Detailed information for compound 1527882

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 353.827 | Formula: C14H16ClN5O2S
  • H donors: 3 H acceptors: 2 LogP: 2.02 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1NC(=S)NCc1nc(Cl)cnc1N
  • InChi: 1S/C14H16ClN5O2S/c1-21-8-3-4-9(11(5-8)22-2)20-14(23)18-6-10-13(16)17-7-12(15)19-10/h3-5,7H,6H2,1-2H3,(H2,16,17)(H2,18,20,23)
  • InChiKey: OQZVSWDFZHBRDG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase-activated protein kinase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Schistosoma japonicum ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative Get druggable targets OG5_131483 All targets in OG5_131483
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Brugia malayi map kinase activated protein kinase protein 2 Get druggable targets OG5_131483 All targets in OG5_131483
Echinococcus granulosus MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Echinococcus multilocularis MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase-activated protein kinase 2 370 aa 303 aa 26.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lysosomal alpha mannosidase 0.0096 0.0106 0.0106
Entamoeba histolytica beta-galactosidase, putative 0.036 0.1192 0.3606
Trichomonas vaginalis alpha-glucosidase, putative 0.0647 0.237 0.546
Loa Loa (eye worm) amylo-alpha-1,6-glucosidase 0.0273 0.0836 0.0836
Echinococcus granulosus beta galactosidase 0.0898 0.3403 0.3403
Schistosoma mansoni alpha-glucosidase 0.2207 0.878 1
Loa Loa (eye worm) beta-glucuronidase 0.0279 0.0857 0.0857
Echinococcus granulosus alpha glucosidase 0.0167 0.0397 0.0397
Brugia malayi carbohydrate phosphorylase 0.0703 0.2601 0.2601
Echinococcus multilocularis alpha glucosidase 0.0167 0.0397 0.0397
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0528 0.1216
Trypanosoma brucei glycosyl hydrolase-like protein 0.032 0.1028 0.4072
Mycobacterium leprae Putative uncharacterized protein ML2045 0.0167 0.0397 0.5
Giardia lamblia Glycogen phosphorylase 0.0703 0.2601 1
Brugia malayi Pre-SET motif family protein 0.0223 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0411 0.1399 0.1399
Brugia malayi Melibiase family protein 0.0339 0.1104 0.1104
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0167 0.0397 0.0397
Schistosoma mansoni hypothetical protein 0.0187 0.0479 0.0545
Trichomonas vaginalis alpha-glucosidase, putative 0.0647 0.237 0.546
Schistosoma mansoni hypothetical protein 0.0406 0.1379 0.1571
Brugia malayi lysosomal alpha-mannosidase 0.0096 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0142 0.0296 0.0296
Loa Loa (eye worm) glycosyl hydrolase family 38 protein 0.0206 0.056 0.056
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0304 0.0961 1
Treponema pallidum hypothetical protein 0.0142 0.0296 0.5
Schistosoma mansoni thyroid hormone receptor 0.0135 0.0269 0.0306
Trichomonas vaginalis glycoside hydrolase, putative 0.0746 0.2779 0.6402
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0416 0.1423 0.1423
Brugia malayi Glycosyl hydrolases family 38 protein 0.0206 0.056 0.056
Schistosoma mansoni alpha-l-fucosidase 0.1016 0.3888 0.4429
Loa Loa (eye worm) hypothetical protein 0.0096 0.0106 0.0106
Echinococcus multilocularis alpha mannosidase 2 0.0096 0.0106 0.0106
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0647 0.237 0.546
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0446 0.1544 0.3557
Schistosoma mansoni alpha-amylase 0.0167 0.0397 0.0453
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0956 0.2202
Schistosoma mansoni alpha-glucosidase 0.2207 0.878 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.2503 1 1
Brugia malayi hypothetical protein 0.0142 0.0296 0.0296
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0416 0.1423 0.162
Brugia malayi manba-prov protein 0.0438 0.151 0.151
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0528 0.1216
Brugia malayi Glycosyl hydrolases family 38 protein 0.0096 0.0106 0.0106
Echinococcus granulosus fucosidase alpha L 1 tissue 0.1383 0.5396 0.5396
Echinococcus multilocularis beta mannosidase 0.0159 0.0366 0.0366
Plasmodium vivax hypothetical protein, conserved 0.0274 0.084 0.5
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0562 0.202 0.4653
Schistosoma mansoni glycogen phosphorylase 0.0703 0.2601 0.2963
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.1383 0.5396 0.5396
Brugia malayi Trehalase family protein 0.0142 0.0296 0.0296
Echinococcus multilocularis non lysosomal glucosylceramidase 0.0244 0.0714 0.0714
Leishmania major alpha glucosidase II subunit, putative 0.0647 0.237 1
Trypanosoma cruzi inosine-adenosine-guanosine-nucleosidehydrolase, putative 0.0468 0.1636 0.6758
Trichomonas vaginalis conserved hypothetical protein 0.0639 0.2337 0.5383
Loa Loa (eye worm) alpha amylase 0.0167 0.0397 0.0397
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.032 0.1028 0.1264
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0096 0.0106 0.012
Trichomonas vaginalis alpha-glucosidase, putative 0.0647 0.237 0.546
Brugia malayi hypothetical protein 0.0411 0.1399 0.1399
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0206 0.056 0.1291
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0956 0.2202
Brugia malayi trehalase 0.0142 0.0296 0.0296
Loa Loa (eye worm) trehalase 0.0411 0.1399 0.1399
Brugia malayi hypothetical protein 0.0142 0.0296 0.0296
Schistosoma mansoni glycogen phosphorylase 0.0304 0.0961 0.1095
Onchocerca volvulus Trehalase homolog 0.0411 0.1399 0.1721
Schistosoma mansoni alpha-amylase 0.0167 0.0397 0.0453
Loa Loa (eye worm) hypothetical protein 0.0096 0.0106 0.0106
Echinococcus granulosus snurportin 1 0.0339 0.1105 0.1105
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0303 0.0956 0.0956
Schistosoma mansoni beta-galactosidase 0.0898 0.3403 0.3875
Schistosoma mansoni hypothetical protein 0.0339 0.1105 0.1258
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0416 0.1423 0.162
Entamoeba histolytica glycogenphosphorylase, putative 0.0304 0.0961 0.2558
Echinococcus granulosus glycogen phosphorylase 0.0703 0.2601 0.2601
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0416 0.1423 0.162
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0416 0.1423 0.1423
Brugia malayi trehalase I 0.0142 0.0296 0.0296
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.0627 0.0627
Echinococcus multilocularis geminin 0.0187 0.0479 0.0479
Trichomonas vaginalis maltase-glucoamylase, putative 0.0647 0.237 0.546
Toxoplasma gondii Amylo-alpha-1,6-glucosidase 0.0562 0.202 0.6304
Onchocerca volvulus 0.0411 0.1399 0.1721
Schistosoma mansoni beta-mannosidase 0.0218 0.0606 0.069
Brugia malayi map kinase activated protein kinase protein 2 0.0217 0.0606 0.0606
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0304 0.0961 0.1781
Loa Loa (eye worm) hypothetical protein 0.0562 0.202 0.202
Schistosoma mansoni bile acid beta-glucosidase-related 0.0244 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0411 0.1399 0.1399
Brugia malayi RNA, U transporter 1 0.009 0.0083 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0956 0.2202
Loa Loa (eye worm) hypothetical protein 0.0898 0.3403 0.3403
Trichomonas vaginalis alpha-glucosidase, putative 0.0647 0.237 0.546
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.032 0.1028 0.2367
Chlamydia trachomatis glycogen phosphorylase 0.0703 0.2601 0.5
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.2503 1 1
Loa Loa (eye worm) hypothetical protein 0.0898 0.3403 0.3403
Brugia malayi Glycosyl hydrolases family 31 protein 0.032 0.1028 0.1028
Loa Loa (eye worm) trehalase 0.0411 0.1399 0.1399
Trichomonas vaginalis alpha-glucosidase, putative 0.032 0.1028 0.2367
Onchocerca volvulus Glucosylceramidase homolog 0.0199 0.0528 0.065
Brugia malayi Trehalase family protein 0.0411 0.1399 0.1399
Brugia malayi Trehalase family protein 0.0411 0.1399 0.1399
Echinococcus multilocularis beta galactosidase 0.0898 0.3403 0.3403
Loa Loa (eye worm) glycogen phosphorylase 0.0703 0.2601 0.2601
Loa Loa (eye worm) hypothetical protein 0.0268 0.0815 0.0815
Brugia malayi Trehalase family protein 0.0411 0.1399 0.1399
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0145 0.0309 0.0711
Trichomonas vaginalis alpha-glucosidase, putative 0.032 0.1028 0.2367
Brugia malayi Trehalase protein 5 0.0142 0.0296 0.0296
Brugia malayi Alpha-L-fucosidase family protein 0.1016 0.3888 0.3888
Brugia malayi Trehalase family protein 0.0411 0.1399 0.1399
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0647 0.237 0.546
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0303 0.0956 0.0956
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0562 0.202 0.4653
Trichomonas vaginalis beta-glucosidase, putative 0.1126 0.4341 1
Mycobacterium ulcerans trehalose synthase TreS 0.0167 0.0397 0.0736
Trichomonas vaginalis sucrase-isomaltase, putative 0.0617 0.2248 0.5178
Trichomonas vaginalis beta-mannosidase, putative 0.0218 0.0606 0.1396
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.032 0.1028 0.2861
Trichomonas vaginalis glycogen phosphorylase, putative 0.0703 0.2601 0.5992
Loa Loa (eye worm) trehalase 0.0142 0.0296 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.0411 0.1399 0.3223
Schistosoma mansoni alpha glucosidase 0.0647 0.237 0.27
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0956 0.2202
Mycobacterium tuberculosis Trehalose synthase TreS 0.0167 0.0397 0.4134
Loa Loa (eye worm) manba-prov protein 0.0159 0.0366 0.0366
Brugia malayi Amylo-alpha-1,6-glucosidase family protein 0.0562 0.202 0.202
Leishmania major inosine-adenosine-guanosine-nucleoside hydrolase, putative 0.0468 0.1636 0.4531
Schistosoma mansoni glycogen phosphorylase 0.0703 0.2601 0.2963
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0446 0.1544 0.3557
Onchocerca volvulus 0.0411 0.1399 0.1721
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0617 0.2248 0.8396
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0528 0.1216
Schistosoma mansoni hypothetical protein 0.0722 0.2679 0.3052
Onchocerca volvulus 0.0411 0.1399 0.1721
Brugia malayi Trehalase family protein 0.0142 0.0296 0.0296
Trypanosoma cruzi hypothetical protein, conserved 0.0647 0.237 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.0296 0.0296
Loa Loa (eye worm) glycosyl hydrolase family 2 0.0302 0.0952 0.0952
Echinococcus granulosus lysosomal alpha mannosidase 0.0096 0.0106 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.0209 0.0572 0.1318
Echinococcus granulosus non lysosomal glucosylceramidase 0.0244 0.0714 0.0714
Echinococcus granulosus neutral alpha glucosidase AB 0.0647 0.237 0.237
Brugia malayi hypothetical protein 0.0142 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0411 0.1399 0.1399
Mycobacterium ulcerans alpha-mannosidase 0.0206 0.056 0.1038
Entamoeba histolytica glycogen phosphorylase, putative 0.0304 0.0961 0.2558
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0528 0.1216
Echinococcus multilocularis bile acid beta glucosidase 0.0244 0.0714 0.0714
Brugia malayi Glycosyl hydrolases family 2, sugar binding domain containing protein 0.0302 0.0952 0.0952
Trichomonas vaginalis glycoside hydrolases, putative 0.1126 0.4341 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.032 0.1028 0.2367
Brugia malayi follicle stimulating hormone receptor 0.025 0.0741 0.0741
Loa Loa (eye worm) hypothetical protein 0.0339 0.1104 0.1104
Loa Loa (eye worm) TRE-1 protein 0.0411 0.1399 0.1399
Echinococcus multilocularis lysosomal alpha glucosidase 0.2503 1 1
Schistosoma mansoni alpha-amylase 0.0167 0.0397 0.0453
Onchocerca volvulus Glycogen phosphorylase homolog 0.0703 0.2601 0.32
Trichomonas vaginalis alpha-mannosidase, putative 0.0206 0.056 0.1291
Onchocerca volvulus 0.0411 0.1399 0.1721
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0956 0.2202
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0647 0.237 0.8953
Loa Loa (eye worm) hypothetical protein 0.0411 0.1399 0.1399
Schistosoma mansoni hypothetical protein 0.0409 0.1394 0.1588
Trichomonas vaginalis glycogen phosphorylase, putative 0.0703 0.2601 0.5992
Trichomonas vaginalis alpha-glucosidase, putative 0.0647 0.237 0.546
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0227 0.0227
Trichomonas vaginalis alpha-glucosidase, putative 0.032 0.1028 0.2367
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0227 0.0227
Onchocerca volvulus 0.0253 0.0753 0.0926
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0647 0.237 0.237
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0274 0.084 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.0741 0.0741
Schistosoma mansoni mannosidase alpha class 2a 0.0096 0.0106 0.012
Entamoeba histolytica glycogen phosphorylase, putative 0.0703 0.2601 1
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.0606 0.069
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0416 0.1423 0.1423
Loa Loa (eye worm) TRE-2 protein 0.0411 0.1399 0.1399
Entamoeba histolytica glycogen debranching enzyme, putative 0.0562 0.202 0.7364
Schistosoma mansoni bile acid beta-glucosidase-related 0.0244 0.0714 0.0814
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0139 0.0285 0.0656
Onchocerca volvulus 0.0096 0.0106 0.013
Loa Loa (eye worm) hypothetical protein 0.0411 0.1399 0.1399
Loa Loa (eye worm) trehalase 0.0142 0.0296 0.0296
Onchocerca volvulus 0.0411 0.1399 0.1721
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0339 0.1105 0.1105
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0096 0.0106 0.012
Onchocerca volvulus 0.0096 0.0106 0.013
Trichomonas vaginalis set domain proteins, putative 0.0253 0.0753 0.1735
Echinococcus granulosus beta mannosidase 0.0159 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0165 0.0389 0.0389
Schistosoma mansoni hypothetical protein 0.0187 0.0479 0.0545
Echinococcus multilocularis glycogen debranching enzyme 0.0562 0.202 0.202
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0647 0.237 1
Trypanosoma brucei glucosidase, putative 0.0647 0.237 1
Echinococcus granulosus glycogen phosphorylase 0.0703 0.2601 0.2601
Trypanosoma cruzi inosine-adenosine-guanosine-nucleosidehydrolase, putative 0.0468 0.1636 0.6758
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.032 0.1028 0.4072
Trichomonas vaginalis glucosylceramidase, putative 0.0209 0.0572 0.1318
Schistosoma mansoni alpha-amylase 0.0167 0.0397 0.0453
Trypanosoma brucei inosine-adenosine-guanosine-nucleosidehydrolase 0.0468 0.1636 0.6758
Schistosoma mansoni thyroid hormone receptor 0.0135 0.0269 0.0306
Brugia malayi Glycosyl hydrolases family 31 protein 0.0647 0.237 0.237
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.032 0.1028 0.4072
Loa Loa (eye worm) hypothetical protein 0.032 0.1028 0.1028
Onchocerca volvulus 0.2048 0.8129 1
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0528 0.1216
Entamoeba histolytica glycogen phosphorylase, putative 0.0304 0.0961 0.2558
Loa Loa (eye worm) hypothetical protein 0.0142 0.0296 0.0296
Schistosoma mansoni alpha-amylase 0.0167 0.0397 0.0453
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0217 0.0606 0.0606
Loa Loa (eye worm) hypothetical protein 0.0142 0.0296 0.0296
Echinococcus granulosus bile acid beta glucosidase 0.0244 0.0714 0.0714
Mycobacterium ulcerans alpha-L-fucosidase 0.1383 0.5396 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0339 0.1104 0.1257
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0167 0.0397 0.0397
Echinococcus granulosus glycogen debranching enzyme 0.0562 0.202 0.202
Entamoeba histolytica glycogen phosphorylase, putative 0.0703 0.2601 1
Echinococcus multilocularis snurportin 1 0.0339 0.1105 0.1105
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0528 0.1216
Echinococcus multilocularis Glycosyl transferase, family 35 0.0703 0.2601 0.2601
Mycobacterium tuberculosis Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas 0.0167 0.0397 0.4134
Loa Loa (eye worm) trehalase 0.0411 0.1399 0.1399
Loa Loa (eye worm) alpha-L-fucosidase 0.1016 0.3888 0.3888
Echinococcus granulosus geminin 0.0187 0.0479 0.0479
Brugia malayi Glycosyl hydrolases family 38 protein 0.0096 0.0106 0.0106
Echinococcus multilocularis glycogen phosphorylase 0.0703 0.2601 0.2601
Echinococcus granulosus lysosomal alpha glucosidase 0.2503 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.032 0.1028 0.2367
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0217 0.0606 0.0606
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0528 0.1216
Trichomonas vaginalis trehalase, putative 0.0411 0.1399 0.3223
Loa Loa (eye worm) alpha amylase 0.0167 0.0397 0.0397
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0339 0.1104 0.2543
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.032 0.1028 0.2367
Trichomonas vaginalis beta-galactosidase, putative 0.0639 0.2337 0.5383
Brugia malayi hypothetical protein 0.0126 0.023 0.023
Echinococcus multilocularis glycogen phosphorylase 0.0703 0.2601 0.2601
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0416 0.1423 0.162
Echinococcus granulosus Glycosyl transferase family 35 0.0703 0.2601 0.2601
Brugia malayi Beta-glucuronidase precursor 0.0279 0.0857 0.0857
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0956 0.2202
Trypanosoma cruzi hypothetical protein, conserved 0.0647 0.237 1
Trichomonas vaginalis alpha-glucosidase, putative 0.032 0.1028 0.2367
Schistosoma mansoni hypothetical protein 0.0125 0.0227 0.0259
Echinococcus multilocularis neutral alpha glucosidase AB 0.0647 0.237 0.237
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0339 0.1104 0.1257
Trichomonas vaginalis conserved hypothetical protein 0.0288 0.0896 0.2065
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0217 0.0606 0.0606
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.0269 0.0269

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.5 uM Inhibition of MK2 using biotin-LCAYSRALSRQLSSGVSEIRH substrate ChEMBL. 19423344

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.