Detailed information for compound 25152

Basic information

Technical information
  • TDR Targets ID: 25152
  • Name: 2-[2-(diaminomethylidene)hydrazinyl]butanoic acid
  • MW: 160.174 | Formula: C5H12N4O2
  • H donors: 4 H acceptors: 2 LogP: -0.31 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(C(=O)O)NN=C(N)N
  • InChi: 1S/C5H12N4O2/c1-2-3(4(10)11)8-9-5(6)7/h3,8H,2H2,1H3,(H,10,11)(H4,6,7,9)
  • InChiKey: DJCOQURDTBKSIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[N'-(diaminomethylene)hydrazino]butanoic acid
  • 2-[2-[bis(azanyl)methylidene]hydrazinyl]butanoic acid
  • 2-[N'-(diaminomethylene)hydrazino]butyric acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0269 0.0741 0.0913
Entamoeba histolytica glycogen phosphorylase, putative 0.044 0.1274 0.4131
Echinococcus granulosus geminin 0.0182 0.0469 0.0469
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0037 0.0015 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.1702 0.5217 0.6516
Mycobacterium ulcerans alpha-L-fucosidase 0.1696 0.5196 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.2594 0.8003 0.8003
Loa Loa (eye worm) alpha amylase 0.0153 0.038 0.038
Mycobacterium ulcerans glycosyl hydrolase 0.0068 0.0114 0.021
Brugia malayi hypothetical protein 0.0123 0.0286 0.0286
Trichomonas vaginalis glucosylceramidase, putative 0.1702 0.5217 0.6516
Leishmania major inosine-adenosine-guanosine-nucleoside hydrolase, putative 0.0456 0.1326 0.5583
Brugia malayi hypothetical protein 0.0093 0.0192 0.0192
Brugia malayi Trehalase family protein 0.0269 0.0741 0.0741
Trichomonas vaginalis sucrase-isomaltase, putative 0.0746 0.223 0.2782
Entamoeba histolytica oligo-1,6-glucosidase, putative 0.0153 0.038 0.122
Loa Loa (eye worm) hypothetical protein 0.0311 0.0873 0.0873
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0015 0.0013
Entamoeba histolytica alpha-amylase family protein 0.0037 0.0015 0.0033
Loa Loa (eye worm) glycogen phosphorylase 0.1017 0.3076 0.3076
Trichomonas vaginalis beta-galactosidase, putative 0.0815 0.2446 0.3051
Entamoeba histolytica Inosine-uridine preferring nucleoside hydrolase, putative 0.0052 0.0064 0.0194
Trichomonas vaginalis maltase-glucoamylase, putative 0.0403 0.116 0.1444
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0052 0.0064 0.0074
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.1696 0.5196 0.5196
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0137 0.0328 0.0328
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0146 0.0356 0.0439
Mycobacterium tuberculosis Probable nucleoside hydrolase IunH (purine nucleosidase) 0.0052 0.0064 0.0192
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0146 0.0356 0.0439
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0037 0.0015 0.0033
Loa Loa (eye worm) hypothetical protein 0.0549 0.1615 0.1615
Brugia malayi hypothetical protein 0.0093 0.0192 0.0192
Brugia malayi Pre-SET motif family protein 0.0218 0.0581 0.0581
Trichomonas vaginalis glycogen phosphorylase, putative 0.1017 0.3076 0.384
Brugia malayi Alpha-L-fucosidase family protein 0.134 0.4084 0.4084
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.0218 0.0581 0.2287
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0383 0.1096 0.1228
Echinococcus granulosus lysosomal alpha mannosidase 0.0218 0.0581 0.0581
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0146 0.0356 0.0439
Echinococcus multilocularis alpha glucosidase 0.0153 0.038 0.038
Onchocerca volvulus 0.2629 0.8112 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0311 0.0873 0.0978
Echinococcus granulosus alpha mannosidase 2 0.0054 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0182 0.0469 0.0525
Brugia malayi carbohydrate phosphorylase 0.1017 0.3076 0.3076
Echinococcus granulosus neutral alpha glucosidase AB 0.0776 0.2324 0.2324
Mycobacterium ulcerans glycosidase 0.0037 0.0015 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0776 0.2324 1
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0218 0.0581 0.2287
Echinococcus granulosus Glycosyl transferase family 35 0.1017 0.3076 0.3076
Trichomonas vaginalis alpha-glucosidase, putative 0.0403 0.116 0.1444
Loa Loa (eye worm) hypothetical protein 0.0065 0.0105 0.0105
Loa Loa (eye worm) glycosyl hydrolase family 2 0.0366 0.1043 0.1043
Mycobacterium ulcerans trehalose synthase TreS 0.0037 0.0015 0.002
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0776 0.2324 0.29
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0146 0.0356 0.0439
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.2594 0.8003 0.8003
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0146 0.0356 0.0439
Trichomonas vaginalis beta-mannosidase, putative 0.0275 0.0759 0.0943
Schistosoma mansoni glycogen phosphorylase 0.044 0.1274 0.1426
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0403 0.116 0.1444
Trichomonas vaginalis set domain proteins, putative 0.0248 0.0675 0.0838
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0096 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.2594 0.8003 1
Echinococcus multilocularis non lysosomal glucosylceramidase 0.0417 0.1204 0.1204
Toxoplasma gondii Amylo-alpha-1,6-glucosidase 0.0549 0.1615 0.695
Mycobacterium ulcerans alpha-mannosidase 0.0338 0.0958 0.1835
Onchocerca volvulus 0.0269 0.0741 0.0913
Brugia malayi trehalase I 0.0093 0.0192 0.0192
Schistosoma mansoni bile acid beta-glucosidase-related 0.0417 0.1204 0.1348
Schistosoma mansoni hypothetical protein 0.0137 0.0328 0.0367
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Echinococcus granulosus alpha mannosidase 2 0.0065 0.0105 0.0105
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0776 0.2324 0.2324
Trypanosoma brucei glucosidase, putative 0.0776 0.2324 1
Entamoeba histolytica glycogen debranching enzyme, putative 0.0549 0.1615 0.5243
Entamoeba histolytica alpha-amylase, putative 0.0037 0.0015 0.0033
Schistosoma mansoni hypothetical protein 0.0033 0.0005 0.0006
Giardia lamblia 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase 0.0549 0.1615 0.5227
Toxoplasma gondii Alpha-amylase AMY3, putative 0.0037 0.0015 0.0065
Echinococcus granulosus lysosomal alpha glucosidase 0.3234 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.1702 0.5217 0.6516
Mycobacterium leprae Putative uncharacterized protein ML2045 0.0153 0.038 0.5
Loa Loa (eye worm) hypothetical protein 0.0065 0.0105 0.0105
Loa Loa (eye worm) alpha-L-fucosidase 0.134 0.4084 0.4084
Trichomonas vaginalis alpha-glucosidase, putative 0.0776 0.2324 0.29
Echinococcus multilocularis beta galactosidase 0.1008 0.3048 0.3048
Trichomonas vaginalis glucosylceramidase, putative 0.2594 0.8003 1
Schistosoma mansoni hypothetical protein 0.0571 0.1683 0.1885
Loa Loa (eye worm) hypothetical protein 0.0282 0.078 0.078
Brugia malayi Beta-glucuronidase precursor 0.0338 0.0955 0.0955
Echinococcus multilocularis geminin 0.0182 0.0469 0.0469
Loa Loa (eye worm) hypothetical protein 0.1124 0.3412 0.3412
Giardia lamblia Hypothetical protein 0.0052 0.0064 0.0161
Schistosoma mansoni alpha-glucosidase 0.2891 0.893 1
Mycobacterium ulcerans maltooligosyltrehalose synthase TreY 0.0037 0.0015 0.002
Echinococcus multilocularis mannosyl oligosaccharide 1,2 alpha mannosidase 0.0146 0.0356 0.0356
Brugia malayi lysosomal alpha-mannosidase 0.0181 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0093 0.0192 0.0192
Schistosoma mansoni phosphorylase B kinase beta kpbb 0.0068 0.0114 0.0128
Trichomonas vaginalis hypothetical protein 0.0052 0.0064 0.0074
Entamoeba histolytica glycogen phosphorylase, putative 0.1017 0.3076 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0092 0.0103
Echinococcus multilocularis thyroid hormone receptor alpha 0.0148 0.0362 0.0362
Echinococcus granulosus tar DNA binding protein 0.0063 0.0096 0.0096
Entamoeba histolytica alpha-amylase family protein 0.0037 0.0015 0.0033
Echinococcus multilocularis glucan (1,4 alpha), branching enzyme 1 0.0037 0.0015 0.0015
Brugia malayi hypothetical protein 0.0068 0.0114 0.0114
Loa Loa (eye worm) myosin heavy chain 0.0068 0.0114 0.0114
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0549 0.1615 0.2014
Loa Loa (eye worm) hypothetical protein 0.0068 0.0114 0.0114
Loa Loa (eye worm) trehalase 0.0269 0.0741 0.0741
Loa Loa (eye worm) hypothetical protein 0.0181 0.0466 0.0466
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Brugia malayi RNA binding protein 0.0063 0.0096 0.0096
Brugia malayi 1,4-alpha-glucan branching enzyme 0.0037 0.0015 0.0015
Schistosoma mansoni bile acid beta-glucosidase-related 0.0417 0.1204 0.1348
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0163 0.0411 0.1535
Trichomonas vaginalis alpha-glucosidase, putative 0.0403 0.116 0.1444
Brugia malayi Amylo-alpha-1,6-glucosidase family protein 0.0549 0.1615 0.1615
Brugia malayi RNA, U transporter 1 0.0088 0.0176 0.0176
Echinococcus granulosus bile acid beta glucosidase 0.0417 0.1204 0.1204
Trichomonas vaginalis alpha-mannosidase, putative 0.0338 0.0958 0.1191
Echinococcus multilocularis bile acid beta glucosidase 0.0417 0.1204 0.1204
Loa Loa (eye worm) hypothetical protein 0.0181 0.0466 0.0466
Onchocerca volvulus 0.0269 0.0741 0.0913
Entamoeba histolytica alpha-amylase, putative 0.0037 0.0015 0.0033
Trichomonas vaginalis trehalase, putative 0.0269 0.0741 0.092
Trichomonas vaginalis amylase, putative 0.0037 0.0015 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.2594 0.8003 1
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.1163 0.1163
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.0218 0.0581 0.2287
Trypanosoma cruzi hypothetical protein, conserved 0.0776 0.2324 1
Brugia malayi manba-prov protein 0.0501 0.1467 0.1467
Trichomonas vaginalis glucosylceramidase, putative 0.1702 0.5217 0.6516
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0137 0.0328 0.0328
Schistosoma mansoni alpha-l-fucosidase 0.134 0.4084 0.4573
Brugia malayi phosphorylase B kinase beta regulatory chain 0.0068 0.0114 0.0114
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0096 0.0096
Trichomonas vaginalis glucosylceramidase, putative 0.1794 0.5503 0.6874
Onchocerca volvulus 0.0181 0.0466 0.0575
Schistosoma mansoni hypothetical protein 0.0182 0.0469 0.0525
Loa Loa (eye worm) hypothetical protein 0.0068 0.0114 0.0114
Echinococcus granulosus non lysosomal glucosylceramidase 0.0417 0.1204 0.1204
Trichomonas vaginalis alpha-glucosidase, putative 0.0776 0.2324 0.29
Mycobacterium ulcerans maltooligosyltrehalose trehalohydrolase, TreZ 0.0037 0.0015 0.002
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0052 0.0064 0.0074
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0181 0.0466 0.0522
Trichomonas vaginalis amylase, putative 0.0037 0.0015 0.0013
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0383 0.1096 0.1228
Loa Loa (eye worm) mannosidase 0.0146 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0065 0.0105 0.0105
Trichomonas vaginalis glucosylceramidase, putative 0.1702 0.5217 0.6516
Echinococcus multilocularis alpha mannosidase 2 0.0181 0.0466 0.0466
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0096 0.0096
Schistosoma mansoni thyroid hormone receptor 0.0148 0.0362 0.0406
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0383 0.1096 0.1228
Loa Loa (eye worm) hypothetical protein 0.0093 0.0192 0.0192
Schistosoma mansoni hypothetical protein 0.0706 0.2105 0.2357
Onchocerca volvulus Glucosylceramidase homolog 0.1702 0.5217 0.6431
Toxoplasma gondii 1,4-alpha-glucan-branching enzyme 0.0037 0.0015 0.0065
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0212 0.0562 0.0696
Echinococcus multilocularis trehalose 6 phosphate hydrolase 0.0037 0.0015 0.0015
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0153 0.038 0.038
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0096 0.0108
Loa Loa (eye worm) alpha amylase 0.0153 0.038 0.038
Mycobacterium tuberculosis Trehalose synthase TreS 0.0153 0.038 0.1422
Toxoplasma gondii alpha amylase, catalytic domain-containing protein 0.0037 0.0015 0.0065
Echinococcus granulosus alpha glucosidase 0.0153 0.038 0.038
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0072 0.031
Echinococcus granulosus glycogen phosphorylase 0.1017 0.3076 0.3076
Brugia malayi follicle stimulating hormone receptor 0.0244 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0269 0.0741 0.0741
Trichomonas vaginalis conserved hypothetical protein 0.0815 0.2446 0.3051
Brugia malayi Melibiase family protein 0.0311 0.0873 0.0873
Loa Loa (eye worm) trehalase 0.0269 0.0741 0.0741
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0269 0.0741 0.092
Schistosoma mansoni alpha-amylase 0.0153 0.038 0.0425
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0096 0.0096
Mycobacterium tuberculosis Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas 0.0153 0.038 0.1422
Schistosoma mansoni alpha glucosidase 0.0776 0.2324 0.2603
Schistosoma mansoni hypothetical protein 0.0037 0.0015 0.0017
Mycobacterium ulcerans trehalose synthase TreS 0.0153 0.038 0.0722
Echinococcus multilocularis glycogen debranching enzyme 0.0549 0.1615 0.1615
Loa Loa (eye worm) hypothetical protein 0.0093 0.0192 0.0192
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0383 0.1096 0.1096
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0776 0.2324 0.7552
Trichomonas vaginalis glucosylceramidase, putative 0.2594 0.8003 1
Echinococcus granulosus beta galactosidase 0.1008 0.3048 0.3048
Trichomonas vaginalis glucosylceramidase, putative 0.2594 0.8003 1
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Loa Loa (eye worm) trehalase 0.0093 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0176 0.045 0.045
Schistosoma mansoni alpha-glucosidase 0.2891 0.893 1
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0052 0.0064 0.0074
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0403 0.116 0.143
Trichomonas vaginalis alpha-glucosidase, putative 0.0403 0.116 0.1444
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Trichomonas vaginalis glycogen phosphorylase, putative 0.1017 0.3076 0.384
Brugia malayi Glycosyl hydrolases family 31 protein 0.0776 0.2324 0.2324
Loa Loa (eye worm) trehalase 0.0093 0.0192 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.1702 0.5217 0.6516
Loa Loa (eye worm) hypothetical protein 0.0269 0.0741 0.0741
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0403 0.116 0.1444
Schistosoma mansoni thyroid hormone receptor 0.0148 0.0362 0.0406
Echinococcus multilocularis phosphorylase b kinase regulatory 0.0068 0.0114 0.0114
Echinococcus granulosus mannosyl oligosaccharide 12 alpha mannosidase 0.0146 0.0356 0.0356
Onchocerca volvulus Putative phosphorylase b kinase regulatory subunit alpha 0.0068 0.0114 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0282 0.0781 0.097
Loa Loa (eye worm) manba-prov protein 0.0164 0.0412 0.0412
Echinococcus granulosus snurportin 1 0.033 0.0933 0.0933
Loa Loa (eye worm) hypothetical protein 0.0403 0.116 0.116
Schistosoma mansoni hypothetical protein 0.0397 0.1139 0.1276
Trichomonas vaginalis alpha-glucosidase, putative 0.0403 0.116 0.1444
Entamoeba histolytica alpha-amylase family protein 0.0037 0.0015 0.0033
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0311 0.0873 0.0978
Echinococcus granulosus phosphorylase b kinase regulatory 0.0068 0.0114 0.0114
Echinococcus granulosus dnaJ subfamily B 0.0404 0.1163 0.1163
Treponema pallidum hypothetical protein 0.0093 0.0192 0.5
Brugia malayi trehalase 0.0093 0.0192 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.2594 0.8003 1
Loa Loa (eye worm) hypothetical protein 0.0269 0.0741 0.0741
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Brugia malayi hypothetical protein 0.0068 0.0114 0.0114
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0146 0.0356 0.0439
Trichomonas vaginalis amylase, putative 0.0037 0.0015 0.0013
Echinococcus multilocularis neutral alpha glucosidase AB 0.0776 0.2324 0.2324
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0096 0.0108
Trypanosoma brucei inosine-adenosine-guanosine-nucleosidehydrolase 0.0456 0.1326 0.5583
Plasmodium vivax hypothetical protein, conserved 0.032 0.0901 1
Schistosoma mansoni mannosyl-oligosaccharide alpha-12-mannosidase 0.0146 0.0356 0.0399
Brugia malayi Glycosyl hydrolases family 38 protein 0.0181 0.0466 0.0466
Onchocerca volvulus Glycogen phosphorylase homolog 0.1017 0.3076 0.3792
Brugia malayi Trehalase family protein 0.0093 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0269 0.0741 0.0741
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0114 0.0137
Trichomonas vaginalis glycoside hydrolase, putative 0.102 0.3085 0.3851
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0146 0.0356 0.0439
Trichomonas vaginalis alpha-glucosidase, putative 0.0776 0.2324 0.29
Schistosoma mansoni phosphorylase B kinase alpha kpb1 0.0068 0.0114 0.0128
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.3234 1 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0746 0.223 0.7243
Loa Loa (eye worm) hypothetical protein 0.0126 0.0293 0.0293
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.044 0.1274 0.4909
Schistosoma mansoni beta-galactosidase 0.1008 0.3048 0.3413
Schistosoma mansoni alpha-amylase 0.0153 0.038 0.0425
Schistosoma mansoni beta-mannosidase 0.0275 0.0759 0.085
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Echinococcus multilocularis lysosomal alpha glucosidase 0.3234 1 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.3234 1 1
Entamoeba histolytica beta/alpha-amylase precursor, putative 0.0037 0.0015 0.0033
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0146 0.0356 0.0439
Trichomonas vaginalis starch branching enzyme II, putative 0.0037 0.0015 0.0013
Entamoeba histolytica hypothetical protein 0.0037 0.0015 0.0033
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0153 0.038 0.038
Trichomonas vaginalis maltase-glucoamylase, putative 0.0776 0.2324 0.29
Brugia malayi Glycosyl hydrolases family 38 protein 0.0338 0.0958 0.0958
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.044 0.1274 0.2444
Toxoplasma gondii glycosyltransferase 0.0037 0.0015 0.0065
Loa Loa (eye worm) trehalase 0.0269 0.0741 0.0741
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0244 0.0664 0.0664
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.0933 0.0933
Brugia malayi Trehalase family protein 0.0269 0.0741 0.0741
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0114 0.0137
Giardia lamblia Glycogen phosphorylase 0.1017 0.3076 1
Echinococcus granulosus glycogen phosphorylase 0.1017 0.3076 0.3076
Loa Loa (eye worm) hypothetical protein 0.0269 0.0741 0.0741
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0383 0.1096 0.1096
Schistosoma mansoni alpha-amylase 0.0153 0.038 0.0425
Leishmania major alpha glucosidase II subunit, putative 0.0776 0.2324 1
Echinococcus granulosus beta D xylosidase 2 0.0033 0.0005 0.0005
Echinococcus granulosus trehalose 6 phosphate hydrolase 0.0037 0.0015 0.0015
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0218 0.0581 0.0651
Loa Loa (eye worm) TRE-2 protein 0.0269 0.0741 0.0741
Onchocerca volvulus 0.0181 0.0466 0.0575
Onchocerca volvulus Trehalase homolog 0.0269 0.0741 0.0913
Brugia malayi Glycosyl hydrolases family 2, sugar binding domain containing protein 0.0366 0.1043 0.1043
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0114 0.0137
Brugia malayi hypothetical protein 0.0093 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0146 0.0356 0.0356
Schistosoma mansoni glycogen phosphorylase 0.1017 0.3076 0.3445
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0146 0.0356 0.0439
Entamoeba histolytica glycogen phosphorylase, putative 0.044 0.1274 0.4131
Echinococcus multilocularis glycogen phosphorylase 0.1017 0.3076 0.3076
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.0356 0.0439
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0052 0.0064 0.0074
Brugia malayi hypothetical protein 0.0269 0.0741 0.0741
Loa Loa (eye worm) hypothetical protein 0.0068 0.0114 0.0114
Entamoeba histolytica alpha-1,2-mannosidase, putative 0.0858 0.2579 0.8381
Schistosoma mansoni alpha-amylase 0.0153 0.038 0.0425
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0588 0.1736 0.2164
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.032 0.0901 0.5
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0096 0.0096
Trichomonas vaginalis glycoside hydrolases, putative 0.1063 0.3219 0.4019
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0403 0.116 0.4849
Chlamydia trachomatis glycogen phosphorylase 0.1017 0.3076 1
Onchocerca volvulus 0.0248 0.0675 0.0832
Toxoplasma gondii melibiase subfamily protein 0.0383 0.1096 0.4716
Trypanosoma cruzi inosine-adenosine-guanosine-nucleosidehydrolase, putative 0.0456 0.1326 0.5583
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.0581 0.0581
Echinococcus multilocularis phosphorylase b kinase regulatory 0.0068 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0116 0.0262 0.0262
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0146 0.0356 0.0439
Loa Loa (eye worm) glycosyl hydrolase family 38 protein 0.0338 0.0958 0.0958
Echinococcus multilocularis beta D xylosidase 2 0.0033 0.0005 0.0005
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0383 0.1096 0.1228
Entamoeba histolytica beta-galactosidase, putative 0.0477 0.1391 0.4512
Brugia malayi Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1 0.0146 0.0356 0.0356
Echinococcus granulosus phosphorylase b kinase regulatory 0.0068 0.0114 0.0114
Echinococcus multilocularis transfer RNA-Trp 0.0146 0.0356 0.0356
Echinococcus granulosus glycogen debranching enzyme 0.0549 0.1615 0.1615
Brugia malayi TAR-binding protein 0.0063 0.0096 0.0096
Trypanosoma brucei glycosyl hydrolase-like protein 0.0403 0.116 0.4849
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0549 0.1615 0.2014
Trypanosoma cruzi inosine-adenosine-guanosine-nucleosidehydrolase, putative 0.0456 0.1326 0.5583
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0338 0.0958 0.1191
Echinococcus multilocularis lysosomal alpha mannosidase 0.0218 0.0581 0.0581
Onchocerca volvulus 0.0269 0.0741 0.0913
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0588 0.1736 0.2164
Mycobacterium tuberculosis Conserved protein 0.0068 0.0114 0.0386
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0096 0.0108
Trichomonas vaginalis beta-glucosidase, putative 0.1063 0.3219 0.4019
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0146 0.0356 0.0439
Echinococcus granulosus endoplasmic reticulum mannosyl oligosaccharide 0.0146 0.0356 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0105 0.0125
Trichomonas vaginalis glucosylceramidase, putative 0.1794 0.5503 0.6874
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0776 0.2324 1
Schistosoma mansoni glycogen phosphorylase 0.1017 0.3076 0.3445
Schistosoma mansoni alpha-amylase 0.0153 0.038 0.0425
Echinococcus granulosus beta mannosidase 0.0164 0.0412 0.0412
Entamoeba histolytica glycogen phosphorylase, putative 0.1017 0.3076 1
Loa Loa (eye worm) hypothetical protein 0.1008 0.3048 0.3048
Loa Loa (eye worm) hypothetical protein 0.0068 0.0114 0.0114
Entamoeba histolytica alpha-amylase family protein 0.0037 0.0015 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0096 0.0108
Echinococcus multilocularis endoplasmic reticulum mannosyl oligosaccharide 0.0146 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0093 0.0192 0.0192
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0403 0.116 0.4849
Mycobacterium ulcerans maltooligosyltrehalose synthase TreX 0.0037 0.0015 0.002
Brugia malayi Glycosyl hydrolases family 38 protein 0.0181 0.0466 0.0466
Mycobacterium ulcerans glycogen branching protein 0.0037 0.0015 0.002
Echinococcus granulosus glucan 14 alpha branching enzyme 1 0.0037 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0015
Brugia malayi Glycosyl hydrolases family 31 protein 0.0403 0.116 0.116
Brugia malayi phosphorylase B kinase alpha regulatory chain 0.0068 0.0114 0.0114
Onchocerca volvulus 0.0269 0.0741 0.0913
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0311 0.0873 0.1086
Echinococcus multilocularis glycogen phosphorylase 0.1017 0.3076 0.3076
Onchocerca volvulus Phosphorylase b kinase regulatory subunit beta homolog 0.0068 0.0114 0.0141
Leishmania major glycosyl hydrolase-like protein 0.0403 0.116 0.4849
Trichomonas vaginalis alpha-glucosidase, putative 0.0776 0.2324 0.29
Trichomonas vaginalis glucosylceramidase, putative 0.1702 0.5217 0.6516
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0403 0.116 0.3761
Trichomonas vaginalis alpha-glucosidase, putative 0.0403 0.116 0.1444
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Schistosoma mansoni starch branching enzyme II 0.0037 0.0015 0.0017
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0223 0.0596 0.0739
Echinococcus granulosus fucosidase alpha L 1 tissue 0.1696 0.5196 0.5196
Brugia malayi Trehalase family protein 0.0093 0.0192 0.0192
Echinococcus multilocularis beta mannosidase 0.0164 0.0412 0.0412
Trichomonas vaginalis alpha-glucosidase, putative 0.0776 0.2324 0.29
Echinococcus multilocularis snurportin 1 0.033 0.0933 0.0933
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0146 0.0356 0.0439
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Mycobacterium tuberculosis Possible conserved exported protein 0.0858 0.2579 1
Trichomonas vaginalis amylase, putative 0.0037 0.0015 0.0013
Schistosoma mansoni hypothetical protein 0.0404 0.1163 0.1302
Brugia malayi Trehalase family protein 0.0269 0.0741 0.0741
Entamoeba histolytica glycogenphosphorylase, putative 0.044 0.1274 0.4131
Loa Loa (eye worm) TRE-1 protein 0.0269 0.0741 0.0741
Schistosoma mansoni mannosidase alpha class 2a 0.0181 0.0466 0.0522
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Loa Loa (eye worm) beta-glucuronidase 0.0338 0.0955 0.0955
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0383 0.1096 0.1096
Loa Loa (eye worm) RNA binding protein 0.0063 0.0096 0.0096
Trichomonas vaginalis alpha-amylase, putative 0.0037 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0146 0.0356 0.0356
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0116 0.0262 0.0294
Brugia malayi Trehalase protein 5 0.0093 0.0192 0.0192
Brugia malayi Trehalase family protein 0.0269 0.0741 0.0741
Schistosoma mansoni hypothetical protein 0.033 0.0933 0.1044
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0776 0.2324 0.29
Loa Loa (eye worm) amylo-alpha-1,6-glucosidase 0.0267 0.0735 0.0735
Loa Loa (eye worm) hypothetical protein 0.0153 0.0377 0.0377
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0146 0.0356 0.0439
Echinococcus multilocularis Glycosyl transferase, family 35 0.1017 0.3076 0.3076

Activities

Activity type Activity value Assay description Source Reference
MISS T/C (functional) = 1.08 In vivo blood glucose was determined in obese, hyperglycemic, hyperinsulinemic, insulin-resistant KKAy mice after a dose of 500 mg/kg for 4 days ChEMBL. 11312923

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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