Detailed information for compound 878517

Basic information

Technical information
  • TDR Targets ID: 878517
  • Name: 2-[1-[2-(4-fluorophenyl)acetyl]piperidin-4-yl ]-N-methyl-N-prop-2-ynyl-1,3-thiazole-4-carbo xamide
  • MW: 399.482 | Formula: C21H22FN3O2S
  • H donors: 0 H acceptors: 3 LogP: 2.63 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)c1csc(n1)C1CCN(CC1)C(=O)Cc1ccc(cc1)F)CC#C
  • InChi: 1S/C21H22FN3O2S/c1-3-10-24(2)21(27)18-14-28-20(23-18)16-8-11-25(12-9-16)19(26)13-15-4-6-17(22)7-5-15/h1,4-7,14,16H,8-13H2,2H3
  • InChiKey: GHUZITMRMSWOOD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[1-[2-(4-fluorophenyl)acetyl]-4-piperidyl]-N-methyl-N-prop-2-ynyl-thiazole-4-carboxamide
  • 2-[1-[2-(4-fluorophenyl)-1-oxoethyl]-4-piperidinyl]-N-methyl-N-prop-2-ynyl-4-thiazolecarboxamide
  • 2-[1-[2-(4-fluorophenyl)acetyl]-4-piperidyl]-N-methyl-N-propargyl-thiazole-4-carboxamide
  • 2-[1-[2-(4-fluorophenyl)ethanoyl]piperidin-4-yl]-N-methyl-N-prop-2-ynyl-1,3-thiazole-4-carboxamide
  • Oprea1_722877

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica PH domain containing protein kinase, putative 0.0038 0.0139 0.0778
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0059 0.0473 0.0574
Echinococcus granulosus tyrosine kinase 0.0036 0.0112 0.0112
Trypanosoma cruzi polo-like protein kinase, putative 0.0121 0.1459 0.3355
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.1459 0.8157
Trichomonas vaginalis cyclins, putative 0.0076 0.0739 0.4104
Echinococcus granulosus serine/threonine protein kinase 0.0038 0.0139 0.0139
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0058 0.0457 0.0559
Echinococcus multilocularis cyclin dependent kinase 1 0.0111 0.1297 0.1585
Entamoeba histolytica cell division protein kinase 2, putative 0.0111 0.1297 0.7262
Toxoplasma gondii hypothetical protein 0.0032 0.0045 0.0252
Echinococcus multilocularis cyclin dependent kinase 0.0111 0.1297 0.1585
Loa Loa (eye worm) hypothetical protein 0.0033 0.007 0.0083
Brugia malayi Cyclin C 0.0094 0.1032 0.1247
Brugia malayi Protein kinase domain containing protein 0.0036 0.0112 0.0123
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0301 0.0301
Echinococcus granulosus cyclins 0.0047 0.0282 0.0282
Onchocerca volvulus 0.0077 0.0765 0.0807
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0613 0.1119
Loa Loa (eye worm) hypothetical protein 0.0043 0.022 0.0266
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0048 0.0301 0.0301
Echinococcus granulosus tyrosine protein kinase Src42A 0.0048 0.0301 0.0301
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0033 0.007 0.0083
Onchocerca volvulus Serine\/threonine kinase homolog 0.0121 0.1459 0.1665
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0058 0.0457 0.0559
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0048 0.0301 0.0368
Trichomonas vaginalis cyclin D, putative 0.0047 0.0282 0.1526
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0301 0.0368
Brugia malayi Sex muscle abnormal protein 5 0.003 0.0025 0.0017
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0221 0.3034 0.3697
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.007 0.0654 0.1504
Entamoeba histolytica protein kinase domain containing protein 0.0067 0.0601 0.3363
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.1459 0.2664
Loa Loa (eye worm) hypothetical protein 0.0043 0.022 0.0266
Schistosoma mansoni tyrosine kinase 0.0377 0.5476 1
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0142 0.1786 0.1786
Echinococcus multilocularis aurora kinase A 0.0142 0.1786 0.2183
Schistosoma mansoni tyrosine kinase 0.0284 0.4025 0.7351
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0058 0.0457 0.1051
Toxoplasma gondii AGC kinase 0.0058 0.0457 0.256
Schistosoma mansoni tyrosine kinase 0.0328 0.4715 0.861
Trichomonas vaginalis cyclin B, putative 0.0076 0.0739 0.4104
Brugia malayi Protein kinase domain containing protein 0.0033 0.007 0.0073
Entamoeba histolytica protein kinase, putative 0.0057 0.0448 0.2509
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0047 0.0282 0.0344
Toxoplasma gondii AGC kinase 0.0058 0.0457 0.256
Echinococcus granulosus RNA directed DNA polymerase 0.0046 0.0275 0.0275
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.1297 0.2368
Loa Loa (eye worm) hypothetical protein 0.0029 0.0006 0.0005
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0058 0.0457 0.1051
Entamoeba histolytica protein kinase 2, putative 0.0035 0.0101 0.0567
Trichomonas vaginalis AGC family protein kinase 0.0033 0.007 0.0335
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0043 0.022 0.0402
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0305 0.4348 1
Brugia malayi Protein kinase domain containing protein 0.0068 0.0613 0.0735
Trichomonas vaginalis AGC family protein kinase 0.006 0.0486 0.2676
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0613 0.339
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0765 0.4246
Giardia lamblia Hypothetical protein 0.0047 0.0282 0.1526
Loa Loa (eye worm) SRC-1 0.0048 0.0301 0.0365
Brugia malayi MAP kinase sur-1 0.007 0.0654 0.0785
Trypanosoma cruzi Protein kinase B 0.0038 0.0139 0.032
Trypanosoma brucei aurora B kinase 0.0142 0.1786 0.4107
Echinococcus multilocularis PAK box P21 Rho binding 0.0029 0.0011 0.0013
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0067 0.0601 0.0729
Schistosoma mansoni tyrosine kinase 0.0259 0.3627 0.6623
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.058 0.3204
Brugia malayi Cyclin, N-terminal domain containing protein 0.0047 0.0282 0.0331
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.007 0.0654 0.1504
Brugia malayi Protein kinase domain containing protein 0.0036 0.0112 0.0123
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0038 0.0139 0.032
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0048 0.0301 0.0368
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0142 0.1786 1
Entamoeba histolytica protein kinase, putative 0.0029 0.001 0.0057
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0043 0.022 0.0402
Echinococcus multilocularis roundabout 2 0.006 0.0499 0.061
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0112 0.0134
Loa Loa (eye worm) hypothetical protein 0.0046 0.0275 0.0333
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0112 0.0134
Giardia lamblia Kinase, AGC PKA 0.0058 0.0457 0.2514
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0048 0.0301 0.0368
Echinococcus granulosus roundabout 2 0.006 0.0499 0.0499
Loa Loa (eye worm) TK protein kinase 0.0036 0.0112 0.0134
Brugia malayi SH2 domain containing protein 0.0036 0.0112 0.0123
Trichomonas vaginalis CMGC family protein kinase 0.007 0.0654 0.3623
Leishmania major protein kinase A catalytic subunit 0.0058 0.0457 0.1051
Entamoeba histolytica cyclin family protein 0.0047 0.0282 0.1578
Brugia malayi p70 ribosomal S6 kinase beta 0.0057 0.0448 0.0534
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0067 0.0601 0.1381
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0068 0.0613 0.0749
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0058 0.0457 0.2113
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0036 0.0112 0.0137
Echinococcus multilocularis serine:threonine protein kinase N2 0.0033 0.007 0.0086
Trypanosoma brucei cdc2-related kinase 3 0.0111 0.1297 0.2982
Entamoeba histolytica cyclin, putative 0.0076 0.0739 0.414
Loa Loa (eye worm) hypothetical protein 0.0053 0.0387 0.0469
Loa Loa (eye worm) sex muscle abnormal protein 5 0.003 0.0025 0.0027
Onchocerca volvulus 0.0364 0.5272 0.6378
Schistosoma mansoni growth factor receptor-bound protein 0.003 0.0025 0.0045
Trichomonas vaginalis AGC family protein kinase 0.006 0.0486 0.2676
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0111 0.1297 0.1578
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0029 0.0011 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0932 0.1701
Echinococcus multilocularis serine threonine protein kinase 0.0081 0.082 0.1003
Onchocerca volvulus 0.055 0.8202 1
Echinococcus granulosus Immunoglobulin 0.0043 0.022 0.022
Loa Loa (eye worm) cyclin domain-containing protein 0.0047 0.0282 0.0341
Trichomonas vaginalis AGC family protein kinase 0.006 0.0486 0.2676
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0305 0.4348 1
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0142 0.1786 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0277 0.3914 0.477
Plasmodium falciparum serine/threonine protein kinase, putative 0.0142 0.1786 1
Echinococcus multilocularis cyclins 0.0047 0.0282 0.0344
Echinococcus granulosus protein kinase c epsilon type 0.0042 0.0205 0.0205
Schistosoma mansoni nephrin 0.0052 0.0374 0.0682
Trypanosoma cruzi cdc2-related kinase 3 0.0111 0.1297 0.2982
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0932 0.1701
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0067 0.0601 0.3363
Trypanosoma cruzi cyclin, putative 0.0076 0.0739 0.17
Loa Loa (eye worm) variant SH3 domain-containing protein 0.003 0.0025 0.0027
Brugia malayi serine/threonine protein kinase 6 0.0142 0.1786 0.2167
Brugia malayi SH2 domain containing protein 0.0036 0.0112 0.0123
Brugia malayi protein kinase C II. 0.0042 0.0205 0.0237
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0112 0.0134
Echinococcus granulosus twitchin 0.0064 0.0548 0.0548
Plasmodium vivax protein kinase Crk2 0.0111 0.1297 0.7097
Echinococcus multilocularis neuroglian 0.0052 0.0374 0.0457
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0033 0.007 0.0086
Brugia malayi Protein kinase domain containing protein 0.0036 0.0112 0.0123
Schistosoma mansoni tyrosine kinase 0.0266 0.3739 0.6827
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0035 0.0101 0.0101
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0601 0.3322
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.1786 0.3261
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0058 0.0457 0.0559
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0036 0.0112 0.0112
Loa Loa (eye worm) cyclin C 0.0094 0.1032 0.1256
Echinococcus granulosus cyclin dependent kinase 0.0111 0.1297 0.1297
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0133 0.1642 0.1642
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0101 0.1134 0.138
Schistosoma mansoni tyrosine kinase 0.0048 0.0301 0.055
Loa Loa (eye worm) AUR protein kinase 0.0142 0.1786 0.2175
Entamoeba histolytica hypothetical protein 0.0074 0.0717 0.4012
Entamoeba histolytica protein kinase, putative 0.0067 0.0601 0.3363
Leishmania major protein kinase, putative 0.0142 0.1786 0.4107
Schistosoma mansoni vesicular amine transporter 0.0043 0.022 0.0402
Trichomonas vaginalis cyclins, putative 0.0076 0.0739 0.4104
Trichomonas vaginalis AGC family protein kinase 0.0033 0.007 0.0335
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.058 0.3204
Echinococcus multilocularis c src tyrosine kinase 0.0048 0.0301 0.0368
Brugia malayi phosphoinositide-dependent protein kinase I 0.0068 0.0613 0.0735
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.1134 0.2071
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0111 0.1297 0.1578
Schistosoma mansoni serine/threonine-protein kinase 0.0038 0.0139 0.0254
Onchocerca volvulus 0.0067 0.0601 0.0604
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0027
Loa Loa (eye worm) TK/EGFR protein kinase 0.0328 0.4715 0.5747
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.03 0.4265 0.5214
Schistosoma mansoni kinase 0.0067 0.0603 0.11
Echinococcus granulosus NDR protein kinase 0.0033 0.007 0.007
Trichomonas vaginalis cyclin H, putative 0.0074 0.0717 0.3975
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0058 0.0457 0.0457
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0029 0.0011 0.0013
Schistosoma mansoni tyrosine kinase 0.0036 0.0112 0.0205
Trypanosoma cruzi aurora B kinase, putative 0.0142 0.1786 0.4107
Echinococcus granulosus tyrosine protein kinase Srms 0.0036 0.0112 0.0112
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.007 0.0654 0.1504
Echinococcus multilocularis protein kinase shaggy 0.0067 0.0601 0.0734
Schistosoma mansoni adapter molecule crk 0.003 0.0025 0.0045
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.1297 0.7245
Schistosoma mansoni tyrosine kinase 0.0036 0.0113 0.0206
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0432 0.6346 0.7736
Entamoeba histolytica protein kinase, putative 0.0033 0.007 0.0394
Echinococcus multilocularis cyclins 0.0047 0.0282 0.0344
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0058 0.0457 0.1051
Trypanosoma brucei rac serine-threonine kinase, putative 0.006 0.0486 0.1117
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0111 0.1297 0.1297
Trichomonas vaginalis CMGC family protein kinase 0.007 0.0654 0.3623
Leishmania major protein kinase A catalytic subunit isoform 2 0.0058 0.0457 0.1051
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0094 0.1032 0.1032
Entamoeba histolytica cell division protein kinase 2, putative 0.0111 0.1297 0.7262
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0457 0.0835
Echinococcus multilocularis cyclin dependent kinase 7 0.0101 0.1134 0.1387
Giardia lamblia G2/mitotic-specific cyclin B 0.0076 0.0739 0.4104
Trichomonas vaginalis AGC family protein kinase 0.006 0.0486 0.2676
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0133 0.1642 0.2007
Leishmania major protein kinase A catalytic subunit isoform 1 0.0058 0.0457 0.1051
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.1297 0.7245
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0301 0.0301
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0221 0.3034 0.3709
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0121 0.1459 0.1783
Brugia malayi Immunoglobulin I-set domain containing protein 0.0432 0.6346 0.7734
Echinococcus multilocularis cyclin B 0.0076 0.0739 0.0904
Schistosoma mansoni growth factor receptor-bound protein 0.003 0.0025 0.0045
Trichomonas vaginalis cyclins, putative 0.0047 0.0282 0.1526
Giardia lamblia Kinase, CMGC CDK 0.0111 0.1297 0.7245
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0305 0.4348 0.53
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0058 0.0457 0.256
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0029 0.001 0.0057
Loa Loa (eye worm) hypothetical protein 0.0043 0.022 0.0266
Plasmodium falciparum cyclin 0.0047 0.0282 0.1578
Loa Loa (eye worm) cyclin domain-containing protein 0.0168 0.22 0.268
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0058 0.0457 0.0457
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0067 0.0601 0.1381
Schistosoma mansoni cell adhesion molecule 0.0051 0.0346 0.0632
Loa Loa (eye worm) hypothetical protein 0.0537 0.8006 0.976
Schistosoma mansoni serine/threonine protein kinase 0.0221 0.3034 0.554
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0654 0.1194
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0301 0.0368
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.007 0.0654 0.1504
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0112 0.0134
Trichomonas vaginalis CMGC family protein kinase 0.007 0.0654 0.3623
Echinococcus granulosus cyclin B3 1 0.0047 0.0282 0.0282
Echinococcus granulosus protein kinase c iota type 0.004 0.0182 0.0182
Echinococcus granulosus c src tyrosine kinase 0.0048 0.0301 0.0301
Brugia malayi Serine/threonine-protein kinase Nek7 0.0252 0.3522 0.4287
Entamoeba histolytica protein kinase , putative 0.0142 0.1786 1
Brugia malayi map kinase activated protein kinase protein 2 0.0221 0.3034 0.369
Entamoeba histolytica protein kinase, putative 0.0142 0.1786 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0277 0.3914 0.4784
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0197 0.2653 0.3233
Echinococcus multilocularis 0.0094 0.103 0.1259
Entamoeba histolytica protein kinase, putative 0.0068 0.0613 0.3431
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.03 0.4265 0.4265
Plasmodium vivax glycogen synthase kinase 3, putative 0.0067 0.0601 0.2964
Brugia malayi Variant SH3 domain containing protein 0.003 0.0025 0.0017
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0613 0.339
Schistosoma mansoni cyclin B 0.0076 0.0739 0.135
Echinococcus granulosus neuroglian 0.0052 0.0374 0.0374
Echinococcus granulosus growth factor receptor bound protein 2 0.003 0.0025 0.0025
Entamoeba histolytica protein kinase, putative 0.006 0.0486 0.2721
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0033 0.007 0.007
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0206 0.2799 0.341
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0057 0.0448 0.0543
Brugia malayi Protein kinase domain containing protein 0.0036 0.0112 0.0123
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0029 0.0011 0.0013
Echinococcus multilocularis cyclins 0.0047 0.0282 0.0344
Trypanosoma brucei polo-like protein kinase 0.0121 0.1459 0.3355
Echinococcus multilocularis insulin receptor 0.0377 0.5476 0.6694
Echinococcus multilocularis mitogen activated protein kinase 11 0.0305 0.4348 0.5315
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0108 0.0548
Loa Loa (eye worm) AUR protein kinase 0.0142 0.1786 0.2175
Loa Loa (eye worm) hypothetical protein 0.0043 0.0223 0.0268
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0033 0.007 0.0083
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0048 0.0301 0.0368
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0068 0.0613 0.0613
Entamoeba histolytica serine/threonine protein kinase, putative 0.0121 0.1459 0.8168
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.1459 0.8157
Echinococcus granulosus cyclins 0.0047 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0076 0.0739 0.0899
Leishmania major cyclin 0.0076 0.0739 0.17
Trichomonas vaginalis cyclin B, putative 0.0076 0.0739 0.4104
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0067 0.0601 0.1097
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0111 0.1297 0.1578
Echinococcus granulosus aurora kinase A 0.0142 0.1786 0.1786
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0058 0.0457 0.0559
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0613 0.339
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.1459 0.8157
Schistosoma mansoni cyclin B3 0.0047 0.0282 0.0515
Brugia malayi Protein kinase domain containing protein 0.0036 0.0112 0.0123
Trypanosoma cruzi cdc2-related kinase 1 0.0111 0.1297 0.2982
Echinococcus granulosus mitogen activated protein kinase 0.007 0.0654 0.0654
Trichomonas vaginalis CMGC family protein kinase 0.007 0.0654 0.3623
Brugia malayi Variant SH3 domain containing protein 0.003 0.0025 0.0017
Trypanosoma brucei cdc2-related kinase 1 0.0111 0.1297 0.2982
Echinococcus multilocularis RNA directed DNA polymerase 0.0046 0.0275 0.0337
Brugia malayi Protein kinase domain containing protein 0.055 0.8202 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0739 0.0899
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0058 0.0457 0.0457
Loa Loa (eye worm) IKK protein kinase 0.055 0.8202 1
Brugia malayi Protein kinase c protein 2 0.0066 0.0585 0.0701
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0033 0.007 0.0086
Trichomonas vaginalis cyclin B, putative 0.0076 0.0739 0.4104
Echinococcus multilocularis mitogen activated protein kinase 14 0.0305 0.4348 0.5315
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0058 0.0457 0.1051
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0112 0.0134
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0121 0.1459 0.1459
Echinococcus granulosus serine threonine protein kinase nrc 0.0035 0.0101 0.0101
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.1297 0.2368
Brugia malayi Furin-like cysteine rich region family protein 0.0328 0.4715 0.5743
Schistosoma mansoni tyrosine kinase 0.0048 0.0301 0.055
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.003 0.0025 0.0045
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0046 0.0275 0.0337
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0112 0.0134
Loa Loa (eye worm) hypothetical protein 0.0043 0.022 0.0266
Echinococcus granulosus cyclin dependent kinase 7 0.0101 0.1134 0.1134
Toxoplasma gondii AGC kinase 0.0057 0.0448 0.2509
Echinococcus granulosus insulin receptor 0.0377 0.5476 0.5476
Brugia malayi Tyrosine-protein kinase abl-1 0.0149 0.1897 0.2302
Echinococcus multilocularis tyrosine protein kinase Abl 0.014 0.1755 0.2145
Echinococcus granulosus protein kinase shaggy 0.0067 0.0601 0.0601
Echinococcus granulosus fibroblast growth factor receptor 4 0.0133 0.1642 0.1642
Schistosoma mansoni g1/s-specific cyclin C 0.0094 0.1032 0.1885
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0112 0.0134
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.1297 0.7245
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0048 0.0301 0.055
Giardia lamblia Aurora kinase 0.0142 0.1786 1
Trichomonas vaginalis cyclin B3, putative 0.0047 0.0282 0.1526
Loa Loa (eye worm) CDC7 protein kinase 0.0077 0.0765 0.0929
Echinococcus multilocularis growth factor receptor bound protein 2 0.003 0.0025 0.003
Echinococcus multilocularis mitogen activated protein kinase 14 0.0305 0.4348 0.5315
Entamoeba histolytica cyclin family protein 0.0047 0.0282 0.1578
Brugia malayi SRC-1 0.0048 0.0301 0.0355
Schistosoma mansoni serine/threonine protein kinase 0.0252 0.3522 0.6432
Echinococcus granulosus cyclin b3 0.0047 0.0282 0.0282
Brugia malayi Protein kinase domain containing protein 0.006 0.0486 0.058
Echinococcus multilocularis cyclins 0.0047 0.0282 0.0344
Schistosoma mansoni tyrosine kinase 0.0048 0.0301 0.055
Brugia malayi Fibronectin type III domain containing protein 0.0043 0.022 0.0256
Echinococcus granulosus cyclin dependent kinase 5 0.0111 0.1297 0.1297
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0068 0.0613 0.0744
Loa Loa (eye worm) hypothetical protein 0.0051 0.0346 0.0419
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0302 0.0552
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0548 0.8181 1
Loa Loa (eye worm) AGC/PKA protein kinase 0.0058 0.0457 0.0555
Echinococcus multilocularis serine:threonine protein kinase N2 0.0033 0.007 0.0086
Giardia lamblia Cyclin A 0.0047 0.0282 0.1526
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0142 0.1786 1
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0058 0.0457 0.1051
Loa Loa (eye worm) AGC/NDR protein kinase 0.0033 0.007 0.0083
Schistosoma mansoni serine/threonine kinase 0.0033 0.007 0.0128
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.007 0.0654 0.1504
Schistosoma mansoni tyrosine kinase 0.0048 0.0301 0.055
Echinococcus granulosus protein kinase C gamma type 0.0081 0.082 0.082
Loa Loa (eye worm) AGC/PKN protein kinase 0.0033 0.007 0.0083
Schistosoma mansoni tyrosine kinase 0.0035 0.0104 0.019
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.006 0.0499 0.0606
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0142 0.1786 0.2183
Echinococcus granulosus cyclins 0.0047 0.0282 0.0282
Trichomonas vaginalis cyclin B, putative 0.0047 0.0282 0.1526
Schistosoma mansoni serine/threonine protein kinase 0.0206 0.2799 0.5111
Giardia lamblia Kinase, CDC7 0.0077 0.0765 0.4246
Echinococcus granulosus tyrosine protein kinase ABL1 0.0277 0.3914 0.3914
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0121 0.1459 0.3355
Loa Loa (eye worm) hypothetical protein 0.0058 0.0457 0.0555
Loa Loa (eye worm) AGC/AKT protein kinase 0.006 0.0486 0.059
Schistosoma mansoni nck2/grb4 0.003 0.0025 0.0045
Onchocerca volvulus 0.0077 0.0765 0.0807
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0601 0.3322
Echinococcus multilocularis tyrosine kinase 0.0036 0.0112 0.0137
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.1459 0.8157
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0765 0.1396
Trypanosoma cruzi cdc2-related kinase 1 0.0111 0.1297 0.2982
Echinococcus granulosus cyclins 0.0047 0.0282 0.0282
Echinococcus multilocularis tyrosine protein kinase Blk 0.0036 0.0112 0.0137
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0765 0.4246
Brugia malayi P38 map kinase family protein 2 0.0305 0.4348 0.5295
Trypanosoma cruzi polo-like protein kinase, putative 0.0121 0.1459 0.3355
Schistosoma mansoni cyclins 0.0047 0.0282 0.0515
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0305 0.4348 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.007 0.0654 0.08
Echinococcus granulosus cyclins 0.0047 0.0282 0.0282
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1786 1
Brugia malayi hypothetical protein 0.0043 0.022 0.0256
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0206 0.2798 0.3421
Echinococcus granulosus mitogen activated protein kinase 14 0.0305 0.4348 0.4348
Schistosoma mansoni tyrosine kinase 0.023 0.3167 0.5783
Entamoeba histolytica PH domain containing protein kinase, putative 0.006 0.0495 0.2772
Echinococcus multilocularis protein kinase c iota type 0.004 0.0182 0.0222
Echinococcus multilocularis cyclin B3 1 0.0047 0.0282 0.0344
Echinococcus granulosus Protein kinase C brain isozyme 0.0088 0.0932 0.0932
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0247 0.3443 0.3443
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0133 0.1642 0.2007
Brugia malayi Cyclin, N-terminal domain containing protein 0.0076 0.0739 0.0889
Giardia lamblia Kinase, AGC PKA 0.0035 0.0101 0.0509
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.007 0.0654 0.1504
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0048 0.0301 0.0301
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0058 0.0457 0.1051
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0134
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0112 0.0137
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0048 0.0301 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0282 0.1526
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.007 0.0654 0.3662
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0121 0.1459 0.1776
Entamoeba histolytica p21-activated kinase 0.0032 0.0049 0.0273
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0029 0.0011 0.0011
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0548 0.8181 0.8181
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0058 0.0457 0.256
Brugia malayi Tyrosine-protein kinase abl-1 0.014 0.1755 0.2129
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0094 0.1032 0.1262
Loa Loa (eye worm) hypothetical protein 0.03 0.4265 0.5199
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0067 0.0601 0.0729
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0205 0.0374
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0457 0.0835
Echinococcus granulosus epidermal growth factor receptor 0.0328 0.4715 0.4715
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0377 0.5476 0.5476
Trichomonas vaginalis cyclins, putative 0.0076 0.0739 0.4104
Brugia malayi serine/threonine-protein kinase plk-2 0.0121 0.1459 0.1767
Brugia malayi Protein kinase domain containing protein 0.0077 0.0765 0.092
Echinococcus granulosus defective proboscis extension response 0.0043 0.022 0.022
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0305 0.4348 1
Brugia malayi serine/threonine-protein kinase 6 0.0142 0.1786 0.2167
Trypanosoma brucei protein kinase, putative 0.007 0.0654 0.1504
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.022 0.0256
Brugia malayi Hr1 repeat family protein 0.0033 0.007 0.0073
Brugia malayi Protein kinase domain containing protein 0.0111 0.1297 0.157
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0111 0.1297 0.2982
Loa Loa (eye worm) hypothetical protein 0.0043 0.022 0.0266
Trichomonas vaginalis AGC family protein kinase 0.006 0.0486 0.2676
Echinococcus granulosus tyrosine kinase 0.0036 0.0112 0.0112
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0067 0.0601 0.0601
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.03 0.4265 0.7789
Entamoeba histolytica protein kinase, putative 0.0029 0.0011 0.0061
Echinococcus multilocularis cyclin 0.0094 0.1032 0.1262
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0225 0.3086 0.376
Entamoeba histolytica PH domain containing protein kinase, putative 0.0038 0.0139 0.0778
Loa Loa (eye worm) AUR protein kinase 0.0142 0.1786 0.2175
Echinococcus granulosus tyrosine protein kinase Lyn 0.0059 0.0476 0.0476
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0112 0.0134
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0457 0.2514
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0457 0.0835
Brugia malayi Protein kinase domain containing protein 0.0206 0.2799 0.3404
Trypanosoma cruzi cyclin, putative 0.0076 0.0739 0.17
Echinococcus multilocularis mitogen activated protein kinase 0.007 0.0654 0.08
Entamoeba histolytica protein kinase, putative 0.006 0.0486 0.2721
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.1459 0.8157
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0033 0.007 0.007
Schistosoma mansoni atypical protein kinase C 0.004 0.0182 0.0332
Echinococcus multilocularis cyclin b3 0.0047 0.0282 0.0344
Brugia malayi Protein kinase domain containing protein 0.0197 0.2653 0.3226
Loa Loa (eye worm) NEK/NEK6 protein kinase 0.0252 0.3522 0.4292
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.007 0.0128
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1786 1
Brugia malayi Protein kinase domain containing protein 0.0377 0.5476 0.6672
Brugia malayi Cyclin, N-terminal domain containing protein 0.0076 0.0739 0.0889
Loa Loa (eye worm) hypothetical protein 0.0143 0.1807 0.22
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0067 0.0601 0.0734
Echinococcus granulosus mitogen activated protein kinase 11 0.0305 0.4348 0.4348
Echinococcus multilocularis cyclins 0.0047 0.0282 0.0344
Onchocerca volvulus Tyrosine kinase homolog 0.0391 0.5702 0.6909
Echinococcus multilocularis Immunoglobulin 0.0043 0.022 0.0269
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.007 0.0128
Brugia malayi cell division control protein 2 homolog 0.0111 0.1297 0.157
Brugia malayi serine/threonine-protein kinase PAK 7 0.0225 0.3086 0.3754
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0068 0.0613 0.0744
Entamoeba histolytica protein kinase, putative 0.0142 0.1786 1
Echinococcus multilocularis Immunoglobulin 0.0043 0.022 0.0269
Chlamydia trachomatis serine/threonine protein kinase 0.0252 0.3522 0.5
Loa Loa (eye worm) hypothetical protein 0.0143 0.1807 0.22
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1786 1
Trypanosoma cruzi CYC2-like cyclin, putative 0.0076 0.0739 0.17
Brugia malayi hypothetical protein 0.0036 0.0112 0.0123
Trypanosoma cruzi cdc2-related kinase 3 0.0111 0.1297 0.2982
Trichomonas vaginalis AGC family protein kinase 0.0033 0.007 0.0335
Echinococcus granulosus tyrosine protein kinase Src64B 0.0048 0.0301 0.0301
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.1459 0.8157
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0221 0.3034 0.3034
Echinococcus multilocularis serine:threonine protein kinase 38 0.0033 0.007 0.0086
Schistosoma mansoni tyrosine kinase 0.0377 0.5476 1
Trichomonas vaginalis cyclin B, putative 0.0076 0.0739 0.4104
Giardia lamblia Kinase, PLK 0.0121 0.1459 0.8157
Schistosoma mansoni protein kinase 0.0142 0.1786 0.3261
Trichomonas vaginalis AGC family protein kinase 0.006 0.0486 0.2676
Giardia lamblia Kinase, CMGC GSK 0.0067 0.0601 0.3322
Schistosoma mansoni tyrosine kinase 0.023 0.3167 0.5783
Schistosoma mansoni protein kinase 0.0029 0.0011 0.002
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0048 0.0301 0.0368
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0033 0.007 0.0086
Giardia lamblia Kinase, CMGC MAPK 0.007 0.0654 0.3623
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0377 0.5476 0.6694
Entamoeba histolytica protein kinase, putative 0.0032 0.0049 0.0273
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0112 0.0134
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0076 0.0739 0.17
Echinococcus granulosus serine:threonine protein kinase N2 0.0033 0.007 0.007
Echinococcus multilocularis epidermal growth factor receptor 0.0328 0.4715 0.5764
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.007 0.0654 0.1504
Plasmodium falciparum protein kinase 5 0.0111 0.1297 0.7262
Schistosoma mansoni tyrosine kinase 0.023 0.3167 0.5783
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0033 0.007 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.007 0.0128
Loa Loa (eye worm) hypothetical protein 0.011 0.1279 0.1556
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0142 0.1786 1
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0058 0.0457 0.0545
Schistosoma mansoni protein kinase 0.0029 0.0011 0.002
Entamoeba histolytica protein kinase, putative 0.0029 0.0011 0.0061
Echinococcus granulosus cyclin B 0.0076 0.0739 0.0739
Loa Loa (eye worm) AGC/PKA protein kinase 0.0058 0.0457 0.0555
Schistosoma mansoni tyrosine kinase 0.0247 0.3443 0.6288
Toxoplasma gondii aurora kinase 0.0142 0.1786 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0043 0.022 0.0269
Echinococcus multilocularis protein kinase c epsilon type 0.0042 0.0205 0.025
Echinococcus granulosus tyrosine protein kinase Blk 0.0036 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.006 0.0499 0.0606
Echinococcus granulosus cyclin dependent kinase 1 0.0111 0.1297 0.1297
Trichomonas vaginalis cyclin A, putative 0.0076 0.0739 0.4104
Echinococcus granulosus cyclin 0.0094 0.1032 0.1032
Echinococcus multilocularis cyclins 0.0047 0.0282 0.0344
Loa Loa (eye worm) TK/INSR protein kinase 0.0377 0.5476 0.6675
Onchocerca volvulus 0.0076 0.0739 0.0776
Schistosoma mansoni protein kinase 0.0197 0.2653 0.4845
Loa Loa (eye worm) TK protein kinase 0.0143 0.1795 0.2187
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0111 0.1297 0.7262
Schistosoma mansoni protein kinase 0.0029 0.0011 0.002
Echinococcus granulosus NCK adaptor protein 0.003 0.0025 0.0025
Brugia malayi Protein kinase domain containing protein 0.0185 0.2457 0.2986
Trypanosoma cruzi cyclin 6, putative 0.0076 0.0739 0.17
Brugia malayi intracellular kinase 0.0067 0.0601 0.072
Echinococcus granulosus epidermal growth factor receptor 0.0247 0.3443 0.3443
Echinococcus multilocularis NCK adaptor protein 0.003 0.0025 0.003
Echinococcus multilocularis tyrosine protein kinase shark 0.0284 0.4025 0.4921
Echinococcus multilocularis CDC7 cell division cycle 7 0.0077 0.0765 0.0935
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1786 1
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.1134 0.2071
Echinococcus multilocularis mitogen activated protein kinase 11 0.0305 0.4348 0.5315
Trichomonas vaginalis AGC family protein kinase 0.006 0.0486 0.2676
Schistosoma mansoni serine/threonine-protein kinase 0.0038 0.0139 0.0254
Echinococcus granulosus mitogen activated protein kinase 3 0.007 0.0654 0.0654
Brugia malayi Protein kinase domain containing protein 0.0033 0.007 0.0073
Trichomonas vaginalis cyclins, putative 0.0076 0.0739 0.4104
Loa Loa (eye worm) hypothetical protein 0.0167 0.218 0.2656
Entamoeba histolytica protein kinase domain containing protein 0.0142 0.1786 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0051 0.0346 0.0346
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.007 0.0654 0.0795
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0048 0.0301 0.0368
Trypanosoma brucei mitotic cyclin 6 0.0076 0.0739 0.17
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0047 0.0282 0.0282
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0029 0.0011 0.0013
Trypanosoma brucei protein kinase, putative 0.0067 0.0601 0.1381
Schistosoma mansoni tyrosine kinase 0.0133 0.1642 0.2999
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0035 0.0101 0.0567
Schistosoma mansoni tyrosine kinase 0.0247 0.3443 0.6288
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0206 0.2798 0.2798
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0036 0.0112 0.0112
Echinococcus granulosus tyrosine protein kinase shark 0.0284 0.4025 0.4025
Brugia malayi serine/threonine kinase 12 0.0142 0.1786 0.2167
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0765 0.4246
Echinococcus multilocularis cyclins 0.0047 0.0282 0.0344
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.007 0.0128
Plasmodium falciparum glycogen synthase kinase 3 0.0067 0.0601 0.3363
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0035 0.0101 0.0124
Loa Loa (eye worm) hypothetical protein 0.01 0.1122 0.1365
Echinococcus multilocularis rac serine:threonine kinase 0.0038 0.0139 0.017
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0301 0.0368
Echinococcus multilocularis cyclin dependent kinase 5 0.0111 0.1297 0.1585
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0058 0.0457 0.1051
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0112 0.0134
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0035 0.0101 0.0233
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0042 0.0205 0.0247
Entamoeba histolytica protein kinase domain containing protein 0.0067 0.0601 0.3363
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0047 0.0282 0.0282
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0029 0.0011 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.1459 0.8157
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0111 0.1297 0.2982
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0048 0.0301 0.0301
Echinococcus multilocularis tyrosine protein kinase Srms 0.0036 0.0112 0.0137
Echinococcus multilocularis cyclin dependent kinase 1 0.0111 0.1297 0.1585
Giardia lamblia Kinase, CMGC GSK 0.0067 0.0601 0.3322
Brugia malayi cyclin-dependent kinase 7 homolog 0.0101 0.1134 0.1371
Brugia malayi protein-tyrosine kinase 0.0036 0.0112 0.0123
Brugia malayi hypothetical protein 0.0143 0.1807 0.2192
Brugia malayi Cyclin, N-terminal domain containing protein 0.0168 0.22 0.2672
Entamoeba histolytica cyclin, putative 0.0047 0.0282 0.1578
Trichomonas vaginalis cyclins, putative 0.0044 0.0243 0.1308
Echinococcus multilocularis epidermal growth factor receptor 0.0247 0.3443 0.4209
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0033 0.007 0.007
Entamoeba histolytica protein kinase, putative 0.0032 0.0049 0.0273
Brugia malayi Immunoglobulin I-set domain containing protein 0.0143 0.1795 0.2179
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0047 0.0282 0.0345
Entamoeba histolytica PH domain containing protein kinase, putative 0.006 0.0495 0.2772
Echinococcus granulosus CDC7 cell division cycle 7 0.0077 0.0765 0.0765
Trichomonas vaginalis cyclin D, putative 0.0047 0.0282 0.1526
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0036 0.0112 0.0627
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0088 0.0932 0.1139
Giardia lamblia Kinase, CMGC CDK 0.0111 0.1297 0.7245

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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