Detailed information for compound 1154331

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 565.189 | Formula: C33H45ClN4O2
  • H donors: 2 H acceptors: 2 LogP: 5.42 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(CC1(CCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(cc1)Cl)NC(=O)CC1NCc2c1cccc2)C
  • InChi: 1S/C33H45ClN4O2/c1-24(2)22-33(14-6-3-7-15-33)38-18-16-37(17-19-38)32(40)30(20-25-10-12-27(34)13-11-25)36-31(39)21-29-28-9-5-4-8-26(28)23-35-29/h4-5,8-13,24,29-30,35H,3,6-7,14-23H2,1-2H3,(H,36,39)/t29?,30-/m1/s1
  • InChiKey: ZPRSAUKSZDKCHQ-BDCODIICSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni axis inhibition protein axin 0.0029 0.0232 0.0232
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0015 0.0086 0.0963
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0033 0.0284 0.3307
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0033 0.0284 0.1749
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0557 0.3901
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0033 0.0284 0.0279
Mycobacterium leprae putative cytochrome p450 0.0013 0.006 0.5
Onchocerca volvulus 0.0085 0.0849 0.0828
Loa Loa (eye worm) TAR-binding protein 0.0134 0.1389 0.1372
Brugia malayi hypothetical protein 0.0085 0.0849 0.0844
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0033 0.0284 0.0279
Echinococcus multilocularis synaptojanin 1 0.0033 0.0284 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0232 0.498
Schistosoma mansoni ap endonuclease 0.0049 0.0461 0.0461
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0084 0.084 0.084
Echinococcus granulosus tumor protein p63 0.0332 0.3575 0.3575
Echinococcus granulosus expressed conserved protein 0.0884 0.9635 0.9635
Brugia malayi hypothetical protein 0.0085 0.0849 0.0844
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0086 0.0086
Plasmodium vivax exodeoxyribonuclease III, putative 0.0033 0.0284 0.3307
Toxoplasma gondii rhoptry neck protein RON1 0.0085 0.0849 0.5933
Echinococcus multilocularis fras1 related extracellular matrix protein 0.0009 0.0023 0.0023
Trichomonas vaginalis DNA polymerase eta, putative 0.0032 0.0272 0.5842
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0033 0.0284 0.0279
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.1389 0.1372
Loa Loa (eye worm) hypothetical protein 0.0033 0.0284 0.0265
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0033 0.0284 0.6114
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0015 0.0086 0.178
Echinococcus granulosus dna polymerase kappa 0.0032 0.0272 0.0272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0557 0.3901
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0232 0.0232
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0561 0.3891
Onchocerca volvulus 0.0137 0.1421 0.1401
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0458 0.0453
Echinococcus granulosus lamin dm0 0.0028 0.0226 0.0226
Onchocerca volvulus 0.0085 0.0849 0.0828
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0086 0.178
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0033 0.0284 0.6114
Leishmania major DNA polymerase kappa, putative 0.0016 0.01 0.0411
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0186 0.128
Trypanosoma cruzi DNA polymerase eta, putative 0.0011 0.0043 0.0269
Loa Loa (eye worm) hypothetical protein 0.0917 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0011 0.0043 0.0038
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0134 0.1389 0.1389
Schistosoma mansoni regulator of G protein signaling 0.0029 0.0232 0.0232
Echinococcus granulosus phospholipase A2 receptor 1 0.0009 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0086 0.178
Leishmania major hypothetical protein, unknown function 0.0137 0.1421 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0557 0.3901
Trypanosoma cruzi DNA polymerase kappa, putative 0.0032 0.0272 0.1883
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0033 0.0284 0.1971
Echinococcus granulosus regulator of G protein signaling 3 0.0029 0.0232 0.0232
Echinococcus multilocularis musashi 0.0028 0.0226 0.0226
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0049 0.0461 0.3223
Echinococcus granulosus intermediate filament protein 0.0028 0.0226 0.0226
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0033 0.0284 0.0279
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0011 0.0043 0.0043
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0033 0.0284 0.0284
Onchocerca volvulus 0.0015 0.0086 0.0063
Loa Loa (eye worm) hypothetical protein 0.0049 0.0458 0.0439
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0086 0.178
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0033 0.0284 0.6114
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0272 0.1886
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0033 0.0284 0.1973
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0033 0.0284 0.1919
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.006 0.004
Echinococcus multilocularis expressed conserved protein 0.0884 0.9635 0.9635
Loa Loa (eye worm) hypothetical protein 0.0033 0.0284 0.0265
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0013 0.006 0.0324
Echinococcus multilocularis prolyl 4 hydroxylase subunit alpha 1 0.0137 0.1421 0.1421
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0232 0.498
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0013 0.006 0.0324
Schistosoma mansoni DNA polymerase eta 0.0011 0.0043 0.0043
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0013 0.006 0.0394
Loa Loa (eye worm) hypothetical protein 0.0013 0.0061 0.0042
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0011 0.0043 0.0023
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0033 0.0284 0.6114
Loa Loa (eye worm) ShTK domain-containing protein 0.0009 0.0023 0.0003
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0033 0.0284 0.6114
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0013 0.006 0.0391
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0067 0.0067
Trypanosoma brucei DNA polymerase IV, putative 0.0032 0.0272 0.1886
Echinococcus granulosus lamin 0.0028 0.0226 0.0226
Brugia malayi Cathepsin L-like cysteine proteinase 0.001 0.0031 0.0026
Trypanosoma brucei DNA polymerase IV, putative 0.0027 0.0215 0.1486
Brugia malayi hypothetical protein 0.0029 0.0232 0.0227
Echinococcus multilocularis axis inhibition protein axin 0.0029 0.0232 0.0232
Mycobacterium ulcerans DNA polymerase IV 0.0032 0.0272 0.41
Trypanosoma cruzi DNA polymerase kappa, putative 0.0032 0.0272 0.1883
Echinococcus multilocularis lamin dm0 0.0028 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0085 0.0849 0.083
Loa Loa (eye worm) acetyltransferase 0.0084 0.084 0.0821
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0557 0.3899
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0557 0.3901
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0033 0.0284 0.0265
Echinococcus granulosus cathepsin L cysteine protease 0.0008 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0086 0.178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0086 0.178
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.0137 0.1421 1
Onchocerca volvulus 0.0015 0.0086 0.0063
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.0213
Trypanosoma brucei DNA polymerase eta, putative 0.0011 0.0043 0.0273
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.1389 0.1385
Trypanosoma brucei unspecified product 0.0027 0.0215 0.1486
Echinococcus granulosus cathepsin L 0.0008 0.0005 0.0005
Onchocerca volvulus 0.0028 0.0226 0.0204
Brugia malayi Lectin C-type domain containing protein 0.0009 0.0023 0.0018
Brugia malayi Lectin C-type domain containing protein 0.0009 0.0023 0.0018
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0013 0.006 0.0324
Loa Loa (eye worm) hypothetical protein 0.0085 0.0849 0.083
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0025 0.0189 0.2187
Mycobacterium tuberculosis Probable exported protein 0.0033 0.0284 0.4524
Mycobacterium ulcerans DNA polymerase IV 0.0032 0.0272 0.41
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0003
Plasmodium falciparum apical sushi protein 0.0085 0.0849 1
Leishmania major cathepsin L-like protease 0.0015 0.0086 0.0313
Brugia malayi Cathepsin L-like precursor 0.0015 0.0086 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0134 0.1389 0.1389
Brugia malayi Regulator of G protein signaling domain containing protein 0.0029 0.0232 0.0227
Echinococcus multilocularis neutral sphingomyelinase 0.0917 1 1
Schistosoma mansoni hypothetical protein 0.0016 0.0089 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.01 0.0673
Mycobacterium leprae Conserved hypothetical protein 0.0013 0.006 0.5
Schistosoma mansoni cpg binding protein 0.0031 0.0265 0.0265
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0029 0.0232 0.0232
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0033 0.0284 0.0265
Schistosoma mansoni nocturnin 0.0033 0.0284 0.0284
Echinococcus granulosus dnaJ subfamily B 0.0424 0.4581 0.4581
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0033 0.0284 0.1973
Trypanosoma cruzi cruzipain precursor, putative 0.0058 0.0557 0.3899
Brugia malayi hypothetical protein 0.0233 0.2477 0.2473
Trypanosoma cruzi mitochondrial protein 99, putative 0.0033 0.0284 0.1971
Brugia malayi Cathepsin L-like precursor 0.0015 0.0086 0.0081
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0013 0.006 0.0324
Schistosoma mansoni hypothetical protein 0.0424 0.4581 0.4581
Echinococcus multilocularis cathepsin L cysteine protease 0.0015 0.0086 0.0086
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0033 0.0284 0.1919
Schistosoma mansoni tar DNA-binding protein 0.0134 0.1389 0.1389
Leishmania major cathepsin L-like protease 0.0058 0.0557 0.373
Entamoeba histolytica deoxycytidyl transferase, putative 0.0011 0.0043 0.0835
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0576 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0232 0.498
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0272 0.1886
Echinococcus multilocularis phospholipase A2 receptor 1 0.0009 0.0023 0.0023
Schistosoma mansoni regulator of G protein signaling 0.0029 0.0232 0.0232
Echinococcus granulosus regulator of G protein signaling 3 0.0029 0.0232 0.0232
Echinococcus multilocularis tumor protein p63 0.0332 0.3575 0.3575
Brugia malayi Cytochrome P450 family protein 0.0013 0.006 0.0055
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0033 0.0284 0.1919
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0013 0.006 0.0324
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.006 0.0391
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0272 0.1886
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0272 0.1886
Onchocerca volvulus 0.0085 0.0849 0.0828
Trypanosoma brucei 2OG-Fe(II) oxygenase superfamily, putative 0.0137 0.1421 1
Brugia malayi Lectin C-type domain containing protein 0.0009 0.0023 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0008 0.0005 0.0004
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0049 0.0461 0.5409
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0016 0.0089 0.0089
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0013 0.006 0.0324
Schistosoma mansoni tar DNA-binding protein 0.0134 0.1389 0.1389
Onchocerca volvulus 0.0028 0.0226 0.0204
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0033 0.0284 0.1971
Brugia malayi Cathepsin L-like precursor 0.001 0.0031 0.0026
Toxoplasma gondii hypoxia- inducible factor prolyl hydroxylase (phd2), putative 0.0137 0.1421 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0015 0.0086 0.0086
Onchocerca volvulus 0.001 0.0031 0.0008
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0083 0.0064
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0033 0.0284 0.1973
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0049 0.0461 1
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0009 0.0023 0.0003
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0033 0.0284 0.6114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0086 0.178
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0029 0.0232 0.0232
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0033 0.0284 0.3307
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0441 0.0436
Brugia malayi intermediate filament protein 0.0028 0.0226 0.0221
Schistosoma mansoni hypothetical protein 0.0016 0.0089 0.0089
Brugia malayi Cathepsin L-like precursor 0.0015 0.0086 0.0081
Loa Loa (eye worm) hypothetical protein 0.0085 0.0849 0.083
Treponema pallidum exodeoxyribonuclease (exoA) 0.0049 0.0461 1
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0033 0.0284 0.3307
Onchocerca volvulus Putative neutral sphingomyelinase 0.0917 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0086 0.0081
Brugia malayi Cathepsin L-like precursor 0.0015 0.0086 0.0081
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0031 0.0566
Echinococcus granulosus hypothetical protein 0.0884 0.9635 0.9635
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0016 0.01 0.1065
Toxoplasma gondii tetratricopeptide repeat-containing protein 0.0137 0.1421 1
Onchocerca volvulus 0.0015 0.0086 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0086 0.178
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0003
Onchocerca volvulus 0.0015 0.0086 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0008 0.0005 0.0004
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0085 0.0849 0.083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0557 0.3901
Echinococcus multilocularis regulator of G protein signaling 7 0.0029 0.0232 0.0232
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0029 0.0232 0.0213
Echinococcus multilocularis cpg binding protein 0.0031 0.0265 0.0265
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0576 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0226 0.0207
Echinococcus granulosus regulator of G protein signaling 7 0.0029 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0085 0.0849 0.083
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0013 0.006 0.0324
Echinococcus granulosus lymphocyte antigen 75 0.0009 0.0023 0.0023
Schistosoma mansoni carbon catabolite repressor protein 0.0033 0.0284 0.0284
Trypanosoma cruzi 2OG-Fe(II) oxygenase superfamily, putative 0.0137 0.1421 1
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0083 0.0078
Onchocerca volvulus 0.0085 0.0849 0.0828
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0557 0.3899
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0272 0.1886
Echinococcus granulosus prolyl 4 hydroxylase subunit alpha 1 0.0137 0.1421 0.1421
Schistosoma mansoni regulator of G protein signaling 0.0029 0.0232 0.0232
Brugia malayi Lectin C-type domain containing protein 0.0009 0.0023 0.0018
Schistosoma mansoni axis inhibition protein axin 0.0029 0.0232 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0031 0.0566
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0013 0.006 0.0324
Leishmania major cathepsin L-like protease 0.0015 0.0086 0.0313
Brugia malayi hypothetical protein 0.0029 0.0232 0.0227
Entamoeba histolytica acetyltransferase, GNAT family 0.0023 0.0167 0.3548
Trypanosoma cruzi mitochondrial protein 99, putative 0.0033 0.0284 0.1971
Echinococcus multilocularis lamin 0.0028 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0003
Onchocerca volvulus Cathepsin L homolog 0.0015 0.0086 0.0063
Brugia malayi Cathepsin L-like precursor 0.0015 0.0086 0.0081
Schistosoma mansoni c4b-binding protein beta chain 0.0085 0.0849 0.0849
Echinococcus granulosus neutral sphingomyelinase 0.0917 1 1
Trypanosoma brucei RNA editing exonuclease 2 0.0033 0.0284 0.1973
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0086 0.178
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0013 0.006 0.0324
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0013 0.006 0.0324
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0061 0.04
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.006 0.0391
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0049 0.0461 0.0461
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.4581 0.4581
Brugia malayi Cathepsin L-like precursor 0.0015 0.0086 0.0081
Schistosoma mansoni synaptojanin 0.0033 0.0284 0.0284
Brugia malayi Cytochrome P450 family protein 0.0013 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0011
Loa Loa (eye worm) hypothetical protein 0.0085 0.0849 0.083
Loa Loa (eye worm) hypothetical protein 0.0085 0.0849 0.083
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0049 0.0461 0.5
Schistosoma mansoni hypothetical protein 0.0047 0.0441 0.0441
Brugia malayi PXA domain containing protein 0.0029 0.0232 0.0227
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0013 0.006 0.0324
Echinococcus granulosus axis inhibition protein axin 0.0029 0.0232 0.0232
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0016 0.01 0.0411
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0013 0.006 0.0324
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0013 0.006 0.0324
Schistosoma mansoni lamin 0.0028 0.0226 0.0226
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0284 0.3307
Echinococcus granulosus expressed protein 0.0555 0.6025 0.6025
Echinococcus multilocularis regulator of G protein signaling 0.0029 0.0232 0.0232
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0033 0.0284 0.3307
Schistosoma mansoni regulator of G protein signaling 0.0029 0.0232 0.0232
Onchocerca volvulus 0.0085 0.0849 0.0828
Onchocerca volvulus 0.0085 0.0849 0.0828
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0029 0.0232 0.0213
Echinococcus multilocularis C type lectin domian containing protein 0.0085 0.0849 0.0849
Brugia malayi prolyl 4-hydroxylase 0.0137 0.1421 0.1417
Brugia malayi hypothetical protein 0.0085 0.0849 0.0844
Loa Loa (eye worm) RNA binding protein 0.0134 0.1389 0.1372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0557 0.3901
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0033 0.0284 0.6114
Echinococcus multilocularis beta adrenergic receptor kinase 0.0029 0.0232 0.0232
Brugia malayi A-kinase anchor protein 10, precursor 0.0029 0.0232 0.0227
Leishmania major cathepsin L-like protease 0.0058 0.0557 0.373
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0033 0.0284 0.1973
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0246 0.0227
Brugia malayi hypothetical protein 0.0085 0.0849 0.0844
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0049 0.0461 0.5409
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0086 0.0066
Schistosoma mansoni hypothetical protein 0.0033 0.0284 0.0284
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0033 0.0284 0.6114
Echinococcus granulosus dna polymerase eta 0.0011 0.0043 0.0043
Onchocerca volvulus 0.0047 0.0441 0.0418
Brugia malayi CXXC zinc finger family protein 0.003 0.0246 0.0241
Echinococcus multilocularis traf and tnf receptor associated protein 0.0033 0.0284 0.0284
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0033 0.0284 0.1971
Leishmania major hypothetical protein, conserved 0.0033 0.0284 0.1749
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0013 0.006 0.0125
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.0213
Leishmania major cathepsin L-like protease 0.0058 0.0557 0.373
Schistosoma mansoni ap endonuclease 0.0049 0.0461 0.0461
Echinococcus granulosus regulator of G protein signaling 7 0.0029 0.0232 0.0232
Echinococcus granulosus cysteine protease 0.0008 0.0005 0.0005
Brugia malayi hypothetical protein 0.0085 0.0849 0.0844
Onchocerca volvulus 0.0033 0.0284 0.0262
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0576 0.0576
Toxoplasma gondii hypothetical protein 0.0009 0.0023 0.0064
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0005 0.0005
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0033 0.0284 0.1971
Leishmania major cytochrome p450-like protein 0.0013 0.006 0.0125
Schistosoma mansoni cript-related 0.0033 0.0284 0.0284
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0013 0.006 0.0324
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0089 0.0089
Schistosoma mansoni fras1 related extracellular matrix protein 0.0009 0.0023 0.0023
Brugia malayi CCR4 0.0033 0.0284 0.0279
Entamoeba histolytica cysteine protease, putative 0.0015 0.0086 0.178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0086 0.178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0086 0.178
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0033 0.0284 0.1971
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0086 0.178
Toxoplasma gondii exonuclease III APE 0.0049 0.0461 0.318
Brugia malayi GCC2 and GCC3 family protein 0.0085 0.0849 0.0844
Echinococcus multilocularis axis inhibition protein axin 0.0029 0.0232 0.0232
Onchocerca volvulus 0.0033 0.0284 0.0262
Echinococcus granulosus cathepsin l cysteine peptidase 0.0015 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0233 0.2477 0.2462
Loa Loa (eye worm) cysteine protease 0.0015 0.0086 0.0066
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0033 0.0284 0.6114
Echinococcus granulosus synaptojanin 1 0.0033 0.0284 0.0284
Echinococcus multilocularis regulator of G protein signaling 3 0.0029 0.0232 0.0232
Schistosoma mansoni hypothetical protein 0.0009 0.0023 0.0023
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0033 0.0284 0.1973
Leishmania major hypothetical protein, conserved 0.0033 0.0284 0.1749
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0084 0.084 0.084
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0013 0.006 0.0324
Giardia lamblia hypothetical protein 0.0033 0.0284 0.5095
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0015 0.0086 0.0086
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0576 1
Echinococcus multilocularis deoxyribonuclease 1 2 0.0033 0.0284 0.0284
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0061 0.04
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0186 0.128
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0025 0.0189 0.4042
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.002 0.002
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0029 0.0232 0.0213
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0033 0.0284 0.0284
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0033 0.0284 0.6114
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0089 0.007
Echinococcus multilocularis 0.0013 0.006 0.006
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.2477 0.2477
Loa Loa (eye worm) fibroinase 0.0015 0.0086 0.0066
Schistosoma mansoni intermediate filament proteins 0.0028 0.0226 0.0226
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0226 0.0221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0557 0.3901
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0033 0.0284 0.6114
Loa Loa (eye worm) hypothetical protein 0.0024 0.0186 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0061 0.04
Brugia malayi exodeoxyribonuclease III family protein 0.0049 0.0461 0.0457
Echinococcus multilocularis tar DNA binding protein 0.0134 0.1389 0.1389
Loa Loa (eye worm) hypothetical protein 0.0033 0.0284 0.0265
Schistosoma mansoni survival motor neuron protein 0.0047 0.0441 0.0441
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0003
Echinococcus granulosus traf and tnf receptor associated protein 0.0033 0.0284 0.0284
Echinococcus multilocularis dna polymerase eta 0.0011 0.0043 0.0043
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0009 0.0023 0.0003
Echinococcus multilocularis cathepsin L 0.0008 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0016 0.0089 0.0089
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0576 1
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.006 0.0391
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0049 0.0461 0.7854
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0033 0.0284 0.1971
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.002 0.002
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0033 0.0284 0.6114
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0033 0.0284 0.1971
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0086 0.178
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0049 0.0461 0.7783
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0033 0.0284 0.1973
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0086 0.178
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0029 0.0232 0.498
Schistosoma mansoni cadherin 0.0009 0.0023 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0013 0.006 0.0324
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0576 0.3865
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0032 0.0272 0.5842
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0033 0.0284 0.6114
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.0213
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0086 0.178
Plasmodium falciparum DNase I-like protein, putative 0.0033 0.0284 0.3307
Brugia malayi RNA binding protein 0.0134 0.1389 0.1385
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0029 0.0232 0.0232
Brugia malayi pregnancy-associated plasma protein-A 0.0085 0.0849 0.0844
Loa Loa (eye worm) cytochrome P450 0.0013 0.006 0.004
Toxoplasma gondii cytochrome p450 superfamily protein 0.0013 0.006 0.0329
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0049 0.0461 0.0461
Echinococcus granulosus cpg binding protein 0.0031 0.0265 0.0265
Echinococcus granulosus histone acetyltransferase KAT2B 0.0081 0.0814 0.0814
Echinococcus granulosus cathepsin l1 0.0015 0.0086 0.0086
Leishmania major cytochrome p450-like protein 0.0013 0.006 0.0125
Leishmania major cytochrome p450-like protein 0.0013 0.006 0.0125
Trypanosoma brucei cytochrome P450, putative 0.0013 0.006 0.0394
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0086 0.178
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0086 0.178
Schistosoma mansoni terminal deoxycytidyl transferase 0.0011 0.0043 0.0043
Loa Loa (eye worm) RGS-3 protein 0.0029 0.0232 0.0213
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0033 0.0284 0.0265
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.0213
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0089 0.0089
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0009 0.0023 0.0023
Echinococcus multilocularis c4b binding protein beta chain 0.0085 0.0849 0.0849
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0033 0.0284 0.1971
Brugia malayi TAR-binding protein 0.0134 0.1389 0.1385
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0272 0.1886
Leishmania major hypothetical protein, conserved 0.0137 0.1421 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0033 0.0284 0.1971
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0232 0.498
Trypanosoma cruzi DNA polymerase kappa, putative 0.0032 0.0272 0.1883
Schistosoma mansoni hypothetical protein 0.0009 0.0023 0.0023
Loa Loa (eye worm) prolyl 4-hydroxylase 2 0.0137 0.1421 0.1404
Schistosoma mansoni neutral sphingomyelinase 0.0917 1 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0033 0.0284 0.6114
Plasmodium vivax apical sushi protein, putative 0.0085 0.0849 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0086 0.178
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0458 0.0453
Schistosoma mansoni hypothetical protein 0.0013 0.006 0.006
Echinococcus granulosus C type lectin 0.0009 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0085 0.0849 0.083
Echinococcus multilocularis expressed protein 0.0555 0.6025 0.6025
Leishmania major cysteine peptidase A (CPA) 0.0015 0.0086 0.0313
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0232 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0015 0.0086 0.178
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0226 0.0207
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0033 0.0284 0.0265
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0613 0.0613
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0086 0.178
Brugia malayi Regulator of G protein signaling domain containing protein 0.0029 0.0232 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0086 0.178
Loa Loa (eye worm) hypothetical protein 0.0016 0.0089 0.007
Onchocerca volvulus 0.0015 0.0086 0.0063
Trypanosoma cruzi DNA polymerase kappa, putative 0.0032 0.0272 0.1883
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.006 0.0391
Onchocerca volvulus 0.0085 0.0849 0.0828
Giardia lamblia Inositol 5-phosphatase 4 0.0033 0.0284 0.5095
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0033 0.0284 0.6114
Brugia malayi Lectin C-type domain containing protein 0.0009 0.0023 0.0018
Echinococcus multilocularis conserved hypothetical protein 0.0884 0.9635 0.9635
Echinococcus multilocularis regulator of G protein signaling 7 0.0029 0.0232 0.0232
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0029 0.0232 0.0227
Loa Loa (eye worm) hypothetical protein 0.0013 0.0061 0.0042
Echinococcus granulosus cytochrome P450 2K1 0.0013 0.006 0.006
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0033 0.0284 0.0279
Brugia malayi Cytochrome P450 family protein 0.0013 0.006 0.0055
Brugia malayi acetyltransferase, GNAT family protein 0.0084 0.084 0.0835
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0089 0.0089
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.006 0.004
Schistosoma mansoni synaptojanin 0.0033 0.0284 0.0284
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0272 0.1886
Schistosoma mansoni Galactose-specific lectin (PAL) 0.0009 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0557 0.3901
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0009 0.0023 0.0003
Schistosoma mansoni lamin 0.0028 0.0226 0.0226
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0033 0.0284 0.6114
Brugia malayi hypothetical protein 0.0085 0.0849 0.0844
Brugia malayi hypothetical protein 0.0085 0.0849 0.0844
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0086 0.178
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.0213
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0454 0.0454
Brugia malayi Lectin C-type domain containing protein 0.0009 0.0023 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0576 0.0576
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0049 0.0461 0.3226
Leishmania major cathepsin L-like protease 0.0015 0.0086 0.0313
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0013 0.006 0.0324
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0287 0.0283
Echinococcus granulosus C type lectin domian containing protein 0.0085 0.0849 0.0849
Brugia malayi cathepsin L-like precursor 0.001 0.0031 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0086 0.178
Toxoplasma gondii rhoptry neck protein RON9 0.0085 0.0849 0.5933
Brugia malayi Cytochrome P450 family protein 0.0048 0.0442 0.0437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0086 0.178
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0033 0.0284 0.0279
Loa Loa (eye worm) hypothetical protein 0.0137 0.1421 0.1404
Leishmania major hypothetical protein, conserved 0.0033 0.0284 0.1749
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0033 0.0284 0.1919
Loa Loa (eye worm) hypothetical protein 0.0049 0.0454 0.0435
Echinococcus multilocularis cysteine protease 0.0015 0.0086 0.0086
Brugia malayi Cathepsin L-like precursor 0.001 0.0031 0.0026
Echinococcus multilocularis cysteine protease 0.0015 0.0086 0.0086
Onchocerca volvulus 0.0085 0.0849 0.0828
Onchocerca volvulus 0.0049 0.0454 0.0432
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0033 0.0284 0.3307
Echinococcus granulosus c4b binding protein beta chain 0.0085 0.0849 0.0849
Echinococcus granulosus tar DNA binding protein 0.0134 0.1389 0.1389
Loa Loa (eye worm) PXA domain-containing protein 0.0029 0.0232 0.0213
Onchocerca volvulus 0.0015 0.0086 0.0063
Trichomonas vaginalis ap endonuclease, putative 0.0049 0.0461 1
Brugia malayi cytochrome P450 0.0013 0.006 0.0055
Leishmania major cathepsin L-like protease 0.0015 0.0086 0.0313
Giardia lamblia Histone acetyltransferase GCN5 0.0023 0.0167 0.1857
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0033 0.0284 0.1971
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0033 0.0284 0.0284
Onchocerca volvulus 0.0085 0.0849 0.0828
Echinococcus multilocularis Regulator of G protein signaling 20 0.0029 0.0232 0.0232
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0033 0.0284 0.3307
Onchocerca volvulus 0.0015 0.0086 0.0063
Schistosoma mansoni hypothetical protein 0.0009 0.0023 0.0023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0049 0.0461 0.3223
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0015 0.0086 0.0963
Brugia malayi Lectin C-type domain containing protein 0.0009 0.0023 0.0018
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0871 0.9501 0.9501
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0049 0.0461 0.0442
Schistosoma mansoni z-protein (S1r protein) 0.0029 0.0232 0.0232
Schistosoma mansoni regulator of G protein signaling 0.0029 0.0232 0.0232
Loa Loa (eye worm) CYP4Cod1 0.0013 0.006 0.004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0089 0.0089
Plasmodium falciparum cysteine proteinase falcipain 3 0.0015 0.0086 0.0963
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0013 0.006 0.0324
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0011
Schistosoma mansoni cpg binding protein 0.003 0.0246 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0232 0.0232
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0226 0.0207
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0033 0.0284 0.1749
Brugia malayi ImpB/MucB/SamB family protein 0.0011 0.0043 0.0038
Echinococcus multilocularis dna polymerase kappa 0.0032 0.0272 0.0272
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0458 0.0439
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0015 0.0086 0.0086
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.2477 0.2477
Echinococcus multilocularis C type lectin 0.0009 0.0023 0.0023
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0033 0.0284 0.0279
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0086 0.0086
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0033 0.0284 0.0265
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0049 0.0461 0.3036
Echinococcus multilocularis lymphocyte antigen 75 0.0009 0.0023 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0013 0.006 0.0324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0031 0.0566
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0557 0.3899
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0003
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0033 0.0284 0.0265
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0201
Echinococcus granulosus beta-adrenergic receptor kinase 0.0029 0.0232 0.0232
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0442 0.0423
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0033 0.0284 0.0284
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0033 0.0284 0.1971
Echinococcus multilocularis regulator of G protein signaling 3 0.0029 0.0232 0.0232
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0009 0.0023 0.0003
Entamoeba histolytica hypothetical protein 0.0029 0.0232 0.498
Schistosoma mansoni cytochrome P450 0.0013 0.006 0.006
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0029 0.0232 0.0232
Schistosoma mansoni tar DNA-binding protein 0.0134 0.1389 0.1389
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0086 0.0574
Schistosoma mansoni hypothetical protein 0.0034 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0034 0.0287 0.0268
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.0137 0.1421 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0086 0.0066
Brugia malayi PXA domain containing protein 0.0029 0.0232 0.0227
Echinococcus granulosus fras1 related extracellular matrix protein 0.0009 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0011
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0033 0.0284 0.1919
Echinococcus multilocularis GPCR, family 2 0.0016 0.0089 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0557 0.3901
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0033 0.0284 0.0284
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0011 0.0043 0.0043
Brugia malayi regulator of G-protein signaling rgs-7 0.0029 0.0232 0.0227
Trichomonas vaginalis Phospholipase C precursor, putative 0.0033 0.0284 0.6114
Leishmania major pantothenate kinase subunit, putative 0.0033 0.0284 0.1749
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0232 0.498
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0015 0.0086 0.0066
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0033 0.0284 0.0284
Entamoeba histolytica hypothetical protein 0.0029 0.0232 0.498
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0025 0.0189 0.4042
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0025 0.0189 0.1247
Entamoeba histolytica hypothetical protein 0.0029 0.0232 0.498
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.0213
Echinococcus granulosus histone acetyltransferase KAT2B 0.0025 0.0189 0.0189
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0576 0.0576
Plasmodium vivax vivapain-2 0.0015 0.0086 0.0963
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0053 0.0502 0.3508
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0089 0.0084
Brugia malayi regulator of G-protein signaling egl-10 0.0029 0.0232 0.0227
Toxoplasma gondii cathepsin CPL 0.0015 0.0086 0.0513
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0033 0.0284 0.6114
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0576 0.0576
Schistosoma mansoni prolyl 4-hydroxylase alpha subunit 1 0.0137 0.1421 0.1421
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0019 0.0014
Trichomonas vaginalis ap endonuclease, putative 0.0049 0.0461 1
Trypanosoma brucei DNA polymerase IV, putative 0.0032 0.0272 0.1886
Plasmodium vivax vivapain-2 0.0015 0.0086 0.0963
Loa Loa (eye worm) hypothetical protein 0.0013 0.0067 0.0047
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0033 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0003
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0033 0.0284 0.1919
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0086 0.178
Loa Loa (eye worm) hypothetical protein 0.0085 0.0849 0.083
Trypanosoma cruzi 2OG-Fe(II) oxygenase superfamily, putative 0.0137 0.1421 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0557 0.3901
Brugia malayi polk-prov protein 0.0024 0.0186 0.0181
Onchocerca volvulus 0.0085 0.0849 0.0828
Loa Loa (eye worm) hypothetical protein 0.0137 0.1421 0.1404
Echinococcus granulosus cathepsin l1 0.001 0.0031 0.0031
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0576 0.3992
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0557 0.3901
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0033 0.0284 0.0279
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0049 0.0461 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0086 0.178
Onchocerca volvulus 0.003 0.0246 0.0224
Brugia malayi Sushi domain 0.0085 0.0849 0.0844
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0272 0.1886
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0272 0.1886
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0033 0.0284 0.1971
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0025 0.0189 0.1247
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0089 0.0084
Onchocerca volvulus Cathepsin L homolog 0.0015 0.0086 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0232 0.498
Loa Loa (eye worm) hypothetical protein 0.0094 0.0953 0.0935
Leishmania major RNA-editing complex protein MP100, putative 0.0033 0.0284 0.1749
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0011 0.0043 0.0043
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0013 0.006 0.0324
Schistosoma mansoni cpg binding protein 0.0031 0.0265 0.0265
Echinococcus granulosus Regulator of G protein signaling 20 0.0029 0.0232 0.0232
Schistosoma mansoni cathepsin F (C01 family) 0.001 0.0031 0.0031
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0033 0.0284 0.1919
Echinococcus granulosus GPCR family 2 0.0016 0.0089 0.0089
Echinococcus multilocularis cathepsin L cysteine protease 0.0015 0.0086 0.0086
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0029 0.0232 0.0232
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0033 0.0284 0.1973
Onchocerca volvulus Cathepsin F homolog 0.0015 0.0086 0.0063
Brugia malayi hypothetical protein 0.0009 0.0023 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0086 0.178
Plasmodium falciparum histone acetyltransferase GCN5 0.0023 0.0167 0.1919
Leishmania major endonuclease/exonuclease protein-like protein 0.0033 0.0284 0.1749
Leishmania major cathepsin L-like protease 0.0015 0.0086 0.0313
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0033 0.0284 0.6114
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.042 0.2934
Echinococcus granulosus axis inhibition protein axin 0.0029 0.0232 0.0232
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0033 0.0284 0.6114
Loa Loa (eye worm) ctsf protein 0.0015 0.0086 0.0066

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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