Detailed information for compound 1167425

Basic information

Technical information
  • TDR Targets ID: 1167425
  • Name: N-(furan-2-ylmethyl)-5,7-dimethyl-[1,2,4]tria zolo[1,5-a]pyrimidine-2-carboxamide
  • MW: 271.275 | Formula: C13H13N5O2
  • H donors: 1 H acceptors: 4 LogP: 1.1 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)n2c(n1)nc(n2)C(=O)NCc1ccco1
  • InChi: 1S/C13H13N5O2/c1-8-6-9(2)18-13(15-8)16-11(17-18)12(19)14-7-10-4-3-5-20-10/h3-6H,7H2,1-2H3,(H,14,19)
  • InChiKey: VOFNIOCBZLBWPE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-furylmethyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide
  • ZINC02886507
  • SDCCGMLS-0009032.P002
  • MLS000066649
  • N-(2-furylmethyl)-5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide
  • SMR000082568
  • STK340956

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0045 0.0136
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0036 0.0012 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0244 0.0894
Mycobacterium tuberculosis Probable exported protein 0.0036 0.0012 0.0545
Leishmania major 4-coumarate:coa ligase-like protein 0.0123 0.022 0.4588
Trichomonas vaginalis replication factor C large subunit, putative 0.0041 0.0023 0.0248
Schistosoma mansoni hypothetical protein 0.005 0.0045 0.0136
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0038 0.011
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0036 0.0012 0.0001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0036 0.0012 0.0009
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.022 0.045 0.168
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0012 0.0001
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0229 0.0835
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0048 0.0148
Schistosoma mansoni hypothetical protein 0.0036 0.0012 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0134 0.6071
Loa Loa (eye worm) hypothetical protein 0.0123 0.022 0.0802
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0036 0.0012 0.0001
Onchocerca volvulus Putative neutral sphingomyelinase 0.1135 0.2633 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0023 0.0051
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0036 0.0012 0.0546
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0036 0.0012 0.0001
Echinococcus granulosus Niemann Pick C1 protein 0.0513 0.1149 0.4336
Loa Loa (eye worm) hypothetical protein 0.0036 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0513 0.1149 0.4341
Schistosoma mansoni hypothetical protein 0.0212 0.0432 0.1608
Loa Loa (eye worm) TAR-binding protein 0.0134 0.0244 0.0894
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0244 0.0894
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0036 0.0012 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0038 0.011
Brugia malayi DKFZp564C0469 protein 0.0041 0.0023 0.0051
Loa Loa (eye worm) hypothetical protein 0.0041 0.0023 0.0051
Onchocerca volvulus 0.0041 0.0023 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0012 0.0009
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0036 0.0012 0.0001
Entamoeba histolytica hypothetical protein 0.0037 0.0015 0.0025
Schistosoma mansoni chromosome transmission fidelity factor 0.0041 0.0023 0.0051
Treponema pallidum DNA ligase (lig) 0.0041 0.0023 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0036 0.0012 0.0000014634
Echinococcus granulosus geminin 0.0175 0.0343 0.1264
Echinococcus granulosus expressed conserved protein 0.0482 0.1075 0.4053
Entamoeba histolytica hypothetical protein 0.0037 0.0015 0.0025
Mycobacterium ulcerans hypothetical protein 0.0123 0.022 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0012 0.0009
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0041 0.0023 0.0248
Echinococcus multilocularis conserved hypothetical protein 0.1099 0.2547 0.2538
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0036 0.0012 0.0546
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0521 0.1168 0.4413
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0513 0.1149 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0036 0.0012 0.0546
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0038 0.01
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0175 0.0343 0.0332
Loa Loa (eye worm) hypothetical protein 0.0153 0.0291 0.1074
Entamoeba histolytica acyl-CoA synthetase, putative 0.0123 0.022 0.1831
Echinococcus granulosus replication factor c subunit 1 0.0041 0.0023 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0123 0.022 0.0802
Plasmodium vivax acetyl-CoA synthetase, putative 0.0036 0.0012 0.0001
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0015 0.002
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0244 0.0894
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0123 0.022 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0048 0.0148
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0012 0.0546
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0036 0.0012 0.0009
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0041 0.0023 0.0239
Loa Loa (eye worm) hypothetical protein 0.0052 0.0048 0.0148
Echinococcus multilocularis nibrin 0.0041 0.0023 0.0011
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0036 0.0012 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0023 0.0248
Echinococcus granulosus tumor protein p63 0.1048 0.2424 0.9202
Onchocerca volvulus 0.0153 0.0291 0.1065
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0012 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0226 0.0466 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0092 0.0146 0.6617
Loa Loa (eye worm) hypothetical protein 0.027 0.0569 0.213
Echinococcus multilocularis Niemann Pick C1 protein 0.0733 0.1674 0.1664
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0123 0.022 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0123 0.022 1
Schistosoma mansoni synaptojanin 0.0036 0.0012 0.0009
Onchocerca volvulus 0.0036 0.0012 0.0000055757
Giardia lamblia Replication factor C, subunit 1 0.0041 0.0023 1
Entamoeba histolytica hypothetical protein 0.0037 0.0015 0.0025
Schistosoma mansoni hypothetical protein 0.0175 0.0343 0.1272
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0092 0.0146 0.6422
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0015 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.022 0.045 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0146 0.0519
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0038 0.0026
Trypanosoma cruzi FHA domain containing protein, putative 0.0041 0.0023 0.0239
Plasmodium falciparum replication factor C subunit 1, putative 0.0041 0.0023 0.0813
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0134 0.6071
Schistosoma mansoni hypothetical protein 0.0037 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0012 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0038 0.01
Echinococcus multilocularis tumor protein p63 0.1048 0.2424 0.2415
Loa Loa (eye worm) hypothetical protein 0.0041 0.0023 0.0051
Loa Loa (eye worm) hypothetical protein 0.0036 0.0012 0.0009
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0015 0.0011
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0041 0.0023 0.0248
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0038 0.011
Echinococcus granulosus Niemann Pick C1 protein 0.0733 0.1674 0.6338
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0023 0.0239
Echinococcus multilocularis sterol regulatory element binding protein 0.022 0.045 0.0439
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0134 0.6071
Entamoeba histolytica acyl-coA synthetase, putative 0.0123 0.022 0.1831
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0036 0.0012 0.0546
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0012 0.0546
Loa Loa (eye worm) hypothetical protein 0.0041 0.0023 0.0051
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0036 0.0012 0.0013
Schistosoma mansoni hypothetical protein 0.0212 0.0432 0.1608
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0036 0.0012 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0123 0.022 0.0802
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0036 0.0012 0.0009
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0036 0.0012 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0123 0.022 1
Echinococcus multilocularis replication factor c subunit 1 0.0041 0.0023 0.0011
Leishmania major pantothenate kinase subunit, putative 0.0041 0.0024 0.0265
Mycobacterium ulcerans acetyl-CoA synthetase 0.0036 0.0012 0.0001
Echinococcus multilocularis tar DNA binding protein 0.0134 0.0244 0.0232
Plasmodium vivax replication factor C subunit 1, putative 0.0041 0.0023 0.0813
Brugia malayi Pax transcription activation domain interacting protein 0.0041 0.0023 0.0051
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0036 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0092 0.0146 0.0519
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0012 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0229 0.0835
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0041 0.0023 0.0239
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0041 0.0023 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0036 0.0012 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0134 0.6071
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0175 0.0343 0.1271
Plasmodium vivax acyl-CoA synthetase, putative 0.0092 0.0146 1
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.0513 0.191
Brugia malayi hypothetical protein 0.0041 0.0023 0.0051
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0036 0.0012 0.0546
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.0343 0.1271
Schistosoma mansoni DNA ligase IV 0.0041 0.0023 0.0051
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0036 0.0012 0.0001
Brugia malayi TAR-binding protein 0.0134 0.0244 0.0894
Loa Loa (eye worm) hypothetical protein 0.0092 0.0146 0.0519
Trypanosoma cruzi hypothetical protein, conserved 0.0226 0.0466 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0036 0.0012 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0012 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0012 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0123 0.022 1
Entamoeba histolytica hypothetical protein 0.0037 0.0015 0.0025
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0012 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0023 0.0248
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.0513 0.0501
Schistosoma mansoni cellular tumor antigen P53 0.0153 0.0291 0.1074
Brugia malayi RNA binding protein 0.0134 0.0244 0.0894
Brugia malayi CHE-14 protein 0.022 0.045 0.168
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0023 0.0248
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0036 0.0012 0.0546
Loa Loa (eye worm) hypothetical protein 0.022 0.045 0.168
Echinococcus multilocularis Niemann Pick C1 protein 0.0513 0.1149 0.1138
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0244 0.0894
Brugia malayi hypothetical protein 0.0041 0.0023 0.0051
Brugia malayi Niemann-Pick C1 protein precursor 0.0513 0.1149 0.4341
Brugia malayi CCR4 0.0036 0.0012 0.0009
Schistosoma mansoni hypothetical protein 0.0212 0.0432 0.1608
Schistosoma mansoni ap endonuclease 0.0036 0.0012 0.0009
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0041 0.0024 0.0265
Schistosoma mansoni survival motor neuron protein 0.005 0.0045 0.0136
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.0244 0.0894
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0244 0.0894
Brugia malayi map kinase activated protein kinase protein 2 0.0175 0.0343 0.1271
Schistosoma mansoni neutral sphingomyelinase 0.1135 0.2633 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0012 0.0009
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0036 0.0012 0.0545
Loa Loa (eye worm) hypothetical protein 0.0041 0.0023 0.0051
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0036 0.0012 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0012 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0038 0.011
Toxoplasma gondii ATPase, AAA family protein 0.0041 0.0023 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0048 0.0148
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0012 0.0546
Loa Loa (eye worm) oxidoreductase 0.0036 0.0012 0.0009
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0036 0.0012 0.0009
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0036 0.0012 0.0013
Toxoplasma gondii propionate-CoA ligase 0.0036 0.0012 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0012 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0012 0.0546
Loa Loa (eye worm) hypothetical protein 0.0246 0.0513 0.1918
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0023 0.0239
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0036 0.0012 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0023 0.0248
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0123 0.022 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0012 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0123 0.022 0.0802
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0041 0.0023 0.0096
Brugia malayi hypothetical protein 0.0246 0.0513 0.1918
Echinococcus multilocularis expressed conserved protein 0.0482 0.1075 0.1064
Leishmania major hypothetical protein, conserved 0.0226 0.0466 1
Loa Loa (eye worm) hypothetical protein 0.1135 0.2633 1
Echinococcus granulosus Protein patched homolog 1 0.022 0.045 0.1672
Schistosoma mansoni patched 1 0.022 0.045 0.168
Schistosoma mansoni hypothetical protein 0.0212 0.0432 0.1608
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.1135 0.2633 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0123 0.022 0.4588
Schistosoma mansoni carbon catabolite repressor protein 0.0036 0.0012 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0023 0.0248
Schistosoma mansoni nocturnin 0.0036 0.0012 0.0009
Echinococcus multilocularis expressed conserved protein 0.1099 0.2547 0.2538
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0092 0.0146 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0036 0.0012 0.0009
Echinococcus granulosus nibrin 0.0041 0.0023 0.0041
Schistosoma mansoni microtubule-associated protein tau 0.0718 0.1639 0.621
Echinococcus granulosus neutral sphingomyelinase 0.1135 0.2633 1
Echinococcus granulosus expressed conserved protein 0.1099 0.2547 0.967
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0036 0.0012 0.0001
Loa Loa (eye worm) RNA binding protein 0.0134 0.0244 0.0894
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0036 0.0012 0.0009
Echinococcus multilocularis neutral sphingomyelinase 0.1135 0.2633 0.2625
Onchocerca volvulus 0.0036 0.0012 0.0000055757
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0123 0.022 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0123 0.022 1
Onchocerca volvulus 0.0123 0.022 0.0794
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0036 0.0012 0.0009
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0036 0.0012 0.0009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0038 0.011
Brugia malayi MH2 domain containing protein 0.0127 0.0229 0.0835
Brugia malayi topoisomerase 0.0041 0.0023 0.0051
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0041 0.0023 0.0521
Onchocerca volvulus 0.0036 0.0012 0.0000055757
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0041 0.0023 0.0248
Schistosoma mansoni ap endonuclease 0.0036 0.0012 0.0009
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0036 0.0012 0.0009
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0041 0.0023 0.0051
Schistosoma mansoni topbp1 0.0041 0.0023 0.0051
Entamoeba histolytica acyl-CoA synthetase, putative 0.0123 0.022 0.1831
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0036 0.0012 0.0546
Echinococcus multilocularis geminin 0.0175 0.0343 0.0332
Echinococcus multilocularis protein dispatched 1 0.0251 0.0525 0.0513
Loa Loa (eye worm) hypothetical protein 0.0123 0.022 0.0802
Brugia malayi exodeoxyribonuclease III family protein 0.0036 0.0012 0.0009
Plasmodium falciparum acyl-CoA synthetase 0.0092 0.0146 1
Onchocerca volvulus 0.005 0.0045 0.0127
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0036 0.0012 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0123 0.022 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0123 0.022 0.4588
Trypanosoma brucei hypothetical protein, conserved 0.0226 0.0466 1
Schistosoma mansoni synaptojanin 0.0036 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0092 0.0146 0.0519
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0036 0.0012 0.0009
Schistosoma mansoni topbp1 0.0041 0.0023 0.0051
Schistosoma mansoni hypothetical protein 0.0175 0.0343 0.1272
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.0244 0.0894
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0036 0.0012 0.0000055757
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0012 0.0009
Echinococcus granulosus microtubule associated protein 2 0.0718 0.1639 0.6207
Echinococcus granulosus hypothetical protein 0.1099 0.2547 0.967
Onchocerca volvulus 0.0036 0.0012 0.0000055757
Schistosoma mansoni acetyl-CoA synthetase 0.0036 0.0012 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0012 0.0009
Entamoeba histolytica hypothetical protein 0.0041 0.0023 0.0096
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0175 0.0343 0.1263
Loa Loa (eye worm) hypothetical protein 0.0092 0.0146 0.0519
Loa Loa (eye worm) hypothetical protein 0.0123 0.022 0.0802
Loa Loa (eye worm) hypothetical protein 0.0041 0.0023 0.0051
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0123 0.022 1
Schistosoma mansoni cript-related 0.0036 0.0012 0.0009
Echinococcus granulosus sterol regulatory element binding protein 0.022 0.045 0.1672
Echinococcus granulosus tar DNA binding protein 0.0134 0.0244 0.0885
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0038 0.0026
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0036 0.0012 0.0001
Brugia malayi hypothetical protein 0.0037 0.0015 0.002
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0041 0.0023 0.9997
Mycobacterium ulcerans acyl-CoA synthetase 0.0123 0.022 1
Echinococcus multilocularis protein patched 0.022 0.045 0.0439
Echinococcus multilocularis microtubule associated protein 2 0.0718 0.1639 0.1629
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0041 0.0023 0.0522
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0012 0.0001
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0041 0.0023 0.0248

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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