TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 400.433 | Formula: C22H20N6O2
H donors: 4 H acceptors: 3 LogP: 3.55 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1c(C)noc1C)Nc1ccc2c(c1)c(n[nH]2)c1[nH]c2c(c1)ccc(c2)C
InChi: 1S/C22H20N6O2/c1-11-4-5-14-9-19(24-18(14)8-11)21-16-10-15(6-7-17(16)26-27-21)23-22(29)25-20-12(2)28-30-13(20)3/h4-10,24H,1-3H3,(H,26,27)(H2,23,25,29)
InChiKey: QDLVVVNAGFJUMN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	IL2-inducible T-cell kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129320	All targets in OG5_129320
Echinococcus granulosus	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma japonicum	Tyrosine-protein kinase BTK, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma japonicum	ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative	Get druggable targets OG5_129320	All targets in OG5_129320

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.008	0.157	0.157
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.008	0.157	0.157
Trypanosoma brucei	Metacaspase-4	0.0093	0.2083	1
Schistosoma mansoni	synaptotagmin	0.008	0.157	0.157
Brugia malayi	Copine VIII	0.008	0.157	0.4029
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0169	0.5287	0.5287
Echinococcus multilocularis	macrophage expressed protein	0.0281	1	1
Brugia malayi	C2 domain containing protein	0.008	0.157	0.4029
Trypanosoma cruzi	metacaspase 5, putative	0.0093	0.2083	1
Brugia malayi	Variant SH3 domain containing protein	0.0085	0.1767	0.4534
Entamoeba histolytica	Rap/Ran GTPase activating protein, putative	0.008	0.157	0.5
Entamoeba histolytica	C2 domain containing protein	0.008	0.157	0.5
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0093	0.2083	0.0608
Onchocerca volvulus	Putative cc2d1b protein	0.008	0.157	0.4029
Echinococcus granulosus	unc 13 munc13	0.008	0.157	0.157
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.008	0.157	0.157
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0093	0.2083	0.2083
Loa Loa (eye worm)	synaptotagmin-1	0.008	0.157	0.4029
Loa Loa (eye worm)	C2 domain-containing protein	0.008	0.157	0.4029
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.008	0.157	0.157
Entamoeba histolytica	protein kinase, putative	0.008	0.157	0.5
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2083	0.5343
Entamoeba histolytica	hypothetical protein	0.008	0.157	0.5
Schistosoma mansoni	phospholipase C-like protein 2 plc-L2	0.008	0.157	0.157
Schistosoma mansoni	nedd-4-like E3 ubiquitin-protein ligase	0.008	0.157	0.157
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0085	0.1767	0.4534
Onchocerca volvulus		0.008	0.157	0.4029
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Brugia malayi	Synapse defective protein 1	0.008	0.157	0.4029
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.008	0.157	0.157
Plasmodium falciparum	perforin-like protein 2	0.0281	1	1
Onchocerca volvulus		0.008	0.157	0.4029
Brugia malayi	protein kinase C II.	0.008	0.157	0.4029
Loa Loa (eye worm)	C2 domain-containing protein	0.008	0.157	0.4029
Entamoeba histolytica	hypothetical protein	0.008	0.157	0.5
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.008	0.157	0.157
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.008	0.157	0.157
Schistosoma mansoni	serine/threonine protein kinase	0.008	0.157	0.157
Entamoeba histolytica	DENN domain protein	0.008	0.157	0.5
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.008	0.157	0.157
Loa Loa (eye worm)	Nedd4-PD	0.008	0.157	0.4029
Brugia malayi	C2 domain containing protein	0.008	0.157	0.4029
Echinococcus multilocularis	copine 9	0.008	0.157	0.157
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Loa Loa (eye worm)	C2 domain-containing protein	0.008	0.157	0.4029
Echinococcus multilocularis	synaptotagmin 15	0.008	0.157	0.157
Brugia malayi	Protein kinase c protein 2	0.008	0.157	0.4029
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.008	0.157	0.4029
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Trypanosoma brucei	metacaspase 5, putative	0.0093	0.2083	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Echinococcus multilocularis	caspase 2	0.0136	0.3898	0.3898
Echinococcus multilocularis	protein piccolo	0.008	0.157	0.157
Loa Loa (eye worm)	C2 domain-containing protein	0.008	0.157	0.4029
Loa Loa (eye worm)	C2 domain-containing protein	0.008	0.157	0.4029
Entamoeba histolytica	hypothetical protein, conserved	0.008	0.157	0.5
Echinococcus granulosus	synaptotagmin	0.008	0.157	0.157
Entamoeba histolytica	hypothetical protein	0.008	0.157	0.5
Entamoeba histolytica	C2 domain containing protein	0.008	0.157	0.5
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.008	0.157	0.157
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.008	0.157	0.4029
Brugia malayi	Copine family protein	0.008	0.157	0.4029
Onchocerca volvulus		0.008	0.157	0.4029
Schistosoma mansoni	fer-1-related	0.008	0.157	0.157
Echinococcus multilocularis	serine threonine protein kinase	0.008	0.157	0.157
Schistosoma mansoni	hypothetical protein	0.008	0.157	0.157
Echinococcus granulosus	synaptotagmin 2	0.008	0.157	0.157
Echinococcus granulosus	copine 9	0.008	0.157	0.157
Schistosoma mansoni	synaptotagmin	0.008	0.157	0.157
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Entamoeba histolytica	C2 domain containing protein	0.008	0.157	0.5
Echinococcus multilocularis	synaptotagmin 2	0.008	0.157	0.157
Entamoeba histolytica	C2 domain containing protein	0.008	0.157	0.5
Schistosoma mansoni	hypothetical protein	0.008	0.157	0.157
Echinococcus granulosus	Immunoglobulin E set	0.008	0.157	0.157
Brugia malayi	Cell death protein 3 precursor	0.0136	0.3898	1
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.008	0.157	0.157
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0093	0.2083	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0093	0.2083	1
Plasmodium vivax	perforin-like protein 3	0.0281	1	1
Entamoeba histolytica	hypothetical protein	0.008	0.157	0.5
Echinococcus multilocularis	caspase 8	0.0093	0.2083	0.2083
Schistosoma mansoni	tyrosine kinase	0.0164	0.5094	0.5094
Plasmodium vivax	perforin-like protein 5	0.0281	1	1
Plasmodium vivax	hypothetical protein, conserved	0.0093	0.2083	0.0608
Echinococcus multilocularis	extended synaptotagmin 2	0.008	0.157	0.157
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.2083	1
Brugia malayi	Synaptotagmin protein 3	0.008	0.157	0.4029
Schistosoma mansoni	synaptotagmin	0.008	0.157	0.157
Plasmodium vivax	perforin-like protein 2	0.0281	1	1
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.008	0.157	0.157
Plasmodium vivax	perforin-like protein 4	0.0281	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.2083	1
Plasmodium vivax	perforin-like protein 1	0.0281	1	1
Echinococcus granulosus	protein kinase C gamma type	0.008	0.157	0.157
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.008	0.157	0.157
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0169	0.5287	0.5287
Echinococcus multilocularis	synaptotagmin	0.008	0.157	0.157
Echinococcus granulosus	Protein kinase C brain isozyme	0.008	0.157	0.157
Toxoplasma gondii	MAC/Perforin domain-containing protein	0.0281	1	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Entamoeba histolytica	C2 domain containing protein	0.008	0.157	0.5
Echinococcus granulosus	myoferlin	0.008	0.157	0.157
Echinococcus granulosus	otoferlin	0.008	0.157	0.157
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0093	0.2083	1
Schistosoma mansoni	hypothetical protein	0.008	0.157	0.157
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Onchocerca volvulus	Cell death protein 3 homolog	0.0136	0.3898	1
Schistosoma mansoni	rho gtpase activating protein	0.008	0.157	0.157
Echinococcus granulosus	synaptotagmin	0.008	0.157	0.157
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Schistosoma mansoni	synaptotagmin 12	0.008	0.157	0.157
Echinococcus multilocularis	NEDD4 E3 ubiquitin protein ligase WWP1	0.008	0.157	0.157
Entamoeba histolytica	C2 domain containing protein	0.008	0.157	0.5
Echinococcus multilocularis	caspase	0.0169	0.5287	0.5287
Echinococcus granulosus	NEDD4 E3 ubiquitin protein ligase WWP1	0.008	0.157	0.157
Schistosoma mansoni	serine/threonine protein kinase	0.008	0.157	0.157
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0093	0.2083	1
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.2083	1
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.2083	1
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0093	0.2083	0.0608
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0093	0.2083	1
Schistosoma mansoni	caspase-3 (C14 family)	0.0169	0.5287	0.5287
Brugia malayi	C2 domain containing protein	0.008	0.157	0.4029
Loa Loa (eye worm)	C2 domain-containing protein	0.008	0.157	0.4029
Leishmania major	metacaspase, putative	0.0093	0.2083	1
Entamoeba histolytica	calcium-binding protein, putative	0.008	0.157	0.5
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.008	0.157	0.4029
Toxoplasma gondii	perforin-like protein PLP1	0.0281	1	1
Entamoeba histolytica	protein kinase, putative	0.008	0.157	0.5
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0093	0.2083	1
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.2083	1
Trypanosoma cruzi	metacaspase, putative	0.0093	0.2083	1
Onchocerca volvulus		0.008	0.157	0.4029
Loa Loa (eye worm)	phosphatidylinositol 3-kinase catalytic subunit gamma	0.008	0.157	0.4029
Echinococcus granulosus	UNCoordinated family member unc 13	0.008	0.157	0.157
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.008	0.157	0.157
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Brugia malayi	C2 domain containing protein	0.008	0.157	0.4029
Trypanosoma brucei	metacaspase MCA2	0.0093	0.2083	1
Brugia malayi	C2 domain containing protein	0.008	0.157	0.4029
Brugia malayi	NEDD4.2	0.008	0.157	0.4029
Echinococcus granulosus	active breakpoint cluster region	0.008	0.157	0.157
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Echinococcus multilocularis	synaptotagmin	0.008	0.157	0.157
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Brugia malayi	C2 domain containing protein	0.008	0.157	0.4029
Echinococcus granulosus	intersectin 2	0.0083	0.1695	0.1695
Schistosoma mansoni	synaptotagmin-like protein	0.008	0.157	0.157
Echinococcus granulosus	copine 9	0.008	0.157	0.157
Echinococcus multilocularis	synaptotagmin	0.008	0.157	0.157
Schistosoma mansoni	synaptic ras gtpase activating protein syngap	0.008	0.157	0.157
Brugia malayi	calpain 5	0.008	0.157	0.4029
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Echinococcus granulosus	protein kinase c epsilon type	0.008	0.157	0.157
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Schistosoma mansoni	copine	0.008	0.157	0.157
Echinococcus granulosus	neural cell expressed developmentally	0.008	0.157	0.157
Echinococcus multilocularis	intersectin 2	0.0083	0.1695	0.1695
Trypanosoma cruzi	metacaspase, putative	0.0093	0.2083	1
Onchocerca volvulus		0.008	0.157	0.4029
Loa Loa (eye worm)	hypothetical protein	0.0136	0.3898	1
Schistosoma mansoni	hypothetical protein	0.008	0.157	0.157
Brugia malayi	LD23056p	0.008	0.157	0.4029
Echinococcus multilocularis	UNCoordinated family member (unc 13)	0.008	0.157	0.157
Trypanosoma cruzi	metacaspase 5, putative	0.0093	0.2083	1
Schistosoma mansoni	caspase-7 (C14 family)	0.0136	0.3898	0.3898
Plasmodium falciparum	perforin-like protein 3	0.0281	1	1
Entamoeba histolytica	C2 domain containing protein	0.008	0.157	0.5
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0093	0.2083	0.0608
Echinococcus multilocularis	active breakpoint cluster region	0.008	0.157	0.157
Plasmodium falciparum	metacaspase-like protein	0.0093	0.2083	0.0608
Schistosoma mansoni	E3 ubiquitin-protein ligase nedd-4	0.008	0.157	0.157
Brugia malayi	C2 domain containing protein	0.008	0.157	0.4029
Schistosoma mansoni	glut4 vesicle protein-related	0.008	0.157	0.157
Echinococcus granulosus	macrophage expressed protein	0.0281	1	1
Echinococcus multilocularis	neural cell expressed, developmentally	0.008	0.157	0.157
Brugia malayi	Synaptotagmin I	0.008	0.157	0.4029
Brugia malayi	WW domain containing protein	0.008	0.157	0.4029
Schistosoma mansoni	synaptotagmin	0.008	0.157	0.157
Schistosoma mansoni	synaptotagmin	0.008	0.157	0.157
Trypanosoma brucei	metacaspase	0.0093	0.2083	1
Echinococcus granulosus	synaptotagmin	0.008	0.157	0.157
Echinococcus granulosus	synaptotagmin protein 4	0.008	0.157	0.157
Plasmodium falciparum	perforin-like protein 5	0.0281	1	1
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.008	0.157	0.157
Echinococcus multilocularis	protein kinase c epsilon type	0.008	0.157	0.157
Entamoeba histolytica	C2 domain protein, putative	0.008	0.157	0.5
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.008	0.157	0.157
Schistosoma mansoni	synaptotagmin	0.008	0.157	0.157
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Schistosoma mansoni	Mername-AA248 (C02 family)	0.008	0.157	0.157
Echinococcus multilocularis	copine 9	0.008	0.157	0.157
Echinococcus granulosus	caspase 8	0.0093	0.2083	0.2083
Onchocerca volvulus		0.008	0.157	0.4029
Echinococcus multilocularis	unc 13 (munc13)	0.008	0.157	0.157
Schistosoma mansoni	hypothetical protein	0.008	0.157	0.157
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0093	0.2083	1
Schistosoma mansoni	unc-13 (munc13)	0.008	0.157	0.157
Schistosoma mansoni	rab3 interacting molecule (rim)-related	0.008	0.157	0.157
Plasmodium falciparum	perforin-like protein 1	0.0281	1	1
Onchocerca volvulus		0.008	0.157	0.4029
Echinococcus granulosus	caspase 3	0.0076	0.1389	0.1389
Entamoeba histolytica	hypothetical protein, conserved	0.008	0.157	0.5
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Schistosoma mansoni	unc-13 (munc13)	0.008	0.157	0.157
Trypanosoma cruzi	metacaspase, putative	0.0093	0.2083	1
Brugia malayi	C2 domain containing protein	0.008	0.157	0.4029
Brugia malayi	C2 domain containing protein	0.008	0.157	0.4029
Echinococcus granulosus	caspase 2	0.0136	0.3898	0.3898
Schistosoma mansoni	protein kinase C	0.008	0.157	0.157
Brugia malayi	Synapse defective protein 1	0.008	0.157	0.4029
Brugia malayi	C2 domain containing protein	0.008	0.157	0.4029
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.008	0.157	0.157
Trypanosoma cruzi	metacaspase, putative	0.0093	0.2083	1
Echinococcus granulosus	caspase	0.0169	0.5287	0.5287
Echinococcus granulosus	extended synaptotagmin 2	0.008	0.157	0.157
Schistosoma mansoni	caspase-7 (C14 family)	0.0169	0.5287	0.5287
Brugia malayi	C2 domain containing protein	0.008	0.157	0.4029
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Schistosoma mansoni	hypothetical protein	0.0281	1	1
Entamoeba histolytica	hypothetical protein	0.008	0.157	0.5
Schistosoma mansoni	synaptotagmin 12	0.008	0.157	0.157
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0093	0.2083	0.5343
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.008	0.157	0.4029
Entamoeba histolytica	hypothetical protein	0.008	0.157	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.008	0.157	0.157
Trypanosoma brucei	metacaspase MCA3	0.0093	0.2083	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Schistosoma mansoni	unc-13 (munc13)	0.008	0.157	0.157
Echinococcus multilocularis	myoferlin	0.008	0.157	0.157
Echinococcus multilocularis	calpain 5	0.008	0.157	0.157
Brugia malayi	C2 domain containing protein	0.008	0.157	0.4029
Schistosoma mansoni	otoferlin	0.008	0.157	0.157
Echinococcus granulosus	protein piccolo	0.008	0.157	0.157
Echinococcus multilocularis	caspase 3	0.0076	0.1389	0.1389
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.008	0.157	0.157
Echinococcus multilocularis		0.008	0.157	0.157
Echinococcus granulosus	calpain 5	0.008	0.157	0.157
Brugia malayi	phospholipase C homolog	0.008	0.157	0.4029
Entamoeba histolytica	C2 domain containing protein	0.008	0.157	0.5
Entamoeba histolytica	C2 domain containing protein	0.008	0.157	0.5
Plasmodium falciparum	metacaspase 1	0.0093	0.2083	0.0608
Loa Loa (eye worm)	copine family protein	0.008	0.157	0.4029
Echinococcus multilocularis	synaptotagmin protein 4	0.008	0.157	0.157
Onchocerca volvulus	Multiple C2 domain and transmembrane region protein homolog	0.008	0.157	0.4029
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.008	0.157	0.157
Echinococcus multilocularis	synaptotagmin	0.008	0.157	0.157
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.008	0.157	0.4029
Echinococcus multilocularis	synaptotagmin	0.008	0.157	0.157
Echinococcus granulosus	synaptotagmin 15	0.008	0.157	0.157
Brugia malayi	C2 domain containing protein	0.008	0.157	0.4029
Loa Loa (eye worm)	hypothetical protein	0.008	0.157	0.4029
Plasmodium vivax	metacaspase 1, putative	0.0093	0.2083	0.0608
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.2083	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0093	0.2083	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0167	0.5218	0.5218
Echinococcus granulosus	synaptotagmin	0.008	0.157	0.157
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.008	0.157	0.157
Echinococcus granulosus	synaptotagmin	0.008	0.157	0.157
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0167	0.5218	0.5218
Schistosoma mansoni	mctp-related	0.008	0.157	0.157
Plasmodium falciparum	perforin-like protein 4	0.0281	1	1
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.008	0.157	0.157
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.008	0.157	0.157
Schistosoma mansoni	rabphilin-3a	0.008	0.157	0.157
Onchocerca volvulus		0.008	0.157	0.4029
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.008	0.157	0.157
Brugia malayi	C2 domain containing protein	0.008	0.157	0.4029
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0093	0.2083	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.072 uM	Inhibition of recombinant GST-tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay	ChEMBL.	21316219

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1684531

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1502348