TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 385.419 | Formula: C22H19N5O2
H donors: 4 H acceptors: 2 LogP: 3.34 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc2c(c1)c(n[nH]2)c1cc2c([nH]1)cc(cc2)C)NCc1ccco1
InChi: 1S/C22H19N5O2/c1-13-4-5-14-10-20(25-19(14)9-13)21-17-11-15(6-7-18(17)26-27-21)24-22(28)23-12-16-3-2-8-29-16/h2-11,25H,12H2,1H3,(H,26,27)(H2,23,24,28)
InChiKey: VPCYKVAPRAETDI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	IL2-inducible T-cell kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129320	All targets in OG5_129320
Echinococcus multilocularis	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Echinococcus granulosus	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma japonicum	ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma japonicum	Tyrosine-protein kinase BTK, putative	Get druggable targets OG5_129320	All targets in OG5_129320

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0023	0.1063	0.5
Brugia malayi	C2 domain containing protein	0.0023	0.1063	0.7852
Trypanosoma brucei	C2 domain containing protein, putative	0.0023	0.1063	0.5
Brugia malayi	C2 domain containing protein	0.0023	0.1063	0.7852
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0023	0.1063	0.1083
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0007	0.0053	0.0053
Onchocerca volvulus		0.0023	0.1063	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Echinococcus multilocularis	unc 13 (munc13)	0.0023	0.1063	0.1063
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.1063	0.5
Echinococcus granulosus	Protein kinase C brain isozyme	0.0023	0.1063	0.1063
Schistosoma mansoni	nedd-4-like E3 ubiquitin-protein ligase	0.0023	0.1063	0.1083
Schistosoma mansoni	rabphilin-3a	0.0023	0.1063	0.1083
Echinococcus granulosus	UNCoordinated family member unc 13	0.0023	0.1063	0.1063
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.0023	0.1063	0.1063
Trypanosoma brucei	cAMP binding protein, putative	0.0023	0.1063	0.5
Echinococcus granulosus	synaptotagmin 2	0.0023	0.1063	0.1063
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0023	0.1063	0.5
Trichomonas vaginalis	calcium-dependent lipid-binding protein, putative	0.0023	0.1063	0.5
Loa Loa (eye worm)	C2 domain-containing protein	0.0023	0.1063	0.7852
Brugia malayi	calpain 5	0.0023	0.1063	0.7852
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Schistosoma mansoni	synaptotagmin	0.0023	0.1063	0.1083
Trypanosoma brucei	phosphoinositide-specific phospholipase C	0.0023	0.1063	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0007	0.0053	0.039
Brugia malayi	C2 domain containing protein	0.0023	0.1063	0.7852
Plasmodium vivax	perforin-like protein 4	0.0081	0.4635	1
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0023	0.1063	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0023	0.1063	0.5
Trichomonas vaginalis	copine, putative	0.0023	0.1063	0.5
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0023	0.1063	0.5
Plasmodium falciparum	perforin-like protein 4	0.0081	0.4635	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0007	0.0053	0.0053
Trichomonas vaginalis	copine, putative	0.0023	0.1063	0.5
Echinococcus multilocularis	copine 9	0.0023	0.1063	0.1063
Trichomonas vaginalis	vab10 spectraplakin, putative	0.0023	0.1063	0.5
Leishmania major	phospholipase c-like protein	0.0023	0.1063	0.5
Entamoeba histolytica	C2 domain containing protein	0.0023	0.1063	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0007	0.0053	0.0053
Schistosoma mansoni	tyrosine kinase	0.0164	0.9816	1
Plasmodium vivax	perforin-like protein 1	0.0081	0.4635	1
Echinococcus granulosus	synaptotagmin protein 4	0.0023	0.1063	0.1063
Schistosoma mansoni	hypothetical protein	0.0081	0.4635	0.4721
Entamoeba histolytica	C2 domain containing protein	0.0023	0.1063	0.5
Entamoeba histolytica	hypothetical protein	0.0023	0.1063	0.5
Plasmodium falciparum	perforin-like protein 1	0.0081	0.4635	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Echinococcus multilocularis	copine 9	0.0023	0.1063	0.1063
Schistosoma mansoni	synaptotagmin	0.0023	0.1063	0.1083
Schistosoma mansoni	synaptotagmin 12	0.0023	0.1063	0.1083
Echinococcus multilocularis	serine threonine protein kinase	0.0023	0.1063	0.1063
Leishmania major	hypothetical protein, conserved	0.0023	0.1063	0.5
Toxoplasma gondii	perforin-like protein PLP1	0.0081	0.4635	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.1063	0.5
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.0023	0.1063	0.1063
Leishmania major	hypothetical protein, conserved	0.0023	0.1063	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Echinococcus granulosus	protein kinase C gamma type	0.0023	0.1063	0.1063
Echinococcus multilocularis	synaptotagmin	0.0023	0.1063	0.1063
Echinococcus granulosus	synaptotagmin 15	0.0023	0.1063	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0023	0.1063	0.1083
Leishmania major	hypothetical protein, conserved	0.0023	0.1063	0.5
Trypanosoma brucei	C2 domain containing protein, putative	0.0023	0.1063	0.5
Brugia malayi	NEDD4.2	0.0023	0.1063	0.7852
Schistosoma mansoni	tyrosine kinase	0.0007	0.0053	0.0054
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0028	0.1353	1
Trypanosoma cruzi	cAMP binding protein, putative	0.0023	0.1063	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Loa Loa (eye worm)	Nedd4-PD	0.0023	0.1063	0.7852
Echinococcus granulosus	synaptotagmin	0.0023	0.1063	0.1063
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Entamoeba histolytica	C2 domain containing protein	0.0023	0.1063	0.5
Schistosoma mansoni	synaptotagmin	0.0023	0.1063	0.1083
Entamoeba histolytica	C2 domain containing protein	0.0023	0.1063	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0023	0.1063	0.5
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0023	0.1063	0.7852
Echinococcus multilocularis	intersectin 2	0.0026	0.1246	0.1246
Trypanosoma cruzi	Coiled-coil and C2 domain-containing protein	0.0023	0.1063	0.5
Trichomonas vaginalis	annexin VII, putative	0.0023	0.1063	0.5
Echinococcus granulosus	synaptotagmin	0.0023	0.1063	0.1063
Entamoeba histolytica	hypothetical protein	0.0023	0.1063	0.5
Brugia malayi	C2 domain containing protein	0.0023	0.1063	0.7852
Loa Loa (eye worm)	C2 domain-containing protein	0.0023	0.1063	0.7852
Schistosoma mansoni	hypothetical protein	0.0023	0.1063	0.1083
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0007	0.0053	0.0053
Plasmodium vivax	perforin-like protein 2	0.0081	0.4635	1
Brugia malayi	phospholipase C homolog	0.0023	0.1063	0.7852
Entamoeba histolytica	C2 domain containing protein	0.0023	0.1063	0.5
Entamoeba histolytica	C2 domain containing protein	0.0023	0.1063	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0023	0.1063	0.5
Onchocerca volvulus		0.0023	0.1063	0.5
Leishmania major	c2 domain protein, putative	0.0023	0.1063	0.5
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0023	0.1063	0.5
Brugia malayi	C2 domain containing protein	0.0023	0.1063	0.7852
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Schistosoma mansoni	hypothetical protein	0.0023	0.1063	0.1083
Echinococcus granulosus	macrophage expressed protein	0.0081	0.4635	0.4635
Plasmodium vivax	perforin-like protein 5	0.0081	0.4635	1
Brugia malayi	Synaptotagmin I	0.0023	0.1063	0.7852
Entamoeba histolytica	C2 domain containing protein	0.0023	0.1063	0.5
Entamoeba histolytica	calcium-binding protein, putative	0.0023	0.1063	0.5
Brugia malayi	C2 domain containing protein	0.0023	0.1063	0.7852
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0023	0.1063	0.1083
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Leishmania major	c2 domain protein, putative	0.0023	0.1063	0.5
Echinococcus multilocularis	protein piccolo	0.0023	0.1063	0.1063
Echinococcus granulosus	extended synaptotagmin 2	0.0023	0.1063	0.1063
Loa Loa (eye worm)	C2 domain-containing protein	0.0023	0.1063	0.7852
Schistosoma mansoni	unc-13 (munc13)	0.0023	0.1063	0.1083
Echinococcus granulosus	NEDD4 E3 ubiquitin protein ligase WWP1	0.0023	0.1063	0.1063
Echinococcus multilocularis	c src tyrosine kinase	0.0007	0.0053	0.0053
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0023	0.1063	0.5
Trypanosoma brucei	Coiled-coil and C2 domain-containing protein	0.0023	0.1063	0.5
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0023	0.1063	0.1063
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Brugia malayi	SRC-1	0.0007	0.0053	0.039
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0023	0.1063	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0007	0.0053	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Trypanosoma brucei	C2 domain containing protein, putative	0.0023	0.1063	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Brugia malayi	C2 domain containing protein	0.0023	0.1063	0.7852
Entamoeba histolytica	Rap/Ran GTPase activating protein, putative	0.0023	0.1063	0.5
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.0023	0.1063	0.1063
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0007	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Brugia malayi	Synapse defective protein 1	0.0023	0.1063	0.7852
Trypanosoma brucei	synaptotagmin, putative	0.0023	0.1063	0.5
Plasmodium vivax	perforin-like protein 3	0.0081	0.4635	1
Echinococcus multilocularis	active breakpoint cluster region	0.0023	0.1063	0.1063
Onchocerca volvulus		0.0023	0.1063	0.5
Schistosoma mansoni	copine	0.0023	0.1063	0.1083
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0007	0.0053	0.0053
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0007	0.0053	0.0053
Trypanosoma brucei	predicted C2 domain protein	0.0023	0.1063	0.5
Trichomonas vaginalis	Proline-rich protein, putative	0.0023	0.1063	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Trypanosoma cruzi	synaptotagmin, putative	0.0023	0.1063	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Brugia malayi	C2 domain containing protein	0.0023	0.1063	0.7852
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.0023	0.1063	0.1063
Leishmania major	hypothetical protein, conserved	0.0023	0.1063	0.5
Schistosoma mansoni	mctp-related	0.0023	0.1063	0.1083
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Schistosoma mansoni	hypothetical protein	0.0023	0.1063	0.1083
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Echinococcus granulosus	myoferlin	0.0023	0.1063	0.1063
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.0023	0.1063	0.1063
Schistosoma mansoni	tyrosine kinase	0.0007	0.0053	0.0054
Schistosoma mansoni	hypothetical protein	0.0023	0.1063	0.1083
Onchocerca volvulus		0.0023	0.1063	0.5
Schistosoma mansoni	glut4 vesicle protein-related	0.0023	0.1063	0.1083
Brugia malayi	C2 domain containing protein	0.0023	0.1063	0.7852
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0023	0.1063	0.5
Trichomonas vaginalis	copine, putative	0.0023	0.1063	0.5
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0023	0.1063	0.7852
Loa Loa (eye worm)	copine family protein	0.0023	0.1063	0.7852
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Brugia malayi	Protein kinase c protein 2	0.0023	0.1063	0.7852
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Echinococcus granulosus	active breakpoint cluster region	0.0023	0.1063	0.1063
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0007	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Trypanosoma cruzi	C2 domain containing protein, putative	0.0023	0.1063	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Leishmania major	hypothetical protein, conserved	0.0023	0.1063	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0007	0.0053	0.0053
Brugia malayi	Synapse defective protein 1	0.0023	0.1063	0.7852
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.1063	0.5
Schistosoma mansoni	synaptotagmin-like protein	0.0023	0.1063	0.1083
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0023	0.1063	0.1063
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0007	0.0053	0.0053
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.1063	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0028	0.1353	1
Echinococcus granulosus	protein piccolo	0.0023	0.1063	0.1063
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0007	0.0053	0.0053
Plasmodium falciparum	perforin-like protein 5	0.0081	0.4635	1
Schistosoma mansoni	otoferlin	0.0023	0.1063	0.1083
Echinococcus multilocularis	extended synaptotagmin 2	0.0023	0.1063	0.1063
Toxoplasma gondii	MAC/Perforin domain-containing protein	0.0081	0.4635	1
Brugia malayi	Copine family protein	0.0023	0.1063	0.7852
Brugia malayi	WW domain containing protein	0.0023	0.1063	0.7852
Entamoeba histolytica	hypothetical protein	0.0023	0.1063	0.5
Echinococcus multilocularis	myoferlin	0.0023	0.1063	0.1063
Trichomonas vaginalis	Circumsporozoite protein precursor, putative	0.0023	0.1063	0.5
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0023	0.1063	0.1063
Loa Loa (eye worm)	SRC-1	0.0007	0.0053	0.039
Entamoeba histolytica	protein kinase, putative	0.0023	0.1063	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Loa Loa (eye worm)	phosphatidylinositol 3-kinase catalytic subunit gamma	0.0023	0.1063	0.7852
Echinococcus multilocularis	UNCoordinated family member (unc 13)	0.0023	0.1063	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Echinococcus granulosus	neural cell expressed developmentally	0.0023	0.1063	0.1063
Schistosoma mansoni	synaptic ras gtpase activating protein syngap	0.0023	0.1063	0.1083
Loa Loa (eye worm)	C2 domain-containing protein	0.0023	0.1063	0.7852
Schistosoma mansoni	synaptotagmin	0.0023	0.1063	0.1083
Schistosoma mansoni	tyrosine kinase	0.0007	0.0053	0.0054
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0023	0.1063	0.1063
Echinococcus granulosus	synaptotagmin	0.0023	0.1063	0.1063
Trypanosoma cruzi	phosphoinositide-specific phospholipase C, putative	0.0023	0.1063	0.5
Schistosoma mansoni	rab3 interacting molecule (rim)-related	0.0023	0.1063	0.1083
Onchocerca volvulus	Multiple C2 domain and transmembrane region protein homolog	0.0023	0.1063	0.5
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.0023	0.1063	0.1063
Leishmania major	hypothetical protein, conserved	0.0023	0.1063	0.5
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0023	0.1063	0.1083
Brugia malayi	Copine VIII	0.0023	0.1063	0.7852
Trichomonas vaginalis	splicing factor 3A subunit, putative	0.0023	0.1063	0.5
Brugia malayi	C2 domain containing protein	0.0023	0.1063	0.7852
Entamoeba histolytica	DENN domain protein	0.0023	0.1063	0.5
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.0023	0.1063	0.1063
Onchocerca volvulus		0.0023	0.1063	0.5
Echinococcus granulosus	calpain 5	0.0023	0.1063	0.1063
Onchocerca volvulus		0.0023	0.1063	0.5
Echinococcus multilocularis	synaptotagmin protein 4	0.0023	0.1063	0.1063
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0023	0.1063	0.1063
Leishmania major	copine i-like protein	0.0023	0.1063	0.5
Brugia malayi	C2 domain containing protein	0.0023	0.1063	0.7852
Trichomonas vaginalis	copine, putative	0.0023	0.1063	0.5
Schistosoma mansoni	protein kinase C	0.0023	0.1063	0.1083
Echinococcus granulosus	synaptotagmin	0.0023	0.1063	0.1063
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Schistosoma mansoni	fer-1-related	0.0023	0.1063	0.1083
Entamoeba histolytica	C2 domain containing protein	0.0023	0.1063	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.1063	0.5
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0023	0.1063	0.1063
Trypanosoma brucei	predicted C2 domain protein	0.0023	0.1063	0.5
Trypanosoma cruzi	C2 domain/Ankyrin repeats (3 copies), putative	0.0023	0.1063	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.1063	0.1083
Echinococcus granulosus	intersectin 2	0.0026	0.1246	0.1246
Echinococcus granulosus	unc 13 munc13	0.0023	0.1063	0.1063
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0167	1	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Brugia malayi	C2 domain containing protein	0.0023	0.1063	0.7852
Echinococcus granulosus	copine 9	0.0023	0.1063	0.1063
Echinococcus granulosus	Immunoglobulin E set	0.0023	0.1063	0.1063
Echinococcus multilocularis		0.0023	0.1063	0.1063
Echinococcus multilocularis	neural cell expressed, developmentally	0.0023	0.1063	0.1063
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0023	0.1063	0.7852
Schistosoma mansoni	phospholipase C-like protein 2 plc-L2	0.0023	0.1063	0.1083
Entamoeba histolytica	C2 domain protein, putative	0.0023	0.1063	0.5
Loa Loa (eye worm)	C2 domain-containing protein	0.0023	0.1063	0.7852
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0007	0.0053	0.0053
Echinococcus multilocularis	synaptotagmin	0.0023	0.1063	0.1063
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.1063	0.5
Trypanosoma brucei	C2 domain/Ankyrin repeats (3 copies), putative	0.0023	0.1063	0.5
Echinococcus multilocularis	synaptotagmin	0.0023	0.1063	0.1063
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0007	0.0053	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Schistosoma mansoni	rho gtpase activating protein	0.0023	0.1063	0.1083
Schistosoma mansoni	unc-13 (munc13)	0.0023	0.1063	0.1083
Trichomonas vaginalis	synaptotagmin, putative	0.0023	0.1063	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.1063	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.1063	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Brugia malayi	C2 domain containing protein	0.0023	0.1063	0.7852
Entamoeba histolytica	hypothetical protein	0.0023	0.1063	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0007	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0007	0.0053	0.0053
Echinococcus granulosus	synaptotagmin	0.0023	0.1063	0.1063
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0007	0.0053	0.0054
Trypanosoma cruzi	synaptotagmin, putative	0.0023	0.1063	0.5
Echinococcus multilocularis	synaptotagmin	0.0023	0.1063	0.1063
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Echinococcus granulosus	protein kinase c epsilon type	0.0023	0.1063	0.1063
Echinococcus multilocularis	synaptotagmin	0.0023	0.1063	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0023	0.1063	0.1063
Entamoeba histolytica	protein kinase, putative	0.0023	0.1063	0.5
Schistosoma mansoni	tyrosine kinase	0.0007	0.0053	0.0054
Entamoeba histolytica	C2 domain containing protein	0.0023	0.1063	0.5
Echinococcus multilocularis	NEDD4 E3 ubiquitin protein ligase WWP1	0.0023	0.1063	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Schistosoma mansoni	hypothetical protein	0.0023	0.1063	0.1083
Trichomonas vaginalis	synaptotagmin, putative	0.0023	0.1063	0.5
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.0023	0.1063	0.1063
Trichomonas vaginalis	synaptotagmin, putative	0.0023	0.1063	0.5
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0023	0.1063	0.1063
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.1063	0.5
Schistosoma mansoni	synaptotagmin	0.0023	0.1063	0.1083
Plasmodium falciparum	perforin-like protein 3	0.0081	0.4635	1
Trichomonas vaginalis	ion channel nompc, putative	0.0023	0.1063	0.5
Trypanosoma brucei	predicted C2 domain protein	0.0023	0.1063	0.5
Onchocerca volvulus		0.0023	0.1063	0.5
Echinococcus multilocularis	protein kinase c epsilon type	0.0023	0.1063	0.1063
Trichomonas vaginalis	synaptotagmin, putative	0.0023	0.1063	0.5
Entamoeba histolytica	hypothetical protein	0.0023	0.1063	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0007	0.0053	0.0053
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0007	0.0053	0.0053
Echinococcus granulosus	copine 9	0.0023	0.1063	0.1063
Schistosoma mansoni	unc-13 (munc13)	0.0023	0.1063	0.1083
Schistosoma mansoni	synaptotagmin 12	0.0023	0.1063	0.1083
Echinococcus multilocularis	macrophage expressed protein	0.0081	0.4635	0.4635
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.1063	0.1083
Onchocerca volvulus	Putative cc2d1b protein	0.0023	0.1063	0.5
Leishmania major	hypothetical protein, conserved	0.0023	0.1063	0.5
Brugia malayi	protein kinase C II.	0.0023	0.1063	0.7852
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0023	0.1063	0.7852
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.1063	0.1083
Trypanosoma brucei	C2 domain containing protein, putative	0.0023	0.1063	0.5
Schistosoma mansoni	synaptotagmin	0.0023	0.1063	0.1083
Entamoeba histolytica	hypothetical protein, conserved	0.0023	0.1063	0.5
Entamoeba histolytica	hypothetical protein	0.0023	0.1063	0.5
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.0023	0.1063	0.1063
Chlamydia trachomatis	hypothetical protein	0.0081	0.4635	0.5
Echinococcus multilocularis	synaptotagmin 15	0.0023	0.1063	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1063	0.7852
Leishmania major	hypothetical protein, conserved	0.0023	0.1063	0.5
Echinococcus multilocularis	synaptotagmin 2	0.0023	0.1063	0.1063
Brugia malayi	C2 domain containing protein	0.0023	0.1063	0.7852
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.0023	0.1063	0.7852
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.1063	0.5
Loa Loa (eye worm)	synaptotagmin-1	0.0023	0.1063	0.7852
Echinococcus multilocularis	calpain 5	0.0023	0.1063	0.1063
Trichomonas vaginalis	copine, putative	0.0023	0.1063	0.5
Onchocerca volvulus		0.0023	0.1063	0.5
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0023	0.1063	0.1063
Echinococcus granulosus	otoferlin	0.0023	0.1063	0.1063
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0007	0.0053	0.0053
Loa Loa (eye worm)	C2 domain-containing protein	0.0023	0.1063	0.7852
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0023	0.1063	0.5
Brugia malayi	LD23056p	0.0023	0.1063	0.7852
Brugia malayi	Synaptotagmin protein 3	0.0023	0.1063	0.7852
Schistosoma mansoni	E3 ubiquitin-protein ligase nedd-4	0.0023	0.1063	0.1083
Plasmodium falciparum	perforin-like protein 2	0.0081	0.4635	1
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.0023	0.1063	0.1063

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.31 uM	Inhibition of recombinant GST-tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay	ChEMBL.	21316219

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1684533

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1502350