TDR Targets

Basic information

Technical information

TDR Targets ID: 956166
Name: 3-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl] -2-[(E)-2-phenylethenyl]quinazolin-4-one
MW: 438.501 | Formula: C25H18N4O2S
H donors: 0 H acceptors: 3 LogP: 4.93 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)c1nnc(s1)n1c(/C=C/c2ccccc2)nc2c(c1=O)cccc2
InChi: 1S/C25H18N4O2S/c1-31-19-14-12-18(13-15-19)23-27-28-25(32-23)29-22(16-11-17-7-3-2-4-8-17)26-21-10-6-5-9-20(21)24(29)30/h2-16H,1H3/b16-11+
InChiKey: UEWXVYIRZGDCHQ-LFIBNONCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(E)-2-phenylvinyl]quinazolin-4-one
3-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(E)-2-phenylvinyl]-4-quinazolinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1754	0.6177
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0439	0.0586
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0187	0.0134
Brugia malayi	ecdysteroid receptor	0.0012	0.0045	0.016
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0187	0.0134
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0045	0.0045
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0187	0.0134
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0439	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0045	0.016
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0045	0.0054
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.0449	0.569	1
Schistosoma mansoni	patched 1	0.0041	0.0418	0.0493
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0493	0.058
Brugia malayi	steroid hormone receptor	0.0012	0.0045	0.016
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.0588	0.0588
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0439	0.1547
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0045	0.016
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0045	0.0054
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0171	0.2104	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0045	0.0054
Brugia malayi	Muscleblind-like protein	0.0144	0.1754	0.6177
Plasmodium vivax	peptide deformylase, putative	0.0449	0.569	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0045	0.016
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0045	0.0054
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0187	0.066
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0439	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0045	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0045	0.016
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.0588	0.0692
Treponema pallidum	polypeptide deformylase (def)	0.0449	0.569	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.0123	0.1481	0.5215
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0054	0.0588	0.2069
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0045	0.0045
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0045	0.016
Onchocerca volvulus		0.0047	0.0493	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0045	0.016
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0045	0.016
Mycobacterium ulcerans	lipase LipD	0.0042	0.0439	0.0586
Schistosoma mansoni	hypothetical protein	0.0039	0.0399	0.047
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0054	0.0588	0.2069
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0439	0.1547
Brugia malayi	beta-lactamase	0.0042	0.0439	0.1547
Echinococcus granulosus	microtubule associated protein 2	0.0667	0.8494	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0399	0.047
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1754	0.6177
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.0439	0.0606
Echinococcus multilocularis	muscleblind protein	0.0144	0.1754	0.1754
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0588	0.0692
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0045	0.016
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0439	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0045	0.016
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0418	0.0493
Brugia malayi	beta-lactamase family protein	0.0042	0.0439	0.1547
Schistosoma mansoni	hypothetical protein	0.0014	0.0075	0.0088
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0045	0.0054
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0045	0.0054
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0045	0.016
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0045	0.016
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0439	0.1547
Echinococcus granulosus	expressed conserved protein	0.0089	0.1045	0.123
Brugia malayi	Niemann-Pick C1 protein precursor	0.0095	0.1119	0.3941
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0439	0.1547
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0187	0.0155
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0045	0.016
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0439	0.1547
Schistosoma mansoni	microtubule-associated protein tau	0.0667	0.8494	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.0439	0.0606
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.0439	0.0606
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0045	0.0045
Echinococcus multilocularis	microtubule associated protein 2	0.0667	0.8494	0.8494
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0439	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0113	0.0396
Brugia malayi	Raf kinase	0.0051	0.0548	0.1929
Plasmodium falciparum	peptide deformylase	0.0449	0.569	1
Mycobacterium ulcerans	peptide deformylase	0.0449	0.569	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0042	0.0439	0.0586
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0045	0.016
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0439	0.0517
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.0439	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0439	0.1547
Brugia malayi	GoLoco motif family protein	0.0014	0.0075	0.0265
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0045	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0187	0.066
Echinococcus granulosus	survival motor neuron protein 1	0.0228	0.2839	0.3343
Echinococcus multilocularis	protein patched	0.0041	0.0418	0.0418
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0095	0.1119	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.1138	0.134
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0588	0.0692
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0439	0.0517
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0045	0.0045
Trypanosoma brucei	Polypeptide deformylase 1	0.0171	0.2104	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0271	0.3391	0.5886
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0045	0.0054
Echinococcus multilocularis	Niemann Pick C1 protein	0.0136	0.1646	0.1646
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0439	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0051	0.0548	0.0645
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0045	0.0045
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0439	0.0606
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0045	0.0054
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0045	0.016
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0045	0.0054
Chlamydia trachomatis	peptide deformylase	0.0449	0.569	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0113	0.0396
Brugia malayi	GoLoco motif family protein	0.0014	0.0075	0.0265
Brugia malayi	nuclear hormone receptor	0.0012	0.0045	0.016
Echinococcus granulosus	Niemann Pick C1 protein	0.0136	0.1646	0.1937
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0045	0.016
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.0439	0.0606
Schistosoma mansoni	hypothetical protein	0.0039	0.0399	0.047
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0075	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0418	0.1474
Mycobacterium leprae	Probable lipase LipE	0.0042	0.0439	0.0458
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0045	0.016
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0113	0.0396
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0045	0.0054
Loa Loa (eye worm)	GoLoco domain-containing protein family protein	0.0014	0.0075	0.0265
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0045	0.016
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0045	0.016
Toxoplasma gondii	hypothetical protein	0.0449	0.569	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0418	0.0418
Onchocerca volvulus		0.0042	0.0439	0.8803
Loa Loa (eye worm)	hypothetical protein	0.005	0.0537	0.1891
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0045	0.016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0045	0.016
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0439	0.0606
Brugia malayi	MH2 domain containing protein	0.0123	0.1481	0.5215
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.0439	0.0606
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0045	0.0045
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0187	0.066
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0418	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0113	0.0396
Mycobacterium leprae	conserved hypothetical protein	0.0042	0.0439	0.0458
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0045	0.016
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0045	0.016
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.0588	0.0692
Loa Loa (eye worm)	MH2 domain-containing protein	0.0123	0.1481	0.5215
Brugia malayi	hypothetical protein	0.0228	0.2839	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0493	0.1736
Echinococcus multilocularis	expressed conserved protein	0.0089	0.1045	0.1045
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0439	1
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0045	0.016
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0171	0.2104	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.0588	0.0588
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0187	0.0134
Loa Loa (eye worm)	raf kinase	0.0051	0.0548	0.1929
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0113	0.0022
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0187	0.0134
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0045	0.0054
Trypanosoma brucei	Peptide deformylase 2	0.0171	0.2104	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0439	0.1547
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0439	0.0606
Leishmania major	hypothetical protein, conserved	0.0042	0.0439	0.1315
Mycobacterium ulcerans	beta-lactamase	0.0042	0.0439	0.0586
Echinococcus multilocularis	muscleblind protein 1	0.0144	0.1754	0.1754
Echinococcus multilocularis	G protein signaling modulator 2	0.0014	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0187	0.066
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.0439	0.0606
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0045	0.0054
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0045	0.0054
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0045	0.016
Echinococcus multilocularis	survival motor neuron protein 1	0.0228	0.2839	0.2839
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0045	0.016
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0418	0.1474
Onchocerca volvulus		0.0042	0.0439	0.8803
Echinococcus granulosus	Niemann Pick C1 protein	0.0095	0.1119	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0045	0.016
Onchocerca volvulus		0.0042	0.0439	0.8803
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0171	0.2104	1
Onchocerca volvulus		0.0023	0.0187	0.3169
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0187	0.0134
Echinococcus granulosus	muscleblind protein	0.0144	0.1754	0.2065
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0045	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0045	0.016
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0045	0.016
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0493	0.0493
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0045	0.0054
Schistosoma mansoni	hypothetical protein	0.0047	0.0493	0.058
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0045	0.0045
Brugia malayi	beta-lactamase family protein	0.0042	0.0439	0.1547
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.0548	0.0645
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0045	0.016
Brugia malayi	CHE-14 protein	0.0041	0.0418	0.1474
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0042	0.0439	0.0586
Leishmania major	polypeptide deformylase-like protein, putative	0.0171	0.2104	1
Schistosoma mansoni	coup transcription factor	0.0012	0.0045	0.0054
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0045	0.016
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0187	0.066
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0045	0.0045
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0588	0.0692
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0187	0.066
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0045	0.0054
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0045	0.0054
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0187	0.0134
Schistosoma mansoni	hypothetical protein	0.0039	0.0399	0.047
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0045	0.016
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0439	0.1547
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1119	0.3941
Trichomonas vaginalis	esterase, putative	0.0042	0.0439	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0095	0.1119	0.1119
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0045	0.016
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0187	0.0155
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0045	0.0054
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0171	0.2104	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0439	0.0517
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0045	0.016
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.0449	0.569	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0113	0.0396
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0045	0.0054
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0045	0.0054
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0439	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0439	0.1547
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0051	0.0548	0.0548
Loa Loa (eye worm)	hypothetical protein	0.0228	0.2839	1
Echinococcus granulosus	G protein signaling modulator 2	0.0014	0.0075	0.0088
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.0449	0.569	0.5
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0187	0.0134

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 36 %	Sedative-hypnotic effect in mouse assessed as inhibition of locomotor activity at 100 mg/kg, ip by actophotometer	ChEMBL.	17418452
Inhibition (functional)	= 38 %	Antifungal activity against Candida albicans MTCC 227 assessed as inhibition of growth zone at 40 ug/ml after 2 to 3 days by cup-plate method relative to clotrimazole	ChEMBL.	No reference
Inhibition (functional)	= 46 %	Antibacterial activity against Escherichia coli MTCC 40 assessed as inhibition of growth zone at 20 ug/ml after 24 hr by cup-plate method relative to norfloxacin	ChEMBL.	No reference
MIC (functional)	= 10.82 ug ml-1	Antibacterial activity against Escherichia coli MTCC 40 after 24 hr by cup-plate method	ChEMBL.	No reference
MIC (functional)	= 22.63 ug ml-1	Antifungal activity against Candida albicans MTCC 227 after 2 to 3 days by cup-plate method	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL452781

Bibliographic References

No literature references available for this target.

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Detailed information for compound 956166