Detailed view for TVAG_299100

Basic information

TDR Targets ID: 890920
Trichomonas vaginalis, ATP-dependent RNA helicase, putative
Source Database / ID: 

pI: 8.1882 | Length (AA): 1006 | MW (Da): 113433 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00270   DEAD/DEAH box helicase
PF00271   Helicase conserved C-terminal domain
PF00575   S1 RNA binding domain
PF04408   Helicase associated domain (HA2)
PF07717   Oligonucleotide/oligosaccharide-binding (OB)-fold

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004386   helicase activity  
GO:0003676   nucleic acid binding  

Metabolic Pathways

Spliceosome (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126599)

Species Accession Gene Product
Arabidopsis thaliana AT4G16680   putative RNA helicase
Arabidopsis thaliana AT1G32490   DEAH RNA helicase homolog PRP2
Arabidopsis thaliana AT2G47250   putative pre-mRNA-splicing factor ATP-dependent RNA helicase
Arabidopsis thaliana AT3G26560   probable pre-mRNA-splicing factor ATP-dependent RNA helicase
Arabidopsis thaliana AT5G13010   RNA helicase family protein
Arabidopsis thaliana AT3G62310   RNA helicase family protein
Arabidopsis thaliana AT2G35340   protein MATERNAL EFFECT EMBRYO ARREST 29
Babesia bovis BBOV_I002940   RNA helicase, putative
Babesia bovis BBOV_IV011160   RNA helicase, putative
Babesia bovis BBOV_IV002560   DEAH box RNA helicase, putative
Babesia bovis BBOV_I004340   pre-mRNA splicing factor RNA helicase, putative
Brugia malayi Bm1_28720   pre-mRNA splicing factor ATP-dependent RNA helicase, putative
Brugia malayi Bm1_50870   ATP-dependent helicase DHX8
Brugia malayi Bm1_46020   Probable pre-mRNA splicing factor ATP-dependent RNA helicase mog-1
Brugia malayi Bm1_46075   Pre-mRNA splicing factor ATP-dependent RNA helicase F56D2.6
Candida albicans CaO19.9255   potential helicase similar to S. cerevisiae PRP43 (YGL120C) DEAH box helicase involved in pre-mRNA splicing
Candida albicans CaO19.11516   DEAH box helicase involved in pre-mRNA splicing
Candida albicans CaO19.5865   potential helicase similar to S. cerevisiae PRP2 (YNR011C) spliceosomal DEAD box ATPase that functions just prior to first step
Candida albicans CaO19.2818   DEAH box helicase involved in pre-mRNA splicing
Candida albicans CaO19.10336   DEAH box helicase involved in pre-mRNA splicing
Candida albicans CaO19.1687   potential helicase similar to S. cerevisiae PRP43 (YGL120C) DEAH box helicase involved in pre-mRNA splicing
Candida albicans CaO19.4033   DEAH box helicase involved in pre-mRNA splicing
Candida albicans CaO19.13287   potential helicase similar to S. cerevisiae PRP2 (YNR011C) spliceosomal DEAD box ATPase that functions just prior to first step
Caenorhabditis elegans CELE_K03H1.2   Protein MOG-1
Caenorhabditis elegans CELE_F56D2.6   Protein F56D2.6, isoform B
Caenorhabditis elegans CELE_C04H5.6   Protein MOG-4
Caenorhabditis elegans CELE_EEED8.5   Protein MOG-5
Cryptosporidium hominis Chro.10299   hypothetical protein
Cryptosporidium hominis Chro.60176   pre-mRNA splicing factor ATP-dependent RNA helicase
Cryptosporidium hominis Chro.80471   RNA helicase
Cryptosporidium hominis Chro.70079   DEAH-box RNA helicase
Cryptosporidium parvum cgd7_640   Prp16p pre-mRNA splicing factor. HrpA family SFII helicase
Cryptosporidium parvum cgd8_4100   PRP43 involved in spliceosome disassembly mRNA splicing
Cryptosporidium parvum cgd1_2650   hypothetical protein
Cryptosporidium parvum cgd6_1410   pre-mRNA splicing factor ATP-dependent RNA helicase, putative
Dictyostelium discoideum DDB_G0270110   DEAD/DEAH box helicase
Dictyostelium discoideum DDB_G0291183   DEAD/DEAH box helicase
Dictyostelium discoideum DDB_G0285937   DEAD/DEAH box helicase
Dictyostelium discoideum DDB_G0285843   DEAD/DEAH box helicase
Dictyostelium discoideum DDB_G0285213   DEAD/DEAH box helicase
Drosophila melanogaster Dmel_CG8241   peanuts
Drosophila melanogaster Dmel_CG10689   lethal (2) 37Cb
Drosophila melanogaster Dmel_CG11107   CG11107 gene product from transcript CG11107-RA
Drosophila melanogaster Dmel_CG32604   lethal (1) G0007
Escherichia coli b1413   putative ATP-dependent helicase
Escherichia coli b0148   putative ATP-dependent helicase
Echinococcus granulosus EgrG_000904900   pre mRNA splicing factor ATP dependent RNA
Echinococcus granulosus EgrG_000904800   DSS1 SEM1 domain containing protein
Echinococcus granulosus EgrG_001199400   pre mRNA splicing factor ATP dependent
Echinococcus granulosus EgrG_001027700   ATP dependent RNA helicase DHX8
Echinococcus granulosus EgrG_000214600   pre mRNA splicing factor ATP dependent
Entamoeba histolytica EHI_184530   helicase, putative
Entamoeba histolytica EHI_148930   helicase, putative
Entamoeba histolytica EHI_122790   helicase, putative
Entamoeba histolytica EHI_096230   helicase, putative
Echinococcus multilocularis EmuJ_001199400   pre mRNA splicing factor ATP dependent
Echinococcus multilocularis EmuJ_000214600   pre mRNA splicing factor ATP dependent
Echinococcus multilocularis EmuJ_001027700   ATP dependent RNA helicase DHX8
Echinococcus multilocularis EmuJ_000904800   DSS1 (SEM1) domain containing protein
Echinococcus multilocularis EmuJ_000904900   pre mRNA splicing factor ATP dependent RNA
Giardia lamblia GL50803_15930   RNA helicase, putative
Giardia lamblia GL50803_17539   RNA helicase, putative
Homo sapiens ENSG00000109606   DEAH (Asp-Glu-Ala-His) box helicase 15
Homo sapiens ENSG00000204560   DEAH (Asp-Glu-Ala-His) box polypeptide 16
Homo sapiens ENSG00000067596   DEAH (Asp-Glu-Ala-His) box polypeptide 8
Homo sapiens ENSG00000140829   DEAH (Asp-Glu-Ala-His) box polypeptide 38
Leishmania braziliensis LbrM.34.1120   pre-mRNA splicing factor ATP-dependent RNA helicase, putative
Leishmania braziliensis LbrM.35.3050   pre-mRNA splicing factor ATP-dependent RNA helicase, putative,dead/h helicase, putative
Leishmania braziliensis LbrM.24.1110   pre-mRNA splicing factor, putative
Leishmania donovani LdBPK_351210.1   pre-mRNA splicing factor ATP-dependent RNA helicase, putative
Leishmania donovani LdBPK_241120.1   pre-mRNA-splicing factor ATP-dependent RNA helicase, putative
Leishmania donovani LdBPK_362970.1   pre-mRNA splicing factor ATP-dependent RNA helicase, putative
Leishmania infantum LinJ.24.1120   pre-mRNA splicing factor, putative
Leishmania infantum LinJ.36.2970   pre-mRNA splicing factor ATP-dependent RNA helicase, putative,dead/h helicase, putative
Leishmania infantum LinJ.35.1210   pre-mRNA splicing factor ATP-dependent RNA helicase, putative
Leishmania major LmjF.36.2830   pre-mRNA splicing factor ATP-dependent RNA helicase, putative,dead/h helicase, putative
Leishmania major LmjF.24.1100   pre-mRNA splicing factor, putative
Leishmania major LmjF.35.1200   pre-mRNA splicing factor ATP-dependent RNA helicase, putative
Leishmania mexicana LmxM.24.1100   pre-mRNA splicing factor, putative
Leishmania mexicana LmxM.36.2830   pre-mRNA splicing factor ATP-dependent RNA helicase, putative,dead/h helicase, putative
Leishmania mexicana LmxM.34.1200   pre-mRNA splicing factor ATP-dependent RNA helicase, putative
Loa Loa (eye worm) LOAG_02619   dead box protein 15
Loa Loa (eye worm) LOAG_14297   DEAH box polypeptide 8
Loa Loa (eye worm) LOAG_01737   hypothetical protein
Loa Loa (eye worm) LOAG_03362   hypothetical protein
Loa Loa (eye worm) LOAG_11401   Dhx8 protein
Loa Loa (eye worm) LOAG_07948   sex determination protein MOG-1
Loa Loa (eye worm) LOAG_06523   pre-mRNA splicing factor ATP-dependent RNA helicase
Mus musculus ENSMUSG00000037993   DEAH (Asp-Glu-Ala-His) box polypeptide 38
Mus musculus ENSMUSG00000029169   DEAH (Asp-Glu-Ala-His) box polypeptide 15
Mus musculus ENSMUSG00000034931   DEAH (Asp-Glu-Ala-His) box polypeptide 8
Mus musculus ENSMUSG00000024422   DEAH (Asp-Glu-Ala-His) box polypeptide 16
Neospora caninum NCLIV_026800   hypothetical protein
Neospora caninum NCLIV_024300   hypothetical protein
Neospora caninum NCLIV_033280   hypothetical protein
Neospora caninum NCLIV_055860   hypothetical protein
Oryza sativa 4345304   Os08g0335000
Oryza sativa 9266959   Os11g0515900
Oryza sativa 4343339   Os07g0508000
Oryza sativa 4340964   Os06g0343100
Oryza sativa 4329095   Os02g0301500
Oryza sativa 9268581   Os03g0282700
Oryza sativa 4332645   Os03g0314100
Oryza sativa 4338675   Os05g0389800
Onchocerca volvulus OVOC7027  
Plasmodium berghei PBANKA_1140200   pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16, putative
Plasmodium berghei PBANKA_0514100   pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative
Plasmodium berghei PBANKA_0818600   pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative
Plasmodium falciparum PF3D7_1030100   pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative
Plasmodium falciparum PF3D7_1364300   pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
Plasmodium falciparum PF3D7_0917600   pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative
Plasmodium knowlesi PKNH_0614800   pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative
Plasmodium knowlesi PKNH_0715600   pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative
Plasmodium knowlesi PKNH_1107000   pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16, putative
Plasmodium vivax PVX_111220   RNA helicase, putative
Plasmodium vivax PVX_099300   pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative
Plasmodium vivax PVX_115175   pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16, putative
Plasmodium yoelii PY04108   ATP-dependent helicase ddx8
Plasmodium yoelii PY00835   pre-mRNA splicing factor ATP-dependent RNA helicase-like protein-related
Plasmodium yoelii PY04107   Unknown protein
Plasmodium yoelii PY06080   ATP-dependent RNA helicase-like protein
Saccharomyces cerevisiae YER013W   DEAH-box ATP-dependent RNA helicase PRP22
Saccharomyces cerevisiae YNR011C   DEAH-box RNA-dependent ATPase PRP2
Saccharomyces cerevisiae YGL120C   DEAH-box ATP-dependent RNA helicase PRP43
Saccharomyces cerevisiae YKR086W   DEAH-box RNA helicase PRP16
Schistosoma japonicum Sjp_0057890   ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative
Schistosoma japonicum Sjp_0053360   ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative
Schistosoma japonicum Sjp_0013210   ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative
Schistosoma japonicum Sjp_0008450   ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative
Schistosoma mansoni Smp_027970   ATP-dependent RNA Helicase
Schistosoma mansoni Smp_156060   hypothetical protein
Schistosoma mansoni Smp_169650   ATP-dependent RNA Helicase
Schistosoma mansoni Smp_157510   ATP-dependent RNA Helicase
Schmidtea mediterranea mk4.000675.10   Putative pre-mRNA-splicing factor ATP-dependent RNA helicase
Schmidtea mediterranea mk4.001502.00  
Schmidtea mediterranea mk4.000204.00  
Schmidtea mediterranea mk4.017785.00  
Schmidtea mediterranea mk4.000856.08  
Schmidtea mediterranea mk4.000214.11  
Schmidtea mediterranea mk4.003302.02   Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
Schmidtea mediterranea mk4.005198.00   Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5
Schmidtea mediterranea mk4.008785.02   Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
Schmidtea mediterranea mk4.000566.04   Putative atp-dependent RNA helicase
Schmidtea mediterranea mk4.017941.02  
Schmidtea mediterranea mk4.002075.00   Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
Schmidtea mediterranea mk4.002357.02  
Schmidtea mediterranea mk4.002125.02   Putative pre-mRNA-splicing factor ATP-dependent RNA helicase
Schmidtea mediterranea mk4.005392.03  
Schmidtea mediterranea mk4.034582.00  
Schmidtea mediterranea mk4.001355.04   Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
Trypanosoma brucei gambiense Tbg972.10.8930   pre-mRNA splicing factor ATP-dependent RNA helicase, putative,RNA helicase, putative
Trypanosoma brucei gambiense Tbg972.5.1620   pre-mRNA splicing factor ATP-dependent RNA helicase, putative
Trypanosoma brucei Tb927.5.1150   RNA helicase Prp43
Trypanosoma brucei Tb927.11.5730   pre-mRNA-splicing factor ATP-dependent RNA helicase, putative
Trypanosoma brucei Tb927.10.7280   pre-mRNA splicing factor ATP-dependent RNA helicase, putative
Trypanosoma congolense TcIL3000.11.6100   pre-mRNA-splicing factor ATP-dependent RNA helicase, putative
Trypanosoma congolense TcIL3000_5_1020   RNA helicase Prp43
Trypanosoma congolense TcIL3000_5_1050   pre-mRNA splicing factor ATP-dependent RNA helicase, putative
Trypanosoma cruzi TcCLB.503911.20   pre-mRNA splicing factor ATP-dependent RNA helicase, putative
Trypanosoma cruzi TcCLB.507681.220   pre-mRNA splicing factor ATP-dependent RNA helicase, putative
Trypanosoma cruzi TcCLB.506203.70   pre-mRNA-splicing factor ATP-dependent RNA helicase, putative
Trypanosoma cruzi TcCLB.508643.9   pre-mRNA-splicing factor ATP-dependent RNA helicase, putative
Toxoplasma gondii TGME49_233530   hypothetical protein
Toxoplasma gondii TGME49_312280   pre-mRNA-splicing factor ATP-dependent RNA helicase, putative
Toxoplasma gondii TGME49_263650   pre-mRNA-processing protein 8, putative
Toxoplasma gondii TGME49_260200   helicase associated domain (ha2) protein
Toxoplasma gondii TGME49_233520   ATP-dependent RNA helicase
Treponema pallidum TP0526   ATP-dependent helicase (hrpA)
Theileria parva TP03_0394   splicing factor, putative
Theileria parva TP01_1019   ATP-dependent RNA helicase, putative
Theileria parva TP01_0544   RNA helicase, putative
Theileria parva TP01_0641   RNA helicase, putative
Trichomonas vaginalis TVAG_299100   ATP-dependent RNA helicase, putative
Trichomonas vaginalis TVAG_119590   ATP-dependent RNA helicase, putative
Trichomonas vaginalis TVAG_198940   ATP-dependent RNA helicase, putative
Trichomonas vaginalis TVAG_353500   ATP-dependent RNA helicase, putative
Trichomonas vaginalis TVAG_291440   ATP-dependent RNA helicase, putative
Trichomonas vaginalis TVAG_231410   ATP-dependent RNA helicase, putative
Trichomonas vaginalis TVAG_100850   ATP-dependent RNA helicase, putative

Essentiality

TVAG_299100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.7280 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.7280 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.7280 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.7280 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.02.3460 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.3460 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.3460 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.3460 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.5.1150 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.1150 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.5.1150 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.5.1150 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b0148 Escherichia coli non-essential goodall
CELE_K03H1.2 Caenorhabditis elegans embryonic arrest wormbase
CELE_K03H1.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_K03H1.2 Caenorhabditis elegans larval lethal wormbase
CELE_C04H5.6 Caenorhabditis elegans embryonic arrest wormbase
CELE_C04H5.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_C04H5.6 Caenorhabditis elegans larval arrest wormbase
CELE_C04H5.6 Caenorhabditis elegans larval lethal wormbase
CELE_C04H5.6 Caenorhabditis elegans sterile wormbase
CELE_EEED8.5 Caenorhabditis elegans embryonic arrest wormbase
CELE_EEED8.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_EEED8.5 Caenorhabditis elegans larval arrest wormbase
CELE_EEED8.5 Caenorhabditis elegans sterile wormbase
CELE_F56D2.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_F56D2.6 Caenorhabditis elegans larval arrest wormbase
CELE_F56D2.6 Caenorhabditis elegans slow growth wormbase
CELE_F56D2.6 Caenorhabditis elegans sterile wormbase
YKR086W Saccharomyces cerevisiae inviable yeastgenome
YNR011C Saccharomyces cerevisiae inviable yeastgenome
YER013W Saccharomyces cerevisiae inviable yeastgenome
YGL120C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0514100 Plasmodium berghei Essential plasmo
PBANKA_0818600 Plasmodium berghei Essential plasmo
TGME49_312280 Toxoplasma gondii Probably essential sidik
TGME49_263650 Toxoplasma gondii Probably essential sidik
TGME49_233520 Toxoplasma gondii Probably essential sidik
TGME49_260200 Toxoplasma gondii Probably essential sidik
TGME49_233530 Toxoplasma gondii Probably essential sidik
TGME49_312280 Toxoplasma gondii Probably non-essential sidik
TGME49_263650 Toxoplasma gondii Probably non-essential sidik
TGME49_233520 Toxoplasma gondii Probably non-essential sidik
TGME49_260200 Toxoplasma gondii Probably non-essential sidik
TGME49_233530 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Hepatitis C virus Nonstructural protein NS3-4A Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TVAG_299100 (Trichomonas vaginalis), ATP-dependent RNA helicase, putative
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