Detailed view for TcCLB.508555.70

Basic information

TDR Targets ID: 38779
Trypanosoma cruzi, calpain-like cysteine peptidase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.5815 | Length (AA): 1231 | MW (Da): 137861 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00648   Calpain family cysteine protease
PF09149   Domain of unknown function (DUF1935)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0004198   calcium-dependent cysteine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
523 627 1r75 (A) 13 127 19.00 0 0.44 0.21 -0.89
630 1211 1qxp (A) 2 577 22.00 0 1 0.42 0.75
646 946 2g8j (A) 33 298 30.00 0 1 0.47 -0.18
104 225 4jnd (A) 14 160 13.00 0 0.06 0.218006 -0.75
523 619 1r75 (A) 13 119 20.00 0.000000012 0.3 0.303998 -0.4
645 1231 1qxp (A) 12 592 21.00 0 1 0.332048 1.4
646 951 2nqa (A) 23 296 32.00 0.000000000082 0.65 0.309778 1.06
646 1024 2r9f (A) 33 352 28.00 0 1 0.37778 0.72

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_166755)

Species Accession Gene Product
Leishmania braziliensis LbrM.31.0520   calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania donovani LdBPK_310420.1   calpain-like protein, putative
Leishmania infantum LinJ.31.0420   calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania major LmjF.31.0400   calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania mexicana LmxM.30.0400   calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative
Trypanosoma cruzi TcCLB.508555.70   calpain-like cysteine peptidase, putative
Trypanosoma cruzi TcCLB.509237.140   calpain-like cysteine peptidase, putative
Trypanosoma cruzi TcCLB.477983.10   calpain cysteine peptidase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Leishmania major calpain family cysteine protease-like protein 705 aa 27.2% 712 aa Compounds References
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 687 aa 28.7% 697 aa Compounds References
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 732 aa 27.2% 727 aa Compounds References
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 823 aa 28.6% 734 aa Compounds References
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 743 aa 27.4% 766 aa Compounds References
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 855 aa 34.5% 721 aa Compounds References
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 754 aa 25.7% 688 aa Compounds References
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 414 aa 28.0% 361 aa Compounds References
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 723 aa 25.2% 689 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0505 0.2553 0.254
0.0661 0.7862 0.7862
0.064 0.786 0.7859
0.0671 0.4735 0.7883
0.0559 0.3227 0.3246
0.0394 0.3826 0.3826
0.0766 0.786 0.7859
0.0356 0.7832 0.7832
0.0675 0.7906 0.7904
0.0714 0.7845 0.7845
0.0689 0.7841 0.7841
0.0739 0.7574 0.7859
0.0467 0.2542 0.2533
0.1586 0.7835 0.7832
0.0714 0.7832 0.7832
0.0748 0.4711 0.7853
0.0638 0.7847 0.7845
0.0672 0.315 0.7814
0.0655 0.7845 0.7845
0.0724 0.2823 0.7853
0.057 0.2619 0.471
0.0533 0.2641 0.2628
0.0657 0.7871 0.787
0.0654 0.7845 0.7845
0.0638 0.7847 0.7845
0.057 0.2619 0.471
0.0457 0.4243 0.5697
0.0394 0.3826 0.3826
0.0309 0.3091 0.7884
0.0442 0.4771 0.5584
0.0787 0.3614 0.7809
0.0681 0.7861 0.7853
0.0671 0.4735 0.7883
0.0666 0.7888 0.7888
0.0654 0.7845 0.7845
0.0446 0.3582 0.3909
0.0787 0.483 0.7819
0.0505 0.7836 0.7832
0.1575 0.7835 0.7832
0.0676 0.7868 0.7868
0.0668 0.7841 0.7841
0.0709 0.4825 0.7853
0.0661 0.5492 0.7773
0.0684 0.745 0.7821
0.0659 0.7847 0.7845
0.0589 0.2514 0.2941
0.0495 0.3173 0.5288
0.074 0.7926 0.7926
0.0434 0.3527 0.5592
0.0394 0.3826 0.3826
0.051 0.7888 0.7886
0.1497 0.5729 0.7874
0.0476 0.5283 0.5283
0.0692 0.7855 0.7853
0.0394 0.3826 0.3826
0.1497 0.5729 0.7874
0.0642 0.6468 0.7819
0.0723 0.3816 0.7853
0.0636 0.3393 0.7809
0.0632 0.7845 0.7845
0.0724 0.2592 0.7897
0.0774 0.7875 0.7874
0.1418 0.574 0.7879
0.1351 0.7835 0.7832
0.0545 0.2732 0.2714
0.0742 0.7952 0.7952
0.0351 0.7793 0.7769
0.0446 0.4331 0.5515
0.0779 0.7845 0.7845
0.0654 0.7845 0.7845
0.0648 0.6903 0.786
0.0694 0.7805 0.7823
0.0503 0.2633 0.2626
0.0636 0.4521 0.785
0.0756 0.7845 0.7845
0.074 0.7753 0.7871
0.0687 0.5468 0.7838
0.1418 0.574 0.7879
0.0636 0.4198 0.776
0.1218 0.5763 0.7897
0.0447 0.3333 0.558
0.0721 0.7303 0.7925
0.1429 0.7835 0.7832
0.0435 0.4348 0.4329
0.0702 0.4276 0.7853
0.0771 0.7845 0.7845
0.0589 0.2514 0.2941
0.0675 0.4451 0.7819
0.0801 0.7914 0.7913
0.0748 0.5903 0.7862
0.0539 0.2704 0.4972
0.0638 0.7845 0.7845
0.0677 0.7845 0.7845
0.0394 0.3826 0.3826
0.0671 0.3802 0.7802
0.0766 0.7873 0.7868
0.0742 0.7952 0.7952
0.0442 0.4771 0.5584
0.1218 0.5763 0.7897
0.0687 0.7873 0.7868
0.0645 0.3743 0.776
0.0568 0.3079 0.8082
0.0457 0.4243 0.5697
0.1496 0.7835 0.7832
0.0715 0.7873 0.7868
0.0769 0.4591 0.781
0.0511 0.3542 0.3617
0.0636 0.7159 0.7836
0.0665 0.7873 0.7868
0.0695 0.698 0.7824
0.0701 0.7845 0.7845
0.0679 0.787 0.7868
0.0636 0.7159 0.7836
0.0461 0.4502 0.4978
0.0739 0.7701 0.7859
0.0787 0.7824 0.7823
0.0394 0.3826 0.3826
0.0589 0.259 0.2579
0.0677 0.3857 0.7789
0.0757 0.7805 0.78
0.131656 0.793782 0.791754
0.0801 0.7914 0.7913
0.0437 0.2694 0.4189
0.0702 0.2771 0.7853
0.0671 0.5266 0.7853
0.0787 0.7793 0.7772
0.1429 0.7835 0.7832
0.0476 0.5283 0.5283
0.0425 0.4583 0.4582
0.0434 0.4906 0.5588
0.0682 0.2539 0.7802
0.1575 0.784 0.7835
0.049 0.3467 0.4466
0.0724 0.2592 0.7897
0.071 0.7799 0.7792
0.0589 0.2514 0.2941
0.1496 0.7835 0.7832
0.0701 0.7845 0.7845
0.0512 0.2527 0.2521
0.0464 0.428 0.5689
0.0631 0.7845 0.7845
0.0672 0.6937 0.7819
0.0723 0.3816 0.7853
0.0446 0.3582 0.3909
0.0773 0.79 0.7885
0.0446 0.4342 0.5704
0.0702 0.7861 0.7853
0.1139 0.569 0.7846
0.073 0.7873 0.7868
0.04 0.4376 0.4351
0.1497 0.574 0.7879
0.0772 0.7841 0.7841
0.0772 0.7841 0.7841
0.0246 0.259 0.495
0.0682 0.2539 0.7802
0.0675 0.7906 0.7904
0.0435 0.4479 0.5615
0.0654 0.625 0.776
0.0699 0.716 0.7841
0.064 0.787 0.7868
0.0742 0.7845 0.7845
0.0446 0.4317 0.4723
0.0446 0.3582 0.3909
0.0636 0.7159 0.7836
0.0643 0.7845 0.7845
0.1575 0.784 0.7835
0.0653 0.7802 0.7789
0.0446 0.3582 0.3909
0.0675 0.4451 0.7819
0.0645 0.787 0.7868
0.0425 0.505 0.7791
0.0351 0.776 0.776
0.0421 0.3368 0.5504
0.0739 0.7701 0.7859
0.1575 0.7832 0.7832
0.0748 0.2892 0.7789
0.1418 0.574 0.7879
0.0773 0.786 0.7859
0.0724 0.2558 0.7862
0.0770169 0.562926 0.79146
0.0736 0.3119 0.7862
0.0779 0.4799 0.7832
0.1418 0.7835 0.7832
0.154574 0.793748 0.791754
0.0728 0.7841 0.7841
0.0671 0.7053 0.7874
0.0715 0.7811 0.7859
0.0676 0.7855 0.7853
0.0667 0.4528 0.7823
0.0787 0.7859 0.7841
0.0668 0.583 0.79
0.0761 0.5854 0.7853
0.0636 0.3393 0.7809
0.0714 0.7841 0.7841
0.0666 0.712 0.7823
0.1497 0.574 0.7879
0.0687 0.5468 0.7838
0.1575 0.7835 0.7832
0.0545 0.3871 0.5017
0.0723 0.3816 0.7853
0.0692 0.7862 0.7862
0.0631 0.7267 0.7874
0.0671 0.7053 0.7874
0.0696 0.5393 0.7862
0.0748 0.5903 0.7862
0.0483 0.3502 0.5549
0.0671 0.4735 0.7883
0.0457 0.4243 0.5697
0.071 0.778 0.7826
0.067 0.7873 0.7868
0.1429 0.7835 0.7832
0.1139 0.7835 0.7832
0.0636 0.4198 0.776
0.0439 0.5186 0.5545
0.0724 0.787 0.7862
0.1351 0.7835 0.7832
0.0787 0.3614 0.7809
0.0704 0.7823 0.7823
0.0699 0.716 0.7841
0.0449 0.4945 0.5579
0.0505 0.7842 0.7842
0.086 0.652 0.787
0.0446 0.4928 0.5584
0.0476 0.5283 0.5283
0.1508 0.7835 0.7832
0.0727 0.2686 0.776
0.0774 0.7875 0.7874
0.0766 0.786 0.7859
0.0645 0.787 0.7868
0.0702 0.7061 0.7825
0.0695 0.7847 0.7827
0.1586 0.7835 0.7832
0.0467 0.2989 0.3734
0.1497 0.5729 0.7874
0.0692 0.7626 0.7814
0.0637 0.7795 0.776
0.0748 0.3941 0.7892
0.0394 0.3826 0.3826
0.0801 0.7847 0.7847
0.0668 0.7841 0.7841
0.0677 0.7845 0.7845
0.0671 0.4735 0.7883
0.1139 0.5744 0.7884
0.0671 0.7841 0.7841
0.0446 0.3582 0.3909
0.0687 0.5468 0.7838
0.0383 0.2948 0.5309
0.0636 0.4521 0.785
0.1586 0.7835 0.7832
0.0394 0.3826 0.3826
0.0724 0.2592 0.7897
0.0702 0.4276 0.7853
0.078 0.786 0.7859
0.0801 0.7914 0.7913
0.0746 0.7861 0.7853
0.0277 0.3304 0.7804
0.0449 0.4945 0.5579
0.0724 0.2592 0.7897
0.1508 0.7835 0.7832
0.0476 0.5283 0.5283
0.078 0.786 0.7859
0.0671 0.7053 0.7874
0.0655 0.7873 0.7868
0.1273 0.574 0.7879
0.0492 0.317 0.5282
0.045 0.4319 0.5662
0.1591 0.784 0.7835
0.0668 0.583 0.79
0.0639 0.7823 0.7823
0.0672 0.315 0.7814
0.0667 0.7855 0.7853
0.0645 0.3743 0.776
0.0728 0.785 0.785
0.0702 0.432 0.7882
0.0559 0.3227 0.3246
0.0742 0.7952 0.7952
0.0757 0.7805 0.78
0.0505 0.7842 0.7842
0.0659 0.7841 0.7841
0.0686 0.6873 0.7868
0.1139 0.5744 0.7884
0.049 0.3644 0.8117
0.0666 0.712 0.7823
0.0655 0.2774 0.7789
0.0496 0.2617 0.2609
0.0483 0.3544 0.3955
0.05 0.7799 0.776
0.0774 0.7875 0.7874
0.0759 0.786 0.7859
0.0537 0.3724 0.7841
0.1497 0.5729 0.7874
0.1496 0.7835 0.7832
0.0654 0.7845 0.7845
0.1496 0.7835 0.7832
0.0724 0.2823 0.7853
0.0446 0.4331 0.5515
0.0489 0.3134 0.5278
0.0677 0.7841 0.7841
0.1418 0.7835 0.7832
0.0652 0.783 0.7789
0.0344 0.3358 0.7791
0.0383 0.2948 0.5309
0.0763 0.7841 0.7841
0.0589 0.2514 0.2941
0.0758 0.7859 0.7859
0.0708 0.7823 0.7823
0.131656 0.793782 0.791754
0.0545 0.3871 0.5017
0.0435 0.4479 0.5615
0.0772 0.7841 0.7841
0.0389 0.5297 0.5283
0.0519 0.2864 0.3105
0.0425 0.4876 0.7827
0.0652 0.7853 0.7853
0.0435 0.4348 0.4329
0.0714 0.7841 0.7841
0.0687 0.5468 0.7838
0.0633 0.7869 0.7859
0.0642 0.6468 0.7819
0.1508 0.7835 0.7832
0.0802133 0.785785 0.785785
0.064 0.786 0.7859

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.508555.70 (Trypanosoma cruzi), calpain-like cysteine peptidase, putative
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