TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 273.35 | Formula: C15H15NO2S
H donors: 1 H acceptors: 2 LogP: 3.42 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccc(c2c1[nH]c1c2cccc1)S(=O)(=O)C
InChi: 1S/C15H15NO2S/c1-3-10-8-9-13(19(2,17)18)14-11-6-4-5-7-12(11)16-15(10)14/h4-9,16H,3H2,1-2H3
InChiKey: LIGSBFUNSYSFNL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0046	0.0829	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0046	0.0829	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0046	0.0829	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0229	0.0396
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0046	0.0829	1
Leishmania major	cathepsin L-like protease	0.0046	0.0829	0.0829
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0868	0.1419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0046	0.0829	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0031	0.0303	0.0256
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0868	0.1504
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0868	0.1419
Leishmania major	cathepsin L-like protease	0.0046	0.0829	0.0829
Schistosoma mansoni	organic anion transporter	0.0029	0.0229	0.03
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0303	0.0525
Brugia malayi	prolyl oligopeptidase family protein	0.0063	0.1433	0.2485
Onchocerca volvulus		0.0029	0.0229	0.0396
Plasmodium vivax	vivapain-1	0.0024	0.0057	0.0115
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0046	0.0829	1
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0057	0.069
Schistosoma mansoni	cathepsin F (C01 family)	0.0046	0.0829	0.1351
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0046	0.0829	0.0784
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0057	0.069
Onchocerca volvulus	Putative organic anion transporter	0.0029	0.0229	0.0396
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0046	0.0829	0.1351
Loa Loa (eye worm)	fibroinase	0.0046	0.0829	0.1437
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0053	0.1082	0.1039
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0153	0.454	0.7872
Plasmodium vivax	vivapain-2	0.0046	0.0829	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0046	0.0829	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0046	0.0829	0.0784
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0868	0.1419
Onchocerca volvulus	Cathepsin L homolog	0.0046	0.0829	0.1437
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0229	0.0396
Brugia malayi	Cathepsin L-like precursor	0.0046	0.0829	0.1437
Onchocerca volvulus		0.0046	0.0829	0.1437
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0031	0.0303	0.0525
Schistosoma mansoni	organic anion transporter	0.0029	0.0229	0.03
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0029	0.0229	0.03
Onchocerca volvulus		0.0029	0.0229	0.0396
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0038	0.0554	0.1129
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0554	0.0508
Leishmania major	cathepsin L-like protease	0.0046	0.0829	0.0829
Leishmania major	hypothetical protein, conserved	0.0023	0.0048	0.0048
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0044	0.0756	0.9074
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0044	0.0751	0.0706
Onchocerca volvulus		0.0046	0.0829	0.1437
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0554	0.0554
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0044	0.0751	0.0706
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0057	0.069
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0057	0.069
Entamoeba histolytica	hypothetical protein	0.0033	0.0395	0.4762
Entamoeba histolytica	hypothetical protein	0.0033	0.0395	0.4762
Schistosoma mansoni	cathepsin F (C01 family)	0.0046	0.0829	0.1351
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.031	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0046	0.0829	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0229	0.0396
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.031	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0046	0.0829	1
Echinococcus granulosus	cathepsin l1	0.0046	0.0829	0.1351
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0029	0.0229	0.0396
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0063	0.1433	0.2409
Onchocerca volvulus		0.0029	0.0229	0.0396
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0829	0.1437
Brugia malayi	cathepsin L-like precursor	0.0031	0.0303	0.0525
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0044	0.0756	0.1224
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0044	0.0756	0.1064
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0147	0.4331	0.4331
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0046	0.0829	0.0784
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0033	0.0395	0.0591
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0024	0.0057	0.0115
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0046	0.0829	0.1351
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0057	0.069
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0057	0.069
Trypanosoma cruzi	cysteine peptidase, putative	0.0046	0.0829	0.0784
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0046	0.0829	0.0784
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0046	0.0829	1
Onchocerca volvulus		0.0029	0.0229	0.0396
Loa Loa (eye worm)	cysteine protease	0.0046	0.0829	0.1437
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0048	0.0084
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0033	0.0395	0.0591
Mycobacterium ulcerans	hypothetical protein	0.0163	0.4906	1
Leishmania major	cathepsin L-like protease	0.0046	0.0829	0.0829
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0554	0.0508
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0046	0.0829	1
Trypanosoma cruzi	MFS transporter, putative	0.0029	0.0229	0.0181
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0147	0.4331	0.4304
Brugia malayi	hypothetical protein	0.0048	0.0915	0.1587
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0915	0.1587
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0188	0.5768	1
Toxoplasma gondii	cathepsin CPL	0.0046	0.0829	0.1173
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0057	0.069
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0046	0.0829	0.1351
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0034	0.0416	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0046	0.0829	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0046	0.0829	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0046	0.0829	0.0784
Brugia malayi	prostaglandin transporter	0.0029	0.0229	0.0396
Onchocerca volvulus		0.0046	0.0829	0.1437
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0554	0.6436
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0057	0.069
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0046	0.0829	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0046	0.0829	0.1351
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0554	0.6436
Loa Loa (eye worm)	acetyltransferase	0.0149	0.4403	0.7633
Toxoplasma gondii	transporter, major facilitator family protein	0.0029	0.0229	0.0271
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0046	0.0829	0.0784
Trypanosoma cruzi	cysteine peptidase, putative	0.0046	0.0829	0.0784
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0188	0.5768	1
Brugia malayi	Inositol-1	0.0038	0.0554	0.096
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0057	0.069
Entamoeba histolytica	cysteine proteinase, putative	0.0046	0.0829	1
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0303	0.0525
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0034	0.0416	0.0847
Entamoeba histolytica	cysteine proteinase 1, putative	0.0024	0.0057	0.069
Brugia malayi	Papain family cysteine protease containing protein	0.0024	0.0057	0.0099
Brugia malayi	hypothetical protein	0.0033	0.0395	0.0684
Brugia malayi	prolyl oligopeptidase family protein	0.0188	0.5768	1
Brugia malayi	Cathepsin L-like precursor	0.0046	0.0829	0.1437
Trypanosoma cruzi	cysteine proteinase, putative	0.0024	0.0057	0.0009
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0145	0.4258	0.7356
Entamoeba histolytica	cysteine protease, putative	0.0046	0.0829	1
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0057	0.069
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0044	0.0756	0.1064
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0.063	0.5
Onchocerca volvulus		0.0046	0.0829	0.1437
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0046	0.0829	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0024	0.0057	0.0009
Loa Loa (eye worm)	prolyl oligopeptidase	0.0188	0.5768	1
Schistosoma mansoni	transcription factor LCR-F1	0.0033	0.0395	0.0591
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0063	0.1433	0.1392
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0751	0.0706
Onchocerca volvulus	Cathepsin L homolog	0.0046	0.0829	0.1437
Onchocerca volvulus	Putative organic anion transporter	0.0029	0.0229	0.0396
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0046	0.0829	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0046	0.0829	0.0784
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0046	0.0829	1
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0188	0.5768	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0046	0.0829	1
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0057	0.069
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0044	0.0756	0.9064
Brugia malayi	Papain family cysteine protease containing protein	0.0024	0.0057	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0303	0.3182
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0024	0.0057	0.0009
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0029	0.0229	0.03
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0149	0.4403	0.7609
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0046	0.0829	1
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0057	0.069
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0046	0.0829	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0046	0.0829	0.1437
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0038	0.0554	0.6682
Brugia malayi	Cathepsin L-like precursor	0.0046	0.0829	0.1437
Brugia malayi	sodium-independent organic anion transporter family protein	0.0029	0.0229	0.0396
Onchocerca volvulus		0.0046	0.0829	0.1437
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0554	0.087
Brugia malayi	sodium-independent organic anion transporter family protein	0.0029	0.0229	0.0396
Brugia malayi	Cathepsin L-like precursor	0.0046	0.0829	0.1437
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0063	0.1433	0.2409
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0057	0.069
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0063	0.1433	0.2081
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0057	0.069
Leishmania major	cathepsin L-like protease	0.0046	0.0829	0.0829
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0046	0.0829	1
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0063	0.1433	0.1392
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0046	0.0829	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0024	0.0057	0.0009
Entamoeba histolytica	hypothetical protein	0.0033	0.0395	0.4762
Echinococcus multilocularis	cysteine protease	0.0046	0.0829	0.1351
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0149	0.4403	0.7609
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0303	0.0525
Echinococcus multilocularis	cysteine protease	0.0046	0.0829	0.1351
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0229	0.0396
Loa Loa (eye worm)	inositol-1	0.0038	0.0554	0.096
Plasmodium vivax	vivapain-3	0.0024	0.0057	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0229	0.0396
Echinococcus granulosus	cathepsin l1	0.0031	0.0303	0.043
Trypanosoma cruzi	cruzipain precursor, putative	0.0046	0.0829	0.0784
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0057	0.069
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.031	1	1
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0188	0.5768	1
Brugia malayi	Cathepsin L-like precursor	0.0046	0.0829	0.1437
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0303	0.0525
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0868	0.1419
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0063	0.1433	0.1392
Onchocerca volvulus		0.0046	0.0829	0.1437
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0868	0.1419
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0147	0.4331	0.4304
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0046	0.0829	0.0784
Brugia malayi	acetyltransferase, GNAT family protein	0.0149	0.4403	0.7633
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0029	0.0229	0.03
Loa Loa (eye worm)	ctsf protein	0.0046	0.0829	0.1437
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0751	0.0706
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0303	0.3652
Trypanosoma cruzi	cysteine protease, putative	0.0024	0.0057	0.0009
Brugia malayi	hypothetical protein	0.0029	0.0229	0.0396
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0063	0.1433	0.2409
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0046	0.0829	0.0784
Entamoeba histolytica	cysteine proteinase 2	0.0024	0.0057	0.069
Leishmania major	cathepsin L-like protease	0.0046	0.0829	0.0829
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0554	0.0508
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0554	0.087
Trichomonas vaginalis	inositol monophosphatase, putative	0.0038	0.0554	0.6436
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0868	0.1504
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0046	0.0829	1
Onchocerca volvulus	Cathepsin F homolog	0.0046	0.0829	0.1437
Schistosoma mansoni	cathepsin F (C01 family)	0.0031	0.0303	0.043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0046	0.0829	1
Onchocerca volvulus		0.0031	0.0303	0.0525
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0038	0.0554	0.076
Leishmania major	cathepsin L-like protease	0.0046	0.0829	0.0829
Echinococcus multilocularis	cathepsin L cysteine protease	0.0046	0.0829	0.1351
Entamoeba histolytica	hypothetical protein	0.0033	0.0395	0.4762
Loa Loa (eye worm)	STAT protein	0.0153	0.454	0.7872
Trypanosoma cruzi	cysteine peptidase, putative	0.0046	0.0829	0.0784
Leishmania major	cathepsin L-like protease	0.0046	0.0829	0.0829
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0024	0.0057	0.0009
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0046	0.0829	0.1351
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0046	0.0829	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0038	0.0554	0.087
Schistosoma mansoni	hypothetical protein	0.0033	0.0395	0.0591
Brugia malayi	Cathepsin L-like precursor	0.0046	0.0829	0.1437
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0038	0.0554	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0303	0.0525
Brugia malayi	hypothetical protein	0.0029	0.0229	0.0396
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0303	0.3182
Entamoeba histolytica	acetyltransferase, GNAT family	0.004	0.063	0.7601
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0044	0.0756	0.9064
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0046	0.0829	1
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0029	0.0229	0.03
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0046	0.0829	1
Brugia malayi	Papain family cysteine protease containing protein	0.0046	0.0829	0.1437
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0063	0.1433	0.1433
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0057	0.069
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0163	0.4906	1
Leishmania major	cysteine peptidase A (CPA)	0.0046	0.0829	0.0829
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0046	0.0829	0.0784
Plasmodium vivax	vivapain-2	0.0046	0.0829	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0868	0.1419
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0063	0.1433	0.1392
Onchocerca volvulus		0.0029	0.0229	0.0396
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0.063	0.7453
Toxoplasma gondii	1,3-beta-glucan synthase component protein	0.0215	0.6702	1
Echinococcus granulosus	inositol monophosphatase 1	0.0038	0.0554	0.087
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0046	0.0829	1
Toxoplasma gondii	hypothetical protein	0.005	0.0973	0.139
Plasmodium vivax	unspecified product	0.0024	0.0057	0.0115
Brugia malayi	hypothetical protein	0.0023	0.0048	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0229	0.0396
Brugia malayi	sodium-independent organic anion transporter family protein	0.0029	0.0229	0.0396
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0024	0.0057	0.0009
Onchocerca volvulus		0.0046	0.0829	0.1437
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0229	0.0396
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0046	0.0829	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0046	0.0829	0.0784
Trypanosoma cruzi	cysteine peptidase, putative	0.0046	0.0829	0.0784
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0868	0.1419
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0046	0.0829	0.1437
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0057	0.069
Onchocerca volvulus	Putative organic anion transporter	0.0029	0.0229	0.0396

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 12500 ng/ml	Cytotoxicity against mouse P388 cells	ChEMBL.	1791472
MIC (functional)	> 60 ug	Antimicrobial activity against Escherichia coli assessed per disk	ChEMBL.	1791472
MIC (functional)	> 60 ug	Antimicrobial activity against Candida albicans assessed per disk	ChEMBL.	1791472

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23	1791472

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL482813

Bibliographic References

No literature references available for this target.

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Detailed information for compound 986382