Detailed information for compound 977316

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 493.359 | Formula: C22H21BrN8O
  • H donors: 1 H acceptors: 4 LogP: 3.15 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc2c(c1)CCN(CC2)CCn1ncc2c1nc(N)n1c2nc(n1)c1ccco1
  • InChi: 1S/C22H21BrN8O/c23-16-4-3-14-5-7-29(8-6-15(14)12-16)9-10-30-20-17(13-25-30)21-26-19(18-2-1-11-32-18)28-31(21)22(24)27-20/h1-4,11-13H,5-10H2,(H2,24,27)
  • InChiKey: BYBYOCSOAACENO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A2a receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.0246 0.0965 0.0963
Schistosoma mansoni apoptosis regulator bax 0.0162 0.0538 0.0609
Brugia malayi SWIB/MDM2 domain containing protein 0.0076 0.0101 0.0108
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.01 0.0226 0.0241
Schistosoma mansoni opsin-like receptor 0.0246 0.0965 0.1094
Echinococcus multilocularis Tubulin beta 2C chain 0.0132 0.0389 0.0387
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0246 0.0965 0.1094
Echinococcus multilocularis neuropeptide s receptor 0.0781 0.3687 0.3686
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Schistosoma mansoni deoxyribonuclease II-related 0.0072 0.0083 0.0092
Echinococcus granulosus somatostatin receptor 0.0246 0.0965 0.0963
Schistosoma mansoni cercarial elastase (S01 family) 0.0058 0.0014 0.0014
Schistosoma mansoni histamine h1 receptor 0.0246 0.0965 0.1094
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0246 0.0965 0.0963
Brugia malayi G-protein coupled receptor 0.0246 0.0965 0.1038
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0063 0.0035 0.5
Schistosoma mansoni hypothetical protein 0.0076 0.0101 0.0114
Brugia malayi G protein-coupled receptor 0.0246 0.0965 0.1038
Schistosoma mansoni hypothetical protein 0.0111 0.0281 0.0318
Schistosoma mansoni hypothetical protein 0.0162 0.0538 0.0609
Echinococcus granulosus Tubulin beta 2C chain 0.0132 0.0389 0.0387
Onchocerca volvulus Protein ultraspiracle homolog 0.0056 0.0001 0.0004
Echinococcus granulosus biogenic amine 5HT receptor 0.0246 0.0965 0.0963
Brugia malayi Adenylyl cyclase protein 0.0058 0.0013 0.0012
Brugia malayi hypothetical protein 0.0246 0.0965 0.1038
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.2024 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 0.0538 0.0578
Echinococcus multilocularis SWI:SNF matrix associated 0.0076 0.0101 0.01
Echinococcus multilocularis rhodopsin orphan GPCR 0.0246 0.0965 0.0963
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.01 0.0226 0.0224
Loa Loa (eye worm) latrophilin receptor protein 2 0.0412 0.1811 0.1951
Onchocerca volvulus 0.0056 0.0001 0.0004
Schistosoma mansoni hypothetical protein 0.0076 0.0101 0.0114
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0797 0.3766 0.4276
Loa Loa (eye worm) BEN-1 protein 0.0132 0.0389 0.0417
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.0277 0.6528
Toxoplasma gondii PAN domain-containing protein 0.0077 0.0107 0.0068
Mycobacterium ulcerans heat shock protein 90 0.0063 0.0035 0.2051
Echinococcus multilocularis jun protein 0.0094 0.0195 0.0193
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Brugia malayi Calcitonin receptor-like protein seb-1 0.1265 0.6142 0.6619
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0246 0.0965 0.0963
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.011 0.0277 0.7125
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0122 0.0337 0.0336
Loa Loa (eye worm) hypothetical protein 0.0058 0.0014 0.0013
Brugia malayi PAN domain containing protein 0.0077 0.0107 0.0114
Onchocerca volvulus 0.0246 0.0965 0.2561
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0058 0.0014 0.0013
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0246 0.0965 0.0963
Schistosoma mansoni tubulin subunit beta 0.0132 0.0389 0.044
Echinococcus multilocularis neuroendocrine convertase 2 0.0091 0.0179 0.0177
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0058 0.0014 0.0012
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0192 0.0694 0.0693
Loa Loa (eye worm) trypsin family protein 0.0058 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Echinococcus multilocularis deoxyribonuclease ii 0.0072 0.0083 0.0081
Echinococcus multilocularis g-protein coupled receptor 0.0246 0.0965 0.0963
Echinococcus multilocularis Tubulin beta 2C chain 0.0132 0.0389 0.0387
Toxoplasma gondii microneme protein MIC4 0.0077 0.0107 0.0068
Echinococcus granulosus g protein coupled receptor 0.0246 0.0965 0.0963
Brugia malayi hypothetical protein 0.0074 0.0092 0.0098
Schistosoma mansoni serine-type protease inhibitor 0.1789 0.8804 1
Echinococcus granulosus nmda type glutamate receptor 0.0109 0.0273 0.0271
Brugia malayi putative neuropeptide receptor NPR1 0.0246 0.0965 0.1038
Schistosoma mansoni biogenic amine (5HT) receptor 0.0246 0.0965 0.1094
Schistosoma mansoni brg-1 associated factor 0.0076 0.0101 0.0114
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Echinococcus granulosus adenylate cyclase type IX 0.0082 0.0132 0.0131
Toxoplasma gondii PAN domain-containing protein 0.0077 0.0107 0.0068
Schistosoma mansoni hypothetical protein 0.0058 0.0014 0.0014
Onchocerca volvulus 0.0058 0.0013 0.0033
Onchocerca volvulus 0.0077 0.0107 0.0284
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.011 0.0277 0.3407
Echinococcus multilocularis neuropeptide receptor A26 0.0781 0.3687 0.3686
Echinococcus granulosus tm gpcr rhodopsin 0.0246 0.0965 0.0963
Echinococcus granulosus neuropeptide Y receptor 0.0246 0.0965 0.0963
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Loa Loa (eye worm) endoprotease bli-4 0.0145 0.0451 0.0485
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Schistosoma mansoni opsin-like receptor 0.0246 0.0965 0.1094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0246 0.0965 0.1094
Brugia malayi Trypsin family protein 0.0315 0.1318 0.1419
Loa Loa (eye worm) hypothetical protein 0.0315 0.1318 0.1419
Loa Loa (eye worm) apoptosis regulator protein 0.0162 0.0538 0.0578
Brugia malayi G protein-coupled receptor F59B2.13 0.0246 0.0965 0.1038
Echinococcus multilocularis sex peptide receptor 0.0246 0.0965 0.0963
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.0277 0.6528
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0094 0.0195 0.0193
Schistosoma mansoni hypothetical protein 0.0412 0.1811 0.2056
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Echinococcus granulosus heat shock protein 0.0069 0.0068 0.0067
Echinococcus multilocularis neuropeptides capa receptor 0.0246 0.0965 0.0963
Schistosoma mansoni furin-1 (S08 family) 0.0063 0.0036 0.004
Brugia malayi hypothetical protein 0.0246 0.0965 0.1038
Echinococcus multilocularis heat shock protein 90 0.0063 0.0035 0.0033
Brugia malayi Dopamine receptor 0.0246 0.0965 0.1038
Echinococcus multilocularis G protein coupled receptor 139 0.0246 0.0965 0.0963
Toxoplasma gondii microneme protein MIC17A 0.0077 0.0107 0.0068
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0088 0.0163 0.0162
Loa Loa (eye worm) hypothetical protein 0.0058 0.0014 0.0013
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Onchocerca volvulus 0.0246 0.0965 0.2561
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Echinococcus multilocularis enteropeptidase 0.0058 0.0014 0.0012
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.011 0.0277 0.7125
Brugia malayi Trypsin-like protease protein 5 0.0058 0.0014 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0246 0.0965 0.1094
Brugia malayi PAN domain containing protein 0.0077 0.0107 0.0114
Loa Loa (eye worm) hypothetical protein 0.0058 0.0014 0.0013
Schistosoma mansoni opsin-like receptor 0.0246 0.0965 0.1094
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Entamoeba histolytica protein kinase, putative 0.01 0.0226 0.4914
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0246 0.0965 0.1038
Schistosoma mansoni cercarial elastase (S01 family) 0.0058 0.0014 0.0014
Echinococcus granulosus neuropeptides capa receptor 0.0246 0.0965 0.0963
Echinococcus granulosus beta tubulin 0.0132 0.0389 0.0387
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.103 0.4948 0.4947
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0412 0.1811 0.181
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0076 0.0101 0.01
Brugia malayi PAN domain containing protein 0.0077 0.0107 0.0114
Echinococcus granulosus sodium channel protein 0.0203 0.0746 0.0745
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0076 0.0101 0.1045
Onchocerca volvulus 0.0246 0.0965 0.2561
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Brugia malayi Deoxyribonuclease II family protein 0.0072 0.0083 0.0087
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Toxoplasma gondii hypothetical protein 0.0077 0.0107 0.0068
Loa Loa (eye worm) hypothetical protein 0.0077 0.0107 0.0114
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0088 0.0163 0.3633
Echinococcus multilocularis g protein coupled receptor 0.0246 0.0965 0.0963
Echinococcus multilocularis Tubulin beta 2C chain 0.0132 0.0389 0.0387
Onchocerca volvulus 0.0058 0.0014 0.0036
Schistosoma mansoni neuropeptide receptor 0.0246 0.0965 0.1094
Toxoplasma gondii beta-tubulin, putative 0.0132 0.0389 0.0562
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0088 0.0163 0.3633
Brugia malayi RE15519p 0.0246 0.0965 0.1038
Schistosoma mansoni cercarial elastase (S01 family) 0.0058 0.0014 0.0014
Echinococcus granulosus fmrfamide receptor 0.0246 0.0965 0.0963
Echinococcus multilocularis neuropeptide receptor 0.0246 0.0965 0.0963
Trypanosoma brucei beta tubulin 0.0132 0.0389 1
Echinococcus granulosus heat shock protein 90 0.0069 0.0068 0.0067
Trypanosoma brucei beta tubulin 0.0132 0.0389 1
Onchocerca volvulus 0.0076 0.0101 0.0269
Loa Loa (eye worm) tubulin beta-1 chain 0.0132 0.0389 0.0417
Loa Loa (eye worm) TYRA-2 protein 0.0246 0.0965 0.1038
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0412 0.1811 0.1951
Loa Loa (eye worm) endoplasmin 0.0069 0.0068 0.0072
Trichomonas vaginalis deoxyribonuclease II precursor, putative 0.0072 0.0083 0.1351
Brugia malayi brahma associated protein 60 kDa 0.0076 0.0101 0.0108
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0246 0.0965 0.1038
Echinococcus granulosus rhodopsin orphan GPCR 0.0246 0.0965 0.0963
Echinococcus multilocularis fmrfamide receptor 0.0246 0.0965 0.0963
Echinococcus granulosus GPCR family 2 0.0412 0.1811 0.181
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0132 0.0389 0.0387
Plasmodium falciparum tubulin beta chain 0.0132 0.0389 1
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Toxoplasma gondii subtilisin SUB12 0.0083 0.0138 0.0123
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Onchocerca volvulus 0.0246 0.0965 0.2561
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.011 0.0277 0.6528
Echinococcus granulosus rhodopsin orphan GPCR 0.0246 0.0965 0.0963
Schistosoma mansoni biogenic amine receptor 0.0246 0.0965 0.1094
Loa Loa (eye worm) hypothetical protein 0.0797 0.3766 0.4057
Echinococcus multilocularis neuropeptides capa receptor 0.0246 0.0965 0.0963
Brugia malayi larval opioid receptor 0.0246 0.0965 0.1038
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0162 0.0538 0.0578
Echinococcus multilocularis beta tubulin 0.0132 0.0389 0.0387
Schistosoma mansoni heat shock protein 0.0069 0.0068 0.0076
Schistosoma mansoni alpha-1 adrenergic receptor 0.0246 0.0965 0.1094
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Echinococcus granulosus tubulin beta 4A class IVa 0.0132 0.0389 0.0387
Schistosoma mansoni serine-type protease inhibitor 0.1789 0.8804 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0246 0.0965 0.1094
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.0965 0.1038
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0246 0.0965 0.0963
Schistosoma mansoni neuropeptide receptor 0.0246 0.0965 0.1094
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.0694 0.0787
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Echinococcus granulosus neuropeptide receptor 0.0246 0.0965 0.0963
Brugia malayi G-protein coupled receptor 0.0246 0.0965 0.1038
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0246 0.0965 0.0963
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0246 0.0965 0.0963
Onchocerca volvulus 0.0246 0.0965 0.2561
Onchocerca volvulus 0.0246 0.0965 0.2561
Toxoplasma gondii microneme protein MIC17B 0.0077 0.0107 0.0068
Toxoplasma gondii PAN domain-containing protein 0.0077 0.0107 0.0068
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0058 0.0014 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0246 0.0965 0.1094
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Brugia malayi endoprotease bli-4 precursor 0.0145 0.0451 0.0485
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0076 0.0101 0.0108
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0246 0.0965 0.1038
Onchocerca volvulus 0.0074 0.0092 0.0244
Brugia malayi hypothetical protein 0.0246 0.0965 0.1038
Trypanosoma brucei RNA helicase, putative 0.0111 0.0281 0.6659
Echinococcus multilocularis tubulin subunit beta 0.0132 0.0389 0.0387
Entamoeba histolytica tubulin family protein 0.0132 0.0389 1
Brugia malayi AKH receptor 0.0246 0.0965 0.1038
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0246 0.0965 0.0963
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0246 0.0965 0.0963
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0192 0.0694 0.0693
Echinococcus granulosus beta tubulin 0.0132 0.0389 0.0387
Brugia malayi hypothetical protein 0.0246 0.0965 0.1038
Loa Loa (eye worm) hypothetical protein 0.0077 0.0107 0.0114
Brugia malayi Serotonin receptor 0.0246 0.0965 0.1038
Echinococcus granulosus heat shock protein 90 0.0063 0.0035 0.0033
Schistosoma mansoni amine GPCR 0.0246 0.0965 0.1094
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Onchocerca volvulus 0.0077 0.0107 0.0284
Echinococcus multilocularis g protein coupled receptor 0.0246 0.0965 0.0963
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0246 0.0965 0.0963
Schistosoma mansoni hypothetical protein 0.0412 0.1811 0.2056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0246 0.0965 0.0963
Loa Loa (eye worm) hypothetical protein 0.0465 0.2082 0.2242
Brugia malayi neuropeptide F receptor 0.0246 0.0965 0.1038
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Trypanosoma cruzi beta tubulin, putative 0.0132 0.0389 1
Echinococcus granulosus neuropeptide receptor A26 0.0781 0.3687 0.3686
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0076 0.0101 0.0059
Echinococcus multilocularis 0.0117 0.0309 0.0308
Echinococcus granulosus alpha 1A adrenergic receptor 0.0246 0.0965 0.0963
Brugia malayi PAN domain containing protein 0.0077 0.0107 0.0114
Echinococcus granulosus 7tm_1 domain containing protein 0.0246 0.0965 0.0963
Onchocerca volvulus 0.0058 0.0014 0.0036
Brugia malayi hypothetical protein 0.0246 0.0965 0.1038
Trichomonas vaginalis tubulin gamma chain, putative 0.0132 0.0389 1
Onchocerca volvulus 0.0077 0.0107 0.0284
Echinococcus multilocularis allatostatin A receptor 0.0797 0.3766 0.3765
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Onchocerca volvulus 0.0077 0.0107 0.0284
Loa Loa (eye worm) hypothetical protein 0.0145 0.0451 0.0485
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0246 0.0965 0.0963
Echinococcus granulosus neuropeptide receptor 0.0246 0.0965 0.0963
Schistosoma mansoni hypothetical protein 0.0162 0.0538 0.0609
Toxoplasma gondii hypothetical protein 0.0077 0.0107 0.0068
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0128 0.0367 0.0394
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0056 0.0001 0.0004
Echinococcus granulosus tm gpcr rhodopsin 0.0246 0.0965 0.0963
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Toxoplasma gondii PAN domain-containing protein 0.1193 0.5776 1
Echinococcus multilocularis adenylate cyclase type IX 0.0082 0.0132 0.0131
Toxoplasma gondii beta tubulin 0.0132 0.0389 0.0562
Schistosoma mansoni tubulin subunit beta 0.0132 0.0389 0.044
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0122 0.0337 0.0336
Echinococcus granulosus deoxyribonuclease ii 0.0072 0.0083 0.0081
Echinococcus multilocularis Tubulin beta 2C chain 0.0132 0.0389 0.0387
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0203 0.0746 0.0745
Trichomonas vaginalis tubulin, putative 0.0132 0.0389 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0058 0.0014 0.0014
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0246 0.0965 0.1038
Echinococcus granulosus Mastin 0.0058 0.0014 0.0012
Echinococcus multilocularis orexin receptor type 2 0.0246 0.0965 0.0963
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0058 0.0014 0.0012
Toxoplasma gondii PAN/Apple domain-containing protein 0.0077 0.0107 0.0068
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0145 0.0451 0.0511
Trichomonas vaginalis heat shock protein, putative 0.0069 0.0068 0.0936
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0226 0.0255
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Loa Loa (eye worm) neuropeptide F receptor 0.0246 0.0965 0.1038
Brugia malayi latrophilin 2 splice variant baaae 0.0853 0.4048 0.4362
Trypanosoma cruzi heat shock protein 85, putative 0.0063 0.0035 0.0865
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Echinococcus granulosus Tubulin beta 2C chain 0.0132 0.0389 0.0387
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Trypanosoma brucei calpain-like protein, putative 0.011 0.0277 0.6528
Brugia malayi PAN domain containing protein 0.0077 0.0107 0.0114
Onchocerca volvulus 0.0058 0.0014 0.0036
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0259 0.1033 0.1031
Schistosoma mansoni growth hormone secretagogue receptor 0.0246 0.0965 0.1094
Brugia malayi phosphoinositide-dependent protein kinase I 0.01 0.0226 0.0241
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Loa Loa (eye worm) hypothetical protein 0.0077 0.0107 0.0114
Onchocerca volvulus 0.0077 0.0107 0.0284
Schistosoma mansoni neuropeptide f receptor 76f 0.0246 0.0965 0.1094
Schistosoma mansoni cercarial elastase (S01 family) 0.0058 0.0014 0.0014
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0076 0.0101 0.0059
Schistosoma mansoni tubulin subunit beta 0.0132 0.0389 0.044
Schistosoma mansoni neuropeptide F-like receptor 0.0246 0.0965 0.1094
Echinococcus multilocularis somatostatin receptor 0.0246 0.0965 0.0963
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0147 0.0464 0.0463
Toxoplasma gondii microneme protein, putative 0.0077 0.0107 0.0068
Brugia malayi Transforming growth factor beta like domain containing protein 0.0122 0.0337 0.0362
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0315 0.1318 0.1495
Brugia malayi Deoxyribonuclease II family protein 0.0072 0.0083 0.0087
Schistosoma mansoni hypothetical protein 0.0412 0.1811 0.2056
Brugia malayi Endoplasmin precursor 0.0069 0.0068 0.0072
Entamoeba histolytica tubulin family protein 0.0132 0.0389 1
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Echinococcus granulosus glutamate NMDA receptor subunit 0.0259 0.1033 0.1031
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0079 0.0117 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0058 0.0014 0.0014
Trypanosoma cruzi calpain cysteine peptidase, putative 0.011 0.0277 0.7125
Echinococcus granulosus neuropeptide FF receptor 2 0.0465 0.2082 0.2081
Onchocerca volvulus 0.0077 0.0107 0.0284
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0058 0.0014 0.0012
Brugia malayi follicle stimulating hormone receptor 0.0246 0.0965 0.1038
Echinococcus multilocularis fmrfamide receptor 0.0246 0.0965 0.0963
Onchocerca volvulus Neuropeptide F receptor homolog 0.0246 0.0965 0.2561
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0246 0.0965 0.0963
Loa Loa (eye worm) beta-tubulin 0.0132 0.0389 0.0417
Schistosoma mansoni tubulin subunit beta 0.0132 0.0389 0.044
Toxoplasma gondii beta-1 tubulin, putative 0.0132 0.0389 0.0562
Echinococcus granulosus neuroendocrine convertase 2 0.0091 0.0179 0.0177
Loa Loa (eye worm) PAN domain-containing protein 0.0077 0.0107 0.0114
Loa Loa (eye worm) hypothetical protein 0.0159 0.0524 0.0563
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0088 0.0163 0.0162
Brugia malayi neuroendocrine convertase 1 precursor 0.0091 0.0179 0.0191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0246 0.0965 0.1094
Loa Loa (eye worm) hypothetical protein 0.0077 0.0107 0.0114
Schistosoma mansoni hypothetical protein 0.0853 0.4048 0.4597
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0079 0.0117 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0246 0.0965 0.0963
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Brugia malayi hypothetical protein 0.0246 0.0965 0.1038
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Echinococcus granulosus neuropeptide s receptor 0.0781 0.3687 0.3686
Echinococcus multilocularis SWI:SNF matrix associated 0.0076 0.0101 0.01
Echinococcus multilocularis transmembrane protease serine 3 0.0058 0.0014 0.0012
Trypanosoma brucei beta tubulin 0.0132 0.0389 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0246 0.0965 0.1094
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0246 0.0965 0.1094
Schistosoma mansoni endoplasmin 0.0069 0.0068 0.0076
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0246 0.0965 0.2561
Schistosoma mansoni amine GPCR 0.0246 0.0965 0.1094
Loa Loa (eye worm) melatonin receptor type 1A 0.0246 0.0965 0.1038
Echinococcus granulosus orexin receptor type 2 0.0246 0.0965 0.0963
Echinococcus granulosus tachykinin peptides receptor 99D 0.0531 0.2416 0.2415
Brugia malayi Trypsin family protein 0.0058 0.0014 0.0013
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Onchocerca volvulus 0.0077 0.0107 0.0284
Echinococcus multilocularis heat shock protein 90 0.0069 0.0068 0.0067
Brugia malayi PAN domain containing protein 0.0077 0.0107 0.0114
Schistosoma mansoni hypothetical protein 0.0246 0.0965 0.1094
Echinococcus granulosus biogenic amine 5HT receptor 0.0246 0.0965 0.0963
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0246 0.0965 0.1094
Echinococcus granulosus g protein coupled receptor 0.0246 0.0965 0.0963
Loa Loa (eye worm) brahma associated protein 0.0076 0.0101 0.0108
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Schistosoma mansoni hypothetical protein 0.0058 0.0014 0.0014
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.011 0.0277 0.7125
Onchocerca volvulus 0.0246 0.0965 0.2561
Trypanosoma cruzi heat shock protein 90, putative 0.0063 0.0035 0.0865
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0246 0.0965 0.1094
Plasmodium vivax tubulin beta chain, putative 0.0132 0.0389 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0076 0.0101 0.1045
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0246 0.0965 0.1038
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Loa Loa (eye worm) hypothetical protein 0.0091 0.0181 0.0194
Echinococcus granulosus glycoprotein Antigen 5 0.0058 0.0014 0.0012
Brugia malayi Tubulin beta-1 chain 0.0132 0.0389 0.0417
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0246 0.0965 0.1038
Echinococcus multilocularis dro:myosuppressin receptor 0.0246 0.0965 0.0963
Schistosoma mansoni cercarial elastase (S01 family) 0.0058 0.0014 0.0014
Loa Loa (eye worm) neuropeptide F receptor 0.0246 0.0965 0.1038
Onchocerca volvulus 0.0077 0.0107 0.0284
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Echinococcus multilocularis g protein coupled receptor 0.0246 0.0965 0.0963
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0063 0.0035 0.0033
Trichomonas vaginalis tubulin beta chain, putative 0.0132 0.0389 1
Loa Loa (eye worm) hypothetical protein 0.1882 0.9279 1
Echinococcus granulosus Tubulin beta 2C chain 0.0132 0.0389 0.0387
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.011 0.0277 0.7125
Onchocerca volvulus 0.0077 0.0107 0.0284
Loa Loa (eye worm) hypothetical protein 0.0077 0.0107 0.0114
Brugia malayi Latrophilin receptor protein 2 0.0412 0.1811 0.1951
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Brugia malayi Dopamine receptor protein 1 0.0246 0.0965 0.1038
Loa Loa (eye worm) PAN domain-containing protein 0.0077 0.0107 0.0114
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0246 0.0965 0.1094
Echinococcus multilocularis serotonin receptor 0.0246 0.0965 0.0963
Schistosoma mansoni amine GPCR 0.0246 0.0965 0.1094
Loa Loa (eye worm) heat shock protein 90 0.0069 0.0068 0.0072
Loa Loa (eye worm) G-protein coupled receptor 0.0246 0.0965 0.1038
Echinococcus granulosus rhodopsin orphan GPCR 0.0246 0.0965 0.0963
Echinococcus granulosus neuropeptide Y receptor 0.0246 0.0965 0.0963
Trichomonas vaginalis tubulin epsilon chain, putative 0.0132 0.0389 1
Brugia malayi putative neuropeptide receptor 0.0246 0.0965 0.1038
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0246 0.0965 0.1094
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0246 0.0965 0.0963
Loa Loa (eye worm) hypothetical protein 0.0315 0.1318 0.1419
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.01 0.0226 0.0241
Onchocerca volvulus 0.0058 0.0014 0.0036
Brugia malayi Serotonin receptor 0.0246 0.0965 0.1038
Schistosoma mansoni glutamate receptor NMDA 0.0259 0.1033 0.1171
Echinococcus multilocularis neuropeptide receptor 0.0246 0.0965 0.0963
Schistosoma mansoni protein kinase 0.0147 0.0464 0.0526
Brugia malayi PAN domain containing protein 0.0077 0.0107 0.0114
Echinococcus granulosus rhodopsin orphan GPCR 0.0246 0.0965 0.0963
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0162 0.0538 0.0537
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.01 0.0226 0.0224
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0531 0.2416 0.2415
Echinococcus multilocularis serotonin receptor 0.0246 0.0965 0.0963
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0063 0.0035 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0246 0.0965 0.0963
Echinococcus multilocularis neuropeptide Y receptor 0.0246 0.0965 0.0963
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Echinococcus granulosus hypothetical protein 0.0246 0.0965 0.0963
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Echinococcus granulosus dro:myosuppressin receptor 0.0246 0.0965 0.0963
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0246 0.0965 0.1094
Echinococcus granulosus rhodopsin orphan GPCR 0.0246 0.0965 0.0963
Loa Loa (eye worm) tubulin beta chain 0.0132 0.0389 0.0417
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Echinococcus multilocularis glycoprotein Antigen 5 0.0058 0.0014 0.0012
Echinococcus granulosus SWI:SNF matrix associated 0.0076 0.0101 0.01
Echinococcus granulosus serotonin receptor 0.0246 0.0965 0.0963
Onchocerca volvulus Bile acid receptor homolog 0.0056 0.0001 0.0004
Onchocerca volvulus 0.0077 0.0107 0.0284
Trichomonas vaginalis AGC family protein kinase 0.01 0.0226 0.539
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Trichomonas vaginalis DNAse2-prov protein, putative 0.0072 0.0083 0.1351
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Brugia malayi bZIP transcription factor family protein 0.0094 0.0195 0.0208
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Echinococcus granulosus Tubulin beta 2C chain 0.0132 0.0389 0.0387
Echinococcus granulosus endoplasmin 0.0063 0.0035 0.0033
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0246 0.0965 0.1094
Echinococcus multilocularis tubulin beta 1 chain 0.0132 0.0389 0.0387
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0162 0.0538 0.0537
Echinococcus multilocularis SWI:SNF matrix associated 0.0076 0.0101 0.01
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0058 0.0014 0.0014
Trypanosoma cruzi heat shock protein 85, putative 0.0069 0.0068 0.172
Schistosoma mansoni cercarial elastase (S01 family) 0.0058 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0246 0.0965 0.0963
Onchocerca volvulus 0.0246 0.0965 0.2561
Schistosoma mansoni neuropeptide F-like receptor 0.0246 0.0965 0.1094
Brugia malayi PAN domain containing protein 0.0077 0.0107 0.0114
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0147 0.0464 0.0463
Brugia malayi hypothetical protein 0.0246 0.0965 0.1038
Brugia malayi hypothetical protein 0.0246 0.0965 0.1038
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0128 0.0367 0.0394
Echinococcus granulosus tubulin beta 1 chain 0.0132 0.0389 0.0387
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Loa Loa (eye worm) PAN domain-containing protein 0.0077 0.0107 0.0114
Trypanosoma cruzi heat shock protein 90, putative 0.0069 0.0068 0.172
Onchocerca volvulus 0.0246 0.0965 0.2561
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0246 0.0965 0.1094
Loa Loa (eye worm) hypothetical protein 0.0412 0.1811 0.1951
Schistosoma mansoni jun-related protein 0.0076 0.0105 0.0118
Brugia malayi hypothetical protein 0.0246 0.0965 0.1038
Echinococcus granulosus Tubulin beta 2C chain 0.0132 0.0389 0.0387
Loa Loa (eye worm) PAN domain-containing protein 0.0077 0.0107 0.0114
Echinococcus granulosus peptide allatostatin:somatostatin 0.0246 0.0965 0.0963
Loa Loa (eye worm) hypothetical protein 0.0077 0.0107 0.0114
Echinococcus granulosus neuropeptides capa receptor 0.0246 0.0965 0.0963
Echinococcus granulosus 7TM GPCR rhodopsin 0.0246 0.0965 0.0963
Echinococcus multilocularis neuropeptide FF receptor 2 0.0465 0.2082 0.2081
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0079 0.0117 1
Onchocerca volvulus 0.0058 0.0014 0.0036
Trichomonas vaginalis AGC family protein kinase 0.01 0.0226 0.539
Echinococcus multilocularis rhodopsin orphan GPCR 0.0246 0.0965 0.0963
Echinococcus multilocularis GPCR, family 2 0.0412 0.1811 0.181
Echinococcus multilocularis G-protein coupled receptor, putative 0.0246 0.0965 0.0963
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0412 0.1811 0.181
Schistosoma mansoni neuropeptide receptor 0.0246 0.0965 0.1094
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0101 0.1883
Loa Loa (eye worm) deoxyribonuclease II family protein 0.0072 0.0083 0.0087
Brugia malayi hypothetical protein 0.0246 0.0965 0.1038
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0161 0.0536 0.1424
Schistosoma mansoni amine GPCR 0.0246 0.0965 0.1094
Schistosoma mansoni myosin xvIII 0.0246 0.0965 0.1094
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0246 0.0965 0.0963
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0076 0.0101 0.1045
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0058 0.0014 0.0012
Schistosoma mansoni endoplasmin 0.0069 0.0068 0.0076
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0094 0.0195 0.0193
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.103 0.4948 0.4947
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0101 0.1045
Schistosoma mansoni neuropeptide receptor 0.0246 0.0965 0.1094
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Onchocerca volvulus 0.0315 0.1318 0.3499
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0246 0.0965 0.1094
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0246 0.0965 0.1094
Loa Loa (eye worm) hypothetical protein 0.0057 0.0005 0.0004
Echinococcus granulosus tm gpcr rhodopsin 0.0246 0.0965 0.0963
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0192 0.0694 0.0747
Brugia malayi PAN domain containing protein 0.0077 0.0107 0.0114
Onchocerca volvulus 0.0246 0.0965 0.2561
Brugia malayi Dopamine receptor protein 2 0.0246 0.0965 0.1038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0246 0.0965 0.1094
Brugia malayi Protein kinase domain containing protein 0.01 0.0226 0.0241
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0246 0.0965 0.0963
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0315 0.1318 0.1495
Brugia malayi Tachykinin-like peptides receptor 99D 0.0465 0.2082 0.2242
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0058 0.0014 0.0014
Onchocerca volvulus 0.0246 0.0965 0.2561
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0077 0.0107 0.0068
Echinococcus multilocularis heat shock protein 0.0069 0.0068 0.0067
Loa Loa (eye worm) adenylyl cyclase 3 0.0137 0.0415 0.0446
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0246 0.0965 0.1038
Onchocerca volvulus 0.0077 0.0107 0.0284
Brugia malayi brahma associated protein 60 kDa 0.0076 0.0101 0.0108
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Echinococcus multilocularis Mastin 0.0058 0.0014 0.0012
Schistosoma mansoni hypothetical protein 0.0246 0.0965 0.1094
Brugia malayi hypothetical protein 0.0058 0.0014 0.0013
Trypanosoma cruzi heat shock protein 85, putative 0.0069 0.0068 0.172
Echinococcus granulosus transmembrane protease serine 3 0.0058 0.0014 0.0012
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Onchocerca volvulus 0.0246 0.0965 0.2561
Brugia malayi heat shock protein 90 0.0069 0.0068 0.0072
Onchocerca volvulus 0.0257 0.1021 0.2711
Schistosoma mansoni hypothetical protein 0.0246 0.0965 0.1094
Onchocerca volvulus 0.0246 0.0965 0.2561
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.011 0.0277 0.6528
Schistosoma mansoni cercarial elastase (S01 family) 0.0058 0.0014 0.0014
Brugia malayi PAN domain containing protein 0.0077 0.0107 0.0114
Brugia malayi proprotein convertase 2 0.0091 0.0179 0.0191
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Loa Loa (eye worm) hypothetical protein 0.0058 0.0013 0.0012
Trypanosoma brucei calpain, putative 0.011 0.0277 0.6528
Trichomonas vaginalis tubulin alpha chain, putative 0.0132 0.0389 1
Echinococcus multilocularis beta tubulin 0.0132 0.0389 0.0387
Trypanosoma brucei hypothetical protein 0.011 0.0277 0.6528
Schistosoma mansoni hypothetical protein 0.0412 0.1811 0.2056
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Schistosoma mansoni hypothetical protein 0.0076 0.0101 0.0114
Echinococcus multilocularis sodium channel protein 0.0203 0.0746 0.0745
Loa Loa (eye worm) tubulin beta-4 chain 0.0132 0.0389 0.0417
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0246 0.0965 0.1094
Schistosoma mansoni tubulin subunit beta 0.0132 0.0389 0.044
Schistosoma mansoni biogenic amine receptor 0.0246 0.0965 0.1094
Echinococcus granulosus enteropeptidase 0.0058 0.0014 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0246 0.0965 0.0963
Brugia malayi neuropeptide F receptor 0.0246 0.0965 0.1038
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0162 0.0538 0.0609
Loa Loa (eye worm) bone morphogenic protein 6 0.0122 0.0337 0.0362
Echinococcus granulosus adenylate cyclase 9 0.0058 0.0013 0.0011
Trichomonas vaginalis AGC family protein kinase 0.01 0.0226 0.539
Schistosoma mansoni cercarial elastase (S01 family) 0.0058 0.0014 0.0014
Loa Loa (eye worm) tubulin beta-2A chain 0.0132 0.0389 0.0417
Schistosoma mansoni hypothetical protein 0.0076 0.0105 0.0118
Schistosoma mansoni cercarial elastase (S01 family) 0.0058 0.0014 0.0014
Schistosoma mansoni biogenic amine receptor 0.0246 0.0965 0.1094
Giardia lamblia Beta tubulin 0.0132 0.0389 1
Echinococcus granulosus G protein coupled receptor 139 0.0246 0.0965 0.0963
Schistosoma mansoni adenoreceptor 0.0246 0.0965 0.1094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1265 0.6142 0.6619
Schistosoma mansoni cercarial elastase (S01 family) 0.0058 0.0014 0.0014
Loa Loa (eye worm) G-protein coupled receptor 0.0246 0.0965 0.1038
Onchocerca volvulus 0.0246 0.0965 0.2561
Brugia malayi Trypsin family protein 0.0058 0.0014 0.0013
Brugia malayi celfurPC protein 0.0117 0.0309 0.0332
Brugia malayi Trypsin family protein 0.0058 0.0014 0.0013
Loa Loa (eye worm) deoxyribonuclease II family protein 0.0072 0.0083 0.0087
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.011 0.0277 0.3407
Echinococcus granulosus jun protein 0.0094 0.0195 0.0193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0246 0.0965 0.1094
Brugia malayi sulfakinin receptor protein 0.0246 0.0965 0.1038
Giardia lamblia Heat shock protein HSP 90-alpha 0.0069 0.0068 0.0936
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0246 0.0965 0.1038
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Schistosoma mansoni amine GPCR 0.0246 0.0965 0.1094
Trypanosoma cruzi Heat shock protein 83, putative 0.0069 0.0068 0.172
Brugia malayi Melatonin receptor type 1A 0.0246 0.0965 0.1038
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0246 0.0965 0.1094
Loa Loa (eye worm) BEN-1 protein 0.0132 0.0389 0.0417
Echinococcus granulosus g protein coupled receptor 0.0246 0.0965 0.0963
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0079 0.0117 1
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.0277 0.6528
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0079 0.0117 1
Onchocerca volvulus 0.0246 0.0965 0.2561
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0058 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Trichomonas vaginalis deoxyribonuclease II, putative 0.0072 0.0083 0.1351
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0058 0.0014 0.0014
Giardia lamblia Beta tubulin 0.0132 0.0389 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.0277 0.6528
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0203 0.0746 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0246 0.0965 0.0963
Chlamydia trachomatis glutamine binding protein 0.0079 0.0117 1
Brugia malayi map kinase activated protein kinase protein 2 0.0192 0.0694 0.0747
Schistosoma mansoni hypothetical protein 0.0162 0.0538 0.0609
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.0277 0.6528
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Giardia lamblia Beta tubulin 0.0132 0.0389 1
Onchocerca volvulus 0.0246 0.0965 0.2561
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Loa Loa (eye worm) hypothetical protein 0.0058 0.0014 0.0013
Echinococcus granulosus sex peptide receptor 0.0246 0.0965 0.0963
Loa Loa (eye worm) hypothetical protein 0.0077 0.0107 0.0114
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Brugia malayi beta-tubulin, identical 0.0132 0.0389 0.0417
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Loa Loa (eye worm) hypothetical protein 0.0058 0.0014 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0246 0.0965 0.0963
Echinococcus granulosus g-protein coupled receptor 0.0246 0.0965 0.0963
Brugia malayi GnHR receptor homolog 0.0246 0.0965 0.1038
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1882 0.9279 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0132 0.0389 1
Toxoplasma gondii PAN domain-containing protein 0.0077 0.0107 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.0246 0.0965 0.0963
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0109 0.0273 0.0271
Echinococcus multilocularis neuropeptide Y receptor 0.0246 0.0965 0.0963
Echinococcus multilocularis endoplasmin 0.0063 0.0035 0.0033
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Echinococcus granulosus allatostatin A receptor 0.0797 0.3766 0.3765
Echinococcus granulosus tubulin subunit beta 0.0132 0.0389 0.0387
Toxoplasma gondii microneme protein MIC17C 0.0077 0.0107 0.0068
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0246 0.0965 0.0963
Schistosoma mansoni protein kinase 0.0147 0.0464 0.0526
Leishmania major heat shock protein 83-1 0.0069 0.0068 0.0465
Schistosoma mansoni biogenic amine (5HT) receptor 0.0246 0.0965 0.1094
Schistosoma mansoni protein kinase 0.0147 0.0464 0.0526
Loa Loa (eye worm) hypothetical protein 0.0853 0.4048 0.4362
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0076 0.0101 0.01
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0246 0.0965 0.1038
Echinococcus granulosus rhodopsin orphan GPCR 0.0246 0.0965 0.0963
Schistosoma mansoni tubulin subunit beta 0.0132 0.0389 0.044
Trypanosoma brucei beta tubulin 0.0132 0.0389 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0246 0.0965 0.0963
Echinococcus multilocularis adenylate cyclase 9 0.0058 0.0013 0.0011
Onchocerca volvulus 0.0797 0.3766 1
Brugia malayi ORL1-like opioid receptor 0.0246 0.0965 0.1038
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Echinococcus multilocularis nmda type glutamate receptor 0.0109 0.0273 0.0271
Trypanosoma cruzi heat shock protein 85, putative 0.0069 0.0068 0.172
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.011 0.0277 0.3407
Leishmania major beta tubulin 0.0132 0.0389 0.4972
Schistosoma mansoni heat shock protein 0.0069 0.0068 0.0076
Echinococcus granulosus furin 0.0145 0.0451 0.045
Toxoplasma gondii PAN domain-containing protein 0.1193 0.5776 1
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0058 0.0013 0.0033
Loa Loa (eye worm) PAN domain-containing protein 0.0077 0.0107 0.0114
Echinococcus multilocularis Tubulin beta 2C chain 0.0132 0.0389 0.0387
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Schistosoma mansoni hypothetical protein 0.0246 0.0965 0.1094
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Loa Loa (eye worm) hypothetical protein 0.0246 0.0965 0.1038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0246 0.0965 0.0963

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 1.1 nM Antagonist activity at human adenosine A2A receptor ChEMBL. 18558486

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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