Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0112 | 0.0767 | 0.0697 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0027 | 0.0076 | 0.0083 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0112 | 0.0767 | 0.5 |
Leishmania major | delta-5 fatty acid desaturase | 0.0112 | 0.0767 | 0.0697 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0112 | 0.0767 | 0.0844 |
Mycobacterium ulcerans | hypothetical protein | 0.0112 | 0.0767 | 1 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0112 | 0.0767 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0112 | 0.0767 | 1 |
Trypanosoma cruzi | sphingolipid delta 4 desaturase, putative | 0.0112 | 0.0767 | 0.0697 |
Trypanosoma brucei | cytochrome b5-dependent oleate desaturase | 0.0112 | 0.0767 | 0.0697 |
Trypanosoma brucei | delta-4 fatty acid desaturase | 0.0112 | 0.0767 | 0.0697 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0112 | 0.0767 | 1 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0112 | 0.0767 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1145 | 0.9093 | 0.9087 |
Schistosoma mansoni | fatty acid desaturase | 0.0112 | 0.0767 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0061 | 0.0352 | 0.0387 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.1145 | 0.9093 | 0.5 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0112 | 0.0767 | 1 |
Leishmania major | fatty acid desaturase, putative | 0.0112 | 0.0767 | 0.0697 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0112 | 0.0767 | 0.0844 |
Brugia malayi | Fatty acid desaturase family protein | 0.0112 | 0.0767 | 0.0844 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0112 | 0.0767 | 0.5 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0112 | 0.0767 | 0.0697 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0112 | 0.0767 | 0.0697 |
Onchocerca volvulus | 0.1258 | 1 | 1 | |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0112 | 0.0767 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0112 | 0.0767 | 0.0697 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0112 | 0.0767 | 0.0697 |
Leishmania major | delta-6 fatty acid desaturase | 0.0112 | 0.0767 | 0.0697 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0767 | 0.0844 |
Trypanosoma brucei | delta-6 fatty acid desaturase, putative | 0.0112 | 0.0767 | 0.0697 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0112 | 0.0767 | 1 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0112 | 0.0767 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.0076 | 0.0083 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0027 | 0.0076 | 0.0083 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0112 | 0.0767 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1258 | 1 | 1 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0112 | 0.0767 | 0.0697 |
Brugia malayi | acyl-CoA desaturase | 0.1145 | 0.9093 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0112 | 0.0767 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0112 | 0.0767 | 0.0697 |
Trypanosoma cruzi | cytochrome b5-dependent oleate desaturase | 0.0112 | 0.0767 | 0.0697 |
Loa Loa (eye worm) | FAT-3 protein | 0.0112 | 0.0767 | 0.0844 |
Leishmania major | fatty acid desaturase, putative | 0.0112 | 0.0767 | 0.0697 |
Leishmania major | delta-4 fatty acid desaturase | 0.0112 | 0.0767 | 0.0697 |
Trypanosoma brucei | sphingolipid delta 4 desaturase, putative | 0.0112 | 0.0767 | 0.0697 |
Leishmania major | fatty-acid desaturase, putative | 0.1258 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.0076 | 0.0083 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0112 | 0.0767 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0061 | 0.0352 | 0.0387 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0112 | 0.0767 | 1 |
Leishmania major | delta-12 fatty acid desaturase | 0.0112 | 0.0767 | 0.0697 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0112 | 0.0767 | 0.0844 |
Brugia malayi | Fatty acid desaturase family protein | 0.0112 | 0.0767 | 0.0844 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0112 | 0.0767 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1145 | 0.9093 | 0.9087 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.1145 | 0.9093 | 0.5 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0112 | 0.0767 | 0.0697 |
Onchocerca volvulus | 0.1258 | 1 | 1 | |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.1145 | 0.9093 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0027 | 0.0076 | 0.0083 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1258 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 20 % | Neuroprotective activity against human SH-SY5Y cells assessed as inhibition of H2O2-induced cellular damage at 1 uM dosed 1 hr prior to H2O2 challenge after 24 hrs relative to control | ChEMBL. | 18788732 |
Activity (functional) | = 25.2 % | Neuroprotective activity against human SH-SY5Y cells assessed as inhibition of H2O2-induced cellular damage at 10 uM after 24 hrs relative to control | ChEMBL. | 18788732 |
Activity (functional) | = 46 % | Neuroprotective activity against human SH-SY5Y cells assessed as inhibition of H2O2-induced cellular damage at 10 uM dosed 1 hr prior to H2O2 challenge after 24 hrs relative to control | ChEMBL. | 18788732 |
IC50 (ADMET) | > 400 uM | Cytotoxicity against mouse J774 cells after 48 hrs by MTT assay | ChEMBL. | 18788732 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.