Detailed information for compound 1167424

Basic information

Technical information
  • TDR Targets ID: 1167424
  • Name: ethyl 2-oxo-4-phenyl-6-(2,4,5-trimethoxypheny l)-3,6-dihydro-1H-pyrimidine-5-carboxylate
  • MW: 412.436 | Formula: C22H24N2O6
  • H donors: 2 H acceptors: 2 LogP: 2.55 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1=C(NC(=O)NC1c1cc(OC)c(cc1OC)OC)c1ccccc1
  • InChi: 1S/C22H24N2O6/c1-5-30-21(25)18-19(13-9-7-6-8-10-13)23-22(26)24-20(18)14-11-16(28-3)17(29-4)12-15(14)27-2/h6-12,20H,5H2,1-4H3,(H2,23,24,26)
  • InChiKey: PYVOMYJFJCAQEM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-oxo-4-phenyl-6-(2,4,5-trimethoxyphenyl)-3,6-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester
  • 2-keto-4-phenyl-6-(2,4,5-trimethoxyphenyl)-3,6-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester
  • Oprea1_001148

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0327 0.43
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0171 0.4646
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.004 0.0214 0.639
Leishmania major RNA-editing complex protein MP100, putative 0.004 0.0214 0.6108
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.004 0.0214 0.028
Onchocerca volvulus 0.0013 0.0028 0.0022
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.004 0.0214 0.6108
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0089 0.0078
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0124 0.3043
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.004 0.0214 0.0213
Loa Loa (eye worm) Smad1 0.0017 0.0061 0.0079
Echinococcus multilocularis expressed protein 0.0286 0.191 0.1909
Brugia malayi Smad1 0.0017 0.0061 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0234 0.7055
Brugia malayi hypothetical protein 0.0112 0.0713 0.094
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.004 0.0214 0.6108
Schistosoma mansoni smad1 5 8 and 0.0017 0.0061 0.005
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.004 0.0214 0.639
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0054 0.0053
Schistosoma mansoni hypothetical protein 0.0016 0.0054 0.0042
Echinococcus multilocularis phospholipase A2 receptor 1 0.0013 0.0028 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0089 0.0118
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0045 0.102
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.004 0.0214 0.2785
Loa Loa (eye worm) hypothetical protein 0.0015 0.0045 0.0058
Leishmania major DNA polymerase kappa, putative 0.0022 0.0092 0.1931
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0089 0.0078
Brugia malayi MH1 domain containing protein 0.0017 0.0061 0.008
Echinococcus granulosus regulator of G protein signaling 3 0.0015 0.0043 0.0042
Echinococcus granulosus dnaJ subfamily B 0.0396 0.2667 0.2666
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0089 0.0089
Treponema pallidum hypothetical protein 0.004 0.0214 0.4405
Schistosoma mansoni synaptojanin 0.004 0.0214 0.0203
Brugia malayi Nuclear hormone receptor E75 0.001 0.0011 0.0015
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Loa Loa (eye worm) ShTK domain-containing protein 0.0013 0.0028 0.0036
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0014
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0089 0.0103
Loa Loa (eye worm) DR-78 0.001 0.0011 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0089 0.0118
Brugia malayi PXA domain containing protein 0.0015 0.0043 0.0056
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.004 0.0214 0.2626
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0327 1
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.004 0.0214 0.0213
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0045 0.0059
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0089 0.0089
Brugia malayi nuclear receptor RXR 0.001 0.0011 0.0015
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.004 0.0214 0.6108
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0234 0.6824
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0045 0.0044
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0214 0.6108
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.004 0.0214 0.6108
Schistosoma mansoni hypothetical protein 0.0013 0.0028 0.0017
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0264 0.0348
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.004 0.0214 0.2785
Echinococcus granulosus regulator of G protein signaling 3 0.0015 0.0043 0.0042
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0327 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0089 0.0078
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0036
Schistosoma mansoni cadherin 0.0013 0.0028 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0043 0.0242
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.004 0.0214 0.6108
Brugia malayi Lectin C-type domain containing protein 0.0013 0.0028 0.0037
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.004 0.0214 0.6108
Schistosoma mansoni nocturnin 0.004 0.0214 0.0203
Loa Loa (eye worm) hypothetical protein 0.0112 0.0713 0.0939
Echinococcus multilocularis regulator of G protein signaling 7 0.0015 0.0043 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0264 0.0253
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.004 0.0214 0.397
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0089 0.0103
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.031 0.9416
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0264 0.0264
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0045 0.0044
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0011 0.001
Schistosoma mansoni axis inhibition protein axin 0.0015 0.0043 0.0031
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.0484 0.0483
Loa Loa (eye worm) hypothetical protein 0.0032 0.0163 0.0214
Loa Loa (eye worm) hypothetical protein 0.0112 0.0713 0.0939
Trypanosoma brucei unspecified product 0.0036 0.0187 0.5557
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0014
Trichomonas vaginalis heat shock protein, putative 0.002 0.0082 0.1603
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0025
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0033 0.0166 0.2102
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.004 0.0214 0.397
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.002 0.0025
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0327 0.0326
Echinococcus multilocularis heat shock protein 0.0033 0.0171 0.017
Echinococcus granulosus regulator of G protein signaling 7 0.0015 0.0043 0.0042
Echinococcus multilocularis fras1 related extracellular matrix protein 0.0013 0.0028 0.0027
Echinococcus granulosus GPCR family 2 0.0016 0.0054 0.0053
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0133 0.0174
Plasmodium falciparum apical sushi protein 0.0112 0.0713 1
Giardia lamblia Inositol 5-phosphatase 4 0.004 0.0214 0.5176
Echinococcus multilocularis neutral sphingomyelinase 0.1112 0.759 0.759
Brugia malayi hypothetical protein 0.0127 0.0812 0.107
Onchocerca volvulus 0.0013 0.0028 0.0022
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0171 0.5035
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.004 0.0214 0.0281
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Onchocerca volvulus Huntingtin homolog 0.0127 0.0812 0.1057
Brugia malayi hypothetical protein 0.0112 0.0713 0.094
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0184 0.0242
Entamoeba histolytica hypothetical protein 0.0079 0.0484 1
Onchocerca volvulus 0.0013 0.0028 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0089 0.0118
Trichomonas vaginalis bromodomain-containing protein, putative 0.0033 0.0166 0.4486
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.004 0.0214 0.2785
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0124 0.3043
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0055
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.007
Loa Loa (eye worm) RGS-3 protein 0.0015 0.0043 0.0055
Echinococcus multilocularis smad 0.0017 0.0061 0.006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0055
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0043 0.0031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0089 0.0117
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0327 0.0431
Loa Loa (eye worm) hypothetical protein 0.0021 0.0089 0.0117
Schistosoma mansoni smad 0.0017 0.0061 0.005
Brugia malayi MH2 domain containing protein 0.0017 0.0061 0.008
Schistosoma mansoni heat shock protein 0.0033 0.0171 0.016
Echinococcus granulosus Smad4 0.0017 0.0061 0.006
Toxoplasma gondii exonuclease III APE 0.0056 0.0327 0.4423
Loa Loa (eye worm) hypothetical protein 0.004 0.0214 0.028
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0089 0.0118
Schistosoma mansoni Smad4 0.0017 0.0061 0.005
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0171 0.4646
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0089 0.0078
Echinococcus granulosus hypothetical protein 0.1073 0.7318 0.7318
Onchocerca volvulus 0.0112 0.0713 0.0926
Echinococcus granulosus regulator of G protein signaling 7 0.0015 0.0043 0.0042
Brugia malayi Lectin C-type domain containing protein 0.0013 0.0028 0.0037
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0045 0.0059
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0234 0.5435
Onchocerca volvulus 0.0013 0.0028 0.0022
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0036
Trypanosoma brucei heat shock protein, putative 0.0033 0.0171 0.5035
Schistosoma mansoni synaptojanin 0.004 0.0214 0.0203
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0045 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0089 0.0118
Entamoeba histolytica hypothetical protein 0.0015 0.0043 0.0158
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.004 0.0214 0.639
Schistosoma mansoni ap endonuclease 0.0056 0.0327 0.0316
Brugia malayi PXA domain containing protein 0.0015 0.0043 0.0056
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0015 0.0043 0.0055
Schistosoma mansoni heat shock protein 0.0033 0.0171 0.016
Onchocerca volvulus 0.0028 0.0133 0.0161
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0014
Onchocerca volvulus Putative neutral sphingomyelinase 0.1112 0.759 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0009
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0011 0.001
Brugia malayi Lectin C-type domain containing protein 0.0013 0.0028 0.0037
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.004 0.0214 0.397
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.004 0.0214 0.6108
Brugia malayi hypothetical protein 0.0112 0.0713 0.094
Trypanosoma brucei heat shock protein, putative 0.0033 0.0171 0.5035
Echinococcus granulosus axis inhibition protein axin 0.0015 0.0043 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.001
Toxoplasma gondii heat shock protein 75, putative 0.0014 0.0036 0.0215
Schistosoma mansoni regulator of G protein signaling 0.0015 0.0043 0.0031
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0011 0.001
Onchocerca volvulus 0.0112 0.0713 0.0926
Echinococcus multilocularis synaptojanin 1 0.004 0.0214 0.0213
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0045 0.0034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0089 0.0089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0264 0.0264
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0327 0.43
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0234 0.7055
Echinococcus granulosus C type lectin 0.0013 0.0028 0.0027
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0171 0.5035
Brugia malayi hypothetical protein 0.0015 0.0043 0.0056
Brugia malayi hypothetical protein 0.0112 0.0713 0.094
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0014
Onchocerca volvulus 0.0112 0.0713 0.0926
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.004 0.0214 0.397
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0092 0.2517
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.031 0.9416
Onchocerca volvulus 0.0112 0.0713 0.0926
Brugia malayi MH2 domain containing protein 0.0017 0.0061 0.008
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0015 0.0043 0.0242
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0077 0.1421
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0234 0.7055
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0241
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.004 0.0214 0.6108
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0247 0.1641 0.1641
Leishmania major hypothetical protein, conserved 0.004 0.0214 0.6108
Echinococcus granulosus Regulator of G protein signaling 20 0.0015 0.0043 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0234 0.7055
Brugia malayi hypothetical protein 0.0011 0.002 0.0026
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0111 0.0706 0.0705
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0234 0.7055
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0089 0.0118
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0187 0.5557
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0025
Echinococcus granulosus C type lectin domian containing protein 0.0112 0.0713 0.0713
Echinococcus granulosus endoplasmin 0.0027 0.0124 0.0124
Brugia malayi ecdysone receptor 0.001 0.0011 0.0015
Trichomonas vaginalis Phospholipase C precursor, putative 0.004 0.0214 0.6108
Trypanosoma cruzi mitochondrial protein 99, putative 0.004 0.0214 0.6108
Loa Loa (eye worm) hypothetical protein 0.0021 0.0089 0.0117
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0061 0.006
Brugia malayi hypothetical protein 0.001 0.0011 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0234 0.6824
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0015 0.0043 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.006 0.1497
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0033 0.0166 0.1929
Echinococcus granulosus c4b binding protein beta chain 0.0112 0.0713 0.0713
Toxoplasma gondii rhoptry neck protein RON1 0.0112 0.0713 1
Trypanosoma brucei RNA editing exonuclease 2 0.004 0.0214 0.639
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0234 0.7055
Echinococcus multilocularis Smad4 0.0017 0.0061 0.006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0234 0.6824
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0043 0.0242
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0089 0.0118
Plasmodium falciparum heat shock protein 90 0.0033 0.0171 0.1998
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0124 0.1378
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.004 0.0214 0.0281
Schistosoma mansoni heat shock protein 0.0014 0.0036 0.0024
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0089 0.0078
Echinococcus multilocularis regulator of G protein signaling 7 0.0015 0.0043 0.0042
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0089 0.0117
Schistosoma mansoni axis inhibition protein axin 0.0015 0.0043 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0264 0.0264
Brugia malayi polk-prov protein 0.0032 0.0163 0.0215
Schistosoma mansoni cpg binding protein 0.0028 0.0133 0.0122
Echinococcus multilocularis conserved hypothetical protein 0.1073 0.7318 0.7318
Echinococcus granulosus phospholipase A2 receptor 1 0.0013 0.0028 0.0027
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0089 0.0078
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0112 0.0713 0.0939
Brugia malayi CXXC zinc finger family protein 0.0028 0.0133 0.0175
Entamoeba histolytica hypothetical protein 0.0015 0.0043 0.0158
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0033 0.0166 0.4486
Onchocerca volvulus 0.0013 0.0028 0.0022
Schistosoma mansoni cpg binding protein 0.0029 0.0144 0.0133
Leishmania major endonuclease/exonuclease protein-like protein 0.004 0.0214 0.6108
Plasmodium vivax exodeoxyribonuclease III, putative 0.004 0.0214 0.2626
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0234 0.7055
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0171 0.4646
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0089 0.0117
Brugia malayi nuclear hormone receptor 0.001 0.0011 0.0015
Onchocerca volvulus 0.0013 0.0028 0.0022
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.004 0.0214 0.2626
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0327 0.043
Loa Loa (eye worm) heat shock protein 75 0.0014 0.0036 0.0046
Echinococcus multilocularis beta adrenergic receptor kinase 0.0015 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0036
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0234 0.6824
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.004 0.0214 0.2785
Schistosoma mansoni smad1 5 8 and 0.0017 0.0061 0.005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.001
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.004 0.0214 0.0281
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0013 0.0028 0.0036
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.2667 0.2666
Echinococcus multilocularis lymphocyte antigen 75 0.0013 0.0028 0.0027
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0171 0.4646
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0011 0.001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0089 0.0078
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.004 0.0214 0.028
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0171 0.302
Leishmania major hypothetical protein, conserved 0.004 0.0214 0.6108
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.004 0.0214 0.397
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.004 0.0214 0.0213
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0055
Giardia lamblia Histone acetyltransferase GCN5 0.003 0.0148 0.2369
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.004 0.0214 0.2785
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0089 0.0117
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.031 0.4049
Onchocerca volvulus 0.0013 0.0028 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0163 0.4789
Schistosoma mansoni Galactose-specific lectin (PAL) 0.0013 0.0028 0.0017
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0089 0.0089
Schistosoma mansoni survival motor neuron protein 0.0156 0.1011 0.1001
Echinococcus multilocularis traf and tnf receptor associated protein 0.004 0.0214 0.0213
Onchocerca volvulus 0.004 0.0214 0.0267
Echinococcus granulosus smad 0.0017 0.0061 0.006
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.004 0.0214 0.028
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0043 0.0242
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0089 0.0089
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0171 0.5035
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0234 0.7055
Toxoplasma gondii hypothetical protein 0.0013 0.0028 0.0108
Onchocerca volvulus 0.0156 0.1011 0.132
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0327 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.004 0.0214 0.397
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0089 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0163 0.4789
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0089 0.0078
Loa Loa (eye worm) hypothetical protein 0.0052 0.0296 0.0389
Brugia malayi hypothetical protein 0.001 0.0011 0.0015
Brugia malayi MH1 domain containing protein 0.001 0.0008 0.001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0089 0.0117
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0327 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.002 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0089 0.0117
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.002 0.0019
Brugia malayi nuclear receptor NHR-88 0.001 0.0011 0.0015
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0124 0.3043
Loa Loa (eye worm) hypothetical protein 0.0021 0.0089 0.0117
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0033 0.0166 0.2102
Loa Loa (eye worm) hypothetical protein 0.0021 0.0089 0.0117
Brugia malayi A-kinase anchor protein 10, precursor 0.0015 0.0043 0.0056
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.004 0.0214 0.0281
Loa Loa (eye worm) hypothetical protein 0.0112 0.0713 0.0939
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0171 0.4646
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0061 0.006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0089 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0089 0.0118
Trypanosoma brucei heat shock protein, putative 0.0033 0.0171 0.5035
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.004 0.0214 0.639
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Echinococcus multilocularis GPCR, family 2 0.0016 0.0054 0.0053
Entamoeba histolytica hypothetical protein 0.0079 0.0484 1
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0296 0.0389
Leishmania major hypothetical protein, conserved 0.0054 0.031 0.9416
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.004 0.0214 0.6108
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0327 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.0812 0.1069
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0014 0.0036 0.0035
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0011 0.0015
Loa Loa (eye worm) acetyltransferase 0.0111 0.0706 0.0929
Brugia malayi MH1 domain containing protein 0.001 0.0008 0.001
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0296 0.039
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0089 0.0118
Echinococcus multilocularis C type lectin domian containing protein 0.0112 0.0713 0.0713
Loa Loa (eye worm) hypothetical protein 0.0127 0.0812 0.1069
Schistosoma mansoni hypothetical protein 0.0035 0.0184 0.0173
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0014
Schistosoma mansoni smad1 5 8 and 0.0017 0.0061 0.005
Giardia lamblia hypothetical protein 0.004 0.0214 0.5176
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.004 0.0214 0.0281
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.004 0.0214 0.397
Loa Loa (eye worm) hypothetical protein 0.0021 0.0089 0.0117
Onchocerca volvulus 0.004 0.0214 0.0267
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0054 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0089 0.0117
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0089 0.0089
Brugia malayi Lectin C-type domain containing protein 0.0013 0.0028 0.0037
Schistosoma mansoni cpg binding protein 0.0029 0.0144 0.0133
Leishmania major hypothetical protein, conserved 0.004 0.0214 0.6108
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0089 0.0089
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0089 0.0089
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.004 0.0214 0.6108
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0011 0.0015
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0014 0.0036 0.0032
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0107 0.0106
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Echinococcus granulosus beta-adrenergic receptor kinase 0.0015 0.0043 0.0042
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0234 0.7055
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0171 0.0224
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0014
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.004 0.0214 0.0213
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.004 0.0214 0.6108
Onchocerca volvulus 0.0112 0.0713 0.0926
Loa Loa (eye worm) hypothetical protein 0.0112 0.0713 0.0939
Brugia malayi Sushi domain 0.0112 0.0713 0.094
Echinococcus multilocularis deoxyribonuclease 1 2 0.004 0.0214 0.0213
Schistosoma mansoni regulator of G protein signaling 0.0015 0.0043 0.0031
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0323 0.4362
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.004 0.0214 0.0281
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.004 0.0214 0.2785
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0061 0.0079
Echinococcus granulosus heat shock protein 90 0.0027 0.0124 0.0124
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0089 0.0078
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0264 0.0347
Loa Loa (eye worm) hypothetical protein 0.0125 0.08 0.1053
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0327 1
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0171 0.302
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0045 0.0206
Brugia malayi nuclear receptor NHR-67 0.001 0.0011 0.0015
Brugia malayi hypothetical protein 0.0054 0.031 0.0408
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.004 0.0214 0.6108
Echinococcus multilocularis dna polymerase eta 0.0015 0.0045 0.0044
Trypanosoma brucei heat shock protein, putative 0.0033 0.0171 0.5035
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.004 0.0214 0.028
Brugia malayi hypothetical protein 0.0112 0.0713 0.094
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0214 0.6108
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0036
Brugia malayi acetyltransferase, GNAT family protein 0.0111 0.0706 0.093
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.004 0.0214 0.2626
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0061 0.0079
Schistosoma mansoni hypothetical protein 0.0079 0.0484 0.0473
Echinococcus granulosus expressed conserved protein 0.1073 0.7318 0.7318
Echinococcus granulosus survival motor neuron protein 1 0.0763 0.5186 0.5186
Brugia malayi tailless protein 0.001 0.0011 0.0015
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0327 0.0326
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.004 0.0214 0.0281
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0089 0.0089
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0234 0.0234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0089 0.0117
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0171 0.1998
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.004 0.0214 0.6108
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0327 1
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Loa Loa (eye worm) MH2 domain-containing protein 0.0255 0.1692 0.2228
Schistosoma mansoni hypothetical protein 0.0016 0.0054 0.0042
Schistosoma mansoni hypothetical protein 0.0013 0.0028 0.0017
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0027 0.0124 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.0713 0.0939
Brugia malayi hypothetical protein 0.0013 0.0028 0.0037
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0045 0.0058
Schistosoma mansoni microtubule-associated protein tau 0.1463 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0055
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0089 0.0103
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0089 0.0078
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0011 0.0015
Echinococcus granulosus traf and tnf receptor associated protein 0.004 0.0214 0.0213
Brugia malayi pregnancy-associated plasma protein-A 0.0112 0.0713 0.094
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0054 0.0053
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0171 0.217
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.002 0.0019
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0247 0.1641 0.1641
Brugia malayi hypothetical protein 0.0011 0.002 0.0026
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0015 0.0043 0.0042
Entamoeba histolytica sphingomyelinase C precursor, putative 0.004 0.0214 0.397
Echinococcus granulosus neutral sphingomyelinase 0.1112 0.759 0.759
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0055
Plasmodium falciparum DNase I-like protein, putative 0.004 0.0214 0.2626
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.004 0.0214 0.6108
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.004 0.0214 0.397
Echinococcus multilocularis regulator of G protein signaling 3 0.0015 0.0043 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0264 0.0253
Brugia malayi Nuclear hormone receptor E75 0.001 0.0011 0.0015
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0061 0.006
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.004 0.0214 0.6108
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0043 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0089 0.0118
Echinococcus multilocularis heat shock protein 90 0.0033 0.0171 0.017
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Plasmodium falciparum histone acetyltransferase GCN5 0.003 0.0148 0.1652
Loa Loa (eye worm) nuclear factor I 0.001 0.0008 0.0009
Echinococcus multilocularis heat shock protein 90 0.0027 0.0124 0.0124
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0089 0.0118
Trypanosoma brucei heat shock protein 84, putative 0.0014 0.0036 0.0726
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0089 0.0089
Trypanosoma brucei heat shock protein, putative 0.0033 0.0171 0.5035
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0015 0.0043 0.0031
Schistosoma mansoni z-protein (S1r protein) 0.0015 0.0043 0.0031
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.004 0.0214 0.639
Echinococcus granulosus fras1 related extracellular matrix protein 0.0013 0.0028 0.0027
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.004 0.0214 0.028
Entamoeba histolytica hypothetical protein 0.0015 0.0043 0.0158
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0015 0.0043 0.0056
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0011 0.001
Schistosoma mansoni regulator of G protein signaling 0.0015 0.0043 0.0031
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0055
Schistosoma mansoni regulator of G protein signaling 0.0015 0.0043 0.0031
Brugia malayi ecdysteroid receptor 0.0021 0.0089 0.0118
Loa Loa (eye worm) hypothetical protein 0.0112 0.0713 0.0939
Brugia malayi regulator of G-protein signaling rgs-7 0.0015 0.0043 0.0056
Schistosoma mansoni hypothetical protein 0.0013 0.0028 0.0017
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0013 0.0028 0.0017
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0092 0.1667
Brugia malayi nuclear receptor RXR 0.0011 0.002 0.0026
Brugia malayi nuclear receptor NHR-88 0.0021 0.0089 0.0118
Onchocerca volvulus 0.0112 0.0713 0.0926
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0043 0.0242
Echinococcus granulosus heat shock protein 0.0033 0.0171 0.017
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0089 0.0078
Schistosoma mansoni hypothetical protein 0.0156 0.1011 0.1001
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0054 0.0071
Leishmania major DNA polymerase eta, putative 0.0015 0.0045 0.0317
Onchocerca volvulus 0.0013 0.0028 0.0022
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.004 0.0214 0.6108
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0296 0.039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0347 0.0337
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0327 1
Entamoeba histolytica hypothetical protein 0.0079 0.0484 1
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.004 0.0214 0.6108
Echinococcus multilocularis survival motor neuron protein 1 0.0763 0.5186 0.5186
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.004 0.0214 0.6108
Schistosoma mansoni hypothetical protein 0.004 0.0214 0.0203
Giardia lamblia Grp94/Hsp90 0.0027 0.0124 0.1378
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0011 0.001
Brugia malayi regulator of G-protein signaling egl-10 0.0015 0.0043 0.0056
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0089 0.0118
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0014
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0089 0.0089
Echinococcus multilocularis microtubule associated protein 2 0.1463 1 1
Schistosoma mansoni hypothetical protein 0.0024 0.0107 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0112 0.0713 0.0939
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0089 0.0089
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0054 0.0071
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0036
Plasmodium vivax apical sushi protein, putative 0.0112 0.0713 1
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Trypanosoma cruzi pantothenate kinase subunit, putative 0.004 0.0214 0.6108
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0107 0.0106
Entamoeba histolytica acetyltransferase, GNAT family 0.003 0.0148 0.2498
Echinococcus granulosus lymphocyte antigen 75 0.0013 0.0028 0.0027
Trypanosoma brucei heat shock protein, putative 0.0033 0.0171 0.5035
Schistosoma mansoni endoplasmin 0.0033 0.0171 0.016
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0327 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0043 0.0242
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.031 0.4049
Schistosoma mansoni c4b-binding protein beta chain 0.0112 0.0713 0.0703
Brugia malayi CCR4 0.004 0.0214 0.0281
Brugia malayi Regulator of G protein signaling domain containing protein 0.0015 0.0043 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.006 0.1497
Brugia malayi hypothetical protein 0.0763 0.5186 0.6833
Schistosoma mansoni hypothetical protein 0.0016 0.0054 0.0042
Mycobacterium tuberculosis Probable exported protein 0.004 0.0214 0.598
Schistosoma mansoni hypothetical protein 0.0396 0.2667 0.2658
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0327 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0089 0.0118
Echinococcus multilocularis axis inhibition protein axin 0.0015 0.0043 0.0042
Echinococcus multilocularis regulator of G protein signaling 3 0.0015 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0234 0.7055
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0013 0.0028 0.0036
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0247 0.1641 0.1632
Brugia malayi hypothetical protein 0.0112 0.0713 0.094
Schistosoma mansoni endoplasmin 0.0033 0.0171 0.016
Trypanosoma brucei heat shock protein, putative 0.0033 0.0171 0.5035
Brugia malayi Lectin C-type domain containing protein 0.0013 0.0028 0.0037
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0015 0.0043 0.0031
Brugia malayi Regulator of G protein signaling domain containing protein 0.0015 0.0043 0.0056
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.004 0.0214 0.028
Echinococcus granulosus dna polymerase eta 0.0015 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0763 0.5186 0.6833
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0014
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.0484 0.0473
Schistosoma mansoni coup transcription factor 0.0021 0.0089 0.0078
Brugia malayi MH1 domain containing protein 0.0017 0.0061 0.008
Brugia malayi nuclear hormone receptor 0.0021 0.0089 0.0118
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.004 0.0214 0.0213
Loa Loa (eye worm) hypothetical protein 0.004 0.0214 0.028
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0171 0.4646
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0054 0.0053
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.004 0.0214 0.397
Echinococcus granulosus dna polymerase kappa 0.0043 0.0234 0.0234
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.004 0.0214 0.6108
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0013 0.0028 0.0036
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.002 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0089 0.0089
Brugia malayi hypothetical protein 0.0015 0.0043 0.0056
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0061 0.006
Brugia malayi Hsp90 protein 0.0014 0.0036 0.0047
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0156 0.1011 0.1332
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.004 0.0214 0.2626
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0092 0.1931
Loa Loa (eye worm) hypothetical protein 0.0112 0.0713 0.0939
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0027 0.0124 0.2816
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.031 0.4177
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Onchocerca volvulus 0.0112 0.0713 0.0926
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.002 0.0026
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0089 0.0089
Onchocerca volvulus 0.0013 0.0028 0.0022
Echinococcus granulosus axis inhibition protein axin 0.0015 0.0043 0.0042
Brugia malayi steroid hormone receptor 0.0021 0.0089 0.0118
Onchocerca volvulus Huntingtin homolog 0.0127 0.0812 0.1057
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0089 0.0117
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0011 0.001
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.1112 0.759 1
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0014 0.0036 0.0035
Schistosoma mansoni hypothetical protein 0.0016 0.0054 0.0042
Plasmodium falciparum endoplasmin, putative 0.002 0.0082 0.0689
Schistosoma mansoni neutral sphingomyelinase 0.1112 0.759 0.7587
Trypanosoma cruzi mitochondrial protein 99, putative 0.004 0.0214 0.6108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0264 0.0253
Brugia malayi heat shock protein 90 0.0033 0.0171 0.0225
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0089 0.0089
Schistosoma mansoni regulator of G protein signaling 0.0015 0.0043 0.0031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0036
Brugia malayi Lectin C-type domain containing protein 0.0013 0.0028 0.0037
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.0124 0.3043
Echinococcus multilocularis cpg binding protein 0.0029 0.0144 0.0143
Echinococcus granulosus expressed protein 0.0286 0.191 0.1909
Schistosoma mansoni ap endonuclease 0.0056 0.0327 0.0316
Echinococcus granulosus histone acetyltransferase KAT2B 0.0033 0.0166 0.0166
Echinococcus multilocularis c4b binding protein beta chain 0.0112 0.0713 0.0713
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.006 0.1497
Loa Loa (eye worm) transcription factor SMAD2 0.0255 0.1692 0.2228
Schistosoma mansoni carbon catabolite repressor protein 0.004 0.0214 0.0203
Brugia malayi Lectin C-type domain containing protein 0.0013 0.0028 0.0037
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0011 0.0015
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0045 0.0317
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0124 0.3043
Onchocerca volvulus 0.0112 0.0713 0.0926
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0089 0.0089
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0327 0.65
Trypanosoma brucei heat shock protein, putative 0.0033 0.0171 0.5035
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0887 0.6038 0.6037
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0234 0.6824
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0011 0.0014
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0015 0.0043 0.0055
Loa Loa (eye worm) PXA domain-containing protein 0.0015 0.0043 0.0055
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0043 0.0031
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0011 0.0014
Schistosoma mansoni DNA polymerase eta 0.0015 0.0045 0.0034
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0061 0.005
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.004 0.0214 0.2626
Loa Loa (eye worm) hypothetical protein 0.1112 0.759 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0111 0.0706 0.0695
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0089 0.0118
Onchocerca volvulus 0.0021 0.0089 0.0103
Echinococcus multilocularis C type lectin 0.0013 0.0028 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0089 0.0118
Brugia malayi conserved hypotetical protein 0.001 0.0011 0.0015
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.004 0.0214 0.0281
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0089 0.0078
Echinococcus granulosus synaptojanin 1 0.004 0.0214 0.0213
Echinococcus multilocularis axis inhibition protein axin 0.0015 0.0043 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0089 0.0118
Echinococcus multilocularis Regulator of G protein signaling 20 0.0015 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0014
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0089 0.0117
Echinococcus multilocularis endoplasmin 0.0027 0.0124 0.0124
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0015 0.0043 0.0042
Plasmodium vivax endoplasmin, putative 0.0033 0.0171 0.1998
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0234 0.7055
Toxoplasma gondii rhoptry neck protein RON9 0.0112 0.0713 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0234 0.6824
Brugia malayi GCC2 and GCC3 family protein 0.0112 0.0713 0.094
Toxoplasma gondii Hsp90 domain-containing protein 0.0014 0.0036 0.0215
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.004 0.0214 0.2785
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0043 0.0031
Trichomonas vaginalis endoplasmin, putative 0.002 0.0082 0.1603
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0089 0.0089
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.004 0.0214 0.0203
Brugia malayi hypothetical protein 0.0079 0.0484 0.0638
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0234 0.5435
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0014
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0171 0.217
Leishmania major pantothenate kinase subunit, putative 0.004 0.0214 0.6108
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.031 0.9458
Leishmania major heat shock protein 83-1 0.0033 0.0171 0.4646
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.0124 0.0124
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.004 0.0214 0.397
Loa Loa (eye worm) hypothetical protein 0.0054 0.031 0.0407
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.0484 0.0483
Onchocerca volvulus 0.0112 0.0713 0.0926
Brugia malayi MH2 domain containing protein 0.0255 0.1692 0.2229
Entamoeba histolytica hypothetical protein 0.0079 0.0484 1
Loa Loa (eye worm) endoplasmin 0.0033 0.0171 0.0224
Brugia malayi hypothetical protein 0.0112 0.0713 0.094
Onchocerca volvulus 0.0112 0.0713 0.0926
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0124 0.3043
Brugia malayi hypothetical protein 0.0035 0.0179 0.0236
Echinococcus multilocularis expressed conserved protein 0.1073 0.7318 0.7318
Echinococcus granulosus cpg binding protein 0.0029 0.0144 0.0143
Plasmodium falciparum exodeoxyribonuclease III, putative 0.004 0.0214 0.2626
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0013 0.0028 0.0036
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0327 1
Schistosoma mansoni fras1 related extracellular matrix protein 0.0013 0.0028 0.0017
Echinococcus granulosus histone acetyltransferase KAT2B 0.0108 0.0684 0.0684
Plasmodium vivax hypothetical protein, conserved 0.004 0.0214 0.2626
Brugia malayi Endoplasmin precursor 0.0033 0.0171 0.0225
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0264 0.0264
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.031 0.4049
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0171 0.3365
Echinococcus multilocularis regulator of G protein signaling 0.0015 0.0043 0.0042
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.004 0.0214 0.639
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0014
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.004 0.0214 0.639
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.004 0.0214 0.028
Echinococcus granulosus heat shock protein 90 0.0033 0.0171 0.017
Schistosoma mansoni cript-related 0.004 0.0214 0.0203
Echinococcus granulosus endonuclease exonuclease phosphatase 0.004 0.0214 0.0213
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0015 0.0043 0.0055

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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