TDR Targets

Basic information

Technical information

TDR Targets ID: 1167425
Name: N-(furan-2-ylmethyl)-5,7-dimethyl-[1,2,4]tria zolo[1,5-a]pyrimidine-2-carboxamide
MW: 271.275 | Formula: C13H13N5O2
H donors: 1 H acceptors: 4 LogP: 1.1 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cc(C)n2c(n1)nc(n2)C(=O)NCc1ccco1
InChi: 1S/C13H13N5O2/c1-8-6-9(2)18-13(15-8)16-11(17-18)12(19)14-7-10-4-3-5-20-10/h3-6H,7H2,1-2H3,(H,14,19)
InChiKey: VOFNIOCBZLBWPE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-furylmethyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide
ZINC02886507
SDCCGMLS-0009032.P002
MLS000066649
N-(2-furylmethyl)-5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide
SMR000082568
STK340956

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0521	0.1168	0.4413
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0146	0.0519
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0087	0.0134	0.6071
Brugia malayi	map kinase activated protein kinase protein 2	0.0175	0.0343	0.1271
Schistosoma mansoni	hypothetical protein	0.0175	0.0343	0.1272
Entamoeba histolytica	hypothetical protein	0.0037	0.0015	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0012	0.0009
Schistosoma mansoni	topbp1	0.0041	0.0023	0.0051
Echinococcus multilocularis	microtubule associated protein 2	0.0718	0.1639	0.1629
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0036	0.0012	0.0001
Schistosoma mansoni	hypothetical protein	0.0212	0.0432	0.1608
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0092	0.0146	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0045	0.0136
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0023	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0146	0.0519
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.0244	0.0894
Trypanosoma cruzi	FHA domain containing protein, putative	0.0041	0.0023	0.0239
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0036	0.0012	0.0001
Echinococcus granulosus	tar DNA binding protein	0.0134	0.0244	0.0885
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0015	0.0003
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0036	0.0012	0.0001
Echinococcus multilocularis	tar DNA binding protein	0.0134	0.0244	0.0232
Echinococcus granulosus	neutral sphingomyelinase	0.1135	0.2633	1
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0175	0.0343	0.1271
Echinococcus granulosus	hypothetical protein	0.1099	0.2547	0.967
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0123	0.022	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0012	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0012	0.0009
Echinococcus multilocularis	Niemann Pick C1 protein	0.0733	0.1674	0.1664
Onchocerca volvulus		0.0041	0.0023	0.0041
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0012	0.0546
Toxoplasma gondii	ATPase, AAA family protein	0.0041	0.0023	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0092	0.0146	0.6617
Mycobacterium ulcerans	acyl-CoA synthetase	0.0123	0.022	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0023	0.0051
Brugia malayi	AMP-binding enzyme family protein	0.0123	0.022	0.0802
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0038	0.011
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.0244	0.0894
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0036	0.0012	0.0546
Echinococcus granulosus	Protein patched homolog 1	0.022	0.045	0.1672
Echinococcus multilocularis	tumor protein p63	0.1048	0.2424	0.2415
Trypanosoma cruzi	hypothetical protein, conserved	0.0226	0.0466	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0123	0.022	1
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0036	0.0012	0.0546
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0134	0.0244	0.0894
Mycobacterium ulcerans	acyl-CoA synthetase	0.0123	0.022	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0036	0.0012	0.0009
Brugia malayi	CCR4	0.0036	0.0012	0.0009
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0123	0.022	1
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0012	0.0546
Schistosoma mansoni	patched 1	0.022	0.045	0.168
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0175	0.0343	0.0332
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0036	0.0012	0.0546
Schistosoma mansoni	acetyl-CoA synthetase	0.0036	0.0012	0.0009
Onchocerca volvulus		0.0036	0.0012	0.0000055757
Loa Loa (eye worm)	hypothetical protein	0.1135	0.2633	1
Trypanosoma brucei	hypothetical protein, conserved	0.0226	0.0466	1
Onchocerca volvulus		0.0153	0.0291	0.1065
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0036	0.0012	0.0000014634
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0038	0.011
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0146	0.0519
Mycobacterium ulcerans	acyl-CoA synthetase	0.0036	0.0012	0.0001
Mycobacterium ulcerans	acyl-CoA synthetase	0.0036	0.0012	0.0001
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0036	0.0012	0.0000055757
Mycobacterium ulcerans	acyl-CoA synthetase	0.0036	0.0012	0.0001
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0036	0.0012	0.0009
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0036	0.0012	0.0009
Leishmania major	4-coumarate:coa ligase-like protein	0.0123	0.022	0.4588
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0012	0.0546
Loa Loa (eye worm)	hypothetical protein	0.022	0.045	0.168
Echinococcus granulosus	expressed conserved protein	0.1099	0.2547	0.967
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0041	0.0023	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0246	0.0513	0.1918
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0038	0.01
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0036	0.0012	0.0001
Schistosoma mansoni	survival motor neuron protein	0.005	0.0045	0.0136
Brugia malayi	hypothetical protein	0.0037	0.0015	0.002
Loa Loa (eye worm)	MH2 domain-containing protein	0.0127	0.0229	0.0835
Onchocerca volvulus	Putative neutral sphingomyelinase	0.1135	0.2633	1
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0041	0.0023	0.0096
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0036	0.0012	0.0009
Schistosoma mansoni	hypothetical protein	0.0212	0.0432	0.1608
Brugia malayi	AMP-binding enzyme family protein	0.0036	0.0012	0.0009
Schistosoma mansoni	hypothetical protein	0.0212	0.0432	0.1608
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0038	0.01
Echinococcus multilocularis	expressed conserved protein	0.0482	0.1075	0.1064
Mycobacterium ulcerans	acyl-CoA synthetase	0.0036	0.0012	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0146	0.0519
Mycobacterium ulcerans	acyl-CoA synthetase	0.0036	0.0012	0.0001
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0087	0.0134	0.6071
Brugia malayi	AMP-binding enzyme family protein	0.0036	0.0012	0.0009
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0036	0.0012	0.0001
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0036	0.0012	0.0009
Brugia malayi	Pax transcription activation domain interacting protein	0.0041	0.0023	0.0051
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0041	0.0023	0.0248
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0036	0.0012	0.0009
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0123	0.022	0.1831
Echinococcus multilocularis	expressed conserved protein	0.1099	0.2547	0.2538
Echinococcus granulosus	microtubule associated protein 2	0.0718	0.1639	0.6207
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0123	0.022	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0123	0.022	1
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0023	0.0248
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0036	0.0012	0.0013
Trypanosoma cruzi	pantothenate kinase subunit, putative	0.0041	0.0024	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0123	0.022	0.0802
Entamoeba histolytica	hypothetical protein	0.0037	0.0015	0.0025
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0036	0.0012	0.0546
Echinococcus granulosus	sterol regulatory element binding protein	0.022	0.045	0.1672
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0036	0.0012	0.0546
Entamoeba histolytica	hypothetical protein	0.0037	0.0015	0.0025
Schistosoma mansoni	hypothetical protein	0.005	0.0045	0.0136
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0041	0.0023	0.0248
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0041	0.0023	0.0522
Trichomonas vaginalis	conserved hypothetical protein	0.022	0.045	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0146	0.0519
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0513	0.1149	1
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0023	0.0248
Schistosoma mansoni	ap endonuclease	0.0036	0.0012	0.0009
Echinococcus granulosus	nibrin	0.0041	0.0023	0.0041
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0036	0.0012	0.0009
Giardia lamblia	Replication factor C, subunit 1	0.0041	0.0023	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0087	0.0134	0.6071
Brugia malayi	TAR-binding protein	0.0134	0.0244	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0012	0.0009
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0023	0.0248
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.0244	0.0894
Echinococcus multilocularis	sterol regulatory element binding protein	0.022	0.045	0.0439
Onchocerca volvulus		0.0036	0.0012	0.0000055757
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0015	0.002
Schistosoma mansoni	nocturnin	0.0036	0.0012	0.0009
Brugia malayi	hypothetical protein	0.0041	0.0023	0.0051
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.0244	0.0894
Echinococcus multilocularis	Niemann Pick C1 protein	0.0513	0.1149	0.1138
Brugia malayi	hypothetical protein	0.0041	0.0023	0.0051
Mycobacterium ulcerans	hypothetical protein	0.0123	0.022	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0012	0.0009
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0036	0.0012	0.0009
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0036	0.0012	0.0009
Entamoeba histolytica	hypothetical protein	0.0037	0.0015	0.0025
Trichomonas vaginalis	replication factor C large subunit, putative	0.0041	0.0023	0.0248
Schistosoma mansoni	hypothetical protein	0.0037	0.0015	0.002
Schistosoma mansoni	carbon catabolite repressor protein	0.0036	0.0012	0.0009
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0036	0.0012	0.0009
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0038	0.011
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0036	0.0012	0.0001
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0087	0.0134	0.6071
Echinococcus granulosus	replication factor c subunit 1	0.0041	0.0023	0.0041
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0123	0.022	1
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0036	0.0012	0.0009
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0015	0.0011
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0012	0.0546
Schistosoma mansoni	synaptojanin	0.0036	0.0012	0.0009
Treponema pallidum	DNA ligase (lig)	0.0041	0.0023	1
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0036	0.0012	0.0001
Plasmodium falciparum	acyl-CoA synthetase	0.0092	0.0146	1
Schistosoma mansoni	ocrl type II inositol 5-phosphatase	0.0036	0.0012	0.0009
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0038	0.0026
Echinococcus granulosus	tumor protein p63	0.1048	0.2424	0.9202
Echinococcus multilocularis	geminin	0.0175	0.0343	0.0332
Leishmania major	hypothetical protein, conserved	0.0226	0.0466	1
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0036	0.0012	0.0546
Loa Loa (eye worm)	transcription factor SMAD2	0.0127	0.0229	0.0835
Leishmania major	4-coumarate:coa ligase-like protein	0.0123	0.022	0.4588
Brugia malayi	AMP-binding enzyme family protein	0.0036	0.0012	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0048	0.0148
Brugia malayi	MH2 domain containing protein	0.0127	0.0229	0.0835
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0123	0.022	1
Echinococcus multilocularis	protein patched	0.022	0.045	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0513	0.1149	0.4341
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0038	0.011
Entamoeba histolytica	acyl-coA synthetase, putative	0.0123	0.022	0.1831
Mycobacterium tuberculosis	Probable exported protein	0.0036	0.0012	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0123	0.022	0.0802
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.022	0.045	0.168
Leishmania major	4-coumarate:coa ligase-like protein	0.0123	0.022	0.4588
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0036	0.0012	0.0001
Onchocerca volvulus		0.005	0.0045	0.0127
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0175	0.0343	0.1263
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0036	0.0012	0.0001
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0048	0.0148
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0041	0.0023	0.0239
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0123	0.022	0.1831
Brugia malayi	topoisomerase	0.0041	0.0023	0.0051
Loa Loa (eye worm)	oxidoreductase	0.0036	0.0012	0.0009
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0023	0.0239
Loa Loa (eye worm)	RNA binding protein	0.0134	0.0244	0.0894
Brugia malayi	AMP-binding enzyme family protein	0.0123	0.022	0.0802
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.0041	0.0023	0.0521
Schistosoma mansoni	hypothetical protein	0.0175	0.0343	0.1272
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0023	0.0248
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0038	0.011
Brugia malayi	exodeoxyribonuclease III family protein	0.0036	0.0012	0.0009
Mycobacterium ulcerans	acyl-CoA synthetase	0.0123	0.022	1
Echinococcus granulosus	survival motor neuron protein 1	0.0246	0.0513	0.191
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0023	0.0239
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0041	0.0023	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0023	0.0051
Schistosoma mansoni	chromosome transmission fidelity factor	0.0041	0.0023	0.0051
Leishmania major	pantothenate kinase subunit, putative	0.0041	0.0024	0.0265
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0036	0.0012	0.0009
Brugia malayi	hypothetical protein	0.0246	0.0513	0.1918
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0041	0.0023	0.0248
Schistosoma mansoni	cript-related	0.0036	0.0012	0.0009
Toxoplasma gondii	propionate-CoA ligase	0.0036	0.0012	0.0013
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0048	0.0148
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.1135	0.2633	1
Loa Loa (eye worm)	hypothetical protein	0.0123	0.022	0.0802
Mycobacterium ulcerans	acyl-CoA synthetase	0.0036	0.0012	0.0001
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0036	0.0012	0.0009
Onchocerca volvulus		0.0036	0.0012	0.0000055757
Echinococcus granulosus	Niemann Pick C1 protein	0.0733	0.1674	0.6338
Plasmodium vivax	replication factor C subunit 1, putative	0.0041	0.0023	0.0813
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0123	0.022	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0513	0.1149	0.4341
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0291	0.1074
Schistosoma mansoni	synaptojanin	0.0036	0.0012	0.0009
Echinococcus granulosus	expressed conserved protein	0.0482	0.1075	0.4053
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0041	0.0023	0.9997
Schistosoma mansoni	DNA ligase IV	0.0041	0.0023	0.0051
Onchocerca volvulus		0.0036	0.0012	0.0000055757
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0036	0.0012	0.0009
Echinococcus granulosus	Niemann Pick C1 protein	0.0513	0.1149	0.4336
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0092	0.0146	0.6422
Plasmodium vivax	acyl-CoA synthetase, putative	0.0092	0.0146	1
Brugia malayi	RNA binding protein	0.0134	0.0244	0.0894
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0036	0.0012	0.0001
Entamoeba histolytica	hypothetical protein	0.0041	0.0023	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0023	0.0051
Brugia malayi	CHE-14 protein	0.022	0.045	0.168
Brugia malayi	DKFZp564C0469 protein	0.0041	0.0023	0.0051
Echinococcus multilocularis	conserved hypothetical protein	0.1099	0.2547	0.2538
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0038	0.0026
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0036	0.0012	0.0001
Echinococcus multilocularis	neutral sphingomyelinase	0.1135	0.2633	0.2625
Brugia malayi	AMP-binding enzyme family protein	0.0036	0.0012	0.0009
Schistosoma mansoni	neutral sphingomyelinase	0.1135	0.2633	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0226	0.0466	1
Echinococcus multilocularis	nibrin	0.0041	0.0023	0.0011
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0048	0.0148
Schistosoma mansoni	cellular tumor antigen P53	0.0153	0.0291	0.1074
Schistosoma mansoni	serine/threonine protein kinase	0.0175	0.0343	0.1271
Echinococcus granulosus	geminin	0.0175	0.0343	0.1264
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0041	0.0023	0.0051
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0036	0.0012	0.0009
Schistosoma mansoni	topbp1	0.0041	0.0023	0.0051
Echinococcus multilocularis	survival motor neuron protein 1	0.0246	0.0513	0.0501
Mycobacterium ulcerans	acyl-CoA synthetase	0.0036	0.0012	0.0001
Schistosoma mansoni	hypothetical protein	0.0212	0.0432	0.1608
Echinococcus multilocularis	replication factor c subunit 1	0.0041	0.0023	0.0011
Mycobacterium ulcerans	acyl-CoA synthetase	0.0036	0.0012	0.0001
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0036	0.0012	0.0009
Loa Loa (eye worm)	CCR4-NOT transcription complex subunit 6 family protein	0.0036	0.0012	0.0009
Loa Loa (eye worm)	TAR-binding protein	0.0134	0.0244	0.0894
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0036	0.0012	0.0546
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0036	0.0012	0.0013
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0041	0.0023	1
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0036	0.0012	0.0009
Onchocerca volvulus		0.0123	0.022	0.0794
Plasmodium falciparum	replication factor C subunit 1, putative	0.0041	0.0023	0.0813
Brugia malayi	AMP-binding enzyme family protein	0.0123	0.022	0.0802
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0023	0.0051
Schistosoma mansoni	microtubule-associated protein tau	0.0718	0.1639	0.621
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0036	0.0012	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0012	0.0009
Loa Loa (eye worm)	hypothetical protein	0.027	0.0569	0.213
Echinococcus multilocularis	protein dispatched 1	0.0251	0.0525	0.0513
Schistosoma mansoni	ap endonuclease	0.0036	0.0012	0.0009
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0036	0.0012	0.0545
Brugia malayi	RNA recognition motif domain containing protein	0.0134	0.0244	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0023	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0023	0.0051
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.0244	0.0894

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.1122 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1872844

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1167425