TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 706.61 | Formula: C29H28F6N4O8S
H donors: 5 H acceptors: 8 LogP: 1.5 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)[C@@H]1CN(C[C@H]1c1cccc(c1)C(=N)N)Cc1ccc(cc1)c1ccccc1S(=O)(=O)N
InChi: 1S/C25H26N4O4S.2C2HF3O2/c26-24(27)19-5-3-4-18(12-19)21-14-29(15-22(21)25(30)31)13-16-8-10-17(11-9-16)20-6-1-2-7-23(20)34(28,32)33;2*3-2(4,5)1(6)7/h1-12,21-22H,13-15H2,(H3,26,27)(H,30,31)(H2,28,32,33);2*(H,6,7)/t21-,22+;;/m0../s1
InChiKey: WSEDDIHAZSWMIB-VSIGASKDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	coagulation factor X	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Trehalase family protein	0.0265	0.0918	0.0964
Onchocerca volvulus		0.0265	0.0918	0.1098
Onchocerca volvulus		0.0166	0.0415	0.0452
Schistosoma mansoni	glycogen phosphorylase	0.0164	0.0407	0.0407
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.0551	0.0555
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0131	0.0242	0.0254
Toxoplasma gondii	aspartyl protease ASP1	0.07	0.3114	1
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0254	0.0859	0.3751
Brugia malayi	lysosomal alpha-mannosidase	0.0096	0.0062	0.0065
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0244	0.0809	0.0849
Brugia malayi	aspartic protease BmAsp-2, identical	0.0166	0.0415	0.0435
Brugia malayi	Trehalase family protein	0.0265	0.0918	0.0964
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0517	0.2188	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0517	0.2188	0.3931
Loa Loa (eye worm)	hypothetical protein	0.0265	0.0918	0.0964
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0166	0.0415	0.0415
Schistosoma mansoni	hypothetical protein	0.0543	0.2318	0.2318
Entamoeba histolytica	glycogenphosphorylase, putative	0.0164	0.0407	0.1859
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0166	0.0415	0.0415
Trichomonas vaginalis	alpha-mannosidase 2c1, putative	0.0206	0.062	0.0697
Echinococcus multilocularis	lysosomal alpha glucosidase	0.1971	0.9528	1
Echinococcus multilocularis	beta galactosidase	0.0747	0.3349	0.3514
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0208	0.063	0.063
Brugia malayi	Glycosyl hydrolases family 38 protein	0.0096	0.0062	0.0065
Toxoplasma gondii	melibiase subfamily protein	0.0208	0.063	0.0796
Trichomonas vaginalis	glycogen debranching enzyme, putative	0.0422	0.171	0.2945
Schistosoma mansoni	alpha-glucosidase	0.1739	0.8355	0.8355
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.07	0.3114	1
Mycobacterium ulcerans	alpha-L-fucosidase	0.1777	0.8549	1
Schistosoma mansoni	memapsin-2 (A01 family)	0.0166	0.0415	0.0415
Brugia malayi	Glycosyl hydrolases family 38 protein	0.0096	0.0062	0.0065
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0379	0.1493	0.2498
Schistosoma mansoni	glycogen phosphorylase	0.0379	0.1493	0.1493
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0166	0.0415	0.0435
Trichomonas vaginalis	glucosylceramidase, putative	0.0294	0.106	0.1605
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0164	0.0407	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0859	0.0902
Schistosoma mansoni	alpha glucosidase	0.0517	0.2188	0.2188
Brugia malayi	carbohydrate phosphorylase	0.0379	0.1493	0.1567
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0486	0.2033	0.3611
Trypanosoma cruzi	hypothetical protein, conserved	0.0517	0.2188	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0203	0.0603	0.0662
Echinococcus granulosus	lysosomal alpha mannosidase	0.0096	0.0062	0.0065
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0517	0.2188	0.3931
Echinococcus granulosus	glycogen phosphorylase	0.0379	0.1493	0.1567
Loa Loa (eye worm)	glycogen phosphorylase	0.0379	0.1493	0.1567
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0166	0.0415	0.0415
Loa Loa (eye worm)	alpha-L-fucosidase	0.1249	0.5883	0.6175
Loa Loa (eye worm)	trehalase	0.0092	0.0043	0.0045
Brugia malayi	Trehalase family protein	0.0092	0.0043	0.0045
Echinococcus granulosus	beta galactosidase	0.0747	0.3349	0.3514
Brugia malayi	Glycosyl hydrolases family 31 protein	0.1971	0.9528	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.1971	0.9528	1
Entamoeba histolytica	glycogen phosphorylase, putative	0.0164	0.0407	0.1859
Schistosoma mansoni	bile acid beta-glucosidase-related	0.0237	0.0773	0.0773
Brugia malayi	Pre-SET motif family protein	0.0244	0.0809	0.0849
Echinococcus multilocularis	glycogen debranching enzyme	0.0422	0.171	0.1795
Trichomonas vaginalis	glucosylceramidase, putative	0.0294	0.106	0.1605
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.0551	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0434	0.0455
Brugia malayi	Amylo-alpha-1,6-glucosidase family protein	0.0422	0.171	0.1795
Trypanosoma cruzi	hypothetical protein, conserved	0.0517	0.2188	1
Brugia malayi	hypothetical protein	0.0095	0.0057	0.006
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0379	0.1493	0.1836
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.0551	0.0555
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0166	0.0415	0.0415
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.07	0.3114	0.3268
Loa Loa (eye worm)	TRE-1 protein	0.0265	0.0918	0.0964
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0517	0.2188	0.3931
Loa Loa (eye worm)	hypothetical protein	0.0747	0.3349	0.3514
Trichomonas vaginalis	alpha-glucosidase, putative	0.0254	0.0859	0.119
Trichomonas vaginalis	conserved hypothetical protein	0.0217	0.0673	0.0805
Trichomonas vaginalis	glucosylceramidase, putative	0.0203	0.0603	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0747	0.3349	0.3514
Brugia malayi	Trehalase family protein	0.0265	0.0918	0.0964
Trichomonas vaginalis	glucosylceramidase, putative	0.0294	0.106	0.1605
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.0193	0.0202
Brugia malayi	trehalase	0.0092	0.0043	0.0045
Echinococcus multilocularis	bile acid beta glucosidase	0.0237	0.0773	0.0811
Trichomonas vaginalis	trehalase, putative	0.0265	0.0918	0.1312
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0228	0.0731	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0062	0.0065
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0254	0.0859	0.3928
Schistosoma mansoni	mannosidase alpha class 2a	0.0096	0.0062	0.0062
Schistosoma mansoni	hypothetical protein	0.0305	0.1118	0.1118
Entamoeba histolytica	glycogen phosphorylase, putative	0.0379	0.1493	0.6826
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.07	0.3114	0.3268
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0254	0.0859	0.119
Echinococcus granulosus	Glycosyl transferase family 35	0.0379	0.1493	0.1567
Schistosoma mansoni	alpha-l-fucosidase	0.1249	0.5883	0.5883
Trichomonas vaginalis	set domain proteins, putative	0.0277	0.0979	0.1437
Schistosoma mansoni	bile acid beta-glucosidase-related	0.0237	0.0773	0.0773
Trichomonas vaginalis	alpha-glucosidase, putative	0.0517	0.2188	0.3931
Schistosoma mansoni	lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1)	0.0096	0.0062	0.0062
Echinococcus multilocularis	alpha mannosidase 2	0.0096	0.0062	0.0065
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0254	0.0859	0.3751
Brugia malayi	Glycosyl hydrolases family 38 protein	0.0206	0.062	0.0651
Loa Loa (eye worm)	trehalase	0.0265	0.0918	0.0964
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0254	0.0859	0.119
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.0551	0.0555
Toxoplasma gondii	Amylo-alpha-1,6-glucosidase	0.0422	0.171	0.4799
Onchocerca volvulus		0.1641	0.7858	1
Brugia malayi	aspartic protease BmAsp-1, identical	0.0166	0.0415	0.0435
Echinococcus granulosus	glycogen debranching enzyme	0.0422	0.171	0.1795
Loa Loa (eye worm)	TRE-2 protein	0.0265	0.0918	0.0964
Trichomonas vaginalis	beta-glucosidase, putative	0.11	0.513	1
Schistosoma mansoni	cathepsin D (A01 family)	0.2065	1	1
Onchocerca volvulus		0.0265	0.0918	0.1098
Plasmodium falciparum	plasmepsin VI	0.07	0.3114	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0294	0.106	0.1605
Trichomonas vaginalis	glycoside hydrolases, putative	0.11	0.513	1
Loa Loa (eye worm)	trehalase	0.0265	0.0918	0.0964
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0254	0.0859	0.1023
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0415	0.0435
Brugia malayi	Melibiase family protein	0.0169	0.0434	0.0455
Loa Loa (eye worm)	trehalase	0.0092	0.0043	0.0045
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0517	0.2188	0.2296
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0208	0.063	0.0661
Trichomonas vaginalis	glucosylceramidase, putative	0.0294	0.106	0.1605
Schistosoma mansoni	lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1)	0.0096	0.0062	0.0062
Schistosoma mansoni	beta-galactosidase	0.0747	0.3349	0.3349
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0208	0.063	0.063
Schistosoma mansoni	alpha-glucosidase	0.1739	0.8355	0.8355
Trichomonas vaginalis	conserved hypothetical protein	0.0265	0.0918	0.1312
Brugia malayi	Pepsin A precursor	0.0166	0.0415	0.0435
Echinococcus granulosus	bile acid beta glucosidase	0.0237	0.0773	0.0811
Brugia malayi	hypothetical protein	0.0166	0.0415	0.0435
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.0551	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0062	0.0065
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.0551	0.0555
Echinococcus granulosus	neutral alpha glucosidase AB	0.0517	0.2188	0.2296
Echinococcus multilocularis	glycogen phosphorylase	0.0379	0.1493	0.1567
Entamoeba histolytica	glycogen phosphorylase, putative	0.0164	0.0407	0.1859
Leishmania major	alpha glucosidase II subunit, putative	0.0517	0.2188	1
Echinococcus granulosus	non lysosomal glucosylceramidase	0.0237	0.0773	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0422	0.171	0.1795
Schistosoma mansoni	hypothetical protein	0.0122	0.0193	0.0193
Onchocerca volvulus		0.0277	0.0979	0.1176
Brugia malayi	hypothetical protein	0.0092	0.0043	0.0045
Plasmodium vivax	aspartyl proteinase, putative	0.07	0.3114	1
Onchocerca volvulus		0.0166	0.0415	0.0452
Entamoeba histolytica	glycogen debranching enzyme, putative	0.0422	0.171	0.7816
Brugia malayi	follicle stimulating hormone receptor	0.0271	0.0948	0.0995
Echinococcus multilocularis	glycogen phosphorylase	0.0379	0.1493	0.1567
Plasmodium falciparum	plasmepsin II	0.07	0.3114	1
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0454	0.0477
Plasmodium falciparum	plasmepsin IV	0.07	0.3114	1
Loa Loa (eye worm)	amylo-alpha-1,6-glucosidase	0.0206	0.0616	0.0647
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0208	0.063	0.0661
Loa Loa (eye worm)	glycosyl hydrolase family 38 protein	0.0206	0.062	0.0651
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0517	0.2188	0.6569
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0294	0.106	0.1113
Entamoeba histolytica	glycogen phosphorylase, putative	0.0379	0.1493	0.6826
Loa Loa (eye worm)	hypothetical protein	0.0265	0.0918	0.0964
Trichomonas vaginalis	alpha-mannosidase, putative	0.0206	0.062	0.0697
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0254	0.0859	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0265	0.0918	0.0964
Loa Loa (eye worm)	hypothetical protein	0.0265	0.0918	0.0964
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0043	0.0045
Plasmodium vivax	plasmepsin IV, putative	0.07	0.3114	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0254	0.0859	0.119
Treponema pallidum	hypothetical protein	0.0092	0.0043	0.5
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0517	0.2188	0.2296
Onchocerca volvulus	Trehalase homolog	0.0265	0.0918	0.1098
Trypanosoma brucei	glucosidase, putative	0.0517	0.2188	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0294	0.106	0.1605
Plasmodium vivax	hypothetical protein, conserved	0.0228	0.0731	0.1171
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.1971	0.9528	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.0385	0.0404
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0548	0.2345	0.4255
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0166	0.0415	0.0415
Brugia malayi	trehalase I	0.0092	0.0043	0.0045
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0254	0.0859	0.119
Trichomonas vaginalis	alpha-glucosidase, putative	0.0517	0.2188	0.3931
Loa Loa (eye worm)	aspartyl protease 6	0.0166	0.0415	0.0435
Trichomonas vaginalis	alpha-glucosidase, putative	0.0254	0.0859	0.119
Trichomonas vaginalis	alpha-mannosidase 2c1, putative	0.0145	0.0311	0.006
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0379	0.1493	0.1567
Plasmodium falciparum	plasmepsin I	0.07	0.3114	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0517	0.2188	0.3931
Echinococcus granulosus	glycogen phosphorylase	0.0379	0.1493	0.1567
Trichomonas vaginalis	alpha-glucosidase, putative	0.0517	0.2188	0.3931
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0379	0.1493	0.2498
Brugia malayi	Trehalase protein 5	0.0092	0.0043	0.0045
Onchocerca volvulus	Glucosylceramidase homolog	0.0193	0.0551	0.0627
Echinococcus multilocularis	fucosidase, alpha L 1, tissue	0.1777	0.8549	0.8973
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0169	0.0434	0.0434
Schistosoma mansoni	thyroid hormone receptor	0.0131	0.0242	0.0242
Brugia malayi	hypothetical protein	0.0166	0.0415	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0043	0.0045
Echinococcus multilocularis	non lysosomal glucosylceramidase	0.0237	0.0773	0.0811
Echinococcus granulosus	fucosidase alpha L 1 tissue	0.1777	0.8549	0.8973
Trichomonas vaginalis	alpha-glucosidase, putative	0.0254	0.0859	0.119
Chlamydia trachomatis	glycogen phosphorylase	0.0379	0.1493	0.5
Mycobacterium leprae	Putative uncharacterized protein ML2045	0.0083	0	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.0551	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0043	0.0045
Trichomonas vaginalis	glycogen debranching enzyme, putative	0.0422	0.171	0.2945
Echinococcus multilocularis	lysosomal alpha mannosidase	0.0096	0.0062	0.0065
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.0193	0.0202
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0166	0.0415	0.0415
Mycobacterium ulcerans	alpha-mannosidase	0.0206	0.062	0.0725
Onchocerca volvulus		0.0265	0.0918	0.1098
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0294	0.106	0.1113
Brugia malayi	Trehalase family protein	0.0092	0.0043	0.0045
Loa Loa (eye worm)	hypothetical protein	0.07	0.3114	0.3268
Schistosoma mansoni	glycogen phosphorylase	0.0379	0.1493	0.1493
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0208	0.063	0.063
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0208	0.063	0.0661
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0548	0.2345	0.4255
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0254	0.0859	0.3751
Brugia malayi	hypothetical protein	0.0092	0.0043	0.0045
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0486	0.2033	0.9292
Brugia malayi	Trehalase family protein	0.0265	0.0918	0.0964
Brugia malayi	hypothetical protein	0.0092	0.0043	0.0045
Onchocerca volvulus		0.0265	0.0918	0.1098
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0208	0.063	0.063
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0169	0.0434	0.0434
Trichomonas vaginalis	alpha-glucosidase, putative	0.0254	0.0859	0.119
Trichomonas vaginalis	alpha-glucosidase, putative	0.0517	0.2188	0.3931
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0043	0.0045
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0517	0.2188	0.2296
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0166	0.0415	0.0435
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.07	0.3114	0.5841
Loa Loa (eye worm)	hypothetical protein	0.0265	0.0918	0.0964
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.07	0.3114	0.3268
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0166	0.0415	0.0415
Giardia lamblia	4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase	0.0422	0.171	1
Onchocerca volvulus		0.0265	0.0918	0.1098
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0164	0.0407	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.1971	0.9528	1
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0169	0.0434	0.0313
Loa Loa (eye worm)	trehalase	0.0265	0.0918	0.0964
Schistosoma mansoni	thyroid hormone receptor	0.0131	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0415	0.0435
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0271	0.0948	0.0995
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.07	0.3114	0.3114
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0166	0.0415	0.0415
Brugia malayi	hypothetical protein	0.0265	0.0918	0.0964
Brugia malayi	Alpha-L-fucosidase family protein	0.1249	0.5883	0.6175

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 600 nM	Binding affinity against Coagulation factor X in an enzyme inhibition assay.	ChEMBL.	10328312
Ki (binding)	= 600 nM	Binding affinity against Coagulation factor X in an enzyme inhibition assay.	ChEMBL.	10328312

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 21691