase family protein 0.0026 0.0123 0.0175
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0139 0.0176
Loa Loa (eye worm) hypothetical protein 0.0148 0.1675 0.2359
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.1403 0.8468
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0026 0.0123 0.0154
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0049 0.0419 0.0405
Trypanosoma cruzi GUP1, putative 0.0049 0.0419 0.2467
Echinococcus multilocularis GPCR, family 2 0.0018 0.002 0.0005
Brugia malayi Inositol-1 0.0039 0.029 0.0413
Schistosoma mansoni sterol O-acyltransferase 1 0.0049 0.0419 0.0576
Toxoplasma gondii t-complex protein beta subunit 0.0027 0.0139 0.2988
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0027 0.0139 0.0755
Loa Loa (eye worm) hhat protein 0.0049 0.0419 0.0569
Loa Loa (eye worm) hypothetical protein 0.0214 0.2511 0.3551
Treponema pallidum alginate O-acetylation protein (algI) 0.0049 0.0419 1
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0146 0.1654 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.1241 0.7483
Leishmania major trypanothione reductase 0.005 0.0429 0.2528
Loa Loa (eye worm) hypothetical protein 0.0049 0.0419 0.0569
Trypanosoma cruzi monoglyceride lipase, putative 0.0146 0.1654 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0458 0.0625
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0422 0.0408
Trypanosoma brucei monoglyceride lipase, putative 0.0146 0.1654 1
Mycobacterium tuberculosis Probable reductase 0.0114 0.1241 0.7483
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0027 0.0139 0.0176
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.029 0.1001
Echinococcus granulosus fatty acid amide hydrolase 1 0.0026 0.0123 0.0154
Loa Loa (eye worm) MBOAT family protein 0.0049 0.0419 0.0569
Brugia malayi diacylglycerol acyltransferase 0.0049 0.0419 0.0596
Loa Loa (eye worm) hypothetical protein 0.0038 0.0281 0.0372
Brugia malayi putative amidase 0.0026 0.0123 0.0175
Echinococcus multilocularis sterol O acyltransferase 1 0.0049 0.0419 0.0405
Loa Loa (eye worm) amidase 0.0026 0.0123 0.0146
Plasmodium falciparum lysophospholipase, putative 0.0146 0.1654 1
Echinococcus granulosus muscleblind protein 0.0148 0.1675 0.2365
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0049 0.0419 0.2467
Schistosoma mansoni hypothetical protein 0.0018 0.002 0.0007
Brugia malayi Latrophilin receptor protein 2 0.0018 0.002 0.0029
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0506 0.0693
Schistosoma mansoni hypothetical protein 0.0049 0.0419 0.0576
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.1241 0.7483
Trypanosoma brucei glycerol uptake protein, putative 0.0049 0.0419 0.2467
Echinococcus granulosus zinc finger protein 0.0521 0.6412 0.9111
Trypanosoma cruzi amidase, putative 0.0026 0.0123 0.0659
Schistosoma mansoni inositol monophosphatase 0.0039 0.029 0.0392
Leishmania major glycerol uptake protein, putative 0.0049 0.0419 0.2467
Echinococcus multilocularis tumor protein p63 0.0356 0.4326 0.4317
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0049 0.0419 0.1851
Schistosoma mansoni zinc finger protein 0.057 0.7036 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0049 0.0419 0.2467
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0112 0.0595
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.1241 0.7483
Trypanosoma cruzi glycerol uptake protein, putative 0.0049 0.0419 0.2467
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0049 0.0419 0.0569
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0112 0.2353
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.029 0.1681
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0139 0.0176
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.029 0.1681
Schistosoma mansoni fatty-acid amide hydrolase 0.0214 0.2511 0.3556
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0026 0.0123 0.3917
Onchocerca volvulus 0.0052 0.0458 1
Loa Loa (eye worm) hhat protein 0.0049 0.0419 0.0569
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0422 0.06
Loa Loa (eye worm) hypothetical protein 0.0049 0.0419 0.0569
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0015 0.0021
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0112 0.0595
Plasmodium falciparum glutathione reductase 0.005 0.0429 0.2528
Trichomonas vaginalis chaperonin, putative 0.0027 0.0139 0.0755
Mycobacterium ulcerans amidase 0.0026 0.0123 0.0659
Leishmania major glycerol uptake protein, putative 0.0049 0.0419 0.2467
Trypanosoma brucei monoglyceride lipase, putative 0.0146 0.1654 1
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0027 0.0139 0.0124
Echinococcus granulosus fatty acid amide hydrolase 1 0.0214 0.2511 0.3556
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0026 0.0123 0.0659
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.1432 0.2012
Schistosoma mansoni hypothetical protein 0.0018 0.002 0.0007
Plasmodium vivax glutathione reductase, putative 0.005 0.0429 0.2528
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.002 0.0029
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0429 0.2528
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0027 0.0139 0.0755
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.029 0.1681
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.1403 0.836
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0027 0.0139 0.0755
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0422 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1654 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0422 0.058
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0026 0.0123 0.0659
Mycobacterium ulcerans peptide amidase, GatA 0.0026 0.0123 0.0659
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.1241 0.7306
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0429 0.0583
Trypanosoma brucei glycerol uptake protein, putative 0.0049 0.0419 0.2467
Schistosoma mansoni hypothetical protein 0.0018 0.002 0.0007
Echinococcus multilocularis zinc finger protein 0.0521 0.6412 0.6407
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.1432 0.2012
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.029 0.1681
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0049 0.0419 0.0576
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.029 0.0392
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.029 0.1681
Trichomonas vaginalis transmembrane protein nessy, putative 0.0049 0.0419 0.2467
Echinococcus granulosus o acyltransferase membrane bound domain 0.0049 0.0419 0.0576
Schistosoma mansoni amidase 0.0214 0.2511 0.3556
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0239 0.1364
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.029 0.1681
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0139 0.0197
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0139 0.0197
Brugia malayi Muscleblind-like protein 0.0148 0.1675 0.2381
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0026 0.0123 0.0108
Brugia malayi glutathione reductase 0.005 0.0429 0.061
Schistosoma mansoni inositol monophosphatase 0.0039 0.029 0.0392
Loa Loa (eye worm) MBOAT family protein 0.0049 0.0419 0.0569
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0429 0.0415
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0112 0.0595
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0026 0.0123 0.267
Brugia malayi hypothetical protein 0.0025 0.0112 0.016
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.029 0.6651
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0049 0.0419 0.0576
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0214 0.2511 0.25
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0422 0.0573
Entamoeba histolytica hypothetical protein 0.0049 0.0419 0.1851
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0429 0.2528
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0422 0.058
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0026 0.0123 0.0154
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0026 0.0123 0.0659
Brugia malayi Thioredoxin reductase 0.005 0.0429 0.061
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0049 0.0419 0.0405
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0146 0.1654 1
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0419 0.2467
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.002 0.0007
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0049 0.0419 0.0576
Echinococcus granulosus fatty acid amide hydrolase 1 0.0214 0.2511 0.3556
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0049 0.0419 0.1851
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0049 0.0419 0.0405
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.1403 0.8468
Schistosoma mansoni hypothetical protein 0.0018 0.002 0.0007
Leishmania major glycerol uptake protein, putative 0.0049 0.0419 0.2467
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1654 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0506 0.0719
Leishmania major glycerol uptake protein, putative 0.0049 0.0419 0.2467
Brugia malayi amidase 0.0214 0.2511 0.3569
Loa Loa (eye worm) hypothetical protein 0.0148 0.1675 0.2359
Trypanosoma cruzi glycerol uptake protein, putative 0.0049 0.0419 0.2467
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0026 0.0123 0.0659
Mycobacterium ulcerans amidase 0.0026 0.0123 0.0659
Trypanosoma cruzi GUP1, putative 0.0049 0.0419 0.2467
Mycobacterium tuberculosis Possible lysophospholipase 0.0146 0.1654 1
Plasmodium falciparum lysophospholipase, putative 0.0146 0.1654 1
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0049 0.0419 0.0576
Echinococcus granulosus tumor protein p63 0.0356 0.4326 0.614
Brugia malayi MBOAT family protein 0.0049 0.0419 0.0596
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0112 0.0595
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0049 0.0419 0.0576
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.1241 0.7483
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.029 0.0276
Brugia malayi MH2 domain containing protein 0.0129 0.1432 0.2035
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0049 0.0419 0.1851
Echinococcus granulosus o acyltransferase membrane bound domain 0.0049 0.0419 0.0576
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0419 0.2467
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0458 0.0632
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0026 0.0123 0.0108
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0026 0.0123 0.0659

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Binding affinity to bovine brain calmodulin assessed as decrease in electrophoretic mobility at 0.033 ug/ml for 1.5 hrs by SDS-PAGE in presence of Ca2+ ions ChEMBL. 12713403

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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