TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 395.493 | Formula: C22H22FN3OS
H donors: 0 H acceptors: 2 LogP: 3.29 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CCN(CCN1Cc1ccccc1F)Cc1scc(n1)c1ccccc1
InChi: 1S/C22H22FN3OS/c23-19-9-5-4-8-18(19)14-26-13-12-25(11-10-22(26)27)15-21-24-20(16-28-21)17-6-2-1-3-7-17/h1-9,16H,10-15H2
InChiKey: XOECHGUJKGGDMT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	polyketide synthase	0.0026	0.0689	0.4065
Echinococcus multilocularis	conserved hypothetical protein	0.0112	0.4208	0.6071
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0058	0.2029	0.5162
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0017	0.0345	0.007
Brugia malayi	Animal haem peroxidase family protein	0.0054	0.1857	0.1833
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0098	0.3645	1
Brugia malayi	Blistered cuticle protein 3	0.0054	0.1857	0.1833
Onchocerca volvulus	Fatty acid synthase homolog	0.0046	0.1532	0.2938
Trypanosoma brucei	trans-sialidase, putative	0.0058	0.2029	0.5162
Trypanosoma brucei	trans-sialidase, putative	0.0058	0.2029	0.5162
Echinococcus multilocularis	neural cadherin	0.0018	0.0356	0.0086
Brugia malayi	MH2 domain containing protein	0.0017	0.0345	0.0316
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0058	0.2029	0.5162
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0305	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Mycobacterium ulcerans	polyketide synthase Pks13	0.0038	0.1208	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0027	0.0754	0.6242
Brugia malayi	Animal haem peroxidase family protein	0.0054	0.1857	0.1833
Echinococcus multilocularis	neurogenic locus protein delta	0.0018	0.0356	0.0086
Schistosoma mansoni	notch	0.0018	0.0356	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1857	0.1833
Loa Loa (eye worm)	MH2 domain-containing protein	0.0253	1	1
Trypanosoma cruzi	trans-sialidase, putative	0.0058	0.2029	0.5162
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0305	0.0009
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0345	0.007
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0016	0.0305	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1857	0.1833
Loa Loa (eye worm)	acyl carrier protein	0.0012	0.0122	0.0093
Schistosoma mansoni	notch	0.0018	0.0356	0.0086
Echinococcus multilocularis	expressed conserved protein	0.0112	0.4208	0.6071
Echinococcus multilocularis	protein jagged 1	0.0018	0.0356	0.0086
Echinococcus granulosus	neurogenic locus notch protein	0.0018	0.0356	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0305	0.0009
Echinococcus granulosus	neutral sphingomyelinase	0.0115	0.4359	0.6305
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1857	0.1833
Toxoplasma gondii	type I fatty acid synthase, putative	0.0018	0.0386	0.3708
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0058	0.2029	0.5162
Echinococcus granulosus	slit 2 protein	0.0018	0.0356	0.0086
Echinococcus multilocularis	tar DNA binding protein	0.007	0.2483	0.339
Echinococcus multilocularis	neutral sphingomyelinase	0.0115	0.4359	0.6305
Loa Loa (eye worm)	hypothetical protein	0.008	0.2918	0.2897
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1857	0.1833
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.1728	0.1703
Loa Loa (eye worm)	blistered cuticle protein 3	0.0054	0.1857	0.1833
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0024	0.062	0.0592
Mycobacterium ulcerans	polyketide synthase	0.0027	0.0754	0.481
Trypanosoma cruzi	trans-sialidase, putative	0.0058	0.2029	0.5161
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1857	0.1833
Echinococcus granulosus	neural cadherin	0.0018	0.0356	0.0086
Echinococcus granulosus	delta-like protein 1	0.0018	0.0356	0.0086
Echinococcus granulosus	notch	0.0018	0.0356	0.0086
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0305	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1857	0.1833
Echinococcus granulosus	neurogenic locus protein delta	0.0018	0.0356	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1857	0.1833
Echinococcus multilocularis	geminin	0.0174	0.6738	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0018	0.0356	0.0327
Schistosoma mansoni	tar DNA-binding protein	0.007	0.2483	0.339
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0305	0.0009
Trypanosoma cruzi	trans-sialidase, putative	0.0058	0.2029	0.5162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.03	0.0271
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.03	0.0271
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0016	0.0305	0.5
Brugia malayi	TAR-binding protein	0.007	0.2483	0.246
Trypanosoma cruzi	trans-sialidase, putative	0.0058	0.2029	0.5161
Echinococcus granulosus	mothers against decapentaplegic 5	0.0017	0.0345	0.007
Brugia malayi	EGF-like domain containing protein	0.0018	0.0356	0.0327
Brugia malayi	Peroxidasin	0.0054	0.1857	0.1833
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0305	0.2322
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0018	0.0356	0.0086
Brugia malayi	notch-like transmembrane receptor	0.0018	0.0356	0.0327
Brugia malayi	EGF-like domain containing protein	0.0018	0.0356	0.0327
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0017	0.0345	0.007
Echinococcus granulosus	protein jagged 2	0.0018	0.0356	0.0086
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0027	0.0754	0.6242
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0026	0.0689	0.4065
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.3645	1
Brugia malayi	MH2 domain containing protein	0.0017	0.0345	0.0316
Loa Loa (eye worm)	MH1 domain-containing protein	0.0017	0.0345	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1857	0.1833
Echinococcus granulosus	neurogenic locus notch protein	0.0018	0.0356	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0115	0.4359	0.4343
Loa Loa (eye worm)	RNA binding protein	0.007	0.2483	0.246
Schistosoma mansoni	hypothetical protein	0.0018	0.0356	0.0086
Trypanosoma cruzi	trans-sialidase, putative	0.0058	0.2029	0.5162
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0027	0.0754	0.481
Echinococcus multilocularis	slit 2 protein	0.0018	0.0356	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1067	0.104
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Onchocerca volvulus	Dual oxidase homolog	0.0054	0.1857	0.3749
Loa Loa (eye worm)	transcription factor SMAD2	0.0253	1	1
Mycobacterium ulcerans	thioesterase	0.0021	0.0514	0.2064
Echinococcus granulosus	protein jagged 1	0.0018	0.0356	0.0086
Trypanosoma brucei	trans-sialidase, putative	0.0058	0.2029	0.5162
Echinococcus granulosus	protein jagged 2	0.0018	0.0356	0.0086
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0017	0.032	0.2574
Echinococcus granulosus	protein jagged 1	0.0018	0.0356	0.0086
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0026	0.0689	0.4065
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0025	0.0657	0.5436
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0027	0.0754	0.6242
Echinococcus granulosus	dual specificity	0.0098	0.3645	0.5196
Brugia malayi	Smad1	0.0017	0.0345	0.0316
Brugia malayi	Animal haem peroxidase family protein	0.0054	0.1857	0.1833
Schistosoma mansoni	Smad4	0.0017	0.0345	0.007
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0.0305	0.2528
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.1728	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Onchocerca volvulus	Peroxidasin homolog	0.0054	0.1857	0.3749
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1857	0.1833
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0098	0.3645	0.3627
Schistosoma mansoni	neutral sphingomyelinase	0.0115	0.4359	0.6305
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1857	0.1833
Loa Loa (eye worm)	animal heme peroxidase	0.0054	0.1857	0.1833
Echinococcus multilocularis	neurogenic locus notch protein	0.0018	0.0356	0.0086
Echinococcus granulosus	fibropellin Ia	0.0018	0.0356	0.0086
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0026	0.0689	0.4065
Brugia malayi	RNA binding protein	0.007	0.2483	0.246
Brugia malayi	Protein kinase domain containing protein	0.0098	0.3645	0.3627
Brugia malayi	hypothetical protein	0.0054	0.1857	0.1833
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0305	0.0277
Echinococcus multilocularis	protein jagged 2	0.0018	0.0356	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Brugia malayi	RNA recognition motif domain containing protein	0.007	0.2483	0.246
Schistosoma mansoni	hypothetical protein	0.0018	0.0356	0.0086
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0305	0.0277
Brugia malayi	EGF-like domain containing protein	0.0018	0.0356	0.0327
Schistosoma mansoni	hypothetical protein	0.0035	0.1067	0.1191
Echinococcus multilocularis	notch	0.0018	0.0356	0.0086
Schistosoma mansoni	notch	0.0018	0.0356	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1728	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Brugia malayi	Cadherin domain containing protein	0.0018	0.0356	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Echinococcus granulosus	neurogenic locus notch protein 4	0.0018	0.0356	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0058	0.2029	0.5162
Entamoeba histolytica	hypothetical protein	0.0098	0.3645	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0018	0.0356	0.0327
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.062	0.0592
Loa Loa (eye worm)	animal heme peroxidase	0.0054	0.1857	0.1833
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0018	0.0356	0.0327
Brugia malayi	Delta serrate ligand family protein	0.0018	0.0356	0.0327
Schistosoma mansoni	notch	0.0018	0.0356	0.0086
Echinococcus multilocularis	peroxidasin	0.0054	0.1857	0.2418
Schistosoma mansoni	notch	0.0018	0.0356	0.0086
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.007	0.2483	0.246
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0026	0.0689	0.5702
Trypanosoma cruzi	trans-sialidase, putative	0.0058	0.2029	0.5161
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.001	0.0064	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Brugia malayi	EGF-like domain containing protein	0.0018	0.0356	0.0327
Echinococcus multilocularis	neurogenic locus protein delta	0.0018	0.0356	0.0086
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0021	0.0484	0.172
Echinococcus multilocularis	protein jagged 1	0.0018	0.0356	0.0086
Loa Loa (eye worm)	notch protein	0.0018	0.0356	0.0327
Onchocerca volvulus	Chorion peroxidase homolog	0.0054	0.1857	0.3749
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0018	0.0356	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Loa Loa (eye worm)	MH2 domain-containing protein	0.0017	0.0345	0.0316
Schistosoma mansoni	hypothetical protein	0.0018	0.0356	0.0086
Schistosoma mansoni	slit	0.0018	0.0356	0.0086
Onchocerca volvulus	Peroxidasin homolog	0.0054	0.1857	0.3749
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0027	0.0754	0.481
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0049	0.1629	0.1604
Schistosoma mansoni	smad	0.0017	0.0345	0.007
Brugia malayi	EGF-like domain containing protein	0.0018	0.0356	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1403	0.1378
Brugia malayi	Animal haem peroxidase family protein	0.0054	0.1857	0.1833
Onchocerca volvulus		0.0054	0.1857	0.3749
Schistosoma mansoni	tar DNA-binding protein	0.007	0.2483	0.339
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0027	0.0754	0.481
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0098	0.3645	1
Onchocerca volvulus	Peroxidase homolog	0.0054	0.1857	0.3749
Echinococcus granulosus	Smad4	0.0017	0.0345	0.007
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.1067	0.104
Onchocerca volvulus	Putative neutral sphingomyelinase	0.0115	0.4359	1
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0058	0.2029	0.5162
Schistosoma mansoni	tar DNA-binding protein	0.007	0.2483	0.339
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0017	0.0345	0.007
Schistosoma mansoni	peroxidasin	0.0054	0.1857	0.2418
Onchocerca volvulus		0.0054	0.1857	0.3749
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0058	0.2029	0.5162
Echinococcus multilocularis	smad	0.0017	0.0345	0.007
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0038	0.1208	1
Loa Loa (eye worm)	Notch2	0.0018	0.0356	0.0327
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0025	0.0657	0.5436
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1857	0.1833
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0018	0.0356	0.0086
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0305	0.0009
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0015	0.0236	0.1953
Schistosoma mansoni	hypothetical protein	0.0018	0.0356	0.0086
Schistosoma mansoni	tar DNA-binding protein	0.007	0.2483	0.339
Echinococcus granulosus	peroxidasin	0.0054	0.1857	0.2418
Loa Loa (eye worm)	animal heme peroxidase	0.0054	0.1857	0.1833
Echinococcus multilocularis	fibropellin Ia	0.0018	0.0356	0.0086
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0038	0.1208	1
Loa Loa (eye worm)	animal heme peroxidase	0.0054	0.1857	0.1833
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0058	0.2029	0.5162
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0026	0.0689	0.5702
Trypanosoma brucei	trans-sialidase, putative	0.0058	0.2029	0.5162
Brugia malayi	GCC2 and GCC3 family protein	0.0018	0.0356	0.0327
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0098	0.3645	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0021	0.0484	0.172
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0305	0.2322
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0021	0.0484	0.172
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0027	0.0754	0.481
Brugia malayi	Muscle positioning protein 4	0.0018	0.0356	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1857	0.1833
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Brugia malayi	MH1 domain containing protein	0.0017	0.0345	0.0316
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0345	0.007
Mycobacterium leprae	Polyketide synthase Pks13	0.0038	0.1208	1
Echinococcus granulosus	geminin	0.0174	0.6738	1
Schistosoma mansoni	peroxidasin	0.0054	0.1857	0.2418
Echinococcus multilocularis	neurogenic locus notch protein	0.0018	0.0356	0.0086
Toxoplasma gondii	EGF family domain-containing protein	0.0018	0.0356	0.3179
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0097	0.3625	0.3606
Echinococcus granulosus	expressed conserved protein	0.0112	0.4208	0.6071
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0026	0.0689	0.5702
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Brugia malayi	EGF-like domain containing protein	0.0018	0.0356	0.0327
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0098	0.3645	1
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0026	0.0689	0.4065
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0018	0.0393	0.3255
Schistosoma mansoni	laminin gamma-3 chain	0.0018	0.0356	0.0086
Brugia malayi	EGF-like domain containing protein	0.0018	0.0356	0.0327
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0305	0.0277
Schistosoma mansoni	serine/threonine protein kinase	0.0098	0.3645	0.5196
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.1728	0.1703
Brugia malayi	Animal haem peroxidase family protein	0.0054	0.1857	0.1833
Trypanosoma cruzi	trans-sialidase, putative	0.0058	0.2029	0.5161
Echinococcus multilocularis	dual specificity	0.0098	0.3645	0.5196
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1857	0.1833
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0227	0.0198
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0058	0.2029	0.5162
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Loa Loa (eye worm)	TAR-binding protein	0.007	0.2483	0.246
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0345	0.007
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0356	0.0327
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0021	0.0514	0.2064
Schistosoma mansoni	notch	0.0018	0.0356	0.0086
Schistosoma mansoni	hypothetical protein	0.0174	0.6738	1
Schistosoma mansoni	hypothetical protein	0.0174	0.6738	1
Schistosoma mansoni	hypothetical protein	0.0018	0.0356	0.0086
Toxoplasma gondii	type I fatty acid synthase, putative	0.0027	0.0754	1
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0115	0.4359	0.4343
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0027	0.0754	0.481
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0021	0.0514	0.4254
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0305	0.0009
Onchocerca volvulus		0.0045	0.1467	0.2775
Trypanosoma brucei	trans-sialidase	0.0058	0.2029	0.5162
Schistosoma mansoni	tar DNA-binding protein	0.007	0.2483	0.339
Trypanosoma brucei	trans-sialidase, putative	0.0058	0.2029	0.5162
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0058	0.2029	0.5162
Onchocerca volvulus		0.0024	0.062	0.0661
Brugia malayi	MH1 domain containing protein	0.0017	0.0345	0.0316
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0026	0.0689	0.4065
Loa Loa (eye worm)	hypothetical protein	0.0097	0.3625	0.3606
Echinococcus granulosus	tar DNA binding protein	0.007	0.2483	0.339
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0017	0.0345	0.007
Mycobacterium ulcerans	thioesterase TesA	0.0021	0.0514	0.2064
Schistosoma mansoni	cell polarity protein	0.0018	0.0356	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1857	0.1833
Loa Loa (eye worm)	fatty acid synthase	0.0025	0.0675	0.0647
Giardia lamblia	High cysteine protein	0.0018	0.0356	0.5
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0026	0.0689	0.0662
Loa Loa (eye worm)	Smad1	0.0017	0.0345	0.0316
Echinococcus granulosus	smad	0.0017	0.0345	0.007
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0058	0.2029	0.5162
Schistosoma mansoni	hypothetical protein	0.0018	0.0356	0.0086
Schistosoma mansoni	hypothetical protein	0.0018	0.0356	0.0086
Echinococcus granulosus	hypothetical protein	0.0112	0.4208	0.6071
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0021	0.0498	0.4119
Schistosoma mansoni	septate junction protein	0.0018	0.0356	0.0086
Brugia malayi	Cadherin domain containing protein	0.0018	0.0356	0.0327
Onchocerca volvulus		0.0054	0.1857	0.3749
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0026	0.0689	0.4065
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0024	0.062	0.5131
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0058	0.2029	0.5162
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.03	0.0271
Entamoeba histolytica	protein kinase, putative	0.0098	0.3645	1
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.03	0.0271
Entamoeba histolytica	protein kinase, putative	0.0098	0.3645	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0018	0.0356	0.0327
Echinococcus multilocularis	Smad4	0.0017	0.0345	0.007
Onchocerca volvulus	Peroxidase homolog	0.0054	0.1857	0.3749

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

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Detailed information for compound 809089