Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.2728 | 0.2728 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1037 | 0.1037 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.1037 | 0.1037 |
Echinococcus multilocularis | serotonin transporter | 0.0073 | 0.0266 | 0.0266 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.0716 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0674 | 0.6287 | 0.6186 |
Schistosoma mansoni | hypothetical protein | 0.1044 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1044 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.2901 | 0.2901 |
Leishmania major | trypanothione reductase | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.1044 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0073 | 0.0266 | 0.0266 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.0597 | 0.8342 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.0597 | 0.8342 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0 | 0.5 |
Onchocerca volvulus | 0.0073 | 0.0266 | 0.5 | |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.0597 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0266 | 0.0266 |
Schistosoma mansoni | calcium-activated potassium channel | 0.1044 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0073 | 0.0266 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0798 | 0.7529 | 0.7529 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.0716 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.0597 | 0.8342 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.015 | 0.1037 | 0.0792 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.1037 | 0.1037 |
Loa Loa (eye worm) | serotonin transporter b | 0.0073 | 0.0266 | 0.0266 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.0716 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.0597 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0266 | 0.0266 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.015 | 0.1037 | 0.1037 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0073 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.3093 | 0.3093 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.0597 | 0.8342 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0073 | 0.0266 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.0716 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0073 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1037 | 0.1037 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Emax (binding) | = 0 % | Intrinsic activity at human 5HT1A receptor expressed in CHO cells by GTPgammaS binding assay relative to serotonin | ChEMBL. | 18571421 |
Ki (binding) | = 13.8 nM | Displacement of [3H]paroxetine from rat cortical 5HTT reuptake site | ChEMBL. | 18571421 |
Ki (binding) | = 97.2 nM | Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cells | ChEMBL. | 18571421 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.