TDR Targets

Basic information

Technical information

TDR Targets ID: 1461595
Name: 3-[1-[(2S)-6-amino-1-oxo-1-piperazin-1-ylhexa n-2-yl]triazol-4-yl]propanoic acid
MW: 338.405 | Formula: C15H26N6O3
H donors: 3 H acceptors: 5 LogP: -3.66 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: NCCCC[C@@H](C(=O)N1CCNCC1)n1nnc(c1)CCC(=O)O
InChi: 1S/C15H26N6O3/c16-6-2-1-3-13(15(24)20-9-7-17-8-10-20)21-11-12(18-19-21)4-5-14(22)23/h11,13,17H,1-10,16H2,(H,22,23)/t13-/m0/s1
InChiKey: JHBOCDVQCYXJHA-ZDUSSCGKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[1-[(1S)-5-amino-1-(piperazine-1-carbonyl)pentyl]triazol-4-yl]propanoic acid
3-[1-[(1S)-5-amino-1-[oxo-(1-piperazinyl)methyl]pentyl]-4-triazolyl]propanoic acid
3-[1-[(1S)-5-amino-1-(piperazine-1-carbonyl)pentyl]triazol-4-yl]propionic acid
3-[1-[(2S)-6-amino-1-oxo-1-piperazin-1-yl-hexan-2-yl]-1,2,3-triazol-4-yl]propanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	trehalase	0.0143	0.0193	0.0193
Trichomonas vaginalis	alpha-glucosidase, putative	0.0652	0.229	0.5168
Brugia malayi	Glycosyl hydrolases family 2, sugar binding domain containing protein	0.0303	0.0852	0.0852
Brugia malayi	Alpha-L-fucosidase family protein	0.1018	0.38	0.38
Loa Loa (eye worm)	hypothetical protein	0.0412	0.1303	0.1303
Brugia malayi	hypothetical protein	0.0412	0.1303	0.1303
Trichomonas vaginalis	set domain proteins, putative	0.027	0.0715	0.1311
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0322	0.0932	0.407
Brugia malayi	Trehalase protein 5	0.0143	0.0193	0.0193
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0322	0.0932	0.1841
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0622	0.2166	0.4865
Schistosoma mansoni	alpha-amylase	0.0167	0.0293	0.0334
Trichomonas vaginalis	beta-glucosidase, putative	0.113	0.4261	1
Brugia malayi	Amylo-alpha-1,6-glucosidase family protein	0.0563	0.1926	0.1926
Trichomonas vaginalis	beta-mannosidase, putative	0.0218	0.0504	0.0792
Trichomonas vaginalis	alpha-glucosidase, putative	0.0322	0.0932	0.1841
Echinococcus multilocularis	lysosomal alpha glucosidase	0.2523	1	1
Echinococcus granulosus	beta galactosidase	0.0901	0.3317	0.3317
Loa Loa (eye worm)	hypothetical protein	0.0412	0.1303	0.1303
Loa Loa (eye worm)	hypothetical protein	0.0901	0.3317	0.3317
Trichomonas vaginalis	conserved hypothetical protein	0.0412	0.1303	0.2751
Echinococcus granulosus	glycogen phosphorylase	0.0726	0.2597	0.2597
Trichomonas vaginalis	glucosylceramidase, putative	0.0199	0.0423	0.0594
Trichomonas vaginalis	alpha-glucosidase, putative	0.0322	0.0932	0.1841
Onchocerca volvulus		0.0412	0.1303	0.1609
Loa Loa (eye worm)	glycosyl hydrolase family 38 protein	0.0207	0.0458	0.0458
Schistosoma mansoni	beta-mannosidase	0.0218	0.0504	0.0575
Trichomonas vaginalis	trehalase, putative	0.0412	0.1303	0.2751
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0314	0.0898	1
Trichomonas vaginalis	glycogen debranching enzyme, putative	0.0563	0.1926	0.4276
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0417	0.1323	0.1509
Brugia malayi	Pre-SET motif family protein	0.0237	0.058	0.058
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0136	0.0165	0.0165
Echinococcus granulosus	alpha glucosidase	0.0167	0.0293	0.0293
Schistosoma mansoni	alpha glucosidase	0.0652	0.229	0.2612
Echinococcus multilocularis	glycogen debranching enzyme	0.0563	0.1926	0.1926
Entamoeba histolytica	glycogen phosphorylase, putative	0.0726	0.2597	1
Schistosoma mansoni	bile acid beta-glucosidase-related	0.0244	0.061	0.0696
Echinococcus multilocularis	beta galactosidase	0.0901	0.3317	0.3317
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0652	0.229	0.229
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0322	0.0932	0.1841
Trichomonas vaginalis	glucosylceramidase, putative	0.0303	0.0852	0.1646
Loa Loa (eye worm)	hypothetical protein	0.0412	0.1303	0.1303
Schistosoma mansoni	hypothetical protein	0.034	0.1005	0.1146
Loa Loa (eye worm)	hypothetical protein	0.0901	0.3317	0.3317
Onchocerca volvulus		0.0412	0.1303	0.1609
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0314	0.0898	0.1206
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0193	0.0193
Trichomonas vaginalis	glucosylceramidase, putative	0.0303	0.0852	0.1646
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0193	0.0193
Echinococcus multilocularis	snurportin 1	0.034	0.1005	0.1005
Trichomonas vaginalis	glucosylceramidase, putative	0.0303	0.0852	0.1646
Brugia malayi	Trehalase family protein	0.0143	0.0193	0.0193
Onchocerca volvulus		0.0412	0.1303	0.1609
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0417	0.1323	0.1509
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0417	0.1323	0.1323
Entamoeba histolytica	glycogenphosphorylase, putative	0.0314	0.0898	0.2628
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0726	0.2597	0.5922
Echinococcus multilocularis	fucosidase, alpha L 1, tissue	0.1386	0.5317	0.5317
Echinococcus granulosus	fucosidase alpha L 1 tissue	0.1386	0.5317	0.5317
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0726	0.2597	0.2597
Echinococcus granulosus	glycogen debranching enzyme	0.0563	0.1926	0.1926
Brugia malayi	hypothetical protein	0.0143	0.0193	0.0193
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0275	0.0739	0.5
Brugia malayi	manba-prov protein	0.0439	0.1415	0.1415
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0417	0.1323	0.1323
Loa Loa (eye worm)	trehalase	0.0143	0.0193	0.0193
Schistosoma mansoni	hypothetical protein	0.0187	0.0375	0.0428
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0652	0.229	0.5168
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0322	0.0932	0.0932
Echinococcus multilocularis	alpha glucosidase	0.0167	0.0293	0.0293
Loa Loa (eye worm)	trehalase	0.0412	0.1303	0.1303
Trichomonas vaginalis	glucosylceramidase, putative	0.0199	0.0423	0.0594
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0652	0.229	1
Echinococcus granulosus	non lysosomal glucosylceramidase	0.0244	0.061	0.061
Treponema pallidum	hypothetical protein	0.0143	0.0193	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0641	0.2246	0.5061
Trypanosoma brucei	inosine-adenosine-guanosine-nucleosidehydrolase	0.047	0.1539	0.672
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0447	0.1445	0.3098
Trypanosoma cruzi	hypothetical protein, conserved	0.0652	0.229	1
Trichomonas vaginalis	glycoside hydrolase, putative	0.0749	0.2691	0.6151
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0126	0.0124	0.0124
Trichomonas vaginalis	glucosylceramidase, putative	0.0199	0.0423	0.0594
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0417	0.1323	0.1509
Loa Loa (eye worm)	alpha-L-fucosidase	0.1018	0.38	0.38
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.2523	1	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.0283	0.0283
Trichomonas vaginalis	glucosylceramidase, putative	0.0303	0.0852	0.1646
Schistosoma mansoni	alpha-glucosidase	0.2223	0.8766	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0237	0.058	0.058
Schistosoma mansoni	alpha-amylase	0.0167	0.0293	0.0334
Brugia malayi	Alpha amylase, catalytic domain containing protein	0.0167	0.0293	0.0293
Brugia malayi	Trehalase family protein	0.0412	0.1303	0.1303
Loa Loa (eye worm)	hypothetical protein	0.0339	0.1002	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0322	0.0932	0.0932
Entamoeba histolytica	glycogen phosphorylase, putative	0.0726	0.2597	1
Brugia malayi	hypothetical protein	0.0143	0.0193	0.0193
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0652	0.229	0.5168
Schistosoma mansoni	hypothetical protein	0.0407	0.1281	0.1461
Trichomonas vaginalis	glucosylceramidase, putative	0.0199	0.0423	0.0594
Entamoeba histolytica	glycogen phosphorylase, putative	0.0314	0.0898	0.2628
Schistosoma mansoni	thyroid hormone receptor	0.0136	0.0165	0.0188
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0652	0.229	0.229
Entamoeba histolytica	beta-galactosidase, putative	0.0362	0.1094	0.3476
Echinococcus multilocularis	geminin	0.0187	0.0375	0.0375
Schistosoma mansoni	alpha-glucosidase	0.2223	0.8766	1
Brugia malayi	Beta-glucuronidase precursor	0.028	0.0756	0.0756
Schistosoma mansoni	beta-galactosidase	0.0901	0.3317	0.3784
Loa Loa (eye worm)	amylo-alpha-1,6-glucosidase	0.0274	0.0734	0.0734
Brugia malayi	Alpha amylase, catalytic domain containing protein	0.0167	0.0293	0.0293
Schistosoma mansoni	alpha-amylase	0.0167	0.0293	0.0334
Schistosoma mansoni	hypothetical protein	0.0724	0.2589	0.2953
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0726	0.2597	0.3207
Loa Loa (eye worm)	beta-glucuronidase	0.028	0.0756	0.0756
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0303	0.0852	0.0852
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0417	0.1323	0.1509
Echinococcus granulosus	glycogen phosphorylase	0.0726	0.2597	0.2597
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0339	0.1002	0.1143
Trichomonas vaginalis	beta-galactosidase, putative	0.0641	0.2246	0.5061
Trichomonas vaginalis	alpha-glucosidase, putative	0.0322	0.0932	0.1841
Trichomonas vaginalis	glucosylceramidase, putative	0.0209	0.0467	0.0703
Trichomonas vaginalis	conserved hypothetical protein	0.0289	0.0795	0.1507
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0339	0.1002	0.2014
Trypanosoma cruzi	hypothetical protein, conserved	0.0652	0.229	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0652	0.229	0.5168
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0322	0.0932	0.407
Schistosoma mansoni	glycogen phosphorylase	0.0726	0.2597	0.2963
Schistosoma mansoni	hypothetical protein	0.0187	0.0375	0.0428
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0339	0.1002	0.1143
Schistosoma mansoni	glycogen phosphorylase	0.0726	0.2597	0.2963
Schistosoma mansoni	alpha-amylase	0.0167	0.0293	0.0334
Mycobacterium leprae	Putative uncharacterized protein ML2045	0.0167	0.0293	0.5
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.034	0.1005	0.1005
Trichomonas vaginalis	glycogen debranching enzyme, putative	0.0563	0.1926	0.4276
Echinococcus granulosus	Glycosyl transferase family 35	0.0726	0.2597	0.2597
Trichomonas vaginalis	glucosylceramidase, putative	0.0199	0.0423	0.0594
Trichomonas vaginalis	alpha-mannosidase 2c1, putative	0.0207	0.0458	0.0679
Brugia malayi	hypothetical protein	0.0143	0.0193	0.0193
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0322	0.0932	0.407
Loa Loa (eye worm)	hypothetical protein	0.0412	0.1303	0.1303
Echinococcus granulosus	lysosomal alpha glucosidase	0.2523	1	1
Schistosoma mansoni	alpha-l-fucosidase	0.1018	0.38	0.4335
Brugia malayi	Trehalase family protein	0.0412	0.1303	0.1303
Schistosoma mansoni	alpha-amylase	0.0167	0.0293	0.0334
Echinococcus multilocularis	beta mannosidase	0.016	0.0262	0.0262
Trypanosoma cruzi	inosine-adenosine-guanosine-nucleosidehydrolase, putative	0.047	0.1539	0.672
Trichomonas vaginalis	alpha-glucosidase, putative	0.0322	0.0932	0.1841
Trichomonas vaginalis	alpha-mannosidase, putative	0.0207	0.0458	0.0679
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0322	0.0932	0.1841
Trichomonas vaginalis	alpha-glucosidase, putative	0.0652	0.229	0.5168
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0652	0.229	0.8665
Toxoplasma gondii	Amylo-alpha-1,6-glucosidase	0.0563	0.1926	0.6236
Trypanosoma cruzi	inosine-adenosine-guanosine-nucleosidehydrolase, putative	0.047	0.1539	0.672
Brugia malayi	carbohydrate phosphorylase	0.0726	0.2597	0.2597
Trichomonas vaginalis	alpha-glucosidase, putative	0.0652	0.229	0.5168
Mycobacterium ulcerans	alpha-mannosidase	0.0207	0.0458	0.0329
Trichomonas vaginalis	alpha-mannosidase 2c1, putative	0.0146	0.0205	0.0059
Mycobacterium ulcerans	alpha-L-fucosidase	0.1386	0.5317	1
Schistosoma mansoni	hypothetical protein	0.0126	0.0124	0.0141
Echinococcus granulosus	bile acid beta glucosidase	0.0244	0.061	0.061
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0322	0.0932	0.2774
Onchocerca volvulus		0.2061	0.8099	1
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0126	0.0124	0.0124
Entamoeba histolytica	glycogen phosphorylase, putative	0.0314	0.0898	0.2628
Loa Loa (eye worm)	alpha amylase	0.0167	0.0293	0.0293
Onchocerca volvulus		0.0412	0.1303	0.1609
Loa Loa (eye worm)	hypothetical protein	0.0563	0.1926	0.1926
Echinococcus multilocularis	non lysosomal glucosylceramidase	0.0244	0.061	0.061
Loa Loa (eye worm)	hypothetical protein	0.027	0.0715	0.0715
Loa Loa (eye worm)	alpha amylase	0.0167	0.0293	0.0293
Brugia malayi	Trehalase family protein	0.0143	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0193	0.0193
Brugia malayi	hypothetical protein	0.0126	0.0125	0.0125
Brugia malayi	Melibiase family protein	0.0339	0.1002	0.1002
Onchocerca volvulus	Trehalase homolog	0.0412	0.1303	0.1609
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0266	0.0702	0.0702
Chlamydia trachomatis	glycogen phosphorylase	0.0726	0.2597	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0209	0.0467	0.0703
Onchocerca volvulus		0.027	0.0715	0.0883
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0652	0.229	0.5168
Plasmodium vivax	hypothetical protein, conserved	0.0275	0.0739	0.5
Brugia malayi	Trehalase family protein	0.0412	0.1303	0.1303
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0417	0.1323	0.1323
Loa Loa (eye worm)	TRE-2 protein	0.0412	0.1303	0.1303
Brugia malayi	follicle stimulating hormone receptor	0.0266	0.0702	0.0702
Echinococcus granulosus	snurportin 1	0.034	0.1005	0.1005
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0322	0.0932	0.1151
Loa Loa (eye worm)	trehalase	0.0412	0.1303	0.1303
Giardia lamblia	Glycogen phosphorylase	0.0726	0.2597	1
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0652	0.229	0.229
Trichomonas vaginalis	alpha-glucosidase, putative	0.0322	0.0932	0.1841
Schistosoma mansoni	hypothetical protein	0.0411	0.1297	0.148
Trichomonas vaginalis	glucosylceramidase, putative	0.0199	0.0423	0.0594
Echinococcus multilocularis	glycogen phosphorylase	0.0726	0.2597	0.2597
Loa Loa (eye worm)	manba-prov protein	0.016	0.0262	0.0262
Echinococcus multilocularis	lysosomal alpha glucosidase	0.2523	1	1
Brugia malayi	Trehalase family protein	0.0412	0.1303	0.1303
Trichomonas vaginalis	alpha-glucosidase, putative	0.0652	0.229	0.5168
Trichomonas vaginalis	glucosylceramidase, putative	0.0303	0.0852	0.1646
Brugia malayi	Glycosyl hydrolases family 38 protein	0.0207	0.0458	0.0458
Onchocerca volvulus		0.0412	0.1303	0.1609
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0193	0.0193
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0726	0.2597	0.5922
Schistosoma mansoni	thyroid hormone receptor	0.0136	0.0165	0.0188
Echinococcus granulosus	neutral alpha glucosidase AB	0.0652	0.229	0.229
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0303	0.0852	0.0852
Schistosoma mansoni	glycogen phosphorylase	0.0314	0.0898	0.1025
Schistosoma mansoni	bile acid beta-glucosidase-related	0.0244	0.061	0.0696
Trichomonas vaginalis	glucosylceramidase, putative	0.0199	0.0423	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0412	0.1303	0.1303
Onchocerca volvulus	Glucosylceramidase homolog	0.0199	0.0423	0.0522
Trichomonas vaginalis	glycoside hydrolases, putative	0.113	0.4261	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0303	0.0852	0.1646
Leishmania major	alpha glucosidase II subunit, putative	0.0652	0.229	1
Echinococcus multilocularis	bile acid beta glucosidase	0.0244	0.061	0.061
Brugia malayi	trehalase	0.0143	0.0193	0.0193
Brugia malayi	trehalase I	0.0143	0.0193	0.0193
Entamoeba histolytica	glycogen debranching enzyme, putative	0.0563	0.1926	0.7086
Loa Loa (eye worm)	glycosyl hydrolase family 2	0.0303	0.0852	0.0852
Trypanosoma brucei	glucosidase, putative	0.0652	0.229	1
Echinococcus granulosus	beta mannosidase	0.016	0.0262	0.0262
Leishmania major	inosine-adenosine-guanosine-nucleoside hydrolase, putative	0.047	0.1539	0.447
Echinococcus multilocularis	glycogen phosphorylase	0.0726	0.2597	0.2597
Loa Loa (eye worm)	TRE-1 protein	0.0412	0.1303	0.1303
Loa Loa (eye worm)	trehalase	0.0412	0.1303	0.1303
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0622	0.2166	0.8128
Echinococcus granulosus	geminin	0.0187	0.0375	0.0375
Loa Loa (eye worm)	glycogen phosphorylase	0.0726	0.2597	0.2597
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0447	0.1445	0.3098

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1621105

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1461595