Detailed information for compound 25152

Basic information

Technical information
  • TDR Targets ID: 25152
  • Name: 2-[2-(diaminomethylidene)hydrazinyl]butanoic acid
  • MW: 160.174 | Formula: C5H12N4O2
  • H donors: 4 H acceptors: 2 LogP: -0.31 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(C(=O)O)NN=C(N)N
  • InChi: 1S/C5H12N4O2/c1-2-3(4(10)11)8-9-5(6)7/h3,8H,2H2,1H3,(H,10,11)(H4,6,7,9)
  • InChiKey: DJCOQURDTBKSIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[N'-(diaminomethylene)hydrazino]butanoic acid
  • 2-[2-[bis(azanyl)methylidene]hydrazinyl]butanoic acid
  • 2-[N'-(diaminomethylene)hydrazino]butyric acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis maltase-glucoamylase, putative 0.0776 0.2324 0.29
Echinococcus multilocularis transfer RNA-Trp 0.0146 0.0356 0.0356
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0146 0.0356 0.0439
Toxoplasma gondii alpha amylase, catalytic domain-containing protein 0.0037 0.0015 0.0065
Mycobacterium tuberculosis Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas 0.0153 0.038 0.1422
Onchocerca volvulus Putative phosphorylase b kinase regulatory subunit alpha 0.0068 0.0114 0.0141
Echinococcus multilocularis Glycosyl transferase, family 35 0.1017 0.3076 0.3076
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0403 0.116 0.4849
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Echinococcus granulosus lysosomal alpha mannosidase 0.0218 0.0581 0.0581
Entamoeba histolytica beta/alpha-amylase precursor, putative 0.0037 0.0015 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.2594 0.8003 1
Onchocerca volvulus 0.0181 0.0466 0.0575
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0282 0.078 0.078
Schistosoma mansoni beta-galactosidase 0.1008 0.3048 0.3413
Trichomonas vaginalis glycoside hydrolases, putative 0.1063 0.3219 0.4019
Loa Loa (eye worm) TRE-2 protein 0.0269 0.0741 0.0741
Echinococcus granulosus beta mannosidase 0.0164 0.0412 0.0412
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Schistosoma mansoni hypothetical protein 0.0404 0.1163 0.1302
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0383 0.1096 0.1228
Onchocerca volvulus 0.0269 0.0741 0.0913
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0096 0.0108
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0096 0.0096
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0776 0.2324 0.7552
Schistosoma mansoni bile acid beta-glucosidase-related 0.0417 0.1204 0.1348
Brugia malayi Beta-glucuronidase precursor 0.0338 0.0955 0.0955
Entamoeba histolytica glycogen phosphorylase, putative 0.044 0.1274 0.4131
Echinococcus multilocularis endoplasmic reticulum mannosyl oligosaccharide 0.0146 0.0356 0.0356
Loa Loa (eye worm) trehalase 0.0269 0.0741 0.0741
Toxoplasma gondii 1,4-alpha-glucan-branching enzyme 0.0037 0.0015 0.0065
Echinococcus multilocularis mannosyl oligosaccharide 1,2 alpha mannosidase 0.0146 0.0356 0.0356
Brugia malayi Trehalase family protein 0.0269 0.0741 0.0741
Trichomonas vaginalis alpha-glucosidase, putative 0.0776 0.2324 0.29
Echinococcus multilocularis glycogen phosphorylase 0.1017 0.3076 0.3076
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0218 0.0581 0.2287
Loa Loa (eye worm) hypothetical protein 0.0269 0.0741 0.0741
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.032 0.0901 0.5
Onchocerca volvulus 0.0269 0.0741 0.0913
Trichomonas vaginalis alpha-mannosidase, putative 0.0338 0.0958 0.1191
Brugia malayi Trehalase family protein 0.0093 0.0192 0.0192
Schistosoma mansoni alpha glucosidase 0.0776 0.2324 0.2603
Brugia malayi TAR-binding protein 0.0063 0.0096 0.0096
Schistosoma mansoni alpha-glucosidase 0.2891 0.893 1
Loa Loa (eye worm) glycosyl hydrolase family 38 protein 0.0338 0.0958 0.0958
Brugia malayi Glycosyl hydrolases family 38 protein 0.0181 0.0466 0.0466
Brugia malayi Trehalase protein 5 0.0093 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0093 0.0192 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0114 0.0137
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0146 0.0356 0.0439
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0181 0.0466 0.0466
Leishmania major alpha glucosidase II subunit, putative 0.0776 0.2324 1
Mycobacterium ulcerans maltooligosyltrehalose synthase TreX 0.0037 0.0015 0.002
Schistosoma mansoni hypothetical protein 0.0033 0.0005 0.0006
Loa Loa (eye worm) TRE-1 protein 0.0269 0.0741 0.0741
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0776 0.2324 0.29
Trichomonas vaginalis alpha-glucosidase, putative 0.0776 0.2324 0.29
Echinococcus granulosus mannosyl oligosaccharide 12 alpha mannosidase 0.0146 0.0356 0.0356
Schistosoma mansoni mannosidase alpha class 2a 0.0181 0.0466 0.0522
Brugia malayi hypothetical protein 0.0123 0.0286 0.0286
Echinococcus multilocularis thyroid hormone receptor alpha 0.0148 0.0362 0.0362
Trypanosoma brucei glucosidase, putative 0.0776 0.2324 1
Trypanosoma cruzi inosine-adenosine-guanosine-nucleosidehydrolase, putative 0.0456 0.1326 0.5583
Toxoplasma gondii glycosyltransferase 0.0037 0.0015 0.0065
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0096 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.2594 0.8003 1
Schistosoma mansoni alpha-l-fucosidase 0.134 0.4084 0.4573
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0776 0.2324 0.2324
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0146 0.0356 0.0439
Trypanosoma cruzi inosine-adenosine-guanosine-nucleosidehydrolase, putative 0.0456 0.1326 0.5583
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0096 0.0096
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0146 0.0356 0.0439
Giardia lamblia Hypothetical protein 0.0052 0.0064 0.0161
Trichomonas vaginalis glycoside hydrolase, putative 0.102 0.3085 0.3851
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0037 0.0015 0.0033
Brugia malayi lysosomal alpha-mannosidase 0.0181 0.0466 0.0466
Entamoeba histolytica glycogen phosphorylase, putative 0.1017 0.3076 1
Entamoeba histolytica hypothetical protein 0.0037 0.0015 0.0033
Schistosoma mansoni hypothetical protein 0.033 0.0933 0.1044
Schistosoma mansoni glycogen phosphorylase 0.1017 0.3076 0.3445
Brugia malayi Glycosyl hydrolases family 38 protein 0.0338 0.0958 0.0958
Echinococcus granulosus lysosomal alpha glucosidase 0.3234 1 1
Loa Loa (eye worm) hypothetical protein 0.0269 0.0741 0.0741
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0072 0.031
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0137 0.0328 0.0328
Loa Loa (eye worm) manba-prov protein 0.0164 0.0412 0.0412
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0383 0.1096 0.1096
Trichomonas vaginalis amylase, putative 0.0037 0.0015 0.0013
Brugia malayi trehalase 0.0093 0.0192 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.2594 0.8003 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.3234 1 1
Onchocerca volvulus Trehalase homolog 0.0269 0.0741 0.0913
Loa Loa (eye worm) glycogen phosphorylase 0.1017 0.3076 0.3076
Mycobacterium ulcerans alpha-mannosidase 0.0338 0.0958 0.1835
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0096 0.0108
Entamoeba histolytica beta-galactosidase, putative 0.0477 0.1391 0.4512
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0052 0.0064 0.0074
Schistosoma mansoni alpha-amylase 0.0153 0.038 0.0425
Brugia malayi carbohydrate phosphorylase 0.1017 0.3076 0.3076
Schistosoma mansoni beta-mannosidase 0.0275 0.0759 0.085
Trichomonas vaginalis glucosylceramidase, putative 0.1702 0.5217 0.6516
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.1696 0.5196 0.5196
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0244 0.0664 0.0664
Trichomonas vaginalis beta-galactosidase, putative 0.0815 0.2446 0.3051
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0776 0.2324 0.29
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0746 0.223 0.7243
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0588 0.1736 0.2164
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0403 0.116 0.1444
Loa Loa (eye worm) hypothetical protein 0.0549 0.1615 0.1615
Echinococcus multilocularis snurportin 1 0.033 0.0933 0.0933
Entamoeba histolytica alpha-amylase family protein 0.0037 0.0015 0.0033
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0153 0.038 0.038
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0181 0.0466 0.0466
Loa Loa (eye worm) alpha-L-fucosidase 0.134 0.4084 0.4084
Echinococcus granulosus snurportin 1 0.033 0.0933 0.0933
Trichomonas vaginalis set domain proteins, putative 0.0248 0.0675 0.0838
Trichomonas vaginalis conserved hypothetical protein 0.0815 0.2446 0.3051
Loa Loa (eye worm) mannosidase 0.0146 0.0356 0.0356
Echinococcus multilocularis phosphorylase b kinase regulatory 0.0068 0.0114 0.0114
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0096 0.0096
Trichomonas vaginalis alpha-glucosidase, putative 0.0403 0.116 0.1444
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0163 0.0411 0.1535
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0311 0.0873 0.0978
Brugia malayi hypothetical protein 0.0068 0.0114 0.0114
Trichomonas vaginalis maltase-glucoamylase, putative 0.0403 0.116 0.1444
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0383 0.1096 0.1228
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0311 0.0873 0.1086
Toxoplasma gondii melibiase subfamily protein 0.0383 0.1096 0.4716
Echinococcus multilocularis glycogen debranching enzyme 0.0549 0.1615 0.1615
Loa Loa (eye worm) hypothetical protein 0.0311 0.0873 0.0873
Trichomonas vaginalis glucosylceramidase, putative 0.1702 0.5217 0.6516
Mycobacterium tuberculosis Possible conserved exported protein 0.0858 0.2579 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.3234 1 1
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Brugia malayi Glycosyl hydrolases family 2, sugar binding domain containing protein 0.0366 0.1043 0.1043
Brugia malayi trehalase I 0.0093 0.0192 0.0192
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0137 0.0328 0.0328
Echinococcus multilocularis beta mannosidase 0.0164 0.0412 0.0412
Giardia lamblia Glycogen phosphorylase 0.1017 0.3076 1
Leishmania major inosine-adenosine-guanosine-nucleoside hydrolase, putative 0.0456 0.1326 0.5583
Echinococcus multilocularis lysosomal alpha glucosidase 0.3234 1 1
Echinococcus multilocularis lysosomal alpha mannosidase 0.0218 0.0581 0.0581
Chlamydia trachomatis glycogen phosphorylase 0.1017 0.3076 1
Loa Loa (eye worm) amylo-alpha-1,6-glucosidase 0.0267 0.0735 0.0735
Loa Loa (eye worm) hypothetical protein 0.0068 0.0114 0.0114
Echinococcus granulosus trehalose 6 phosphate hydrolase 0.0037 0.0015 0.0015
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0153 0.038 0.038
Echinococcus multilocularis alpha mannosidase 2 0.0181 0.0466 0.0466
Echinococcus granulosus beta galactosidase 0.1008 0.3048 0.3048
Echinococcus granulosus glycogen phosphorylase 0.1017 0.3076 0.3076
Mycobacterium ulcerans trehalose synthase TreS 0.0037 0.0015 0.002
Brugia malayi Trehalase family protein 0.0269 0.0741 0.0741
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0146 0.0356 0.0439
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0092 0.0103
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.0218 0.0581 0.2287
Schistosoma mansoni alpha-amylase 0.0153 0.038 0.0425
Entamoeba histolytica alpha-amylase, putative 0.0037 0.0015 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.0356 0.0439
Trichomonas vaginalis sucrase-isomaltase, putative 0.0746 0.223 0.2782
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0105 0.0125
Brugia malayi RNA binding protein 0.0063 0.0096 0.0096
Schistosoma mansoni glycogen phosphorylase 0.1017 0.3076 0.3445
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.1163 0.1163
Echinococcus granulosus endoplasmic reticulum mannosyl oligosaccharide 0.0146 0.0356 0.0356
Trichomonas vaginalis alpha-glucosidase, putative 0.0403 0.116 0.1444
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0383 0.1096 0.1096
Echinococcus multilocularis bile acid beta glucosidase 0.0417 0.1204 0.1204
Loa Loa (eye worm) hypothetical protein 0.1008 0.3048 0.3048
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0146 0.0356 0.0439
Loa Loa (eye worm) alpha amylase 0.0153 0.038 0.038
Echinococcus multilocularis beta galactosidase 0.1008 0.3048 0.3048
Mycobacterium ulcerans glycosidase 0.0037 0.0015 0.002
Brugia malayi Pre-SET motif family protein 0.0218 0.0581 0.0581
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0146 0.0356 0.0439
Trichomonas vaginalis glucosylceramidase, putative 0.1702 0.5217 0.6516
Brugia malayi manba-prov protein 0.0501 0.1467 0.1467
Echinococcus granulosus alpha glucosidase 0.0153 0.038 0.038
Trichomonas vaginalis starch branching enzyme II, putative 0.0037 0.0015 0.0013
Onchocerca volvulus 0.0181 0.0466 0.0575
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0146 0.0356 0.0439
Trichomonas vaginalis beta-glucosidase, putative 0.1063 0.3219 0.4019
Loa Loa (eye worm) hypothetical protein 0.0093 0.0192 0.0192
Loa Loa (eye worm) trehalase 0.0269 0.0741 0.0741
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0096 0.0108
Echinococcus granulosus alpha mannosidase 2 0.0065 0.0105 0.0105
Trichomonas vaginalis glucosylceramidase, putative 0.2594 0.8003 1
Plasmodium vivax hypothetical protein, conserved 0.032 0.0901 1
Mycobacterium tuberculosis Conserved protein 0.0068 0.0114 0.0386
Echinococcus multilocularis glycogen phosphorylase 0.1017 0.3076 0.3076
Toxoplasma gondii Alpha-amylase AMY3, putative 0.0037 0.0015 0.0065
Loa Loa (eye worm) hypothetical protein 0.0269 0.0741 0.0741
Loa Loa (eye worm) hypothetical protein 0.0065 0.0105 0.0105
Loa Loa (eye worm) trehalase 0.0269 0.0741 0.0741
Echinococcus multilocularis geminin 0.0182 0.0469 0.0469
Trichomonas vaginalis amylase, putative 0.0037 0.0015 0.0013
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0146 0.0356 0.0439
Trypanosoma brucei glycosyl hydrolase-like protein 0.0403 0.116 0.4849
Schistosoma mansoni hypothetical protein 0.0037 0.0015 0.0017
Brugia malayi Melibiase family protein 0.0311 0.0873 0.0873
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0096 0.0096
Giardia lamblia 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase 0.0549 0.1615 0.5227
Entamoeba histolytica glycogen phosphorylase, putative 0.044 0.1274 0.4131
Trichomonas vaginalis hypothetical protein 0.0052 0.0064 0.0074
Trichomonas vaginalis amylase, putative 0.0037 0.0015 0.0013
Schistosoma mansoni alpha-amylase 0.0153 0.038 0.0425
Brugia malayi Trehalase family protein 0.0269 0.0741 0.0741
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0114 0.0137
Loa Loa (eye worm) hypothetical protein 0.0146 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0093 0.0192 0.0192
Entamoeba histolytica alpha-amylase family protein 0.0037 0.0015 0.0033
Schistosoma mansoni thyroid hormone receptor 0.0148 0.0362 0.0406
Onchocerca volvulus 0.0269 0.0741 0.0913
Trichomonas vaginalis conserved hypothetical protein 0.0282 0.0781 0.097
Trichomonas vaginalis glucosylceramidase, putative 0.1794 0.5503 0.6874
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0218 0.0581 0.0651
Loa Loa (eye worm) hypothetical protein 0.0065 0.0105 0.0105
Entamoeba histolytica alpha-amylase family protein 0.0037 0.0015 0.0033
Schistosoma mansoni mannosyl-oligosaccharide alpha-12-mannosidase 0.0146 0.0356 0.0399
Brugia malayi Glycosyl hydrolases family 31 protein 0.0403 0.116 0.116
Loa Loa (eye worm) hypothetical protein 0.0126 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0068 0.0114 0.0114
Mycobacterium ulcerans glycogen branching protein 0.0037 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0068 0.0114 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0015 0.0013
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0549 0.1615 0.2014
Trichomonas vaginalis trehalase, putative 0.0269 0.0741 0.092
Loa Loa (eye worm) hypothetical protein 0.0093 0.0192 0.0192
Entamoeba histolytica alpha-amylase family protein 0.0037 0.0015 0.0033
Echinococcus granulosus geminin 0.0182 0.0469 0.0469
Loa Loa (eye worm) trehalase 0.0093 0.0192 0.0192
Echinococcus granulosus Glycosyl transferase family 35 0.1017 0.3076 0.3076
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0052 0.0064 0.0074
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.0218 0.0581 0.2287
Onchocerca volvulus 0.0269 0.0741 0.0913
Onchocerca volvulus 0.2629 0.8112 1
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0037 0.0015 0.0033
Echinococcus multilocularis phosphorylase b kinase regulatory 0.0068 0.0114 0.0114
Brugia malayi hypothetical protein 0.0093 0.0192 0.0192
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0549 0.1615 0.2014
Brugia malayi Alpha-L-fucosidase family protein 0.134 0.4084 0.4084
Trypanosoma cruzi hypothetical protein, conserved 0.0776 0.2324 1
Schistosoma mansoni alpha-amylase 0.0153 0.038 0.0425
Trichomonas vaginalis glucosylceramidase, putative 0.1702 0.5217 0.6516
Brugia malayi hypothetical protein 0.0093 0.0192 0.0192
Loa Loa (eye worm) myosin heavy chain 0.0068 0.0114 0.0114
Schistosoma mansoni phosphorylase B kinase alpha kpb1 0.0068 0.0114 0.0128
Mycobacterium ulcerans maltooligosyltrehalose trehalohydrolase, TreZ 0.0037 0.0015 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.2594 0.8003 1
Schistosoma mansoni starch branching enzyme II 0.0037 0.0015 0.0017
Trichomonas vaginalis alpha-glucosidase, putative 0.0403 0.116 0.1444
Entamoeba histolytica alpha-amylase, putative 0.0037 0.0015 0.0033
Echinococcus granulosus alpha mannosidase 2 0.0054 0.0071 0.0071
Onchocerca volvulus Phosphorylase b kinase regulatory subunit beta homolog 0.0068 0.0114 0.0141
Onchocerca volvulus 0.0248 0.0675 0.0832
Loa Loa (eye worm) hypothetical protein 0.0116 0.0262 0.0262
Trichomonas vaginalis alpha-glucosidase, putative 0.0776 0.2324 0.29
Mycobacterium ulcerans glycosyl hydrolase 0.0068 0.0114 0.021
Toxoplasma gondii Amylo-alpha-1,6-glucosidase 0.0549 0.1615 0.695
Loa Loa (eye worm) hypothetical protein 0.0403 0.116 0.116
Echinococcus granulosus non lysosomal glucosylceramidase 0.0417 0.1204 0.1204
Entamoeba histolytica glycogen phosphorylase, putative 0.1017 0.3076 1
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0212 0.0562 0.0696
Echinococcus granulosus glycogen phosphorylase 0.1017 0.3076 0.3076
Echinococcus multilocularis neutral alpha glucosidase AB 0.0776 0.2324 0.2324
Schistosoma mansoni thyroid hormone receptor 0.0148 0.0362 0.0406
Schistosoma mansoni hypothetical protein 0.0182 0.0469 0.0525
Brugia malayi phosphorylase B kinase beta regulatory chain 0.0068 0.0114 0.0114
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0383 0.1096 0.1228
Trypanosoma brucei inosine-adenosine-guanosine-nucleosidehydrolase 0.0456 0.1326 0.5583
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0096 0.0108
Brugia malayi Glycosyl hydrolases family 38 protein 0.0181 0.0466 0.0466
Mycobacterium tuberculosis Trehalose synthase TreS 0.0153 0.038 0.1422
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0052 0.0064 0.0074
Mycobacterium ulcerans trehalose synthase TreS 0.0153 0.038 0.0722
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0116 0.0262 0.0294
Mycobacterium ulcerans alpha-L-fucosidase 0.1696 0.5196 1
Loa Loa (eye worm) hypothetical protein 0.1124 0.3412 0.3412
Entamoeba histolytica Inosine-uridine preferring nucleoside hydrolase, putative 0.0052 0.0064 0.0194
Echinococcus granulosus glycogen debranching enzyme 0.0549 0.1615 0.1615
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0588 0.1736 0.2164
Mycobacterium tuberculosis Probable nucleoside hydrolase IunH (purine nucleosidase) 0.0052 0.0064 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.1702 0.5217 0.6516
Loa Loa (eye worm) beta-glucuronidase 0.0338 0.0955 0.0955
Trichomonas vaginalis alpha-glucosidase, putative 0.0403 0.116 0.1444
Trichomonas vaginalis glycogen phosphorylase, putative 0.1017 0.3076 0.384
Onchocerca volvulus 0.0269 0.0741 0.0913
Schistosoma mansoni glycogen phosphorylase 0.044 0.1274 0.1426
Brugia malayi follicle stimulating hormone receptor 0.0244 0.0664 0.0664
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0223 0.0596 0.0739
Schistosoma mansoni hypothetical protein 0.0182 0.0469 0.0525
Schistosoma mansoni phosphorylase B kinase beta kpbb 0.0068 0.0114 0.0128
Loa Loa (eye worm) hypothetical protein 0.0269 0.0741 0.0741
Mycobacterium ulcerans maltooligosyltrehalose synthase TreY 0.0037 0.0015 0.002
Brugia malayi 1,4-alpha-glucan branching enzyme 0.0037 0.0015 0.0015
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0383 0.1096 0.1228
Treponema pallidum hypothetical protein 0.0093 0.0192 0.5
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0181 0.0466 0.0522
Loa Loa (eye worm) hypothetical protein 0.0068 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0137 0.0328 0.0367
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.0933 0.0933
Schistosoma mansoni bile acid beta-glucosidase-related 0.0417 0.1204 0.1348
Entamoeba histolytica oligo-1,6-glucosidase, putative 0.0153 0.038 0.122
Schistosoma mansoni hypothetical protein 0.0397 0.1139 0.1276
Loa Loa (eye worm) alpha amylase 0.0153 0.038 0.038
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0403 0.116 0.4849
Trichomonas vaginalis alpha-glucosidase, putative 0.0776 0.2324 0.29
Brugia malayi Trehalase family protein 0.0269 0.0741 0.0741
Echinococcus granulosus beta D xylosidase 2 0.0033 0.0005 0.0005
Loa Loa (eye worm) trehalase 0.0093 0.0192 0.0192
Brugia malayi hypothetical protein 0.0269 0.0741 0.0741
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0146 0.0356 0.0439
Loa Loa (eye worm) hypothetical protein 0.0146 0.0356 0.0356
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0146 0.0356 0.0439
Trichomonas vaginalis alpha-glucosidase, putative 0.0403 0.116 0.1444
Schistosoma mansoni alpha-glucosidase 0.2891 0.893 1
Brugia malayi phosphorylase B kinase alpha regulatory chain 0.0068 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0571 0.1683 0.1885
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.044 0.1274 0.2444
Brugia malayi Amylo-alpha-1,6-glucosidase family protein 0.0549 0.1615 0.1615
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Echinococcus granulosus tar DNA binding protein 0.0063 0.0096 0.0096
Brugia malayi hypothetical protein 0.0093 0.0192 0.0192
Schistosoma mansoni hypothetical protein 0.0706 0.2105 0.2357
Trichomonas vaginalis glucosylceramidase, putative 0.1702 0.5217 0.6516
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0146 0.0356 0.0439
Trichomonas vaginalis glucosylceramidase, putative 0.1794 0.5503 0.6874
Loa Loa (eye worm) glycosyl hydrolase family 2 0.0366 0.1043 0.1043
Trichomonas vaginalis glycogen phosphorylase, putative 0.1017 0.3076 0.384
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.0581 0.0581
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0776 0.2324 1
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.044 0.1274 0.4909
Echinococcus granulosus fucosidase alpha L 1 tissue 0.1696 0.5196 0.5196
Trichomonas vaginalis glucosylceramidase, putative 0.1702 0.5217 0.6516
Brugia malayi RNA, U transporter 1 0.0088 0.0176 0.0176
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0338 0.0958 0.1191
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0052 0.0064 0.0074
Loa Loa (eye worm) hypothetical protein 0.0065 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0176 0.045 0.045
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0403 0.116 0.3761
Echinococcus multilocularis trehalose 6 phosphate hydrolase 0.0037 0.0015 0.0015
Brugia malayi hypothetical protein 0.0068 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0114 0.0137
Mycobacterium leprae Putative uncharacterized protein ML2045 0.0153 0.038 0.5
Echinococcus multilocularis alpha glucosidase 0.0153 0.038 0.038
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0311 0.0873 0.0978
Echinococcus multilocularis glucan (1,4 alpha), branching enzyme 1 0.0037 0.0015 0.0015
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0403 0.116 0.143
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.2594 0.8003 0.8003
Loa Loa (eye worm) hypothetical protein 0.0153 0.0377 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0269 0.0741 0.092
Echinococcus granulosus glucan 14 alpha branching enzyme 1 0.0037 0.0015 0.0015
Echinococcus granulosus neutral alpha glucosidase AB 0.0776 0.2324 0.2324
Trichomonas vaginalis amylase, putative 0.0037 0.0015 0.0013
Echinococcus multilocularis beta D xylosidase 2 0.0033 0.0005 0.0005
Echinococcus granulosus bile acid beta glucosidase 0.0417 0.1204 0.1204
Entamoeba histolytica alpha-1,2-mannosidase, putative 0.0858 0.2579 0.8381
Brugia malayi Glycosyl hydrolases family 31 protein 0.0776 0.2324 0.2324
Echinococcus granulosus dnaJ subfamily B 0.0404 0.1163 0.1163
Trichomonas vaginalis glucosylceramidase, putative 0.2594 0.8003 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.2594 0.8003 0.8003
Leishmania major glycosyl hydrolase-like protein 0.0403 0.116 0.4849
Loa Loa (eye worm) RNA binding protein 0.0063 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0269 0.0741 0.0741
Trichomonas vaginalis beta-mannosidase, putative 0.0275 0.0759 0.0943
Echinococcus multilocularis non lysosomal glucosylceramidase 0.0417 0.1204 0.1204
Entamoeba histolytica glycogen debranching enzyme, putative 0.0549 0.1615 0.5243
Trypanosoma cruzi hypothetical protein, conserved 0.0776 0.2324 1
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Entamoeba histolytica glycogenphosphorylase, putative 0.044 0.1274 0.4131
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0383 0.1096 0.1096
Brugia malayi Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1 0.0146 0.0356 0.0356
Echinococcus granulosus phosphorylase b kinase regulatory 0.0068 0.0114 0.0114
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0403 0.116 0.1444
Trichomonas vaginalis alpha-glucosidase, putative 0.0776 0.2324 0.29
Onchocerca volvulus Glucosylceramidase homolog 0.1702 0.5217 0.6431
Schistosoma mansoni alpha-amylase 0.0153 0.038 0.0425
Echinococcus granulosus phosphorylase b kinase regulatory 0.0068 0.0114 0.0114
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0146 0.0356 0.0439
Brugia malayi Trehalase family protein 0.0093 0.0192 0.0192
Onchocerca volvulus Glycogen phosphorylase homolog 0.1017 0.3076 0.3792

Activities

Activity type Activity value Assay description Source Reference
MISS T/C (functional) = 1.08 In vivo blood glucose was determined in obese, hyperglycemic, hyperinsulinemic, insulin-resistant KKAy mice after a dose of 500 mg/kg for 4 days ChEMBL. 11312923

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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