TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 769.881 | Formula: C46H47N3O8
H donors: 1 H acceptors: 4 LogP: 6.5 Rotable bonds: 20
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)[C@@H](n1nnc(c1)CO[C@@H]1O[C@H](COCc2ccccc2)[C@@H]([C@@H]([C@H]1OCc1ccccc1)OCc1ccccc1)OCc1ccccc1)Cc1ccccc1
InChi: 1S/C46H47N3O8/c50-45(51)40(26-34-16-6-1-7-17-34)49-27-39(47-48-49)32-56-46-44(55-31-38-24-14-5-15-25-38)43(54-30-37-22-12-4-13-23-37)42(53-29-36-20-10-3-11-21-36)41(57-46)33-52-28-35-18-8-2-9-19-35/h1-25,27,40-44,46H,26,28-33H2,(H,50,51)/t40-,41+,42-,43-,44+,46+/m0/s1
InChiKey: RWUXVUTVRJKNCY-LWQOTUEFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein tyrosine phosphatase, non-receptor type 6	Starlite/ChEMBL	References
Homo sapiens	cell division cycle 25B	Starlite/ChEMBL	References
Homo sapiens	protein tyrosine phosphatase, non-receptor type 11	Starlite/ChEMBL	References
Homo sapiens	protein tyrosine phosphatase, non-receptor type 2	Starlite/ChEMBL	References
Homo sapiens	protein tyrosine phosphatase, non-receptor type 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	Get druggable targets OG5_127845	All targets in OG5_127845
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127845	All targets in OG5_127845
Brugia malayi	Protein-tyrosine phosphatase containing protein	Get druggable targets OG5_130331	All targets in OG5_130331
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_130331	All targets in OG5_130331
Onchocerca volvulus		Get druggable targets OG5_127845	All targets in OG5_127845
Entamoeba histolytica	rodhanase-like domain containing protein	Get druggable targets OG5_127845	All targets in OG5_127845
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127845	All targets in OG5_127845
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_130331	All targets in OG5_130331
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133865	All targets in OG5_133865
Trichomonas vaginalis	cdc25b, putative	Get druggable targets OG5_127845	All targets in OG5_127845
Echinococcus granulosus	m phase inducer phosphatasecdc25	Get druggable targets OG5_127845	All targets in OG5_127845
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	Get druggable targets OG5_130331	All targets in OG5_130331
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127845	All targets in OG5_127845
Trichomonas vaginalis	m-phase inducer phosphatase, putative	Get druggable targets OG5_127845	All targets in OG5_127845
Onchocerca volvulus		Get druggable targets OG5_127845	All targets in OG5_127845
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127845	All targets in OG5_127845
Candida albicans	similar to A.nidulans mitotic inducer phosphatase NIMT/CDC25 and to S. cerevisiae MIH1 (YMR036C)	Get druggable targets OG5_127845	All targets in OG5_127845
Brugia malayi	Rhodanese-like domain containing protein	Get druggable targets OG5_127845	All targets in OG5_127845
Trichomonas vaginalis	m-phase inducer phosphatase, putative	Get druggable targets OG5_127845	All targets in OG5_127845
Loa Loa (eye worm)	protein-tyrosine phosphatase	Get druggable targets OG5_133865	All targets in OG5_133865
Schistosoma mansoni	m-phase inducer phosphatase(cdc25)	Get druggable targets OG5_127845	All targets in OG5_127845
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	Get druggable targets OG5_133865	All targets in OG5_133865
Loa Loa (eye worm)	protein-tyrosine phosphatase	Get druggable targets OG5_130331	All targets in OG5_130331
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	Get druggable targets OG5_127845	All targets in OG5_127845
Onchocerca volvulus		Get druggable targets OG5_127845	All targets in OG5_127845
Entamoeba histolytica	rodhanase-like domain containing protein	Get druggable targets OG5_127845	All targets in OG5_127845
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_133865	All targets in OG5_133865
Trichomonas vaginalis	cdc25b, putative	Get druggable targets OG5_127845	All targets in OG5_127845
Onchocerca volvulus		Get druggable targets OG5_127845	All targets in OG5_127845
Trichomonas vaginalis	cdc25c, putative	Get druggable targets OG5_127845	All targets in OG5_127845
Echinococcus multilocularis	m phase inducer phosphatase(cdc25)	Get druggable targets OG5_127845	All targets in OG5_127845
Candida albicans	almost identical to C terminus of CaP19.3071, which is similar to A.nidulans mitotic inducer phosphatase NIMT/CDC25 and to S. ce	Get druggable targets OG5_127845	All targets in OG5_127845
Brugia malayi	Protein-tyrosine phosphatase containing protein	Get druggable targets OG5_133865	All targets in OG5_133865
Brugia malayi	Rhodanese-like domain containing protein	Get druggable targets OG5_127845	All targets in OG5_127845
Schistosoma japonicum	ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative	Get druggable targets OG5_133865	All targets in OG5_133865
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_133865	All targets in OG5_133865
Schistosoma japonicum	ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative	Get druggable targets OG5_127845	All targets in OG5_127845
Schistosoma japonicum	IPR000242,Tyrosine specific protein phosphatase,domain-containing	Get druggable targets OG5_130331	All targets in OG5_130331
Schistosoma japonicum	ko:K07293 protein tyrosine phosphatase, non-receptor type 11, putative	Get druggable targets OG5_130331	All targets in OG5_130331
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	Get druggable targets OG5_127845	All targets in OG5_127845
Entamoeba histolytica	rodhanase-like domain containing protein	Get druggable targets OG5_127845	All targets in OG5_127845
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_130331	All targets in OG5_130331
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_130331	All targets in OG5_130331

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	protein tyrosine phosphatase	protein tyrosine phosphatase, non-receptor type 2	410 aa	335 aa	25.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	C2 domain containing protein	0.0062	0.064	0.064
Schistosoma mansoni	fer-1-related	0.0062	0.064	0.064
Schistosoma mansoni	hypothetical protein	0.0062	0.064	0.064
Trypanosoma brucei	Coiled-coil and C2 domain-containing protein	0.0062	0.064	1
Brugia malayi	Rhodanese-like domain containing protein	0.0068	0.079	0.079
Schistosoma mansoni	synaptotagmin	0.0062	0.064	0.064
Leishmania major	hypothetical protein, conserved	0.0062	0.064	1
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0062	0.064	0.8097
Brugia malayi	WW domain containing protein	0.0062	0.064	0.064
Brugia malayi	C2 domain containing protein	0.0062	0.064	0.064
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Schistosoma mansoni	synaptotagmin	0.0062	0.064	0.064
Trypanosoma cruzi	phosphoinositide-specific phospholipase C, putative	0.0062	0.064	1
Plasmodium vivax	perforin-like protein 4	0.0217	0.4392	1
Echinococcus multilocularis	serine threonine protein kinase	0.0062	0.064	0.064
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0062	0.064	0.064
Schistosoma mansoni	synaptotagmin	0.0062	0.064	0.064
Onchocerca volvulus		0.0062	0.064	0.8097
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.0062	0.064	0.064
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0307	0.6575	0.6575
Schistosoma mansoni	otoferlin	0.0062	0.064	0.064
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Echinococcus multilocularis	synaptotagmin	0.0062	0.064	0.064
Trypanosoma cruzi	hypothetical protein, conserved	0.0062	0.064	1
Leishmania major	hypothetical protein, conserved	0.0062	0.064	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0062	0.064	1
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Trypanosoma cruzi	cAMP binding protein, putative	0.0062	0.064	1
Schistosoma mansoni	glut4 vesicle protein-related	0.0062	0.064	0.064
Echinococcus granulosus	extended synaptotagmin 2	0.0062	0.064	0.064
Echinococcus granulosus	protein kinase C gamma type	0.0062	0.064	0.064
Brugia malayi	Synaptotagmin I	0.0062	0.064	0.064
Trypanosoma cruzi	hypothetical protein, conserved	0.0062	0.064	1
Echinococcus multilocularis	active breakpoint cluster region	0.0062	0.064	0.064
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0062	0.064	0.064
Loa Loa (eye worm)	C2 domain-containing protein	0.0062	0.064	0.064
Echinococcus granulosus	protein piccolo	0.0062	0.064	0.064
Trypanosoma cruzi	hypothetical protein, conserved	0.0062	0.064	1
Brugia malayi	C2 domain containing protein	0.0062	0.064	0.064
Plasmodium vivax	perforin-like protein 1	0.0217	0.4392	1
Trypanosoma cruzi	C2 domain/Ankyrin repeats (3 copies), putative	0.0062	0.064	1
Entamoeba histolytica	DENN domain protein	0.0062	0.064	0.8097
Brugia malayi	Rhodanese-like domain containing protein	0.0068	0.079	0.079
Echinococcus granulosus	myoferlin	0.0062	0.064	0.064
Leishmania major	hypothetical protein, conserved	0.0062	0.064	1
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0062	0.064	0.064
Brugia malayi	Synapse defective protein 1	0.0062	0.064	0.064
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0307	0.6575	0.6575
Brugia malayi	C2 domain containing protein	0.0062	0.064	0.064
Leishmania major	phospholipase c-like protein	0.0062	0.064	1
Toxoplasma gondii	perforin-like protein PLP1	0.0217	0.4392	1
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Trypanosoma brucei	predicted C2 domain protein	0.0062	0.064	1
Onchocerca volvulus		0.0068	0.079	1
Echinococcus granulosus	UNCoordinated family member unc 13	0.0062	0.064	0.064
Entamoeba histolytica	hypothetical protein	0.0062	0.064	0.8097
Echinococcus granulosus	synaptotagmin	0.0062	0.064	0.064
Entamoeba histolytica	hypothetical protein	0.0062	0.064	0.8097
Entamoeba histolytica	C2 domain containing protein	0.0062	0.064	0.8097
Loa Loa (eye worm)	C2 domain-containing protein	0.0062	0.064	0.064
Trichomonas vaginalis	Circumsporozoite protein precursor, putative	0.0062	0.064	0.8097
Entamoeba histolytica	hypothetical protein, conserved	0.0062	0.064	0.8097
Chlamydia trachomatis	hypothetical protein	0.0217	0.4392	0.5
Trichomonas vaginalis	copine, putative	0.0062	0.064	0.8097
Trypanosoma brucei	C2 domain/Ankyrin repeats (3 copies), putative	0.0062	0.064	1
Trypanosoma cruzi	synaptotagmin, putative	0.0062	0.064	1
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0068	0.079	1
Trichomonas vaginalis	synaptotagmin, putative	0.0062	0.064	0.8097
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0307	0.6575	0.6575
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Schistosoma mansoni	synaptotagmin	0.0062	0.064	0.064
Schistosoma mansoni	phospholipase C-like protein 2 plc-L2	0.0062	0.064	0.064
Echinococcus multilocularis	m phase inducer phosphatase(cdc25)	0.0068	0.079	0.079
Entamoeba histolytica	protein kinase, putative	0.0062	0.064	0.8097
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.0062	0.064	0.064
Entamoeba histolytica	C2 domain containing protein	0.0062	0.064	0.8097
Entamoeba histolytica	hypothetical protein	0.0062	0.064	0.8097
Loa Loa (eye worm)	hypothetical protein	0.0068	0.079	0.079
Leishmania major	copine i-like protein	0.0062	0.064	1
Plasmodium falciparum	perforin-like protein 2	0.0217	0.4392	1
Entamoeba histolytica	C2 domain containing protein	0.0062	0.064	0.8097
Trichomonas vaginalis	vab10 spectraplakin, putative	0.0062	0.064	0.8097
Entamoeba histolytica	rodhanase-like domain containing protein	0.0068	0.079	1
Toxoplasma gondii	MAC/Perforin domain-containing protein	0.0217	0.4392	1
Schistosoma mansoni	hypothetical protein	0.0062	0.064	0.064
Entamoeba histolytica	protein kinase, putative	0.0062	0.064	0.8097
Echinococcus granulosus	active breakpoint cluster region	0.0062	0.064	0.064
Echinococcus multilocularis	NEDD4 E3 ubiquitin protein ligase WWP1	0.0062	0.064	0.064
Brugia malayi	protein kinase C II.	0.0062	0.064	0.064
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0307	0.6575	0.6575
Trichomonas vaginalis	copine, putative	0.0062	0.064	0.8097
Echinococcus granulosus	copine 9	0.0062	0.064	0.064
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Leishmania major	hypothetical protein, conserved	0.0062	0.064	1
Entamoeba histolytica	rodhanase-like domain containing protein	0.0068	0.079	1
Echinococcus granulosus	synaptotagmin protein 4	0.0062	0.064	0.064
Trichomonas vaginalis	calcium-dependent lipid-binding protein, putative	0.0062	0.064	0.8097
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0068	0.079	1
Onchocerca volvulus		0.0062	0.064	0.8097
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Plasmodium falciparum	perforin-like protein 3	0.0217	0.4392	1
Trichomonas vaginalis	Proline-rich protein, putative	0.0062	0.064	0.8097
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Trichomonas vaginalis	synaptotagmin, putative	0.0062	0.064	0.8097
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0068	0.079	1
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.064	0.064
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.0062	0.064	0.064
Schistosoma mansoni	synaptic ras gtpase activating protein syngap	0.0062	0.064	0.064
Echinococcus multilocularis	synaptotagmin 15	0.0062	0.064	0.064
Leishmania major	hypothetical protein, conserved	0.0062	0.064	1
Trypanosoma cruzi	C2 domain containing protein, putative	0.0062	0.064	1
Echinococcus multilocularis		0.0062	0.064	0.064
Plasmodium vivax	perforin-like protein 5	0.0217	0.4392	1
Schistosoma mansoni	unc-13 (munc13)	0.0062	0.064	0.064
Echinococcus multilocularis	macrophage expressed protein	0.0217	0.4392	0.4392
Trypanosoma brucei	C2 domain containing protein, putative	0.0062	0.064	1
Brugia malayi	Copine VIII	0.0062	0.064	0.064
Brugia malayi	C2 domain containing protein	0.0062	0.064	0.064
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Echinococcus multilocularis	synaptotagmin 2	0.0062	0.064	0.064
Schistosoma mansoni	copine	0.0062	0.064	0.064
Loa Loa (eye worm)	C2 domain-containing protein	0.0062	0.064	0.064
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0062	0.064	0.8097
Echinococcus granulosus	intersectin 2	0.0062	0.064	0.064
Schistosoma mansoni	hypothetical protein	0.0062	0.064	0.064
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Echinococcus multilocularis	synaptotagmin	0.0062	0.064	0.064
Echinococcus granulosus	calpain 5	0.0062	0.064	0.064
Plasmodium vivax	perforin-like protein 3	0.0217	0.4392	1
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0062	0.064	0.064
Trypanosoma cruzi	hypothetical protein, conserved	0.0062	0.064	1
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Schistosoma mansoni	synaptotagmin 12	0.0062	0.064	0.064
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.0062	0.064	0.064
Schistosoma mansoni	m-phase inducer phosphatase(cdc25)	0.0068	0.079	0.079
Brugia malayi	phospholipase C homolog	0.0062	0.064	0.064
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.0062	0.064	0.064
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Trypanosoma brucei	phosphoinositide-specific phospholipase C	0.0062	0.064	1
Trichomonas vaginalis	copine, putative	0.0062	0.064	0.8097
Leishmania major	c2 domain protein, putative	0.0062	0.064	1
Schistosoma mansoni	hypothetical protein	0.0062	0.064	0.064
Echinococcus granulosus	m phase inducer phosphatasecdc25	0.0068	0.079	0.079
Echinococcus multilocularis	synaptotagmin protein 4	0.0062	0.064	0.064
Echinococcus granulosus	protein kinase c epsilon type	0.0062	0.064	0.064
Trichomonas vaginalis	copine, putative	0.0062	0.064	0.8097
Entamoeba histolytica	C2 domain containing protein	0.0062	0.064	0.8097
Schistosoma mansoni	rabphilin-3a	0.0062	0.064	0.064
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0062	0.064	0.064
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0062	0.064	0.064
Echinococcus multilocularis	myoferlin	0.0062	0.064	0.064
Brugia malayi	C2 domain containing protein	0.0062	0.064	0.064
Schistosoma mansoni	hypothetical protein	0.0062	0.064	0.064
Trypanosoma brucei	C2 domain containing protein, putative	0.0062	0.064	1
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Loa Loa (eye worm)	synaptotagmin-1	0.0062	0.064	0.064
Onchocerca volvulus		0.0062	0.064	0.8097
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0062	0.064	0.064
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Entamoeba histolytica	C2 domain containing protein	0.0062	0.064	0.8097
Echinococcus multilocularis	intersectin 2	0.0062	0.064	0.064
Loa Loa (eye worm)	C2 domain-containing protein	0.0062	0.064	0.064
Leishmania major	hypothetical protein, conserved	0.0062	0.064	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Echinococcus multilocularis	unc 13 (munc13)	0.0062	0.064	0.064
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.0062	0.064	0.064
Onchocerca volvulus		0.0062	0.064	0.8097
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.064	0.064
Plasmodium falciparum	perforin-like protein 4	0.0217	0.4392	1
Brugia malayi	Copine family protein	0.0062	0.064	0.064
Brugia malayi	C2 domain containing protein	0.0062	0.064	0.064
Brugia malayi	LD23056p	0.0062	0.064	0.064
Trichomonas vaginalis	copine, putative	0.0062	0.064	0.8097
Echinococcus multilocularis	copine 9	0.0062	0.064	0.064
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0062	0.064	0.064
Schistosoma mansoni	protein kinase C	0.0062	0.064	0.064
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Brugia malayi	C2 domain containing protein	0.0062	0.064	0.064
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0062	0.064	0.8097
Echinococcus granulosus	synaptotagmin	0.0062	0.064	0.064
Entamoeba histolytica	rodhanase-like domain containing protein	0.0068	0.079	1
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Echinococcus granulosus	macrophage expressed protein	0.0217	0.4392	0.4392
Echinococcus multilocularis	protein kinase c epsilon type	0.0062	0.064	0.064
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Brugia malayi	Protein kinase c protein 2	0.0062	0.064	0.064
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0074	0.0934	0.0934
Schistosoma mansoni	synaptotagmin	0.0062	0.064	0.064
Trypanosoma cruzi	hypothetical protein, conserved	0.0062	0.064	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.064	0.064
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0307	0.6575	0.6575
Trichomonas vaginalis	cdc25b, putative	0.0068	0.079	1
Brugia malayi	C2 domain containing protein	0.0062	0.064	0.064
Echinococcus granulosus	NEDD4 E3 ubiquitin protein ligase WWP1	0.0062	0.064	0.064
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.0068	0.079	1
Trichomonas vaginalis	synaptotagmin, putative	0.0062	0.064	0.8097
Onchocerca volvulus	Putative cc2d1b protein	0.0062	0.064	0.8097
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0661	0.0661
Brugia malayi	C2 domain containing protein	0.0062	0.064	0.064
Entamoeba histolytica	C2 domain containing protein	0.0062	0.064	0.8097
Loa Loa (eye worm)	C2 domain-containing protein	0.0062	0.064	0.064
Schistosoma mansoni	mctp-related	0.0062	0.064	0.064
Entamoeba histolytica	hypothetical protein	0.0062	0.064	0.8097
Loa Loa (eye worm)	hypothetical protein	0.0068	0.079	0.079
Echinococcus granulosus	Immunoglobulin E set	0.0062	0.064	0.064
Echinococcus multilocularis	synaptotagmin	0.0062	0.064	0.064
Schistosoma mansoni	E3 ubiquitin-protein ligase nedd-4	0.0062	0.064	0.064
Schistosoma mansoni	unc-13 (munc13)	0.0062	0.064	0.064
Entamoeba histolytica	C2 domain containing protein	0.0062	0.064	0.8097
Echinococcus granulosus	unc 13 munc13	0.0062	0.064	0.064
Schistosoma mansoni	nedd-4-like E3 ubiquitin-protein ligase	0.0062	0.064	0.064
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0062	0.064	0.064
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0062	0.064	0.064
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0062	0.064	0.8097
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.0062	0.064	0.064
Echinococcus granulosus	Protein kinase C brain isozyme	0.0062	0.064	0.064
Trypanosoma brucei	predicted C2 domain protein	0.0062	0.064	1
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Brugia malayi	C2 domain containing protein	0.0062	0.064	0.064
Echinococcus multilocularis	calpain 5	0.0062	0.064	0.064
Trichomonas vaginalis	synaptotagmin, putative	0.0062	0.064	0.8097
Trichomonas vaginalis	ion channel nompc, putative	0.0062	0.064	0.8097
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Schistosoma mansoni	rho gtpase activating protein	0.0062	0.064	0.064
Loa Loa (eye worm)	copine family protein	0.0062	0.064	0.064
Echinococcus multilocularis	neural cell expressed, developmentally	0.0062	0.064	0.064
Onchocerca volvulus		0.0062	0.064	0.8097
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0062	0.064	0.064
Echinococcus granulosus	copine 9	0.0062	0.064	0.064
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Echinococcus granulosus	synaptotagmin 2	0.0062	0.064	0.064
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Echinococcus multilocularis	synaptotagmin	0.0062	0.064	0.064
Onchocerca volvulus		0.0068	0.079	1
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.0062	0.064	0.064
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0062	0.064	0.064
Trypanosoma cruzi	synaptotagmin, putative	0.0062	0.064	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.0068	0.079	1
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Brugia malayi	Synapse defective protein 1	0.0062	0.064	0.064
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Plasmodium vivax	perforin-like protein 2	0.0217	0.4392	1
Plasmodium falciparum	perforin-like protein 5	0.0217	0.4392	1
Brugia malayi	C2 domain containing protein	0.0062	0.064	0.064
Entamoeba histolytica	hypothetical protein	0.0062	0.064	0.8097
Onchocerca volvulus		0.0062	0.064	0.8097
Trichomonas vaginalis	cdc25c, putative	0.0068	0.079	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Brugia malayi	calpain 5	0.0062	0.064	0.064
Entamoeba histolytica	C2 domain containing protein	0.0062	0.064	0.8097
Brugia malayi	NEDD4.2	0.0062	0.064	0.064
Schistosoma mansoni	rab3 interacting molecule (rim)-related	0.0062	0.064	0.064
Loa Loa (eye worm)	Nedd4-PD	0.0062	0.064	0.064
Brugia malayi	Synaptotagmin protein 3	0.0062	0.064	0.064
Leishmania major	hypothetical protein, conserved	0.0062	0.064	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0307	0.6575	0.6575
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0062	0.064	1
Echinococcus granulosus	synaptotagmin	0.0062	0.064	0.064
Trypanosoma brucei	hypothetical protein, conserved	0.0062	0.064	1
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Brugia malayi	Variant SH3 domain containing protein	0.0074	0.0934	0.0934
Loa Loa (eye worm)	phosphatidylinositol 3-kinase catalytic subunit gamma	0.0062	0.064	0.064
Onchocerca volvulus		0.0068	0.079	1
Schistosoma mansoni	hypothetical protein	0.0217	0.4392	0.4392
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0062	0.064	0.064
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.0062	0.064	0.064
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Echinococcus granulosus	synaptotagmin 15	0.0062	0.064	0.064
Echinococcus granulosus	synaptotagmin	0.0062	0.064	0.064
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Entamoeba histolytica	hypothetical protein, conserved	0.0062	0.064	0.8097
Entamoeba histolytica	calcium-binding protein, putative	0.0062	0.064	0.8097
Trypanosoma cruzi	Coiled-coil and C2 domain-containing protein	0.0062	0.064	1
Trichomonas vaginalis	synaptotagmin, putative	0.0062	0.064	0.8097
Leishmania major	c2 domain protein, putative	0.0062	0.064	1
Entamoeba histolytica	Rap/Ran GTPase activating protein, putative	0.0062	0.064	0.8097
Entamoeba histolytica	C2 domain protein, putative	0.0062	0.064	0.8097
Trypanosoma brucei	hypothetical protein, conserved	0.0062	0.064	1
Onchocerca volvulus	Multiple C2 domain and transmembrane region protein homolog	0.0062	0.064	0.8097
Trypanosoma brucei	predicted C2 domain protein	0.0062	0.064	1
Brugia malayi	C2 domain containing protein	0.0062	0.064	0.064
Echinococcus multilocularis	protein piccolo	0.0062	0.064	0.064
Trichomonas vaginalis	synaptotagmin, putative	0.0062	0.064	0.8097
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.0062	0.064	0.064
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0307	0.6575	0.6575
Trypanosoma brucei	cAMP binding protein, putative	0.0062	0.064	1
Trypanosoma brucei	C2 domain containing protein, putative	0.0062	0.064	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0062	0.064	0.064
Trypanosoma brucei	synaptotagmin, putative	0.0062	0.064	1
Entamoeba histolytica	C2 domain containing protein	0.0062	0.064	0.8097
Loa Loa (eye worm)	C2 domain-containing protein	0.0062	0.064	0.064
Trichomonas vaginalis	cdc25b, putative	0.0068	0.079	1
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Echinococcus granulosus	synaptotagmin	0.0062	0.064	0.064
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0062	0.064	0.064
Echinococcus multilocularis	synaptotagmin	0.0062	0.064	0.064
Trypanosoma cruzi	hypothetical protein, conserved	0.0062	0.064	1
Echinococcus multilocularis	copine 9	0.0062	0.064	0.064
Onchocerca volvulus		0.0068	0.079	1
Entamoeba histolytica	hypothetical protein	0.0062	0.064	0.8097
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Trichomonas vaginalis	synaptotagmin, putative	0.0062	0.064	0.8097
Schistosoma mansoni	synaptotagmin	0.0062	0.064	0.064
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0062	0.064	0.8097
Brugia malayi	C2 domain containing protein	0.0062	0.064	0.064
Echinococcus multilocularis	extended synaptotagmin 2	0.0062	0.064	0.064
Echinococcus multilocularis	UNCoordinated family member (unc 13)	0.0062	0.064	0.064
Plasmodium falciparum	perforin-like protein 1	0.0217	0.4392	1
Onchocerca volvulus		0.0062	0.064	0.8097
Echinococcus granulosus	neural cell expressed developmentally	0.0062	0.064	0.064
Schistosoma mansoni	synaptotagmin-like protein	0.0062	0.064	0.064
Schistosoma mansoni	unc-13 (munc13)	0.0062	0.064	0.064
Leishmania major	hypothetical protein, conserved	0.0062	0.064	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0062	0.064	0.8097
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.064	0.8097
Onchocerca volvulus		0.0062	0.064	0.8097
Schistosoma mansoni	synaptotagmin 12	0.0062	0.064	0.064
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.0062	0.064	0.064
Trichomonas vaginalis	annexin VII, putative	0.0062	0.064	0.8097
Trypanosoma brucei	C2 domain containing protein, putative	0.0062	0.064	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0062	0.064	1
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0062	0.064	0.064
Trichomonas vaginalis	splicing factor 3A subunit, putative	0.0062	0.064	0.8097
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0661	0.0661
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0062	0.064	0.064
Loa Loa (eye worm)	hypothetical protein	0.0062	0.064	0.064
Echinococcus granulosus	otoferlin	0.0062	0.064	0.064

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 7 uM	Inhibition of human recombinant PTP1B by pNPP hydrolysis assay	ChEMBL.	21251827
IC50 (binding)	= 7 uM	Inhibition of human CDC25B by pNPP hydrolysis assay	ChEMBL.	21251827
IC50 (binding)	= 12.6 uM	Inhibition of human TCPTP by pNPP hydrolysis assay	ChEMBL.	21251827
IC50 (binding)	= 17.4 uM	Inhibition of human SHP2 by pNPP hydrolysis assay	ChEMBL.	21251827
IC50 (binding)	= 18.5 uM	Inhibition of human SHP1 by pNPP hydrolysis assay	ChEMBL.	21251827
IC50 (binding)	> 50 uM	Inhibition of human LAR by pNPP hydrolysis assay	ChEMBL.	21251827

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1667959

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1505278