Detailed information for compound 28490

Basic information

Technical information
  • TDR Targets ID: 28490
  • Name: (2E,4E,6E,8R,10S,12E,14R)-N-[(2S)-1-hydroxy-3 -[(1S,2S,6S)-2-hydroxy-3-oxo-7-oxabicyclo[4.1 .0]hept-4-en-2-yl]propan-2-yl]-8,10,12,14-tet ramethylhexadeca-2,4,6,12-tetraenamide
  • MW: 485.655 | Formula: C29H43NO5
  • H donors: 3 H acceptors: 4 LogP: 5.61 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H](C[C@@]1(O)C(=O)C=C[C@H]2[C@@H]1O2)NC(=O)/C=C/C=C/C=C/[C@@H](C[C@@H](C/C(=C/[C@@H](CC)C)/C)C)C
  • InChi: 1S/C29H43NO5/c1-6-20(2)15-22(4)17-23(5)16-21(3)11-9-7-8-10-12-27(33)30-24(19-31)18-29(34)26(32)14-13-25-28(29)35-25/h7-15,20-21,23-25,28,31,34H,6,16-19H2,1-5H3,(H,30,33)/b8-7+,11-9+,12-10+,22-15+/t20-,21+,23+,24+,25+,28+,29-/m1/s1
  • InChiKey: KSIWZCYBCSQXTA-JPOQAJQISA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2E,4E,6E,8R,10S,12E,14R)-N-[(1S)-1-(hydroxymethyl)-2-[(1S,2S,6S)-2-hydroxy-3-oxo-7-oxabicyclo[4.1.0]hept-4-en-2-yl]ethyl]-8,10,12,14-tetramethyl-hexadeca-2,4,6,12-tetraenamide
  • (2E,4E,6E,8R,10S,12E,14R)-N-[(1S)-1-(hydroxymethyl)-2-[(1S,2S,6S)-2-hydroxy-3-oxo-7-oxabicyclo[4.1.0]hept-4-en-2-yl]ethyl]-8,10,12,14-tetramethylhexadeca-2,4,6,12-tetraenamide
  • (2E,4E,6E,8R,10S,12E,14R)-N-[(2S)-1-hydroxy-3-[(1S,2S,6S)-2-hydroxy-3-oxo-7-oxabicyclo[4.1.0]hept-4-en-2-yl]propan-2-yl]-8,10,12,14-tetramethyl-hexadeca-2,4,6,12-tetraenamide
  • (2E,4E,6E,8R,10S,12E,14R)-N-[(1S)-2-hydroxy-1-[[(1S,2S,6S)-2-hydroxy-3-keto-7-oxabicyclo[4.1.0]hept-4-en-2-yl]methyl]ethyl]-8,10,12,14-tetramethyl-hexadeca-2,4,6,12-tetraenamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Neutral sphingomyelinase Starlite/ChEMBL References
Homo sapiens sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein Get druggable targets OG5_130232 All targets in OG5_130232
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_130232 All targets in OG5_130232
Schistosoma japonicum ko:K01117 sphingomyelin phosphodiesterase [EC3.1.4.12], putative Get druggable targets OG5_130232 All targets in OG5_130232
Echinococcus multilocularis neutral sphingomyelinase Get druggable targets OG5_130232 All targets in OG5_130232
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130232 All targets in OG5_130232
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_130232 All targets in OG5_130232
Schistosoma japonicum expressed protein Get druggable targets OG5_130232 All targets in OG5_130232
Candida albicans potential endonuclease/phosphatase similar to S. cerevisiae ISC1 (YER019W) phospholipase C/sphingomyelinase Get druggable targets OG5_130232 All targets in OG5_130232
Schistosoma mansoni neutral sphingomyelinase Get druggable targets OG5_130232 All targets in OG5_130232
Echinococcus granulosus neutral sphingomyelinase Get druggable targets OG5_130232 All targets in OG5_130232
Onchocerca volvulus Putative neutral sphingomyelinase Get druggable targets OG5_130232 All targets in OG5_130232
Candida albicans potential endonuclease/phosphatase similar to S. cerevisiae ISC1 (YER019W) phospholipase C/sphingomyelinase Get druggable targets OG5_130232 All targets in OG5_130232
Echinococcus granulosus hypothetical protein Get druggable targets OG5_130232 All targets in OG5_130232
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_130232 All targets in OG5_130232
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0033 0.0175
Loa Loa (eye worm) dehydrogenase 0.0018 0.0009 0.0003
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0187 0.2464 0.6191
Schistosoma mansoni hypothetical protein 0.0532 0.7481 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0393 0.097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0033 0.0175
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0037 0.0038
Mycobacterium tuberculosis Probable dehydrogenase 0.0126 0.1588 0.158
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0018 0.0009 0.0002
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0062 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1785 0.2377
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0033 0.0175
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0021 0.0087
Loa Loa (eye worm) hypothetical protein 0.0168 0.2189 0.5497
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0027 0.0151 0.0361
Schistosoma mansoni steroid dehydrogenase 0.0018 0.0009 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0033 0.0175
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0003
Brugia malayi PHD-finger family protein 0.003 0.0189 0.0476
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0435 0.3158
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0033 0.0175
Echinococcus granulosus hypothetical protein 0.0018 0.0009 0.0002
Schistosoma mansoni cpg binding protein 0.0028 0.0163 0.0207
Brugia malayi hypothetical protein 0.0019 0.0037 0.0092
Onchocerca volvulus 0.011 0.1358 0.34
Trypanosoma brucei hypothetical protein, conserved 0.011 0.1358 1
Echinococcus granulosus carbonyl reductase 1 0.0018 0.0009 0.0002
Schistosoma mansoni short chain dehydrogenase 0.0018 0.0009 0.0002
Loa Loa (eye worm) oxidoreductase 0.0018 0.0009 0.0003
Schistosoma mansoni short chain dehydrogenase 0.0018 0.0009 0.0002
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0126 0.1588 0.158
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0033 0.0175
Schistosoma mansoni short chain dehydrogenase 0.0018 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0003
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0021 0.0017
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0021 0.0017
Schistosoma mansoni short chain dehydrogenase 0.0018 0.0009 0.0002
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0018 0.0009 0.0002
Schistosoma mansoni retinal dehydrogenase 0.0018 0.0009 0.0002
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0439 0.0577
Mycobacterium ulcerans hypothetical protein 0.011 0.1358 0.4977
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Schistosoma mansoni cpg binding protein 0.0032 0.0213 0.0275
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.1358 0.135
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.2639 0.352
Echinococcus multilocularis neutral sphingomyelinase 0.0291 0.3976 0.5309
Schistosoma mansoni short chain dehydrogenase 0.0018 0.0009 0.0002
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0037 0.0327
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0018 0.0009 0.0002
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0033 0.0033
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.1893 0.2522
Toxoplasma gondii ABC1 family protein 0.011 0.1358 1
Leishmania major trypanothione reductase 0.0055 0.0558 0.2026
Loa Loa (eye worm) hypothetical protein 0.011 0.1358 0.3402
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.1358 0.135
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0851 0.3105
Schistosoma mansoni steroid dehydrogenase 0.0018 0.0009 0.0002
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0033 0.0175
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0033 0.0087
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0511 0.1285
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0163 0.039
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0473 0.0464
Schistosoma mansoni neutral sphingomyelinase 0.0291 0.3976 0.5309
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0027 0.0151 0.4196
Schistosoma mansoni hypothetical protein 0.0401 0.5571 0.7443
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0018 0.0009 0.0023
Schistosoma mansoni hypothetical protein 0.0019 0.0037 0.0038
Schistosoma mansoni short chain dehydrogenase 0.0018 0.0009 0.0002
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.1358 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0027 0.0151 0.0191
Schistosoma mansoni short chain dehydrogenase 0.0018 0.0009 0.0002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.1358 0.3402
Echinococcus granulosus hypothetical protein 0.0018 0.0009 0.0002
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0439 0.1086
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0439 0.0577
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0021 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1785 0.2377
Schistosoma mansoni hypothetical protein 0.0532 0.7481 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0135 0.1493
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0033 0.0087
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.1358 1
Plasmodium falciparum thioredoxin reductase 0.0019 0.0033 0.0281
Loa Loa (eye worm) MBCTL1 0.0054 0.0534 0.1325
Schistosoma mansoni loxhd1 0.0019 0.0037 0.0038
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0037 0.0072
Mycobacterium tuberculosis Probable reductase 0.0126 0.1588 0.158
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0021 0.0087
Echinococcus multilocularis carbonyl reductase 1 0.0018 0.0009 0.0002
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.0805 0.1066
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0851 0.624
Schistosoma mansoni steroid dehydrogenase 0.0018 0.0009 0.0002
Leishmania major hypothetical protein, conserved 0.011 0.1358 0.4977
Loa Loa (eye worm) hypothetical protein 0.0291 0.3976 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0021 0.0033
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0033 0.0087
Brugia malayi jmjC domain containing protein 0.0069 0.0754 0.1897
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.1358 0.1806
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1785 0.2377
Leishmania major hypothetical protein, conserved 0.0026 0.0135 0.0464
Loa Loa (eye worm) hypothetical protein 0.0076 0.0851 0.2124
Brugia malayi beta-lactamase 0.011 0.1358 0.3416
Echinococcus multilocularis expressed conserved protein 0.0278 0.3789 0.506
Schistosoma mansoni zinc finger protein 0.0025 0.0113 0.014
Leishmania major hypothetical protein, conserved 0.0018 0.0021 0.0043
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0439 0.0577
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1785 0.2377
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1785 0.2377
Schistosoma mansoni carbonyl reductase 0.0018 0.0009 0.0002
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0534 0.0704
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0126 0.1588 0.158
Brugia malayi follicle stimulating hormone receptor 0.0239 0.3219 0.8098
Brugia malayi Dehydrogenases, short chain protein 30 0.0018 0.0009 0.0023
Echinococcus multilocularis carbonyl reductase 1 0.0018 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0033
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0439 0.0577
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0132 0.0689
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0272 0.0683
Loa Loa (eye worm) hypothetical protein 0.0036 0.0272 0.0664
Brugia malayi exodeoxyribonuclease III family protein 0.0027 0.0151 0.038
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0037 0.0038
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0027 0.0151 0.1052
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0033 0.0175
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.1358 0.1806
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0558 0.407
Toxoplasma gondii exonuclease III APE 0.0027 0.0151 0.1052
Mycobacterium tuberculosis Conserved protein 0.011 0.1358 0.135
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0689 0.0911
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0021 0.0033
Loa Loa (eye worm) acetyltransferase 0.0154 0.1988 0.4991
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.1358 0.135
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0018 0.0009 0.0002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0027 0.0151 0.4196
Brugia malayi jmjC domain containing protein 0.0018 0.0021 0.0053
Schistosoma mansoni steroid dehydrogenase 0.0018 0.0009 0.0002
Brugia malayi Bromodomain containing protein 0.0079 0.0908 0.2284
Onchocerca volvulus 0.0052 0.0514 0.1272
Echinococcus multilocularis transient receptor potential cation channel 0.0018 0.0009 0.0002
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0514 0.0677
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0033
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0545 0.0719
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0027 0.0151 0.1052
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0018 0.0009 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0033 0.0175
Echinococcus granulosus hypothetical protein 0.0278 0.3789 0.506
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.1358 0.4977
Brugia malayi Muscleblind-like protein 0.0168 0.2189 0.5507
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.007 0.077 0.1919
Echinococcus multilocularis retinol dehydrogenase 11 0.0018 0.0009 0.0002
Echinococcus multilocularis retinol dehydrogenase 11 0.0018 0.0009 0.0002
Brugia malayi jmjC domain containing protein 0.0018 0.0021 0.0053
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0027 0.0151 0.1686
Schistosoma mansoni hypothetical protein 0.0036 0.0272 0.0353
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0033 0.0175
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.1988 0.5001
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0473 0.0622
Brugia malayi hypothetical protein 0.0019 0.0037 0.0092
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0033 0.0175
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0473 0.0622
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0851 0.1128
Onchocerca volvulus 0.0047 0.0439 0.1084
Echinococcus granulosus phd:f box containing protein 0.0018 0.0021 0.0017
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0545 0.0719
Schistosoma mansoni short chain dehydrogenase 0.0018 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.011 0.1358 0.3402
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.1358 0.1806
Echinococcus granulosus expressed conserved protein 0.0278 0.3789 0.506
Echinococcus multilocularis tumor protein p63 0.0358 0.4944 0.6605
Loa Loa (eye worm) hypothetical protein 0.011 0.1358 0.3402
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0435 0.3158
Loa Loa (eye worm) oxidoreductase 0.0018 0.0009 0.0003
Loa Loa (eye worm) hypothetical protein 0.0052 0.0514 0.1275
Mycobacterium tuberculosis Conserved protein 0.011 0.1358 0.135
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0439 0.0577
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0033 0.0175
Echinococcus multilocularis conserved hypothetical protein 0.0018 0.0009 0.0002
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0027 0.0151 0.0142
Trypanosoma brucei trypanothione reductase 0.0055 0.0558 0.407
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0069 0.0754 0.0998
Echinococcus multilocularis carbonyl reductase 1 0.0018 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.032
Treponema pallidum exodeoxyribonuclease (exoA) 0.0027 0.0151 0.1445
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.1358 0.135
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0132 0.1213
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0805 0.2008
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0204 0.2719 1
Mycobacterium ulcerans beta-lactamase 0.011 0.1358 0.4977
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0033 0.0175
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0135 0.0931
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.027 0.0351
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.1785 0.4489
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0018 0.0009 0.0002
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0021 0.0017
Plasmodium vivax hypothetical protein, conserved 0.011 0.1358 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0021 0.0087
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0018 0.0009 0.0002
Brugia malayi mbt repeat family protein 0.0047 0.0439 0.1104
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0851 1
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0439 0.0577
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0805 0.1066
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0021 0.0017
Echinococcus granulosus carbonyl reductase 1 0.0018 0.0009 0.0002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.1785 0.4478
Echinococcus multilocularis cpg binding protein 0.0032 0.0213 0.0275
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0558 0.0736
Echinococcus multilocularis geminin 0.0532 0.7481 1
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0033 0.0175
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0204 0.2719 1
Schistosoma mansoni jumonji domain containing protein 0.0069 0.0754 0.0998
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0033 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0101 0.0125
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0072 0.0085
Echinococcus granulosus tumor protein p63 0.0358 0.4944 0.6605
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.1988 0.265
Echinococcus multilocularis retinol dehydrogenase 13 0.0018 0.0009 0.0002
Schistosoma mansoni cpg binding protein 0.0032 0.0213 0.0275
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1358 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0435 0.3158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0072
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.1358 0.4977
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0033 0.0175
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0435 0.3158
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0027 0.0151 0.1052
Schistosoma mansoni rab6-interacting 0.0019 0.0037 0.0038
Echinococcus granulosus cpg binding protein 0.0032 0.0213 0.0275
Brugia malayi dehydrogenases, short chain protein 2 0.0018 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0805 0.1066
Schistosoma mansoni bromodomain containing protein 0.0068 0.074 0.0979
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0033 0.0087
Echinococcus granulosus neutral sphingomyelinase 0.0291 0.3976 0.5309
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0027 0.0151 0.0523
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0033 0.0281
Echinococcus granulosus carbonyl reductase 1 0.0018 0.0009 0.0002
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0347 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0018 0.0009 0.0023
Mycobacterium leprae Probable lipase LipE 0.011 0.1358 0.7563
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.5571 0.7443
Echinococcus granulosus retinol dehydrogenase 11 0.0018 0.0009 0.0002
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0851 0.1128
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0132 0.146
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0101 0.0125
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0511 0.1285
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0003
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0439 0.1084
Trichomonas vaginalis ap endonuclease, putative 0.0027 0.0151 0.1052
Schistosoma mansoni steroid dehydrogenase 0.0018 0.0009 0.0002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0534 0.0704
Schistosoma mansoni lipoxygenase 0.0054 0.0545 0.0719
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.2639 0.352
Loa Loa (eye worm) oxidoreductase 0.0018 0.0009 0.0003
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0018 0.0009 0.0002
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0021 0.0017
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0204 0.2719 0.2712
Echinococcus granulosus retinol dehydrogenase 11 0.0018 0.0009 0.0002
Brugia malayi Retinol dehydrogenase 12 0.0018 0.0009 0.0023
Brugia malayi Doublecortin family protein 0.0019 0.0037 0.0092
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0003
Toxoplasma gondii thioredoxin reductase 0.0055 0.0558 0.407
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0534 0.0704
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0534 0.1343
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0851 1
Echinococcus granulosus WW domain containing oxidoreductase 0.0018 0.0009 0.0002
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0037 0.0038
Loa Loa (eye worm) glutathione reductase 0.0055 0.0558 0.1387
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0021 0.0017
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0033 0.0281
Loa Loa (eye worm) hypothetical protein 0.011 0.1358 0.3402
Loa Loa (eye worm) hypothetical protein 0.0047 0.0444 0.1098
Mycobacterium tuberculosis Probable hydrolase 0.011 0.1358 0.135
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0126 0.1588 0.158
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0621 0.082
Echinococcus granulosus steroid dehydrogenase 0.0018 0.0009 0.0002
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.014 0.1793 1
Schistosoma mansoni carbonyl reductase 0.0018 0.0009 0.0002
Onchocerca volvulus 0.0019 0.0037 0.0069
Echinococcus granulosus oxidoreductase 0.0018 0.0009 0.0002
Echinococcus multilocularis oxidoreductase 0.0018 0.0009 0.0002
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0021 0.0017
Loa Loa (eye worm) oxidoreductase 0.0018 0.0009 0.0003
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0534 0.0704
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0851 0.4719
Loa Loa (eye worm) oxidoreductase 0.0018 0.0009 0.0003
Toxoplasma gondii hypothetical protein 0.0026 0.0132 0.0911
Onchocerca volvulus 0.0019 0.0037 0.0069
Schistosoma mansoni lipoxygenase 0.0019 0.0037 0.0038
Mycobacterium tuberculosis Probable oxidoreductase 0.014 0.1793 0.1785
Brugia malayi hypothetical protein 0.0026 0.0135 0.0339
Plasmodium falciparum thioredoxin reductase 0.0055 0.0558 0.6523
Loa Loa (eye worm) hypothetical protein 0.011 0.1358 0.3402
Loa Loa (eye worm) hypothetical protein 0.0052 0.0511 0.1268
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0033 0.0083
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.1358 0.1806
Loa Loa (eye worm) oxidoreductase 0.0018 0.0009 0.0003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.1358 0.3416
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.1988 0.265
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0027 0.0151 0.1686
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0037 0.0204
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0033 0.0281
Brugia malayi Probable ClpP-like protease 0.0076 0.0851 0.214
Echinococcus multilocularis steroid dehydrogenase 0.0018 0.0009 0.0002
Brugia malayi mbt repeat family protein 0.0047 0.0439 0.1104
Schistosoma mansoni steroid dehydrogenase 0.0018 0.0009 0.0002
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0037 0.0038
Schistosoma mansoni short chain dehydrogenase 0.0018 0.0009 0.0002
Echinococcus multilocularis muscleblind protein 1 0.0168 0.2189 0.2919
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1358 1
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.1358 0.135
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0033 0.0175
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0851 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0027 0.0151 0.0191
Brugia malayi beta-lactamase family protein 0.011 0.1358 0.3416
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0851 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0204 0.2719 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0003
Plasmodium falciparum glutathione reductase 0.0019 0.0033 0.0281
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1785 0.2377
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0291 0.3976 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.2189 0.5497
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0851 1
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0051 0.0107
Schistosoma mansoni steroid dehydrogenase 0.0018 0.0009 0.0002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Loa Loa (eye worm) beta-lactamase 0.011 0.1358 0.3402
Onchocerca volvulus 0.011 0.1358 0.34
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0135 0.0931
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Brugia malayi hypothetical protein 0.0018 0.0009 0.0023
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0021 0.0017
Mycobacterium leprae conserved hypothetical protein 0.011 0.1358 0.7563
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.1325
Schistosoma mansoni short chain dehydrogenase 0.0018 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0003
Mycobacterium tuberculosis Conserved protein 0.011 0.1358 0.135
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0435 0.3158
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0027 0.0151 0.1052
Schistosoma mansoni carbonyl reductase 0.0018 0.0009 0.0002
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0033 0.0699
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0534 0.0704
Echinococcus granulosus zinc finger protein 0.0025 0.0113 0.014
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0435 0.0572
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0033
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0135 0.0931
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0851 0.1128
Echinococcus granulosus RUN 0.0019 0.0037 0.0038
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0851 0.624
Plasmodium vivax JmjC domain containing protein 0.0018 0.0021 0.0087
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0033 0.0087
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0033 0.0087
Schistosoma mansoni ap endonuclease 0.0027 0.0151 0.0191
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0021 0.0017
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0027 0.0151 0.0523
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0439 0.0577
Plasmodium falciparum glutathione reductase 0.0055 0.0558 0.6523
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0033 0.0281
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0473 0.2601
Brugia malayi glutathione reductase 0.0055 0.0558 0.1404
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0754 0.0998
Brugia malayi dehydrogenases, short chain protein 9 0.0018 0.0009 0.0023
Schistosoma mansoni steroid dehydrogenase 0.0018 0.0009 0.0002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Trichomonas vaginalis esterase, putative 0.011 0.1358 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0072
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0204 0.2719 0.684
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0033 0.0175
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1358 1
Schistosoma mansoni hypothetical protein 0.002 0.0051 0.0057
Schistosoma mansoni ap endonuclease 0.0027 0.0151 0.0191
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0204 0.2719 0.3628
Brugia malayi Thioredoxin reductase 0.0055 0.0558 0.1404
Onchocerca volvulus Putative neutral sphingomyelinase 0.0291 0.3976 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0132 0.0911
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0347 1
Onchocerca volvulus 0.011 0.1358 0.34
Loa Loa (eye worm) hypothetical protein 0.0038 0.0305 0.0749
Plasmodium vivax glutathione reductase, putative 0.0055 0.0558 0.407
Echinococcus multilocularis steroid dehydrogenase 0.0018 0.0009 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0021 0.0033
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0558 0.407
Loa Loa (eye worm) dehydrogenase 0.0018 0.0009 0.0003
Schistosoma mansoni short chain dehydrogenase 0.0018 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.011 0.1358 0.3402
Echinococcus multilocularis zinc finger protein 0.0025 0.0113 0.014
Trichomonas vaginalis ap endonuclease, putative 0.0027 0.0151 0.1052
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0616 0.4498
Loa Loa (eye worm) hypothetical protein 0.0047 0.0439 0.1086
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.027 0.0351
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1358 1
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0018 0.0009 0.0002
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0037 0.0038
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0072 0.0085
Loa Loa (eye worm) oxidoreductase 0.0018 0.0009 0.0003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0003
Schistosoma mansoni short chain dehydrogenase 0.0018 0.0009 0.0002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0558 0.0549
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0101 0.0125
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.014 0.1793 0.1785
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0018 0.0009 0.0002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.014 0.1793 0.1785
Loa Loa (eye worm) oxidoreductase 0.0018 0.0009 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0135 0.0931
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1785 0.2377
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0033 0.0033
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0204 0.2719 0.3628
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0689 0.0911
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0558 0.1387
Schistosoma mansoni rab6-interacting 0.0019 0.0037 0.0038
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0021 0.0017
Brugia malayi Dehydrogenases, short chain protein 2 0.0018 0.0009 0.0023
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0126 0.1588 0.158
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0851 0.624
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0033 0.0175
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0021 0.0087
Schistosoma mansoni short chain dehydrogenase 0.0018 0.0009 0.0002
Schistosoma mansoni short chain dehydrogenase 0.0018 0.0009 0.0002
Echinococcus multilocularis muscleblind protein 0.0168 0.2189 0.2919
Brugia malayi CXXC zinc finger family protein 0.0028 0.0163 0.0409
Echinococcus granulosus geminin 0.0532 0.7481 1
Echinococcus granulosus carbonyl reductase 1 0.0018 0.0009 0.0002
Brugia malayi hypothetical protein 0.0018 0.0009 0.0023
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0021 0.0087
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0033 0.0175
Brugia malayi oxidoreductase 0.0018 0.0009 0.0023
Onchocerca volvulus 0.0028 0.0163 0.0387
Brugia malayi jmjC domain containing protein 0.0018 0.0021 0.0053
Echinococcus granulosus dnaJ subfamily B 0.0401 0.5571 0.7443
Brugia malayi jmjC domain containing protein 0.0018 0.0021 0.0053
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0851 0.3105
Schistosoma mansoni hypothetical protein 0.03 0.4103 0.548
Brugia malayi jmjC domain containing protein 0.0072 0.0805 0.2025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0003
Schistosoma mansoni steroid dehydrogenase 0.0018 0.0009 0.0002
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0033 0.0087
Echinococcus granulosus muscleblind protein 0.0168 0.2189 0.2919
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Loa Loa (eye worm) oxidoreductase 0.0018 0.0009 0.0003
Echinococcus multilocularis RUN 0.0019 0.0037 0.0038
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0009 0.0023
Schistosoma mansoni steroid dehydrogenase 0.0018 0.0009 0.0002
Schistosoma mansoni polycystin 1-related 0.0019 0.0037 0.0038
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0558 0.0736
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0473 0.0464
Schistosoma mansoni short chain dehydrogenase 0.0018 0.0009 0.0002
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0135 0.1493
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0021 0.0017
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0018 0.0009 0.0003
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0347 0.4018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0511 0.1268
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0069 0.0754 0.0998
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0204 0.2719 0.3628
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0003
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.1358 0.135
Brugia malayi beta-lactamase family protein 0.011 0.1358 0.3416
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.3219 0.8094
Mycobacterium ulcerans lipase LipD 0.011 0.1358 0.4977
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0033 0.0033
Brugia malayi Bromodomain containing protein 0.0042 0.0358 0.0901
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0037 0.0038
Echinococcus multilocularis conserved hypothetical protein 0.0278 0.3789 0.506
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1358 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0135 0.0931
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0021 0.0139
Echinococcus multilocularis carbonyl reductase 1 0.0018 0.0009 0.0002
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0126 0.1588 0.8853

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.1 uM Inhibitory concentration against liposaccharide induced IL-1beta production in human peripheral monocytes ChEMBL. 11392536
IC50 (functional) = 0.1 uM Inhibitory concentration against liposaccharide induced IL-1beta production in human peripheral monocytes ChEMBL. 11392536
IC50 (binding) = 1 uM Inhibitory concentration against neutral sphingomyelinase (N-Smase) from rat brain microsomes ChEMBL. 11392536
IC50 (binding) = 1 uM Inhibitory activity of the compound against neutral sphingomyelinase (N-SMase) from bovine brain microsomes ChEMBL. 12482429
IC50 (binding) = 1 uM Inhibitory concentration against neutral sphingomyelinase (N-Smase) from rat brain microsomes ChEMBL. 11392536
IC50 (binding) = 1 uM Inhibitory activity of the compound against neutral sphingomyelinase (N-SMase) from bovine brain microsomes ChEMBL. 12482429
IC50 (binding) = 1 uM Inhibitory concentration against the membrane neutral magnesium-dependent Sphingomyelinase (N-SMase) using rat brain microsomes as the enzyme source ChEMBL. 12781174
IC50 (binding) = 49.3 uM Inhibitory concentration against lysosomal neutral sphingomyelinase (N-Smase) ChEMBL. 11392536
IC50 (binding) = 49.3 uM Inhibitory concentration against lysosomal neutral sphingomyelinase (N-Smase) ChEMBL. 11392536

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 11392536

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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