pI: 6.652 |
Length (AA): 631 |
MW (Da): 70989 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 301 | 1zwx (A) | 42 | 332 | 22.00 | 0 | 1 | 0.696851 | -0.48 |
28 | 255 | 1zwx (A) | 68 | 289 | 29.00 | 0.00024 | 0.99 | 0.526631 | 0.3 |
440 | 589 | 4xgc (C) | 96 | 257 | 28.00 | 0.95 | 0.09 | 0.126018 | 1.67 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_130232)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_54240 | Endonuclease/Exonuclease/phosphatase family protein |
Candida albicans | CaO19.6629 | potential endonuclease/phosphatase similar to S. cerevisiae ISC1 (YER019W) phospholipase C/sphingomyelinase |
Candida albicans | CaO19.13950 | potential endonuclease/phosphatase similar to S. cerevisiae ISC1 (YER019W) phospholipase C/sphingomyelinase |
Caenorhabditis elegans | CELE_T27F6.6 | Protein T27F6.6 |
Drosophila melanogaster | Dmel_CG12034 | CG12034 gene product from transcript CG12034-RA |
Echinococcus granulosus | EgrG_001052200 | expressed conserved protein |
Echinococcus granulosus | EgrG_000372200 | neutral sphingomyelinase |
Echinococcus granulosus | EgrG_000705800 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000372200 | neutral sphingomyelinase |
Echinococcus multilocularis | EmuJ_000705800 | conserved hypothetical protein |
Echinococcus multilocularis | EmuJ_001052200 | expressed conserved protein |
Homo sapiens | ENSG00000135587 | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) |
Loa Loa (eye worm) | LOAG_05145 | hypothetical protein |
Mus musculus | ENSMUSG00000019822 | sphingomyelin phosphodiesterase 2, neutral |
Onchocerca volvulus | OVOC8931 | Putative neutral sphingomyelinase |
Saccharomyces cerevisiae | YER019W | inositol phosphosphingolipid phospholipase |
Schistosoma japonicum | Sjp_0211770 | ko:K01117 sphingomyelin phosphodiesterase [EC3.1.4.12], putative |
Schistosoma japonicum | Sjp_0312040 | expressed protein |
Schistosoma mansoni | Smp_162880 | neutral sphingomyelinase |
Schmidtea mediterranea | mk4.019670.01 | Putative neutral sphingomyelinase |
Schmidtea mediterranea | mk4.000653.02 | Sphingomyelin phosphodiesterase 2 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) | Compounds | References |
Rattus norvegicus | Neutral sphingomyelinase | Compounds | References |