TDR Targets

Basic information

Technical information

TDR Targets ID: 989082
Name: 5-methyl-N,7-di(phenyl)imidazo[5,1-f][1,2,4]t riazin-2-amine
MW: 301.345 | Formula: C18H15N5
H donors: 1 H acceptors: 3 LogP: 3.7 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1nc(n2c1cnc(n2)Nc1ccccc1)c1ccccc1
InChi: 1S/C18H15N5/c1-13-16-12-19-18(21-15-10-6-3-7-11-15)22-23(16)17(20-13)14-8-4-2-5-9-14/h2-12H,1H3,(H,21,22)
InChiKey: VMVVGNPEKKNKGG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-methyl-N,7-di(phenyl)-2-imidazo[5,1-f][1,2,4]triazinamine
(5-methyl-7-phenyl-imidazo[5,1-f][1,2,4]triazin-2-yl)-phenyl-amine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	polo-like kinase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	Serine/threonine-protein kinase PLK1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	PLK/PLK1 protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei gambiense	polo-like protein kinase,protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei	polo-like protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania infantum	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania mexicana	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Giardia lamblia	Kinase, PLK	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Onchocerca volvulus	Serine\/threonine kinase homolog	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Brugia malayi	serine/threonine-protein kinase plk-2	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania braziliensis	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Entamoeba histolytica	serine/threonine protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	ko:K06631 polo-like kinase 1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0006	0.0006
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.016	0.0723
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.016	0.0116
Brugia malayi	Nuclear hormone receptor E75	0.0011	0.0006	0.0041
Schistosoma mansoni	DNA polymerase eta	0.0023	0.016	0.016
Brugia malayi	serine/threonine-protein kinase plk-2	0.0114	0.1361	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0011	0.0006	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0007
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.016	0.016
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0006	0.0006
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.016	0.0723
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.0165	0.0165
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0165	0.1216
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0068	0.0012
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0007
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0012	0.0023	0.0023
Toxoplasma gondii	FAD-dependent glycerol-3-phosphate dehydrogenase	0.0053	0.0553	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0165	0.0203
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0053	0.0553	0.3274
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.0165	0.0165
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0624	0.0766
Echinococcus granulosus	glycerol 3 phosphate dehydrogenase	0.0053	0.0553	0.0553
Schistosoma mansoni	NAD dehydrogenase	0.0053	0.0553	0.0553
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.0165	0.0165
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.0165	0.0165
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.016	0.0723
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.0165	0.1216
Brugia malayi	ecdysteroid receptor	0.0023	0.0165	0.1216
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.016	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0165	0.0203
Brugia malayi	RE18450p	0.0053	0.0553	0.4064
Loa Loa (eye worm)	hypothetical protein	0.0023	0.016	0.0196
Brugia malayi	dimethylglycine dehydrogenase, mitochondrial precursor, putative	0.0053	0.0553	0.4064
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0114	0.1361	1
Onchocerca volvulus	Bile acid receptor homolog	0.0023	0.0165	0.118
Echinococcus granulosus	tumor protein p63	0.0396	0.506	0.506
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.016	0.0723
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.016	0.0723
Schistosoma mansoni	fad oxidoreductase	0.0053	0.0553	0.0553
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0165	0.1216
Brugia malayi	nuclear hormone receptor	0.0023	0.0165	0.1216
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.0165	0.0165
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.016	0.016
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0012	0.0023	0.0023
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.0165	0.1216
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0007
Echinococcus multilocularis	dna polymerase eta	0.0023	0.016	0.016
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.016	0.0723
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0165	0.1216
Echinococcus multilocularis	microtubule associated protein 2	0.0772	1	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0011	0.0006	0.0006
Trypanosoma brucei	polo-like protein kinase	0.0114	0.1361	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0007
Schistosoma mansoni	thyroid hormone receptor	0.031	0.3935	0.3935
Schistosoma mansoni	coup transcription factor	0.0023	0.0165	0.0165
Echinococcus multilocularis	thyroid hormone receptor alpha	0.031	0.3935	0.3935
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0011	0.0006	0.0007
Schistosoma mansoni	nuclear receptor	0.0011	0.0006	0.0006
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0006	0.0006
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0023	0.0167
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0053	0.0553	0.3274
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.0165	0.0165
Schistosoma mansoni	glycerol-3-phosphate dehydrogenase	0.0053	0.0553	0.0553
Schistosoma mansoni	cellular tumor antigen P53	0.0058	0.0624	0.0624
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.016	0.0723
Echinococcus granulosus	dna polymerase kappa	0.0023	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0023	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0553	0.0679
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.016	0.016
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.0165	0.0165
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.016	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0023	0.0028
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.0165	0.0203
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.016	0.0723
Leishmania major	glycerol-3-phosphate dehydrogenase-like protein	0.0053	0.0553	0.3761
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.0604	0.3702
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.0165	0.0203
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.063	0.8141	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0011	0.0006	0.0007
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.016	0.0723
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0012	0.0023	0.0028
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0165	0.0165
Trypanosoma brucei	electron transfer flavoprotein-ubiquinone oxidoreductase, putative	0.0053	0.0553	0.3761
Brugia malayi	nuclear hormone receptor	0.0011	0.0006	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0553	0.0679
Brugia malayi	conserved hypotetical protein	0.0011	0.0006	0.0041
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0011	0.0006	0.0041
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.0336	0.0336
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0165	0.0203
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.0165	0.0203
Mycobacterium leprae	PROBABLE D-AMINO ACID OXIDASE AAO	0.063	0.8141	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0305	0.121
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0053	0.0553	0.0603
Brugia malayi	hypothetical protein	0.0011	0.0006	0.0041
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0287	0.3632	0.3632
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0023	0.0165	0.118
Echinococcus multilocularis	FAD dependent oxidoreductase domain containing protein	0.0053	0.0553	0.0553
Loa Loa (eye worm)	CYP4Cod1	0.0015	0.0066	0.0081
Entamoeba histolytica	anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative	0.0053	0.0553	0.3274
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.0165	0.1216
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0053	0.0553	0.3761
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0114	0.1361	0.1671
Schistosoma mansoni	hypothetical protein	0.0287	0.3632	0.3632
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0114	0.1361	0.1361
Trypanosoma brucei	DNA polymerase eta, putative	0.0023	0.016	0.0723
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.0165	0.0203
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.0165	0.0203
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.016	0.0723
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.1361	1
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0006	0.0006
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0114	0.1361	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0165	0.0165
Loa Loa (eye worm)	cytochrome P450 family protein	0.0015	0.0066	0.0081
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0114	0.1361	1
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase GlpD2	0.0053	0.0553	0.0603
Loa Loa (eye worm)	cytochrome P450 family protein	0.0015	0.0066	0.0081
Schistosoma mansoni	zinc finger protein	0.0011	0.0006	0.0006
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.0165	0.1216
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0165	0.0203
Loa Loa (eye worm)	glycerol-3-phosphate dehydrogenase	0.0053	0.0553	0.0679
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.016	0.0116
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.0604	0.3702
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.016	0.0723
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.038	0.038
Onchocerca volvulus	Dimethylglycine dehydrogenase, mitochondrial homolog	0.0053	0.0553	0.4039
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0007
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.0165	0.0203
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.0165	0.0165
Schistosoma mansoni	nuclear receptor nhr-48	0.0011	0.0006	0.0006
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.0165	0.0203
Trypanosoma brucei	unspecified product	0.0016	0.0068	0.0012
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.038	0.038
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.1361	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0007
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0165	0.1216
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.1361	1
Onchocerca volvulus	Putative fad oxidoreductase	0.0053	0.0553	0.4039
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0165	0.0165
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0012	0.0023	0.0023
Schistosoma mansoni	kinase	0.0058	0.0624	0.0624
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0011	0.0006	0.0006
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0053	0.0553	0.3761
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.0165	0.1216
Brugia malayi	orphan nuclear receptor NR2E1	0.0011	0.0006	0.0041
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.016	0.0723
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0053	0.0553	0.3761
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.0165	0.1216
Trypanosoma brucei	unspecified product	0.0016	0.0068	0.0012
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0165	0.0165
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.0336	0.0413
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.0165	0.0165
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0011	0.0006	0.0006
Echinococcus granulosus	FAD dependent oxidoreductase domain containing protein	0.0053	0.0553	0.0553
Echinococcus multilocularis	nuclear receptor nhr 48	0.0011	0.0006	0.0006
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.0336	0.0336
Trypanosoma cruzi	FAD dependent oxidoreductase, putative	0.0053	0.0553	0.3761
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.0165	0.1216
Schistosoma mansoni	d-amino acid oxidase	0.063	0.8141	0.8141
Brugia malayi	tailless protein	0.0011	0.0006	0.0041
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.0165	0.0165
Brugia malayi	steroid hormone receptor	0.0023	0.0165	0.1216
Brugia malayi	nuclear hormone receptor family member odr-7	0.0011	0.0006	0.0041
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.016	0.0723
Onchocerca volvulus		0.0023	0.0165	0.118
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.0165	0.0165
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.0165	0.0165
Plasmodium vivax	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0053	0.0553	0.5
Onchocerca volvulus	Protein ultraspiracle homolog	0.0023	0.0165	0.118
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase	0.0053	0.0553	0.0603
Trypanosoma brucei	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0053	0.0553	0.3761
Leishmania major	DNA polymerase kappa, putative	0.0023	0.016	0.0723
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0006	0.0041
Echinococcus multilocularis	tumor protein p63	0.0396	0.506	0.506
Plasmodium falciparum	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0053	0.0553	0.5
Echinococcus granulosus	nuclear receptor nhr 48	0.0011	0.0006	0.0006
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0053	0.0553	0.3761
Echinococcus granulosus	thyroid hormone receptor alpha	0.0011	0.0006	0.0006
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.1361	1
Onchocerca volvulus	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog	0.0053	0.0553	0.4039
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0011	0.0006	0.0006
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase, putative	0.0053	0.0553	0.3761
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0007
Schistosoma mansoni	serine/threonine protein kinase	0.0114	0.1361	0.1361
Loa Loa (eye worm)	hypothetical protein	0.063	0.8141	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0011	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0023	0.0028
Brugia malayi	nuclear receptor RXR	0.0012	0.0023	0.0167
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0305	0.121
Toxoplasma gondii	hypothetical protein	0.0053	0.0553	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0007
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.016	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0165	0.0203
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0011	0.0006	0.0006
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.016	0.0723
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.016	0.0196
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	0.0578	0.7451	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0274	0.0336
Schistosoma mansoni	ATP:guanidino kinase (Smc74)	0.0053	0.0553	0.0553
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.0165	0.1216
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.0336	0.247
Brugia malayi	Cytochrome P450 family protein	0.0015	0.0066	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0553	0.0679
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0287	0.3632	0.3632
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.016	0.1174
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.016	0.0723
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0011	0.0006	0.0006
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.0165	0.0203
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.0165	0.0165
Mycobacterium ulcerans	thiamine biosynthesis oxidoreductase ThiO	0.0053	0.0553	0.0603
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.1361	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0011	0.0006	0.0041
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0165	0.1216
Brugia malayi	nuclear receptor NHR-67	0.0011	0.0006	0.0041
Brugia malayi	nuclear receptor RXR	0.0011	0.0006	0.0041
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 20	0.0053	0.0553	0.3761
Schistosoma mansoni	fad oxidoreductase	0.0053	0.0553	0.0553
Trypanosoma cruzi	DNA polymerase eta, putative	0.0023	0.016	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0165	0.0203
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0165	0.1216
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.0165	0.0165
Onchocerca volvulus		0.0058	0.0624	0.456
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0165	0.1216
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0165	0.0203
Schistosoma mansoni	thyroid hormone receptor	0.031	0.3935	0.3935
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.1361	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0068	0.0012
Leishmania major	DNA polymerase eta, putative	0.0023	0.016	0.0723
Giardia lamblia	Kinase, PLK	0.0114	0.1361	1
Brugia malayi	hypothetical protein	0.0012	0.0023	0.0167
Trypanosoma brucei	unspecified product	0.0023	0.016	0.0723
Leishmania major	hypothetical protein, conserved	0.0053	0.0553	0.3761
Trypanosoma brucei	FAD dependent oxidoreductase, putative	0.0053	0.0553	0.3761
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0023	0.0023
Brugia malayi	hypothetical protein	0.0011	0.0006	0.0041
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0165	0.0165
Mycobacterium tuberculosis	Possible thiamine biosynthesis oxidoreductase ThiO	0.0053	0.0553	0.0539
Brugia malayi	Nuclear hormone receptor E75	0.0011	0.0006	0.0041
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0165	0.1216
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0007
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.0165	0.0165
Echinococcus granulosus	dna polymerase eta	0.0023	0.016	0.016
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.1361	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0068	0.0012
Brugia malayi	cDNA sequence BC016226	0.0053	0.0553	0.4064
Brugia malayi	ecdysone receptor	0.0011	0.0006	0.0041
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.1361	1
Brugia malayi	hypothetical protein	0.0012	0.0023	0.0167
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.0165	0.0165
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.0165	0.0165
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0023	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0023	0.0028
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0011	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0165	0.0203
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0053	0.0553	0.3761
Echinococcus multilocularis	glycerol 3 phosphate dehydrogenase	0.0053	0.0553	0.0553
Schistosoma mansoni	microtubule-associated protein tau	0.0772	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0023	0.0028
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0114	0.1361	0.1361
Loa Loa (eye worm)	DR-78	0.0011	0.0006	0.0007
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.1361	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.016	0.016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.016	0.0723
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0165	0.0165
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0011	0.0006	0.0006
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.0165	0.1216
Brugia malayi	pyruvate dehydrogenase phosphatase regulatory subunit precursor	0.0053	0.0553	0.4064
Brugia malayi	Cytochrome P450 family protein	0.0015	0.0066	0.0486
Chlamydia trachomatis	D-amino acid dehydrogenase	0.0053	0.0553	0.5
Leishmania major	hypothetical protein, conserved	0.0053	0.0553	0.3761
Schistosoma mansoni	nuclear receptor	0.0011	0.0006	0.0006
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial	0.0053	0.0553	0.3761
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.0165	0.0165

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.2 uM	Inhibition of PLK1 expressed in baculovirus infected Trichoplusia ni cells	ChEMBL.	18929484

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL487976

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 989082