Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cytochrome P450 reductase | 0.0236 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0236 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0209 | 0.7709 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0236 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0236 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0209 | 0.7709 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0146 | 0.2291 | 0.2291 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0236 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0236 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0236 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0236 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0236 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0236 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0236 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0236 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0236 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0236 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0236 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0236 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0236 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0236 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0236 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0146 | 0.2291 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0236 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2 | ChEMBL. | 19569717 | |
Inhibition (binding) | = -17 % | Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells at 10 uM | ChEMBL. | 19569717 |
Inhibition (binding) | = 1 % | Displacement of [3H]PSB-11 from human recombinant adenosine A3 receptor expressed in CHO cells at 1 uM | ChEMBL. | 19569717 |
Inhibition (binding) | = 27 % | Displacement of [3H]CCPA from rat brain cortex adenosine A1 receptor at 1 uM | ChEMBL. | 19569717 |
Ki (binding) | = 1.99 nM | Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells | ChEMBL. | 19569717 |
Ki (binding) | = 41.5 nM | Displacement of [3H]MSX-2 from rat brain striatum adenosine A2A receptor | ChEMBL. | 19569717 |
Ki (binding) | > 1000 nM | Displacement of [3H]CCPA from rat brain cortex adenosine A1 receptor | ChEMBL. | 19569717 |
Ki (binding) | > 1000 nM | Displacement of [3H]PSB-11 from human recombinant adenosine A3 receptor expressed in CHO cells | ChEMBL. | 19569717 |
Ki (binding) | = 3720 nM | Displacement of [3H]MSX-2 from human recombinant adenosine A2A receptor expressed in CHO cells | ChEMBL. | 19569717 |
Ki (binding) | > 10000 nM | Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 19569717 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.