Detailed view for TcCLB.506635.60

Basic information

TDR Targets ID: 37828
Trypanosoma cruzi, Cysteine peptidase, Clan CF, family C15
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.9046 | Length (AA): 231 | MW (Da): 26152 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 226 1iu8 (A) 1 194 21.00 0 0.76 1.13 -0.53
6 225 1x10 (A) 1 207 20.00 0 0.88 1.06 -0.78
6 228 1x10 (A) 1 206 18.00 0 0.98 1.13847 -0.55
6 217 1iu8 (A) 1 182 30.00 0.023 0.35 0.924549 0.71
8 221 2ebj (A) 2 192 24.00 0 1 1.11051 -0.34

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote. Smircich P
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_150045)

Species Accession Gene Product
Leishmania braziliensis LbrM.20.1500   pyroglutamyl-peptidase I (PGP), putative
Leishmania donovani LdBPK_341750.1   pyroglutamyl-peptidase I, putative
Leishmania infantum LinJ.34.1750   pyroglutamyl-peptidase I (PGP), putative
Leishmania major LmjF.34.2000   pyroglutamyl-peptidase I (C15 family)
Leishmania mexicana LmxM.33.2000   pyroglutamyl-peptidase I (PGP), putative,cysteine peptidase, Clan CF, family C15, putative
Trypanosoma brucei gambiense Tbg972.4.2640   pyroglutamyl-peptidase I (PGP), putative,cysteine peptidase, Clan CF, family C15, putative
Trypanosoma brucei Tb927.4.2670   pyroglutamyl-peptidase I, putative
Trypanosoma cruzi TcCLB.508027.110   pyroglutamyl-peptidase I, putative
Trypanosoma cruzi TcCLB.506635.60   Cysteine peptidase, Clan CF, family C15

Essentiality

TcCLB.506635.60 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.2670 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.2670 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.2670 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.4.2670 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major pyroglutamyl-peptidase I (C15 family) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0935 0.3741 0.5132
0.0626068 0.95258 1
0.0439 0.4556 0.5003
0.0849 0.2657 1
0.0459 0.3031 0.4933
0.0994 0.5031 0.5024
0.0986 0.5031 0.5024
0.0986 0.3725 0.512
0.0471 0.5044 0.5044
0.051 0.3009 0.4852
0.0751 0.3747 0.5143
0.0519 0.5078 0.5075
0.0435 0.3469 0.4889
0.044 0.2898 0.5003
0.0425 0.3623 0.4905
0.0422 0.2691 0.6244
0.0442 0.5118 0.5107
0.0469 0.4974 0.4954
0.0487 0.4986 0.5086
0.0442 0.2921 1
0.0505 0.5088 0.5086
0.0445 0.2983 1
0.0468 0.4948 0.4932
0.0514 0.5088 0.5086
0.1844 0.7001 1
0.0986 0.5031 0.5024
0.0519 0.4919 0.4919
0.0505 0.5118 0.5107
0.0445 0.2845 0.4993
0.1445 0.8089 1
0.0519 0.5078 0.5075
0.0471 0.5118 0.5107
0.0418 0.3867 1
0.0468 0.4951 0.4951
0.0514 0.5055 0.5054
0.0453 0.3517 0.5038
0.0442 0.2921 1
0.0448 0.5112 0.5107
0.0493 0.258 0.5163
0.0448 0.4938 0.4933
0.0488 0.504 0.5113
0.0416 0.4726 0.5119
0.0567 0.4241 0.5111
0.0508 0.5054 0.5054
0.0423 0.4854 0.4854
0.0935 0.3741 0.5132
0.048 0.5066 0.5066
0.0986 0.3741 0.5132
0.0422 0.5112 0.5107
0.089 0.2808 1
0.0435 0.3314 0.4933
0.0466 0.5004 0.5003
0.0471 0.5056 0.5086
0.0432 0.4938 0.4933
0.0514 0.3082 0.5024
0.0458 0.4466 0.5006
0.0519 0.5078 0.5075
0.0431 0.5054 0.5054
0.0453 0.3517 0.5038
0.0425 0.5112 0.5107
0.0442 0.3088 0.5141
0.0481 0.5118 0.5107
0.0231 0.4934 0.4879
0.0231 0.4858 0.4858
0.0451 0.3408 0.4954
0.1382 0.8224 1
0.0419 0.2929 0.5066
0.0519 0.5085 0.5044
0.0942 0.5031 0.5024
0.0519 0.5004 0.5003
0.0442 0.2921 1
0.0468 0.4951 0.4951
0.099 0.3493 1
0.0464 0.5004 0.5003
0.0423 0.4132 0.4995
0.0519 0.5194 1
0.0453 0.3517 0.5038
0.0422 0.5088 0.5086
0.0333 0.5046 0.5046
0.0442 0.4587 0.5119
0.133 0.7173 1
0.0487 0.4986 0.5086
0.0935 0.3741 0.5132
0.0429 0.4898 0.4895
0.0455 0.2743 0.5001
0.0427 0.3017 1
0.0333 0.5046 0.5046
0.0445 0.3024 1
0.0448 0.4954 0.4954
0.0461 0.4606 0.5044
0.0935 0.5031 0.5024
0.0432 0.5054 0.5054
0.1902 1 1
0.0986 0.3725 0.512
0.0426 0.4976 0.4974
0.1038 0.5031 0.5024
0.1038 0.5031 0.5024
0.0458 0.4564 0.4945
0.0418 1 1
0.0455 0.2688 0.4933
0.0462 0.5054 0.5054
0.0471 0.5044 0.5044
0.0446 0.5054 0.5054
0.0483 0.4953 0.4933
0.0463 0.4519 0.5008
0.0441 0.5044 0.5044
0.0451 0.4762 0.5
0.0751 0.3747 0.5143
0.0519 0.2689 1
0.0138 0.3266 0.3766
0.0519 1 1
0.0419 0.2652 0.4858
0.0441 0.5044 0.5044
0.0446 0.5044 0.5044
0.0422 0.4878 0.4782
0.0482 0.2993 1
0.1401 1 1
0.1377 0.7731 1
0.0942 0.5031 0.5024
0.0442 0.3088 0.5141
0.1038 0.5043 0.5031
0.0431 0.5054 0.5054
0.0802 0.3776 0.5173
0.0519 0.3666 1
0.0421 0.5004 0.5003
0.0489 0.5054 0.5054
0.0514 0.5088 0.5086
0.0645756 0.618112 0.618112
0.0333 0.5032 0.5024
0.0453 0.3517 0.5038
0.0445 0.2845 0.4993
0.0442 0.3088 0.5141
0.0452 0.4462 0.5107
0.0519 0.4934 0.4886
0.10599 0.632369 0.628754
0.0419 0.2652 0.4858
0.0419 0.4598 0.5033
0.1341 0.7763 1
0.0986 0.3741 0.5132
0.0452 0.5118 0.5107
0.0432 0.5118 0.5107
0.0446 0.4841 0.4794
0.1045 0.5031 0.5024
0.05 0.5088 0.5086
0.124439 0.632309 0.628754
0.0429 0.4898 0.4895
0.0416 0.5054 0.5054
0.0427 0.4475 0.5088
0.0498 0.5054 0.5054
0.0505 0.5088 0.5086
0.0468 0.498 0.5009
0.0986 0.5031 0.5024
0.1902 1 1
0.0443 0.4433 0.4995
0.0423 0.4132 0.4995
0.0493 0.3678 0.4933
0.0487 0.4903 0.5086
0.0438 0.5118 0.5107
0.0457 0.4992 0.5003
0.0431 0.3917 0.4858
0.089 0.5031 0.5024
0.0994 0.5031 0.5024
0.0435 0.5058 0.5054
0.0419 0.2929 0.5066
0.0445 0.2983 1
0.0429 0.4954 0.4954
0.0944 1 1
0.0751 0.3668 0.5057
0.0441 0.4952 0.4933
0.048 0.5044 0.5044
0.0442 0.2921 1
0.1902 1 1
0.1038 0.5024 0.5024
0.051 0.5088 0.5086
0.0442 0.4587 0.5119
0.0436 0.296 0.9998
0.0461 0.4606 0.5044
0.1045 0.5031 0.5024
0.0462 0.5054 0.5054
0.0468 0.4951 0.4951
0.088 1 1
0.047 0.5024 0.5024
0.0235 0.5024 0.5024
0.0446 0.5054 0.5054
0.0485 0.2962 0.4933
0.0986 0.3725 0.512
0.0422 0.5088 0.5086
0.0685291 1 1
0.1049 0.5043 0.5031
0.0454 0.5044 0.5044
0.0552653 0.5 0.5
0.0431 0.5054 0.5054
0.0802 0.3776 0.5173
0.043 0.4955 0.4926
0.0986 0.3725 0.512
0.1844 1 1
0.0519 0.2744 1
0.042 0.4938 0.4858
0.0499 0.4961 0.4949
0.1302 1 1
0.028 0.3195 0.493
0.042 0.5058 0.5054
0.0519 0.2744 1
0.0782 0.3731 1
0.0442 0.5044 0.5044
0.0935 0.5031 0.5024
0.0442 0.2921 1
0.028 0.3123 0.5013
0.0455 0.4952 0.4933
0.051 0.5122 0.5119
0.0417 0.5054 0.5054
0.1045 0.5031 0.5024
0.089 0.5031 0.5024
0.0442 0.4587 0.5119
0.0425 0.3623 0.4905
0.0508 0.5044 0.5044
0.0986 0.5031 0.5024
0.0503 0.5044 0.5044
0.0994 0.5031 0.5024
0.0435 0.5044 0.5044
0.0424 0.5054 0.5054
0.0896 0.2668 1
0.0485 0.372 0.4954
0.1287 0.7047 1
0.1845 1 1
0.042 0.5058 0.5054
0.0471 0.5054 0.5054
0.042 0.5054 0.5054
0.0422 0.2691 0.6244
0.0417 0.5108 0.5086
0.132 1 1
0.0499 0.4961 0.4949
0.0499 0.2841 0.4832
0.1327 0.7723 1
0.05 0.5088 0.5086
0.051 0.5122 0.5119
0.0839 0.3741 0.5132
0.0336 0.5152 0.5149
0.0751 0.5031 0.5024
0.0485 0.372 0.4954
0.0421 0.2708 0.9813
0.1038 0.5043 0.5031
0.0464 0.4844 0.4844
0.0455 0.2688 0.4933
0.0425 0.5112 0.5107
0.0422 0.4933 0.4933
0.0329 0.4948 0.4858
0.0942 0.5031 0.5024
0.0497 0.4977 0.494
0.0419 0.4598 0.5033
0.1371 1 1
0.0427 0.3017 1
0.0456 0.4876 0.4982
0.0508 0.5044 0.5044
0.051 0.5122 0.5119
0.0445 0.5107 0.5107
0.0438 0.4938 0.4933
0.0508 0.5044 0.5044
0.1446 0.8324 1
0.1287 0.7047 1
0.10599 0.632369 0.628754
0.0442 0.3088 0.5141
0.0439 0.4556 0.5003
0.0620024 0.44683 0.628229
0.0431 0.5054 0.5054
0.0419 0.4598 0.5033
0.0519 0.3181 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.506635.60 (Trypanosoma cruzi), Cysteine peptidase, Clan CF, family C15
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