Detailed information for compound 1226548

Basic information

Technical information
  • TDR Targets ID: 1226548
  • Name: N-(2-ethoxyphenyl)-2-[6-methyl-5-(4-methylpip eridin-1-yl)sulfonyl-4-oxothieno[5,4-d]pyrimi din-3-yl]acetamide
  • MW: 504.622 | Formula: C23H28N4O5S2
  • H donors: 1 H acceptors: 4 LogP: 2.97 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOc1ccccc1NC(=O)Cn1cnc2c(c1=O)c(c(s2)C)S(=O)(=O)N1CCC(CC1)C
  • InChi: 1S/C23H28N4O5S2/c1-4-32-18-8-6-5-7-17(18)25-19(28)13-26-14-24-22-20(23(26)29)21(16(3)33-22)34(30,31)27-11-9-15(2)10-12-27/h5-8,14-15H,4,9-13H2,1-3H3,(H,25,28)
  • InChiKey: HNLJYKZVKTUOOD-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(2-ethoxyphenyl)-2-[6-methyl-5-[(4-methyl-1-piperidyl)sulfonyl]-4-oxo-thieno[5,4-d]pyrimidin-3-yl]acetamide
  • N-(2-ethoxyphenyl)-2-[6-methyl-5-[(4-methyl-1-piperidinyl)sulfonyl]-4-oxo-3-thieno[5,4-d]pyrimidinyl]acetamide
  • N-(2-ethoxyphenyl)-2-[4-keto-6-methyl-5-[(4-methyl-1-piperidyl)sulfonyl]thieno[5,4-d]pyrimidin-3-yl]acetamide
  • N-(2-ethoxyphenyl)-2-[6-methyl-5-(4-methylpiperidin-1-yl)sulfonyl-4-oxo-thieno[5,4-d]pyrimidin-3-yl]ethanamide
  • EU-0021392
  • C096-0516
  • NCGC00104014-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0026 0.0078 0.031
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.0149 0.0124
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0345 0.1867
Echinococcus granulosus cathepsin l1 0.0037 0.0149 0.0124
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.0915 0.0893
Entamoeba histolytica cysteine protease, putative 0.0019 0.0031 0.0437
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0031 0.0109 0.0109
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0548 0.3053
Entamoeba histolytica cysteine protease, putative 0.0019 0.0031 0.0437
Leishmania major cathepsin L-like protease 0.0037 0.0149 0.0168
Echinococcus granulosus cathepsin l cysteine peptidase 0.0037 0.0149 0.0124
Mycobacterium ulcerans hypothetical protein 0.0026 0.0078 0.0242
Brugia malayi hypothetical protein 0.012 0.0701 0.3946
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0078 0.0242
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0548 0.3053
Loa Loa (eye worm) ctsf protein 0.0037 0.0149 0.0722
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0108 0.1538
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0078 0.0242
Onchocerca volvulus Cathepsin L homolog 0.0037 0.0149 0.0722
Entamoeba histolytica cysteine protease, putative 0.0019 0.0031 0.0437
Onchocerca volvulus 0.0037 0.0149 0.0722
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0149 0.0725
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0031 0.0437
Leishmania major cathepsin L-like protease 0.0037 0.0149 0.0168
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0031 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0149 0.0725
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.012 0.0701 0.0701
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0108 0.0071
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0031 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0078 0.031
Loa Loa (eye worm) hypothetical protein 0.0277 0.1738 1
Entamoeba histolytica hypothetical protein 0.012 0.0701 1
Trypanosoma cruzi cysteine peptidase, putative 0.014 0.0832 0.188
Schistosoma mansoni microtubule-associated protein tau 0.1528 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0149 0.0725
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0068 0.0973
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0025 0.0025
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0277 0.1738 0.1738
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0034 0.0043
Schistosoma mansoni DNA helicase recq5 0.0028 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0277 0.1738 1
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0034 0.0202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0149 0.0725
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0025 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0832 0.188
Trypanosoma cruzi Cysteine peptidase, Clan CF, family C15 0.0422 0.2691 0.6244
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0078 0.1112
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0108 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0149 0.0725
Onchocerca volvulus 0.0277 0.1738 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0119 0.0119
Loa Loa (eye worm) glutaminase 0.0265 0.1657 0.9527
Toxoplasma gondii cathepsin CPL 0.0037 0.0149 0.2424
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0149 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0832 0.188
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0386
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0211 0.3443
Echinococcus granulosus cysteine protease 0.0019 0.0031 0.0006
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0108 0.0181
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.1485
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0119 0.0119
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0149 0.0277
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0031 0.0109 0.0489
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0031 0.0031
Onchocerca volvulus 0.0037 0.0149 0.0722
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0149 0.0725
Onchocerca volvulus 0.0037 0.0149 0.0722
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0031 0.0031
Entamoeba histolytica cysteine proteinase 2 0.0019 0.0031 0.0437
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0386
Echinococcus multilocularis cathepsin L 0.0019 0.0031 0.0006
Schistosoma mansoni transcription factor LCR-F1 0.012 0.0701 0.0701
Trichomonas vaginalis DNA helicase recq1, putative 0.004 0.0172 0.087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.006 0.03 0.1606
Plasmodium vivax vivapain-2 0.0037 0.0149 0.6538
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0832 0.188
Brugia malayi cathepsin L-like precursor 0.0025 0.0068 0.0253
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0211 0.0187
Brugia malayi Pre-SET motif family protein 0.0032 0.0119 0.0552
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.0149 0.0124
Entamoeba histolytica cysteine protease, putative 0.0019 0.0031 0.0437
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0078 0.0231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0832 0.188
Entamoeba histolytica cysteine protease, putative 0.0019 0.0031 0.0437
Entamoeba histolytica cysteine protease, putative 0.0019 0.0031 0.0437
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0119 0.1949
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0149 0.0149
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0109 0.0489
Trichomonas vaginalis set domain proteins, putative 0.0257 0.1604 0.9671
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.0149 0.0124
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0025 0.0025
Echinococcus granulosus bloom syndrome protein 0.004 0.0172 0.0148
Mycobacterium ulcerans glutaminase 0.0265 0.1657 0.7451
Mycobacterium tuberculosis Conserved hypothetical protein 0.035 0.2215 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0019 0.0031 0.0437
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0186 0.2647
Echinococcus granulosus tumor protein p63 0.0408 0.2601 0.2583
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0108 0.0474
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0149 0.0722
Onchocerca volvulus 0.0025 0.0068 0.0253
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0832 0.188
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0031 0.0437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0149 0.0725
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0025 0.0025
Plasmodium vivax vivapain-2 0.0037 0.0149 0.6538
Onchocerca volvulus 0.0037 0.0149 0.0722
Mycobacterium ulcerans hypothetical protein 0.035 0.2215 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0119 0.0095
Loa Loa (eye worm) acetyltransferase 0.0157 0.0944 0.5367
Leishmania major cysteine peptidase A (CPA) 0.0037 0.0149 0.0168
Onchocerca volvulus 0.0032 0.0119 0.0552
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0149 0.0725
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0149 0.0725
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0078 0.1112
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0064 0.1873
Echinococcus multilocularis tumor protein p63 0.0408 0.2601 0.2583
Loa Loa (eye worm) fibroinase 0.0037 0.0149 0.0722
Echinococcus multilocularis geminin 0.0166 0.1004 0.0981
Echinococcus multilocularis cysteine protease 0.0037 0.0149 0.0124
Onchocerca volvulus 0.0037 0.0149 0.0722
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0149 0.0725
Entamoeba histolytica cysteine protease, putative 0.0019 0.0031 0.0437
Brugia malayi Cathepsin L-like precursor 0.0037 0.0149 0.0722
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0119 0.0119
Trypanosoma cruzi major cysteine proteinase, putative 0.011 0.0633 0.1415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0149 0.0725
Leishmania major cathepsin L-like protease 0.0037 0.0149 0.0168
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0055
Loa Loa (eye worm) RecQ helicase 0.004 0.0172 0.086
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0078 0.5
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.0172 0.087
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0149 0.0722
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.0386
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0091 0.0066
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0093 0.0522 0.1153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0149 0.0725
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0109 0.0084
Schistosoma mansoni hypothetical protein 0.0031 0.0109 0.0109
Trypanosoma cruzi cruzipain precursor, putative 0.014 0.0832 0.188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0832 0.188
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0114 0.0657 0.147
Plasmodium falciparum cysteine proteinase falcipain 3 0.0037 0.0149 0.7613
Brugia malayi Cathepsin L-like cysteine proteinase 0.0025 0.0068 0.0253
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0832 0.188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0149 0.0725
Brugia malayi glutaminase DH11.1 0.0265 0.1657 0.9527
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0037 0.0149 0.7613
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0025 0.0025
Echinococcus granulosus GPCR family 2 0.0031 0.0109 0.0084
Echinococcus multilocularis cysteine protease 0.0037 0.0149 0.0124
Leishmania major cathepsin L-like protease 0.0037 0.0149 0.0168
Brugia malayi Cathepsin L-like precursor 0.0037 0.0149 0.0722
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0034 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0149 0.0725
Onchocerca volvulus Cathepsin F homolog 0.0037 0.0149 0.0722
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0253
Loa Loa (eye worm) hypothetical protein 0.0097 0.0548 0.3053
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.1485
Loa Loa (eye worm) hypothetical protein 0.0027 0.0081 0.0329
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0018 0.0025 0.0025
Onchocerca volvulus 0.0259 0.1619 0.9303
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0037 0.0149 0.7613
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0119 0.0095
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0186 1
Schistosoma mansoni DNA helicase recq1 0.0028 0.0091 0.0091
Brugia malayi Cathepsin L-like precursor 0.0025 0.0068 0.0253
Echinococcus granulosus cathepsin L 0.0019 0.0031 0.0006
Echinococcus multilocularis bloom syndrome protein 0.004 0.0172 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0068 0.0231
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.1397 0.8011
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0664 0.4291 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0078 0.031
Entamoeba histolytica cysteine protease, putative 0.0019 0.0031 0.0437
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0037 0.0149 0.0725
Loa Loa (eye worm) hypothetical protein 0.0026 0.0078 0.031
Echinococcus granulosus cathepsin L cysteine proteinase 0.0037 0.0149 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0832 0.188
Leishmania major cathepsin L-like protease 0.014 0.0832 0.1789
Entamoeba histolytica hypothetical protein 0.012 0.0701 1
Entamoeba histolytica hypothetical protein 0.012 0.0701 1
Brugia malayi Trypsin family protein 0.0277 0.1738 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0149 0.0725
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0091 0.0386
Leishmania major cathepsin L-like protease 0.0037 0.0149 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0832 0.188
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0832 0.188
Entamoeba histolytica cysteine protease, putative 0.0019 0.0031 0.0437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0149 0.0725
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0091 0.0066
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0277 0.1738 0.1738
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.0944 0.5367
Entamoeba histolytica hypothetical protein 0.012 0.0701 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0025 0.0025
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.0944 0.0944
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0149 0.0725
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0211 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0093 0.0522 0.1153
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0253
Loa Loa (eye worm) glutaminase 2 0.0265 0.1657 0.9527
Echinococcus granulosus cathepsin l1 0.0025 0.0068 0.0043
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0025 0.0025
Brugia malayi Cathepsin L-like precursor 0.0037 0.0149 0.0722
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0078 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0078 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0068 0.0231
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0109 0.0084
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0109 0.0489
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0078 0.0242
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0055
Entamoeba histolytica cysteine protease, putative 0.0019 0.0031 0.0437
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0034 0.0235
Schistosoma mansoni hypothetical protein 0.0018 0.0025 0.0025
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0091 0.0066
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0031 0.0437
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0031 0.0034
Onchocerca volvulus 0.0037 0.0149 0.0722
Onchocerca volvulus Cathepsin L homolog 0.0037 0.0149 0.0722
Brugia malayi Cathepsin L-like precursor 0.0037 0.0149 0.0722
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0664 0.4291 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0034 0.0032
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0128 0.0751 0.1692
Echinococcus multilocularis microtubule associated protein 2 0.1528 1 1
Trypanosoma brucei pyroglutamyl-peptidase I, putative 0.0422 0.2691 0.6244
Brugia malayi Cathepsin L-like precursor 0.0025 0.0068 0.0253
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0055
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0025 0.0025
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0109 0.0084
Leishmania major pyroglutamyl-peptidase I (C15 family) 0.0422 0.2691 0.6202
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0078 0.0242
Brugia malayi Bloom's syndrome protein homolog 0.004 0.0172 0.086
Loa Loa (eye worm) hypothetical protein 0.0026 0.0078 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0149 0.0725
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0031 0.0437
Entamoeba histolytica cysteine protease, putative 0.0019 0.0031 0.0437
Brugia malayi Cathepsin L-like precursor 0.0037 0.0149 0.0722
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0314 0.1981 0.4517
Schistosoma mansoni cellular tumor antigen P53 0.006 0.03 0.03
Schistosoma mansoni hypothetical protein 0.0166 0.1004 0.1004
Trypanosoma cruzi cysteine peptidase, putative 0.014 0.0832 0.188
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0664 0.4291 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0078 0.5
Onchocerca volvulus 0.0257 0.1604 0.9214
Brugia malayi Cathepsin L-like precursor 0.0037 0.0149 0.0722
Trypanosoma cruzi cysteine peptidase, putative 0.014 0.0832 0.188
Schistosoma mansoni hypothetical protein 0.0166 0.1004 0.1004
Trichomonas vaginalis glutaminase, putative 0.0265 0.1657 1
Leishmania major mitochondrial DNA polymerase beta 0.0664 0.4291 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0109 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0149 0.0725
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0025 0.0025
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0119 0.0095
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0068 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0078 0.0242
Toxoplasma gondii hypothetical protein 0.0107 0.0613 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0025 0.0025
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0037 0.0149 0.0722
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0109 0.0489
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0149 0.2119
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0211 0.1109
Onchocerca volvulus 0.006 0.03 0.1606
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0078 0.0242
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0093 0.0522 0.1153
Schistosoma mansoni hypothetical protein 0.0018 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0066 0.0345 0.0345
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0078 0.1112
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0186 1
Schistosoma mansoni hypothetical protein 0.0031 0.0109 0.0109
Onchocerca volvulus 0.0037 0.0149 0.0722
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0149 0.2119
Entamoeba histolytica cysteine protease, putative 0.0019 0.0031 0.0437
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0037 0.0149 0.0725
Loa Loa (eye worm) cysteine protease 0.0037 0.0149 0.0722
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0548 0.3053
Schistosoma mansoni glutaminase 0.0265 0.1657 0.1657
Leishmania major cathepsin L-like protease 0.014 0.0832 0.1789
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0091 0.3896
Loa Loa (eye worm) hypothetical protein 0.0066 0.0345 0.1867
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.0944 0.0922
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0061 0.0993
Entamoeba histolytica cysteine protease, putative 0.0019 0.0031 0.0437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0149 0.0725
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0211 0.1109
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0093 0.0522 0.1153
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0155 0.8057
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0025 0.0025
Trypanosoma cruzi pyroglutamyl-peptidase I, putative 0.0422 0.2691 0.6244
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0112 0.0087
Echinococcus multilocularis GPCR, family 2 0.0031 0.0109 0.0084
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0314 0.1981 0.4578
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0091 0.0066
Loa Loa (eye worm) hypothetical protein 0.0032 0.0119 0.0552
Leishmania major cathepsin L-like protease 0.014 0.0832 0.1789
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0078 0.0231
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.0149 0.0124
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0149 0.0725
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0055
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0078 0.0242
Brugia malayi Pre-SET motif family protein 0.0226 0.1397 0.8011
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0078 0.031
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0025 0.0025
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.012 0.0701 0.0678
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0832 0.188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0149 0.0722
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0025 0.0025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0149 0.0725
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0314 0.1981 0.4578
Echinococcus granulosus cathepsin L cysteine protease 0.0019 0.0031 0.0006
Schistosoma mansoni hypothetical protein 0.0031 0.0109 0.0109
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0211 0.3443
Echinococcus granulosus geminin 0.0166 0.1004 0.0981
Entamoeba histolytica cysteine protease, putative 0.0037 0.0149 0.2119
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.012 0.0701 0.0678
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0149 0.0725
Plasmodium vivax SET domain protein, putative 0.0032 0.0119 0.4922
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0253

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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