Detailed information for compound 2076781

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 599.503 | Formula: C22H23F6N5O6S
  • H donors: 2 H acceptors: 8 LogP: -0.34 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(=O)N1CC(=O)N(CC21CCN(C2)Cc1nccs1)c1cccnc1
  • InChi: 1S/C18H21N5O2S.2C2HF3O2/c1-14(24)23-11-17(25)22(15-3-2-5-19-9-15)13-18(23)4-7-21(12-18)10-16-20-6-8-26-16;2*3-2(4,5)1(6)7/h2-3,5-6,8-9H,4,7,10-13H2,1H3;2*(H,6,7)
  • InChiKey: UBVHSSBDOCDRSF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0111 0.0713 0.1703
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0039 0.0106
Onchocerca volvulus Deterin homolog 0.0146 0.0964 0.5137
Mycobacterium ulcerans leucyl aminopeptidase 0.0255 0.1756 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0058 0.0089
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0058 0.0019
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0122 0.0222
Echinococcus multilocularis aminopeptidase N 0.0244 0.1679 0.3275
Brugia malayi Cell death protein 3 precursor 0.0111 0.0713 0.1703
Onchocerca volvulus 0.0111 0.0713 0.3603
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0058 0.0329
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0039 0.0106
Echinococcus granulosus aminopeptidase N 0.0244 0.1679 0.3275
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0039 0.0052
Loa Loa (eye worm) hypothetical protein 0.013 0.0848 0.1649
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0039 0.0106
Schistosoma mansoni aminopeptidase A (M01 family) 0.013 0.0848 0.1599
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0039 0.0017
Plasmodium vivax glutathione reductase, putative 0.0051 0.028 0.0257
Loa Loa (eye worm) hypothetical protein 0.0146 0.0964 0.1877
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0154 0.1025 0.2796
Trypanosoma cruzi aminopeptidase, putative 0.013 0.0848 0.2314
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.013 0.0848 0.2314
Trypanosoma cruzi aminopeptidase, putative 0.0154 0.1025 0.2796
Loa Loa (eye worm) RecQ helicase 0.0023 0.0078 0.0135
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0058 0.011
Echinococcus granulosus leucyl aminopeptidase 0.0051 0.0279 0.0523
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.0848 0.4713
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0146 0.0964 0.1871
Brugia malayi TATA binding protein associated factor 0.013 0.0848 0.2028
Echinococcus granulosus bloom syndrome protein 0.0023 0.0078 0.0128
Entamoeba histolytica aminopeptidase, putative 0.0154 0.1025 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.0154 0.1025 0.2796
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0154 0.1025 0.1949
Brugia malayi intermediate filament protein 0.0029 0.0122 0.0281
Schistosoma mansoni hypothetical protein 0.0111 0.0713 0.1332
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0058 0.0329
Brugia malayi Peptidase family M1 containing protein 0.0154 0.1025 0.2454
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0024 0.0088 0.0096
Echinococcus multilocularis leucine aminopeptidase protein 0.0255 0.1756 0.3426
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0058 0.0565
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0058 0.011
Loa Loa (eye worm) hypothetical protein 0.013 0.0848 0.1649
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0155
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0144 0.0208
Schistosoma mansoni leucine aminopeptidase 0.0051 0.0279 0.0473
Echinococcus granulosus lamin dm0 0.0029 0.0122 0.0214
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0039 0.0106
Echinococcus multilocularis leucyl aminopeptidase 0.0051 0.0279 0.0523
Brugia malayi Peptidase family M1 containing protein 0.0244 0.1679 0.4026
Schistosoma mansoni inhibitor of apoptosis protein 0.0146 0.0964 0.1829
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.0754 0.4165
Schistosoma mansoni hypothetical protein 0.0146 0.0964 0.1829
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0154 0.1025 0.199
Onchocerca volvulus 0.0244 0.1679 0.9491
Trichomonas vaginalis set domain proteins, putative 0.0256 0.1762 1
Loa Loa (eye worm) hypothetical protein 0.013 0.0848 0.1649
Echinococcus multilocularis musashi 0.0029 0.0122 0.0214
Schistosoma mansoni ap endonuclease 0.002 0.0058 0.0037
Loa Loa (eye worm) hypothetical protein 0.009 0.0565 0.1092
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0051 0.0279 0.053
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0039 0.0106
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0078 0.0441
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0144 0.0122
Trypanosoma brucei Aminopeptidase M1, putative 0.0154 0.1025 0.2796
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0154 0.1025 0.199
Echinococcus multilocularis caspase 2 0.0111 0.0713 0.1377
Toxoplasma gondii exonuclease III APE 0.002 0.0058 0.0036
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0144 0.0259
Onchocerca volvulus Cell death protein 3 homolog 0.0111 0.0713 0.3603
Echinococcus multilocularis lamin dm0 0.0029 0.0122 0.0214
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0039 0.0015
Onchocerca volvulus 0.0256 0.1762 1
Plasmodium falciparum M17 leucyl aminopeptidase 0.0255 0.1756 0.1723
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0058 0.0127
Toxoplasma gondii aminopeptidase N protein 0.1394 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0039 0.0106
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0058 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.0964 0.1877
Echinococcus granulosus intermediate filament protein 0.0029 0.0122 0.0214
Trypanosoma brucei aminopeptidase, putative 0.013 0.0848 0.2314
Brugia malayi glutathione reductase 0.0051 0.028 0.0663
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.1394 1 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0051 0.0279 0.0658
Echinococcus granulosus leukotriene A 4 hydrolase 0.0717 0.51 1
Toxoplasma gondii aminopeptidase N, putative 0.1394 1 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0024 0.003
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.028 0.1407
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0255 0.1756 0.4789
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.0848 0.4713
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0039 0.0221
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0144 0.0208
Trypanosoma brucei trypanothione reductase 0.0051 0.028 0.0765
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0154 0.1025 0.199
Plasmodium falciparum thioredoxin reductase 0.0051 0.028 0.0242
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0255 0.1756 0.1736
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.013 0.0848 0.2314
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.028 0.0534
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0154 0.1025 0.199
Echinococcus granulosus apoptotic protease activating factor 1 0.0111 0.0713 0.1377
Loa Loa (eye worm) hypothetical protein 0.0029 0.0118 0.0214
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0154 0.1025 0.2796
Schistosoma mansoni intermediate filament proteins 0.0029 0.0122 0.0163
Echinococcus granulosus lamin 0.0029 0.0122 0.0214
Echinococcus granulosus leucyl aminopeptidase 0.0051 0.0279 0.0523
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.013 0.0848 0.2314
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0154 0.1025 0.1949
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0255 0.1756 0.4789
Echinococcus granulosus caspase 2 0.0111 0.0713 0.1377
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.013 0.0848 0.0827
Brugia malayi Thioredoxin reductase 0.0051 0.028 0.0663
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0051 0.0279 0.076
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0088 0.0239
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0051 0.0279 0.076
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0058 0.0034
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0024 0.0045
Echinococcus granulosus puromycin sensitive aminopeptidase 0.013 0.0848 0.1643
Loa Loa (eye worm) TATA binding protein associated factor 0.013 0.0848 0.1649
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.0754 0.4165
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0154 0.1025 0.5817
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0154 0.1025 0.199
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0057 0.0019
Toxoplasma gondii thioredoxin reductase 0.0051 0.028 0.0259
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0051 0.0279 0.0473
Chlamydia trachomatis cytosol aminopeptidase 0.0255 0.1756 1
Onchocerca volvulus 0.0032 0.0144 0.0137
Loa Loa (eye worm) hypothetical protein 0.0111 0.0713 0.1383
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.028 0.0527
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0144 0.0208
Plasmodium falciparum glutathione reductase 0.0051 0.028 0.0242
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0136 0.0242
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0154 0.1025 0.199
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.013 0.0848 0.1599
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0058 0.0089
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0255 0.1756 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0122 0.0281
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0155
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0144 0.0259
Echinococcus multilocularis lamin 0.0029 0.0122 0.0214
Trypanosoma brucei pyroglutamyl-peptidase I, putative 0.0519 0.3666 1
Brugia malayi hypothetical protein 0.013 0.0848 0.2028
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0122 0.0222
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0039 0.0015
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0058 0.0097
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0146 0.0964 0.2308
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0039 0.0106
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.0754 0.4165
Loa Loa (eye worm) hypothetical protein 0.0032 0.0144 0.0266
Mycobacterium ulcerans aminopeptidase N PepN 0.013 0.0848 0.4714
Schistosoma mansoni caspase-7 (C14 family) 0.0111 0.0713 0.1332
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0039 0.0106
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0146 0.0964 0.1871
Loa Loa (eye worm) glutathione reductase 0.0051 0.028 0.0534
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0058 0.0158
Echinococcus multilocularis leucyl aminopeptidase 0.0051 0.0279 0.0523
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.0754 0.4165
Trypanosoma cruzi pyroglutamyl-peptidase I, putative 0.0519 0.3666 1
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0051 0.0279 0.053
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0154 0.1025 0.199
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.028 0.0257
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0039 0.0106
Loa Loa (eye worm) hypothetical protein 0.0115 0.0742 0.1439
Brugia malayi hypothetical protein 0.0154 0.1025 0.2454
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.013 0.0848 0.0812
Trypanosoma cruzi Cysteine peptidase, Clan CF, family C15 0.0519 0.3666 1
Schistosoma mansoni hypothetical protein 0.0056 0.0315 0.0546
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0255 0.1756 0.4789
Echinococcus multilocularis apoptotic protease activating factor 1 0.0111 0.0713 0.1377
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0039 0.0082
Leishmania major trypanothione reductase 0.0051 0.028 0.0765
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0058 0.0158
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0058 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0051 0.0279 0.076
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0255 0.1756 1
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0255 0.1756 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.028 0.0527
Trypanosoma brucei Aminopeptidase M1, putative 0.0154 0.1025 0.2796
Brugia malayi hypothetical protein 0.0587 0.4162 1
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0051 0.0279 0.0658
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0051 0.0279 0.076
Brugia malayi Pre-SET motif family protein 0.0225 0.1538 0.3686
Loa Loa (eye worm) peptidase family M1 containing protein 0.022 0.1502 0.2933
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0058 0.011
Echinococcus granulosus inhibitor of apoptosis protein 0.0146 0.0964 0.1871
Schistosoma mansoni ap endonuclease 0.002 0.0058 0.0037
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.0848 0.0939
Echinococcus granulosus puromycin sensitive aminopeptidase 0.013 0.0848 0.1643
Onchocerca volvulus 0.013 0.0848 0.4428
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0154 0.1025 0.199
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0039 0.0106
Plasmodium vivax SET domain protein, putative 0.0032 0.0144 0.0121
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.013 0.0848 0.2314
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0154 0.1025 0.2796
Onchocerca volvulus 0.0154 0.1025 0.5506
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0039 0.0106
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0051 0.0279 0.0658
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0069
Toxoplasma gondii leucyl aminopeptidase LAP 0.0255 0.1756 0.1737
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.1538 0.3003
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0039 0.0106
Loa Loa (eye worm) hypothetical protein 0.0111 0.0713 0.1383
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0717 0.51 1
Brugia malayi Pre-SET motif family protein 0.0032 0.0144 0.0335
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0039 0.0106
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0051 0.0279 0.0523
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0154 0.1025 0.5817
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0051 0.0279 0.076
Echinococcus multilocularis leucyl aminopeptidase 0.0051 0.0279 0.0523
Toxoplasma gondii aminopeptidase n, putative 0.1394 1 1
Brugia malayi Peptidase family M1 containing protein 0.013 0.0848 0.2028
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0717 0.51 1
Trypanosoma brucei aminopeptidase, putative 0.0051 0.0279 0.076
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0039 0.0106
Loa Loa (eye worm) hypothetical protein 0.0029 0.0122 0.0222
Leishmania major pyroglutamyl-peptidase I (C15 family) 0.0519 0.3666 1
Schistosoma mansoni lamin 0.0029 0.0122 0.0163
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0043 0.0007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0144 0.0259
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.013 0.0848 0.2314
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0051 0.0279 0.076
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0154 0.1025 0.2796
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0039 0.0221
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0058 0.0158
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0255 0.1756 0.4789
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0154 0.1025 0.199
Schistosoma mansoni lamin 0.0029 0.0122 0.0163
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.028 0.0765
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0039 0.0106
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0078 0.0441
Onchocerca volvulus 0.0146 0.0964 0.5137
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0008
Mycobacterium tuberculosis Probable reductase 0.0116 0.0754 0.4165
Brugia malayi cytosol aminopeptidase 0.0051 0.0279 0.0658
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0039 0.0106
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.0754 0.4165
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0146 0.0964 0.2308
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0154 0.1025 0.199
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0078 0.0175
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0144 0.0208
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.013 0.0848 0.4813
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0039 0.0106
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0146 0.0964 0.1829
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0039 0.0017
Mycobacterium ulcerans aminopeptidase N PepN 0.0154 0.1025 0.5744
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0058 0.0158
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.013 0.0848 0.2314
Echinococcus granulosus leucine aminopeptidase protein 0.0255 0.1756 0.3426
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0051 0.0279 0.076
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0088 0.0148
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0717 0.51 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0039 0.0052
Echinococcus multilocularis inhibitor of apoptosis protein 0.0146 0.0964 0.1871
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.0848 0.4713
Loa Loa (eye worm) aminopeptidase N 0.0154 0.1025 0.1996
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0078 0.0128

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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