Detailed information for compound 1370752

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 389.384 | Formula: C20H11N3O4S
  • H donors: 1 H acceptors: 5 LogP: 4.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C(\c1ccc(o1)c1cccc(c1)[N+](=O)[O-])/O)/c1nc2c(s1)cccc2
  • InChi: 1S/C20H11N3O4S/c21-11-14(20-22-15-6-1-2-7-18(15)28-20)19(24)17-9-8-16(27-17)12-4-3-5-13(10-12)23(25)26/h1-10,24H/b19-14-
  • InChiKey: ZWMNOZAEWUPYGZ-RGEXLXHISA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens myeloid cell leukemia 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0043 0.0254 0.038
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.046 0.1582
Trichomonas vaginalis sucrase-isomaltase, putative 0.0347 0.2613 0.6737
Loa Loa (eye worm) hypothetical protein 0.0032 0.0162 0.0162
Loa Loa (eye worm) beta-glucuronidase 0.0109 0.0766 0.0766
Loa Loa (eye worm) hypothetical protein 0.0172 0.1254 0.1254
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.375 0.375
Loa Loa (eye worm) hypothetical protein 0.0129 0.0916 0.0916
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0098 0.0303
Echinococcus multilocularis neutral alpha glucosidase AB 0.0377 0.2846 0.2846
Loa Loa (eye worm) hypothetical protein 0.0092 0.0629 0.0629
Trypanosoma brucei mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, putative 0.0013 0.0016 0.0015
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0093 0.0636 0.1615
Loa Loa (eye worm) hypothetical protein 0.0129 0.0916 0.0916
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1237 0.1237
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0083 0.0615
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0254 0.0254
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0283 1
Echinococcus multilocularis dna polymerase eta 0.0054 0.0337 0.0337
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0024 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0129 0.0916 0.0916
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0024 0.0042
Loa Loa (eye worm) trehalase 0.0129 0.0916 0.0916
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0098 0.0303
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0172 0.1254 0.3218
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0212 0.0706
Loa Loa (eye worm) hypothetical protein 0.0056 0.0351 0.0351
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0419 0.0419
Trichomonas vaginalis alpha-glucosidase, putative 0.0172 0.1254 0.3218
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0042 0.0105
Loa Loa (eye worm) hypothetical protein 0.0032 0.0162 0.0162
Trypanosoma brucei glycosyl hydrolase-like protein 0.0172 0.1254 0.4384
Trypanosoma brucei unspecified product 0.0023 0.0098 0.0303
Loa Loa (eye worm) TRE-1 protein 0.0129 0.0916 0.0916
Onchocerca volvulus Trehalase homolog 0.0129 0.0916 0.117
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0172 0.1254 0.4384
Loa Loa (eye worm) hypothetical protein 0.0088 0.0597 0.0597
Brugia malayi jmjC domain containing protein 0.0096 0.0663 0.0663
Brugia malayi hypothetical protein 0.0043 0.0254 0.0254
Loa Loa (eye worm) acetyltransferase 0.0175 0.1275 0.1275
Echinococcus granulosus alpha mannosidase 2 0.0032 0.0162 0.0162
Echinococcus granulosus beta galactosidase 0.0554 0.4213 0.4213
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0054 0.0337 0.0337
Echinococcus granulosus dnaJ subfamily B 0.0494 0.375 0.375
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0205 0.1505 0.1742
Schistosoma mansoni alpha glucosidase 0.0377 0.2846 0.3293
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0511 0.0511
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0419 0.1435
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0234 0.0234
Trichomonas vaginalis alpha-glucosidase, putative 0.0377 0.2846 0.7341
Trypanosoma cruzi hypothetical protein, conserved 0.0377 0.2846 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0098 0.0303
Mycobacterium ulcerans hypothetical protein 0.0029 0.0139 0.0085
Echinococcus granulosus peregrin 0.0034 0.0178 0.0178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0307 0.0355
Trichomonas vaginalis trehalase, putative 0.0129 0.0916 0.2343
Brugia malayi hypothetical protein 0.0045 0.0263 0.0263
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0012 0.0012 0.0012
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0029 0.0145 0.0168
Loa Loa (eye worm) RecQ helicase 0.0026 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0084 0.057 0.057
Brugia malayi Trehalase family protein 0.0129 0.0916 0.0916
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0139 0.0085
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0098 0.0038
Entamoeba histolytica hypothetical protein 0.0043 0.0254 0.038
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0083 0.5
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0093 0.0636 0.1615
Schistosoma mansoni cpg binding protein 0.0037 0.0202 0.0233
Loa Loa (eye worm) trehalase 0.0129 0.0916 0.0916
Trichomonas vaginalis alpha-glucosidase, putative 0.0377 0.2846 0.7341
Schistosoma mansoni hypothetical protein 0.01 0.0693 0.0802
Onchocerca volvulus Alhambra homolog 0.0029 0.0145 0.0185
Onchocerca volvulus Glucosylceramidase homolog 0.0334 0.2512 0.3208
Loa Loa (eye worm) TRE-2 protein 0.0129 0.0916 0.0916
Loa Loa (eye worm) hypothetical protein 0.0554 0.4213 0.4213
Schistosoma mansoni hypothetical protein 0.0133 0.0949 0.1099
Loa Loa (eye worm) hypothetical protein 0.0029 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0093 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0083
Brugia malayi trehalase I 0.0045 0.0263 0.0263
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.051 0.3872 0.3872
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0511 0.0511
Trichomonas vaginalis glucosylceramidase, putative 0.0334 0.2512 0.6477
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0083 0.0014
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0117 0.0272
Brugia malayi Glycosyl hydrolases family 2, sugar binding domain containing protein 0.0119 0.0837 0.0837
Schistosoma mansoni DNA polymerase eta 0.0054 0.0337 0.039
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0098 0.0303
Mycobacterium ulcerans alpha-mannosidase 0.0138 0.0989 0.1375
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0098 0.0303
Trichomonas vaginalis glucosylceramidase, putative 0.0352 0.2652 0.6839
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0093 0.0636 0.1615
Onchocerca volvulus Huntingtin homolog 0.0148 0.1065 0.136
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0011
Loa Loa (eye worm) manba-prov protein 0.0079 0.0531 0.0531
Echinococcus granulosus mannosyl oligosaccharide 12 alpha mannosidase 0.0093 0.0636 0.0636
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0098 0.0098
Echinococcus granulosus lysosomal alpha mannosidase 0.0123 0.0874 0.0874
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0098 0.0023
Schistosoma mansoni cpg binding protein 0.0035 0.0186 0.0216
Brugia malayi Trehalase family protein 0.0129 0.0916 0.0916
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0283 0.2254
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0317 0.1075
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) trehalase 0.0045 0.0263 0.0263
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0093 0.0636 0.1615
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0098 0.0113
Entamoeba histolytica beta-galactosidase, putative 0.0119 0.0837 0.1294
Schistosoma mansoni hypothetical protein 0.0205 0.1505 0.1742
Trypanosoma cruzi mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, putative 0.0013 0.0016 0.0015
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0419 0.1435
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0307 0.0307
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0093 0.0636 0.1615
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0377 0.2846 0.7341
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0083
Leishmania major DNA polymerase kappa, putative 0.0023 0.0098 0.0303
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0419 0.1435
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0208 0.0208
Trypanosoma cruzi mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, putative 0.0013 0.0016 0.0015
Schistosoma mansoni hypothetical protein 0.0043 0.0254 0.0294
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0056 0.0351 0.0407
Schistosoma mansoni hypothetical protein 0.01 0.0693 0.0802
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0511 0.0591
Loa Loa (eye worm) hypothetical protein 0.0129 0.0916 0.0916
Loa Loa (eye worm) hypothetical protein 0.0129 0.0916 0.0916
Loa Loa (eye worm) glycosyl hydrolase family 2 0.0119 0.0837 0.0837
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.01 0.0693 0.0693
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0139 0.0139
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.0949 0.0949
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0208 0.0208
Schistosoma mansoni thyroid hormone receptor 0.0144 0.1032 0.1195
Entamoeba histolytica alpha-1,2-mannosidase, putative 0.0834 0.6388 1
Loa Loa (eye worm) trehalase 0.0045 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0045 0.0263 0.0263
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0093 0.0636 0.1615
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0098 0.0303
Echinococcus granulosus cpg binding protein 0.0037 0.0202 0.0202
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0307 0.0355
Echinococcus multilocularis er degradation enhancing alpha mannosidase er degradation enhancer mannosidase alpha 0.0013 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0011
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0098 0.0303
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0098 0.0098
Brugia malayi manba-prov protein 0.0189 0.138 0.138
Trypanosoma cruzi mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, putative 0.0013 0.0016 0.0015
Schistosoma mansoni hypothetical protein 0.0119 0.0837 0.0969
Trichomonas vaginalis alpha-glucosidase, putative 0.0172 0.1254 0.3218
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0145 0.0145
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0387 0.0387
Trichomonas vaginalis alpha-glucosidase, putative 0.0377 0.2846 0.7341
Echinococcus granulosus beta mannosidase 0.0079 0.0531 0.0531
Brugia malayi hypothetical protein 0.0045 0.0263 0.0263
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0098 0.0303
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0093 0.0636 0.1615
Entamoeba histolytica hypothetical protein 0.0043 0.0254 0.038
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0052 0.0363
Trypanosoma brucei mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, putative 0.0013 0.0016 0.0015
Echinococcus granulosus er degradation enhancing alpha mannosidase 0.0013 0.0016 0.0016
Leishmania major DNA polymerase eta, putative 0.0054 0.0337 0.1146
Trichomonas vaginalis beta-glucosidase, putative 0.0395 0.2981 0.7692
Echinococcus multilocularis cpg binding protein 0.0037 0.0202 0.0202
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.1299 1 1
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0231 0.171 0.4398
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.005 0.0307 0.0307
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0013 0.0016 0.0011
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1275 0.1275
Trypanosoma brucei glucosidase, putative 0.0377 0.2846 1
Echinococcus granulosus tar DNA binding protein 0.0076 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0148 0.1065 0.1065
Echinococcus multilocularis lysosomal alpha glucosidase 0.1299 1 1
Schistosoma mansoni hypothetical protein 0.01 0.0693 0.0802
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0117 0.0117
Giardia lamblia PHD finger protein 15 0.0029 0.0145 0.4896
Echinococcus granulosus lysosomal alpha glucosidase 0.1299 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0139 0.0085
Echinococcus granulosus alpha mannosidase 2 0.0026 0.0121 0.0121
Echinococcus granulosus er degradation enhancing alpha mannosidase 0.0013 0.0016 0.0016
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0317 0.2526
Schistosoma mansoni jumonji domain containing protein 0.0076 0.051 0.059
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0013 0.0016 0.0011
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0123 0.0874 0.1011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.2088 0.2088
Schistosoma mansoni mannosyl-oligosaccharidealpha-12-mannosidase-r el ated 0.0013 0.0016 0.0019
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0083 0.0615
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0169 0.123 1
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0012 0.0033
Echinococcus granulosus endoplasmic reticulum mannosyl oligosaccharide 0.0093 0.0636 0.0636
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0098 0.0303
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0139 0.02
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0098 0.0303
Loa Loa (eye worm) mannosidase 0.0093 0.0636 0.0636
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.0123 0.0874 0.3042
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.01 0.0693 0.0693
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0212 0.0706
Onchocerca volvulus 0.0129 0.0916 0.117
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0012 0.0012 0.0012
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0093 0.0636 0.1615
Trypanosoma cruzi hypothetical protein, conserved 0.0377 0.2846 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0377 0.2846 0.7341
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0042 0.0105
Giardia lamblia DINP protein human, muc B family 0.0023 0.0098 0.317
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0511 0.0591
Brugia malayi follicle stimulating hormone receptor 0.028 0.2088 0.2088
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0088 0.0597 0.069
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0139 0.02
Echinococcus multilocularis ER degradation enhancer, mannosidase alpha 0.0013 0.0016 0.0016
Brugia malayi Alpha-mannosidase C1orf22 0.0013 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0636 0.1615
Schistosoma mansoni beta-mannosidase 0.0079 0.0531 0.0615
Onchocerca volvulus 0.0129 0.0916 0.117
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0097 0.067 0.2322
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0208 0.0241
Schistosoma mansoni er degradation-enhancing alpha-mannosidase-like 0.0013 0.0016 0.0019
Brugia malayi Trehalase family protein 0.0045 0.0263 0.0263
Trichomonas vaginalis glycoside hydrolases, putative 0.0395 0.2981 0.7692
Brugia malayi Glycosyl hydrolase family 47 protein 0.0013 0.0016 0.0016
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0317 0.0789
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0307 0.0307
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0006 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0169 0.123 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0377 0.2846 0.7341
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0317 0.0317
Echinococcus granulosus CTD small phosphatase protein like 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0029 0.0139 0.0139
Echinococcus multilocularis er degradation enhancing alpha mannosidase er degradation enhancer mannosidase alpha 0.0013 0.0016 0.0016
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.01 0.0693 0.0802
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0172 0.1254 0.3218
Brugia malayi jmjC domain containing protein 0.0037 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.008 0.0537 0.0537
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0098 0.0023
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0254 0.0294
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0093 0.0636 0.1615
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0032 0.0162 0.0162
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0139 0.0103
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1036 0.1036
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0511 0.0511
Echinococcus granulosus er degradation enhancing alpha mannosidase 0.0013 0.0016 0.0016
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.0949 0.0949
Trichomonas vaginalis maltase-glucoamylase, putative 0.0172 0.1254 0.3218
Entamoeba histolytica hypothetical protein 0.0043 0.0254 0.038
Onchocerca volvulus Huntingtin homolog 0.0148 0.1065 0.136
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0013 0.0016 0.0011
Brugia malayi MH2 domain containing protein 0.0144 0.1036 0.1036
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0123 0.0874 0.3042
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0013 0.0016 0.0011
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0098 0.0223
Onchocerca volvulus 0.0029 0.0139 0.0178
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0663 0.0663
Trichomonas vaginalis beta-mannosidase, putative 0.0079 0.0531 0.1345
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0098 0.0135
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0093 0.0636 0.1615
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0138 0.0989 0.2532
Mycobacterium tuberculosis Possible conserved exported protein 0.0834 0.6388 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0098 0.0303
Echinococcus multilocularis alpha mannosidase 2 0.0088 0.0597 0.0597
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0098 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0172 0.1254 0.3218
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0231 0.171 0.4398
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0098 0.0113
Brugia malayi Alpha-L-fucosidase family protein 0.0527 0.4003 0.4003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0307 0.0355
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0139 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.3872 1
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0234 0.0234
Onchocerca volvulus 0.0088 0.0597 0.0762
Echinococcus multilocularis beta galactosidase 0.0554 0.4213 0.4213
Leishmania major DNA polymerase eta, putative 0.0038 0.0212 0.0706
Brugia malayi Glycosyl hydrolases family 38 protein 0.0088 0.0597 0.0597
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0075 0.0087
Trypanosoma cruzi mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, putative 0.0013 0.0016 0.0015
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0013 0.0016 0.0011
Schistosoma mansoni thyroid hormone receptor 0.0144 0.1032 0.1195
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0012 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0334 0.2512 0.6477
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0042 0.0105
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0117 0.0272
Trypanosoma brucei unspecified product 0.0016 0.0042 0.0105
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0082 0.0555 0.1407
Brugia malayi Alpha-mannosidase C1orf22 0.0013 0.0016 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0145 0.112
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0098 0.0303
Onchocerca volvulus 0.0129 0.0916 0.117
Loa Loa (eye worm) hypothetical protein 0.0554 0.4213 0.4213
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0207 0.0207
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0317 0.0789
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0139 0.0085
Echinococcus multilocularis beta mannosidase 0.0079 0.0531 0.0531
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0419 0.1435
Onchocerca volvulus 0.0129 0.0916 0.117
Loa Loa (eye worm) hypothetical protein 0.0045 0.0263 0.0263
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.3872 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1275 0.1476
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Brugia malayi Glycosyl hydrolases family 38 protein 0.0088 0.0597 0.0597
Brugia malayi PHD-finger family protein 0.0029 0.0145 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0098 0.0303
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0419 0.0485
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0098 0.0303
Brugia malayi Bromodomain containing protein 0.0034 0.0178 0.0178
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0012 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0139 0.0449
Brugia malayi RNA binding protein 0.0076 0.0511 0.0511
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0511 0.0591
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.0145
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0511 0.0591
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0011
Brugia malayi Glycosyl hydrolases family 31 protein 0.0377 0.2846 0.2846
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0347 0.2613 0.4079
Loa Loa (eye worm) hypothetical protein 0.0093 0.0636 0.0636
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0093 0.0636 0.1615
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.01 0.0693 0.0693
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.01 0.0693 0.0693
Brugia malayi TAR-binding protein 0.0076 0.0511 0.0511
Echinococcus multilocularis 0.0012 0.0012 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0139 0.0139
Echinococcus multilocularis mannosyl oligosaccharide 1,2 alpha mannosidase 0.0093 0.0636 0.0636
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0511 0.0591
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0139 0.0449
Trichomonas vaginalis glucosylceramidase, putative 0.0334 0.2512 0.6477
Brugia malayi CXXC zinc finger family protein 0.0035 0.0186 0.0186
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0419 0.0638
Trichomonas vaginalis beta-galactosidase, putative 0.0228 0.1687 0.4338
Treponema pallidum hypothetical protein 0.0045 0.0263 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0172 0.1254 0.3218
Brugia malayi Trehalase family protein 0.0129 0.0916 0.0916
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.0871 0.6675 0.6675
Schistosoma mansoni hypothetical protein 0.0012 0.0011 0.0013
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.6384 0.6384
Trypanosoma cruzi mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, putative 0.0013 0.0016 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0377 0.2846 0.7341
Loa Loa (eye worm) hypothetical protein 0.0045 0.0263 0.0263
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0098 0.0303
Schistosoma mansoni alpha-glucosidase 0.1124 0.8642 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0511 0.0511
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0139 0.0139
Brugia malayi Glycosyl hydrolases family 38 protein 0.0138 0.0989 0.0989
Brugia malayi Trehalase family protein 0.0129 0.0916 0.0916
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0093 0.0695
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0098 0.0098
Trichomonas vaginalis glucosylceramidase, putative 0.0334 0.2512 0.6477
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0377 0.2846 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0263 0.0263
Schistosoma mansoni alpha-l-fucosidase 0.0527 0.4003 0.4632
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0093 0.0636 0.1615
Loa Loa (eye worm) trehalase 0.0129 0.0916 0.0916
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0663 0.0663
Brugia malayi ER degradation-enhancing alpha-mannosidase-like, putative 0.0013 0.0016 0.0016
Schistosoma mansoni mannosidase alpha class 2a 0.0088 0.0597 0.069
Loa Loa (eye worm) hypothetical protein 0.0148 0.1065 0.1065
Echinococcus multilocularis er degradation enhancing alpha mannosidase 0.0013 0.0016 0.0016
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0098 0.0098
Schistosoma mansoni beta-galactosidase 0.0554 0.4213 0.4875
Echinococcus granulosus er degradation enhancer mannosidase alpha 0.0013 0.0016 0.0016
Echinococcus granulosus fucosidase alpha L 1 tissue 0.0871 0.6675 0.6675
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.3872 1
Brugia malayi Alpha-mannosidase C1orf22 0.0013 0.0016 0.0016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0208 0.0241
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0419 0.0419
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0283 0.0426
Brugia malayi PHD-finger family protein 0.0012 0.0007 0.0007
Leishmania major glycosyl hydrolase-like protein 0.0172 0.1254 0.4384
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.051 0.3872 0.3872
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1275 0.1275
Echinococcus multilocularis endoplasmic reticulum mannosyl oligosaccharide 0.0093 0.0636 0.0636
Loa Loa (eye worm) RNA binding protein 0.0076 0.0511 0.0511
Brugia malayi hypothetical protein 0.0045 0.0263 0.0263
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.01 0.0693 0.0693
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0098 0.0223
Plasmodium falciparum phd finger protein, putative 0.0029 0.0145 0.112
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0139 0.0085
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0012 0.0012 0.0033
Trichomonas vaginalis alpha-glucosidase, putative 0.0377 0.2846 0.7341
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0145 0.0168
Trichomonas vaginalis glucosylceramidase, putative 0.0334 0.2512 0.6477
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0139 0.0085
Loa Loa (eye worm) glycosyl hydrolase family 38 protein 0.0138 0.0989 0.0989
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0058 0.0068
Trichomonas vaginalis Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform, putative 0.0013 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Trypanosoma brucei mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, putative 0.0013 0.0016 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.3872 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0145 0.0469
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0307 0.0307
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0317 0.1075
Echinococcus granulosus dna polymerase eta 0.0054 0.0337 0.0337
Trypanosoma cruzi mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, putative 0.0013 0.0016 0.0015
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.1254 0.1254
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0012 0.0014
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0098 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0098 0.0303
Brugia malayi Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1 0.0093 0.0636 0.0636
Brugia malayi Trehalase protein 5 0.0045 0.0263 0.0263
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.3872 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0377 0.2846 0.4445
Onchocerca volvulus 0.0129 0.0916 0.117
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0093 0.0636 0.1615
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0307 0.0307
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0488 0.0565
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0088 0.0597 0.0597
Onchocerca volvulus 0.102 0.7831 1
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0024 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.0334 0.2512 0.6477
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0145 0.0145
Onchocerca volvulus 0.0088 0.0597 0.0762
Brugia malayi Beta-glucuronidase precursor 0.0109 0.0766 0.0766
Echinococcus granulosus neutral alpha glucosidase AB 0.0377 0.2846 0.2846
Trichomonas vaginalis glycoside hydrolase, putative 0.0228 0.1687 0.4338
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0139 0.02
Trichomonas vaginalis alpha-mannosidase, putative 0.0138 0.0989 0.2532
Leishmania major alpha glucosidase II subunit, putative 0.0377 0.2846 1
Schistosoma mansoni mannosyl-oligosaccharide alpha-12-mannosidase 0.0093 0.0636 0.0735
Trypanosoma brucei unspecified product 0.0016 0.0042 0.0105
Brugia malayi hypothetical protein 0.0129 0.0916 0.0916
Onchocerca volvulus 0.0035 0.0186 0.0238
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0139 0.0103
Trichomonas vaginalis glucosylceramidase, putative 0.0334 0.2512 0.6477
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0083
Mycobacterium ulcerans alpha-L-fucosidase 0.0871 0.6675 1
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0337 0.1146
Schistosoma mansoni mannosyl-oligosaccharidealpha-12-mannosidase-r el ated 0.0013 0.0016 0.0019
Trypanosoma brucei mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, putative 0.0013 0.0016 0.0015
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0337 0.1146
Brugia malayi hypothetical protein 0.0148 0.1065 0.1065
Loa Loa (eye worm) hypothetical protein 0.01 0.0693 0.0693
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.1032 0.1032
Echinococcus granulosus microtubule associated protein 2 0.0833 0.6384 0.6384
Echinococcus multilocularis peregrin 0.0034 0.0178 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0916 0.2343
Echinococcus multilocularis transfer RNA-Trp 0.0093 0.0636 0.0636
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0098 0.0303
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0172 0.1254 0.1948
Brugia malayi trehalase 0.0045 0.0263 0.0263
Echinococcus multilocularis lysosomal alpha mannosidase 0.0123 0.0874 0.0874
Loa Loa (eye worm) apoptosis regulator protein 0.01 0.0693 0.0693
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1036 0.1036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0307 0.0307
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0207 0.0207
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0117 0.0117
Echinococcus multilocularis geminin 0.0205 0.1505 0.1505
Trichomonas vaginalis conserved hypothetical protein 0.0228 0.1687 0.4338
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0172 0.1254 0.1602
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0139 0.0085
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0098 0.0303
Trichomonas vaginalis alpha-glucosidase, putative 0.0172 0.1254 0.3218
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0051 0.0137
Echinococcus multilocularis lysosomal alpha glucosidase 0.1299 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0139 0.0449
Brugia malayi Alpha-mannosidase C1orf22 0.0013 0.0016 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.3872 1
Trichomonas vaginalis glucosylceramidase, putative 0.0352 0.2652 0.6839
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.6384 0.7388
Echinococcus granulosus geminin 0.0205 0.1505 0.1505
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0186 0.0186
Loa Loa (eye worm) alpha-L-fucosidase 0.0527 0.4003 0.4003
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0419 0.0419
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0172 0.1254 0.4384
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0024 0.0042
Schistosoma mansoni apoptosis regulator bax 0.01 0.0693 0.0802
Schistosoma mansoni hypothetical protein 0.0494 0.375 0.434
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0145 0.0145
Brugia malayi lysosomal alpha-mannosidase 0.0088 0.0597 0.0597
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.0123 0.0874 0.3042
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0011
Schistosoma mansoni alpha-glucosidase 0.1124 0.8642 1
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0337 0.0337
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0077 0.0514 0.13
Echinococcus granulosus bloom syndrome protein 0.0026 0.0117 0.0117
Brugia malayi Trehalase family protein 0.0045 0.0263 0.0263
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0024 0.0019
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0254 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0011
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0377 0.2846 0.2846
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0145 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0011
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0139 0.5
Trichomonas vaginalis Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA, putative 0.0013 0.0016 0.0011
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0419 0.0419
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0162 0.0389
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0139 0.0085
Echinococcus granulosus dna polymerase kappa 0.0023 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0029 0.0139 0.0139
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0013 0.0016 0.0011
Schistosoma mansoni cpg binding protein 0.0037 0.0202 0.0233

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 120 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
IC50 (functional) = 5.375381589 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1022 (Primary screen preceding this dose-response assay.)] ChEMBL. No reference
Potency (functional) 0.7308 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.3934 uM PUBCHEM_BIOASSAY: qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.0131 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 6.3096 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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