TDR Targets

Basic information

Technical information

TDR Targets ID: 183519
Name: (5Z)-5-[[4-[(2,5,7,8-tetramethyl-6-phenylmeth oxy-3,4-dihydrochromen-2-yl)methoxy]phenyl]me thylidene]-1,3-thiazolidine-2,4-dione
MW: 529.647 | Formula: C31H31NO5S
H donors: 1 H acceptors: 2 LogP: 7.03 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: O=C1NC(=O)/C(=C/c2ccc(cc2)OCC2(C)CCc3c(O2)c(C)c(c(c3C)OCc2ccccc2)C)/S1
InChi: 1S/C31H31NO5S/c1-19-20(2)28-25(21(3)27(19)35-17-23-8-6-5-7-9-23)14-15-31(4,37-28)18-36-24-12-10-22(11-13-24)16-26-29(33)32-30(34)38-26/h5-13,16H,14-15,17-18H2,1-4H3,(H,32,33,34)/b26-16-
InChiKey: PNFBECCMNQTCOM-QQXSKIMKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(5Z)-5-[[4-[(6-benzyloxy-2,5,7,8-tetramethyl-chroman-2-yl)methoxy]phenyl]methylene]thiazolidine-2,4-dione
(5Z)-5-[[4-[(6-benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-yl)methoxy]phenyl]methylene]thiazolidine-2,4-dione
(5Z)-5-[4-[(6-benzoxy-2,5,7,8-tetramethyl-chroman-2-yl)methoxy]benzylidene]thiazolidine-2,4-quinone
(5Z)-5-[[4-[[2,5,7,8-tetramethyl-6-(phenylmethoxy)chroman-2-yl]methoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione
(5Z)-5-[[4-[[2,5,7,8-tetramethyl-6-(phenylmethoxy)chroman-2-yl]methoxy]phenyl]methylene]thiazolidine-2,4-dione
(5Z)-5-[[4-[[2,5,7,8-tetramethyl-6-(phenylmethoxy)-2-chromanyl]methoxy]phenyl]methylene]thiazolidine-2,4-dione
(5Z)-5-[4-[[6-(benzyloxy)-2,5,7,8-tetramethyl-chroman-2-yl]methoxy]benzylidene]thiazolidine-2,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Brugia malayi	C2 domain containing protein	0.0031	0	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0031	0	0.5
Loa Loa (eye worm)	C2 domain-containing protein	0.0031	0	0.5
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0031	0	0.5
Trypanosoma brucei	predicted C2 domain protein	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Leishmania major	hypothetical protein, conserved	0.0031	0	0.5
Schistosoma mansoni	hypothetical protein	0.0108	1	1
Trypanosoma brucei	C2 domain containing protein, putative	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Leishmania major	copine i-like protein	0.0031	0	0.5
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0031	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0031	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0031	0	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0031	0	0.5
Leishmania major	hypothetical protein, conserved	0.0031	0	0.5
Loa Loa (eye worm)	C2 domain-containing protein	0.0031	0	0.5
Loa Loa (eye worm)	phosphatidylinositol 3-kinase catalytic subunit gamma	0.0031	0	0.5
Trypanosoma brucei	synaptotagmin, putative	0.0031	0	0.5
Trypanosoma cruzi	synaptotagmin, putative	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Onchocerca volvulus		0.0031	0	0.5
Trichomonas vaginalis	copine, putative	0.0031	0	0.5
Trichomonas vaginalis	Circumsporozoite protein precursor, putative	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Brugia malayi	phospholipase C homolog	0.0031	0	0.5
Trypanosoma cruzi	C2 domain/Ankyrin repeats (3 copies), putative	0.0031	0	0.5
Onchocerca volvulus		0.0031	0	0.5
Entamoeba histolytica	C2 domain containing protein	0.0031	0	0.5
Trypanosoma cruzi	phosphoinositide-specific phospholipase C, putative	0.0031	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0	0.5
Brugia malayi	NEDD4.2	0.0031	0	0.5
Trichomonas vaginalis	annexin VII, putative	0.0031	0	0.5
Entamoeba histolytica	Rap/Ran GTPase activating protein, putative	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Brugia malayi	Protein kinase c protein 2	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Trypanosoma brucei	Coiled-coil and C2 domain-containing protein	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Entamoeba histolytica	hypothetical protein	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Loa Loa (eye worm)	synaptotagmin-1	0.0031	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0	0.5
Brugia malayi	C2 domain containing protein	0.0031	0	0.5
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.0031	0	0.5
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0031	0	0.5
Toxoplasma gondii	MAC/Perforin domain-containing protein	0.0108	1	1
Echinococcus multilocularis	macrophage expressed protein	0.0108	1	1
Loa Loa (eye worm)	C2 domain-containing protein	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0031	0	0.5
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0031	0	0.5
Brugia malayi	C2 domain containing protein	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0031	0	0.5
Trichomonas vaginalis	Proline-rich protein, putative	0.0031	0	0.5
Plasmodium falciparum	perforin-like protein 2	0.0108	1	1
Entamoeba histolytica	C2 domain containing protein	0.0031	0	0.5
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0031	0	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0031	0	0.5
Entamoeba histolytica	hypothetical protein	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Brugia malayi	C2 domain containing protein	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Entamoeba histolytica	hypothetical protein	0.0031	0	0.5
Loa Loa (eye worm)	copine family protein	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Trypanosoma cruzi	synaptotagmin, putative	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Trichomonas vaginalis	vab10 spectraplakin, putative	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Trypanosoma brucei	C2 domain containing protein, putative	0.0031	0	0.5
Leishmania major	hypothetical protein, conserved	0.0031	0	0.5
Leishmania major	c2 domain protein, putative	0.0031	0	0.5
Onchocerca volvulus		0.0031	0	0.5
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Onchocerca volvulus		0.0031	0	0.5
Trypanosoma brucei	C2 domain/Ankyrin repeats (3 copies), putative	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Leishmania major	hypothetical protein, conserved	0.0031	0	0.5
Entamoeba histolytica	C2 domain containing protein	0.0031	0	0.5
Loa Loa (eye worm)	C2 domain-containing protein	0.0031	0	0.5
Brugia malayi	C2 domain containing protein	0.0031	0	0.5
Brugia malayi	C2 domain containing protein	0.0031	0	0.5
Loa Loa (eye worm)	C2 domain-containing protein	0.0031	0	0.5
Toxoplasma gondii	perforin-like protein PLP1	0.0108	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0031	0	0.5
Trypanosoma cruzi	cAMP binding protein, putative	0.0031	0	0.5
Plasmodium falciparum	perforin-like protein 1	0.0108	1	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Brugia malayi	Copine VIII	0.0031	0	0.5
Plasmodium vivax	perforin-like protein 2	0.0108	1	1
Trypanosoma brucei	hypothetical protein, conserved	0.0031	0	0.5
Plasmodium vivax	perforin-like protein 1	0.0108	1	1
Brugia malayi	C2 domain containing protein	0.0031	0	0.5
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Leishmania major	hypothetical protein, conserved	0.0031	0	0.5
Onchocerca volvulus		0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Brugia malayi	C2 domain containing protein	0.0031	0	0.5
Plasmodium vivax	perforin-like protein 4	0.0108	1	1
Brugia malayi	LD23056p	0.0031	0	0.5
Leishmania major	hypothetical protein, conserved	0.0031	0	0.5
Trichomonas vaginalis	ion channel nompc, putative	0.0031	0	0.5
Leishmania major	hypothetical protein, conserved	0.0031	0	0.5
Entamoeba histolytica	C2 domain containing protein	0.0031	0	0.5
Leishmania major	hypothetical protein, conserved	0.0031	0	0.5
Trichomonas vaginalis	calcium-dependent lipid-binding protein, putative	0.0031	0	0.5
Brugia malayi	C2 domain containing protein	0.0031	0	0.5
Brugia malayi	C2 domain containing protein	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Trichomonas vaginalis	copine, putative	0.0031	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0031	0	0.5
Brugia malayi	C2 domain containing protein	0.0031	0	0.5
Echinococcus granulosus	macrophage expressed protein	0.0108	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Entamoeba histolytica	calcium-binding protein, putative	0.0031	0	0.5
Plasmodium vivax	perforin-like protein 5	0.0108	1	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Trypanosoma brucei	C2 domain containing protein, putative	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0031	0	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0031	0	0.5
Trypanosoma brucei	C2 domain containing protein, putative	0.0031	0	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0031	0	0.5
Entamoeba histolytica	DENN domain protein	0.0031	0	0.5
Trichomonas vaginalis	copine, putative	0.0031	0	0.5
Entamoeba histolytica	hypothetical protein	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Trichomonas vaginalis	copine, putative	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Brugia malayi	WW domain containing protein	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Trypanosoma brucei	phosphoinositide-specific phospholipase C	0.0031	0	0.5
Brugia malayi	Synapse defective protein 1	0.0031	0	0.5
Entamoeba histolytica	C2 domain containing protein	0.0031	0	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0031	0	0.5
Onchocerca volvulus	Multiple C2 domain and transmembrane region protein homolog	0.0031	0	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0031	0	0.5
Brugia malayi	Synaptotagmin I	0.0031	0	0.5
Brugia malayi	protein kinase C II.	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Brugia malayi	calpain 5	0.0031	0	0.5
Entamoeba histolytica	hypothetical protein	0.0031	0	0.5
Trypanosoma brucei	predicted C2 domain protein	0.0031	0	0.5
Trypanosoma cruzi	Coiled-coil and C2 domain-containing protein	0.0031	0	0.5
Trypanosoma brucei	predicted C2 domain protein	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Leishmania major	phospholipase c-like protein	0.0031	0	0.5
Trypanosoma brucei	cAMP binding protein, putative	0.0031	0	0.5
Brugia malayi	C2 domain containing protein	0.0031	0	0.5
Plasmodium falciparum	perforin-like protein 5	0.0108	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Plasmodium falciparum	perforin-like protein 3	0.0108	1	1
Entamoeba histolytica	hypothetical protein	0.0031	0	0.5
Brugia malayi	Synapse defective protein 1	0.0031	0	0.5
Onchocerca volvulus	Putative cc2d1b protein	0.0031	0	0.5
Entamoeba histolytica	C2 domain protein, putative	0.0031	0	0.5
Brugia malayi	Synaptotagmin protein 3	0.0031	0	0.5
Onchocerca volvulus		0.0031	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0	0.5
Onchocerca volvulus		0.0031	0	0.5
Entamoeba histolytica	C2 domain containing protein	0.0031	0	0.5
Brugia malayi	C2 domain containing protein	0.0031	0	0.5
Loa Loa (eye worm)	C2 domain-containing protein	0.0031	0	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Plasmodium vivax	perforin-like protein 3	0.0108	1	1
Onchocerca volvulus		0.0031	0	0.5
Plasmodium falciparum	perforin-like protein 4	0.0108	1	1
Entamoeba histolytica	C2 domain containing protein	0.0031	0	0.5
Trypanosoma cruzi	C2 domain containing protein, putative	0.0031	0	0.5
Loa Loa (eye worm)	Nedd4-PD	0.0031	0	0.5
Trichomonas vaginalis	splicing factor 3A subunit, putative	0.0031	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0	0.5
Entamoeba histolytica	C2 domain containing protein	0.0031	0	0.5
Leishmania major	c2 domain protein, putative	0.0031	0	0.5
Entamoeba histolytica	C2 domain containing protein	0.0031	0	0.5
Brugia malayi	Copine family protein	0.0031	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0	0.5
Brugia malayi	C2 domain containing protein	0.0031	0	0.5
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0031	0	0.5
Trichomonas vaginalis	copine, putative	0.0031	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 12 %	Repression of cyclinD1 level in MCF7 cells at 7.5 uM relative to control	ChEMBL.	16854074
Activity (functional)	= 12 %	Repression of cyclinD1 level in MCF7 cells at 7.5 uM relative to control	ChEMBL.	16854074
Activity (functional)	= 42 %	Repression of cyclinD1 level in MCF7 cells at 5 uM relative to control	ChEMBL.	16854074
Activity (functional)	= 42 %	Repression of cyclinD1 level in MCF7 cells at 5 uM relative to control	ChEMBL.	16854074
Activity (functional)	= 85 %	Repression of cyclinD1 level in MCF7 cells at 2.5 uM relative to control	ChEMBL.	16854074
Activity (functional)	= 85 %	Repression of cyclinD1 level in MCF7 cells at 2.5 uM relative to control	ChEMBL.	16854074
AUC (ADMET)	= 14.4 ug hr-1 ml-1	The AUC(0-t)value of the compound in female wistar rat at 100 mg/kg, p.o. dose	ChEMBL.	10464013
AUC (ADMET)	= 18.5 ug hr-1 ml-1	The AUC(0-infinitive)value of the compound in female wistar rat at 100 mg/kg, p.o. dose	ChEMBL.	10464013
Cmax (ADMET)	= 1.09 ug ml-1	The Cmax value of the compound in female wistar rat at 100 mg/kg, p.o. dose	ChEMBL.	10464013
Fold activation (binding)	= 0.57	Fold activation of the compound against Peroxisome proliferator activated receptor gamma (1 uM)	ChEMBL.	10464013
Fold activation (binding)	= 0.67	Fold activation of the compound against Peroxisome proliferator activated receptor alpha (50 uM)	ChEMBL.	10464013
Fold activation (binding)	= 0.57	Fold activation of the compound against Peroxisome proliferator activated receptor gamma (1 uM)	ChEMBL.	10464013
Fold activation (binding)	= 0.67	Fold activation of the compound against Peroxisome proliferator activated receptor alpha (50 uM)	ChEMBL.	10464013
Kel (ADMET)	= 0.07 hr-1	The Kel value of the compound in female wistar rat at 100 mg/kg, p.o. dose	ChEMBL.	10464013
Reduction (functional)	= 38 %	The compound was tested for percent reduction in plasma triglyceride after 6 days of treatment at a dose of 100 mg/kg/day (oral gavage) in mice	ChEMBL.	10464013
Reduction (functional)	= 38 %	The compound was tested for percent reduction in plasma triglyceride after 6 days of treatment at a dose of 100 mg/kg/day (oral gavage) in mice	ChEMBL.	10464013
Reduction (functional)	= 39 %	The compound was tested for percent reduction in plasma glucose after 6 days of treatment at a dose of 100 mg/kg/day (oral gavage) in mice	ChEMBL.	10464013
Reduction (functional)	= 39 %	The compound was tested for percent reduction in plasma glucose after 6 days of treatment at a dose of 100 mg/kg/day (oral gavage) in mice	ChEMBL.	10464013
T max (ADMET)	= 4.33 hr	The Tmax value of the compound in female wistar rat at 100 mg/kg, p.o. dose	ChEMBL.	10464013
T1/2 (ADMET)	= 10.36 hr	The half life value of the compound in female wistar rat at 100 mg/kg, p.o. dose	ChEMBL.	10464013

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL113301
PubChem: 10530241

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 183519