Detailed information for compound 42639

Basic information

Technical information
  • TDR Targets ID: 42639
  • Name: N-[7-(4-dimethylaminophenyl)-1,6-naphthyridin -5-yl]butane-1,4-diamine
  • MW: 335.446 | Formula: C20H25N5
  • H donors: 2 H acceptors: 2 LogP: 3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCCCNc1nc(cc2c1cccn2)c1ccc(cc1)N(C)C
  • InChi: 1S/C20H25N5/c1-25(2)16-9-7-15(8-10-16)18-14-19-17(6-5-13-22-19)20(24-18)23-12-4-3-11-21/h5-10,13-14H,3-4,11-12,21H2,1-2H3,(H,23,24)
  • InChiKey: SBGMPUIVPOGTGN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [4-[5-(4-aminobutylamino)-1,6-naphthyridin-7-yl]phenyl]-dimethyl-amine
  • 4-aminobutyl-[7-(4-dimethylaminophenyl)-1,6-naphthyridin-5-yl]amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TXK tyrosine kinase Starlite/ChEMBL References
Homo sapiens STE20-like kinase Starlite/ChEMBL References
Homo sapiens lysyl-tRNA synthetase Starlite/ChEMBL References
Homo sapiens spleen tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative Get druggable targets OG5_131855 All targets in OG5_131855
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130670 All targets in OG5_130670
Cryptosporidium parvum lysyl-tRNA synthetase (NOB+tRNA synthetase) Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania donovani lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Trypanosoma congolense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Toxoplasma gondii lysine-tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum ko:K04567 lysyl-tRNA synthetase, class II, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma japonicum Tyrosine-protein kinase BTK, putative Get druggable targets OG5_129320 All targets in OG5_129320
Schistosoma japonicum ko:K05855 spleen tyrosine kinase, putative Get druggable targets OG5_131855 All targets in OG5_131855
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania major lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Brugia malayi lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) STE/STE20/SLK protein kinase Get druggable targets OG5_130670 All targets in OG5_130670
Cryptosporidium hominis Kars protein Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania infantum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Babesia bovis lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma cruzi lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus STE20 serine:threonine protein kinase Get druggable targets OG5_130670 All targets in OG5_130670
Plasmodium knowlesi lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis tyrosine protein kinase Btk29A Get druggable targets OG5_129320 All targets in OG5_129320
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium vivax lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Chlamydia trachomatis lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129320 All targets in OG5_129320
Trypanosoma brucei gambiense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum ko:K08837 serine/threonine kinase 10, putative Get druggable targets OG5_130670 All targets in OG5_130670
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum expressed protein Get druggable targets OG5_130670 All targets in OG5_130670
Theileria parva lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Giardia lamblia Lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni protein kinase Get druggable targets OG5_130670 All targets in OG5_130670
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative Get druggable targets OG5_129320 All targets in OG5_129320
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130670 All targets in OG5_130670
Echinococcus granulosus tyrosine protein kinase Btk29A Get druggable targets OG5_129320 All targets in OG5_129320
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Leishmania braziliensis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis STE20 serine:threonine protein kinase Get druggable targets OG5_130670 All targets in OG5_130670
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0012 0.0012
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0281 0.4987
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0511 0.9203 1
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0397 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0634 0.0649
Schistosoma mansoni tyrosine kinase 0.0018 0.0094 0.006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0266 0.0266
Schistosoma mansoni intermediate filament proteins 0.0028 0.0276 0.0258
Loa Loa (eye worm) norepinephrine transporter 0.0511 0.9203 0.921
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0281 0.1517
Echinococcus multilocularis tyrosine protein kinase Abl 0.0018 0.0094 0.0085
Echinococcus granulosus c src tyrosine kinase 0.0018 0.0094 0.0085
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0087 0.1364 0.1356
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0312 0.5521 1
Echinococcus granulosus pyruvate kinase 0.0034 0.0397 0.0388
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0062 0.0053
Echinococcus granulosus sodium and chloride dependent glycine 0.0087 0.1364 0.1356
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0397 0.0419
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0012 0.0012
Echinococcus granulosus tyrosine protein kinase Src64B 0.0018 0.0094 0.0085
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0281 0.0216
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0018 0.0094 0.0085
Schistosoma mansoni sodium/chloride dependent transporter 0.0511 0.9203 1
Echinococcus granulosus importin subunit beta 1 0.003 0.0311 0.0302
Onchocerca volvulus 0.0087 0.1364 0.1471
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0397 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0712 0.0761
Echinococcus multilocularis pyruvate kinase 0.0018 0.0088 0.0078
Echinococcus multilocularis importin subunit beta 1 0.003 0.0311 0.0302
Brugia malayi Protein kinase domain containing protein 0.0192 0.3313 0.3591
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0634 0.0676
Onchocerca volvulus 0.0087 0.1364 0.1471
Echinococcus granulosus tyrosine kinase 0.0014 0.0012 0.0003
Echinococcus granulosus serotonin transporter 0.0511 0.9203 0.9203
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0087 0.1364 0.1446
Echinococcus granulosus tyrosine protein kinase Src42A 0.0018 0.0094 0.0085
Onchocerca volvulus 0.0028 0.0276 0.0287
Echinococcus granulosus snurportin 1 0.0318 0.5632 0.5628
Schistosoma mansoni ran 0.0022 0.0166 0.0139
Schistosoma mansoni sodium/chloride dependent transporter 0.0087 0.1364 0.1446
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0062
Echinococcus granulosus pyruvate kinase 0.0034 0.0397 0.0388
Schistosoma mansoni pyruvate kinase 0.0018 0.0088 0.0053
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0281 0.1517
Loa Loa (eye worm) hypothetical protein 0.0087 0.1364 0.1365
Echinococcus granulosus pyruvate kinase 0.0018 0.0088 0.0078
Echinococcus multilocularis sodium and chloride dependent glycine 0.0087 0.1364 0.1356
Onchocerca volvulus 0.0087 0.1364 0.1471
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0018 0.0094 0.006
Echinococcus granulosus tyrosine protein kinase ABL1 0.0014 0.0012 0.0003
Echinococcus multilocularis lamin 0.0028 0.0276 0.0266
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0571 0.0757
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0018 0.0094 0.0085
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0087 0.1364 0.1471
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0018 0.0094 0.0085
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0018 0.0094 0.0085
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0087 0.1364 0.1365
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0012 0.0012
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0012 0.0012
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0397 0.0398
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0571 0.0757
Loa Loa (eye worm) hypothetical protein 0.0087 0.1364 0.1365
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0062 0.0062
Echinococcus granulosus lamin dm0 0.0028 0.0276 0.0266
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0014 0.0012 0.0003
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0312 0.5521 1
Echinococcus multilocularis c src tyrosine kinase 0.0018 0.0094 0.0085
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0087 0.1364 0.1356
Loa Loa (eye worm) serotonin transporter b 0.0511 0.9203 0.921
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0087 0.1364 1
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0281 0.6253
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0039 0.0029
Loa Loa (eye worm) solute carrier family 6 member 4 0.0511 0.9203 0.921
Echinococcus multilocularis tyrosine kinase 0.0014 0.0012 0.0003
Mycobacterium ulcerans hypothetical protein 0.0164 0.2795 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.2795 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0634 0.0649
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0166 0.0613
Echinococcus granulosus tyrosine protein kinase Lyn 0.0018 0.0101 0.0091
Echinococcus multilocularis growth factor receptor bound protein 2 0.0015 0.0039 0.003
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0281 0.0272
Loa Loa (eye worm) hypothetical protein 0.0051 0.0712 0.0712
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0087 0.1364 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0087 0.1364 0.1446
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0087 0.1364 0.1471
Schistosoma mansoni hypothetical protein 0.0016 0.0062 0.0025
Brugia malayi intermediate filament protein 0.0028 0.0276 0.0287
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0411 0.0411
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0166 0.0613
Plasmodium falciparum amino acid transporter, putative 0.0087 0.1364 1
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0397 0.2426
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0318 0.5632 0.5636
Brugia malayi Importin beta-1 subunit 0.003 0.0311 0.0325
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0062 0.0053
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0397 0.0462
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0311 0.0271
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0281 0.4033
Schistosoma mansoni tyrosine kinase 0.0018 0.0094 0.006
Loa Loa (eye worm) TK/ABL protein kinase 0.0014 0.0012 0.0012
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0012 0.0012
Echinococcus multilocularis pyruvate kinase 0.0034 0.0397 0.0388
Schistosoma mansoni pyruvate kinase 0.0034 0.0397 0.0391
Echinococcus granulosus lamin 0.0028 0.0276 0.0266
Echinococcus multilocularis musashi 0.0028 0.0276 0.0266
Echinococcus granulosus tyrosine protein kinase Fyn 0.0018 0.0094 0.0085
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0554 1 1
Echinococcus granulosus tyrosine kinase 0.0014 0.0012 0.0003
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0087 0.1364 0.1365
Loa Loa (eye worm) hypothetical protein 0.0554 0.9993 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.1364 0.1365
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0018 0.0094 0.0085
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0018 0.0094 0.0085
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0087 0.1364 0.1446
Echinococcus granulosus sodium and chloride dependent glycine 0.0087 0.1364 0.1356
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0166 0.0157
Schistosoma mansoni protein kinase 0.0192 0.3313 0.3572
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0397 0.0419
Echinococcus multilocularis snurportin 1 0.0318 0.5632 0.5628
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.003 0.0311 0.0311
Giardia lamblia Pyruvate kinase 0.0034 0.0397 1
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0087 0.1364 0.1356
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0087 0.1364 0.1471
Toxoplasma gondii hypothetical protein 0.005 0.069 0.472
Loa Loa (eye worm) hypothetical protein 0.0087 0.1364 0.1365
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0634 0.0634
Schistosoma mansoni ran 0.0022 0.0166 0.0139
Loa Loa (eye worm) hypothetical protein 0.0087 0.1364 0.1365
Echinococcus multilocularis tyrosine protein kinase Blk 0.0014 0.0012 0.0003
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0166 0.0167
Loa Loa (eye worm) hypothetical protein 0.0087 0.1364 0.1365
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.2487 0.4335
Loa Loa (eye worm) hypothetical protein 0.0015 0.0039 0.0039
Echinococcus multilocularis pyruvate kinase 0.0027 0.0263 0.0254
Schistosoma mansoni sodium/chloride dependent transporter 0.0087 0.1371 0.1453
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.2487 0.4335
Echinococcus granulosus tyrosine protein kinase Srms 0.0014 0.0012 0.0003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0062 0.0054
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0087 0.1364 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0281 0.0216
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0192 0.3313 0.3315
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0012 0.0012
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.0039 0.0039
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0018 0.0094 0.0085
Echinococcus multilocularis pyruvate kinase 0.0018 0.0088 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0012 0.0012
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0397 0.0432
Leishmania major pyruvate kinase 0.0034 0.0397 0.0432
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0087 0.1364 0.1471
Echinococcus granulosus tyrosine protein kinase Fyn 0.0018 0.0094 0.0085
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0634 0.0625
Brugia malayi SRC-1 0.0018 0.0094 0.0089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0634 0.0625
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0087 0.1364 0.1446
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0511 0.9203 1
Echinococcus multilocularis geminin 0.0175 0.2993 0.2986
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0087 0.1364 0.1446
Echinococcus multilocularis pyruvate kinase 0.0034 0.0397 0.0388
Chlamydia trachomatis pyruvate kinase 0.0034 0.0397 0.1072
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0014 0.0012 0.0003
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0281 0.0293
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0018 0.0094 0.0085
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0411 0.0434
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.2487 0.4335
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0207 0.0077
Echinococcus granulosus growth factor receptor bound protein 2 0.0015 0.0039 0.003
Echinococcus granulosus NCK adaptor protein 0.0015 0.0039 0.003
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0018 0.0094 0.0085
Loa Loa (eye worm) SRC-1 0.0018 0.0094 0.0094
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0276 0.0287
Schistosoma mansoni lamin 0.0028 0.0276 0.0258
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0748 0.1087
Echinococcus multilocularis serotonin transporter 0.0511 0.9203 0.9203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0634 0.0649
Plasmodium vivax importin-beta 2, putative 0.003 0.0311 0.175
Schistosoma mansoni hypothetical protein 0.0175 0.2993 0.3223
Schistosoma mansoni hypothetical protein 0.0016 0.0062 0.0025
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0037 0.0027
Echinococcus granulosus GPCR family 2 0.0016 0.0062 0.0053
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0207 0.1779
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0062 0.0054
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0166 0.0166
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0397 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0087 0.1364 0.1356
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0634 0.0625
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0571 0.0757
Brugia malayi hypothetical protein 0.0087 0.1364 0.1471
Entamoeba histolytica hypothetical protein 0.0024 0.0207 0.7243
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0205 0.7161
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0014 0.0012 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0087 0.1364 1
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0012 0.0012
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0014 0.0012 0.0003
Echinococcus multilocularis GPCR, family 2 0.0016 0.0062 0.0053
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0281 0.0216
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0397 0.0432
Schistosoma mansoni tyrosine kinase 0.0018 0.0094 0.006
Loa Loa (eye worm) hypothetical protein 0.0087 0.1364 0.1365
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0397 0.0419
Loa Loa (eye worm) hypothetical protein 0.0511 0.9203 0.921
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0397 0.0432
Loa Loa (eye worm) hypothetical protein 0.0028 0.0276 0.0276
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0397 0.075
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0281 0.0265
Plasmodium falciparum importin beta, putative 0.003 0.0311 0.175
Echinococcus multilocularis lamin dm0 0.0028 0.0276 0.0266
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0207 0.1779
Echinococcus multilocularis NCK adaptor protein 0.0015 0.0039 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0281 0.0282
Schistosoma mansoni importin beta-1 0.003 0.0311 0.0297
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0397 0.0398
Plasmodium falciparum transporter, putative 0.0087 0.1364 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0166 0.0613
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0087 0.1364 1
Schistosoma mansoni hypothetical protein 0.0035 0.0411 0.0406
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0087 0.1364 0.1446
Schistosoma mansoni tyrosine kinase 0.0145 0.2442 0.2622
Brugia malayi Tyrosine-protein kinase abl-1 0.0018 0.0094 0.0089
Echinococcus multilocularis tyrosine protein kinase shark 0.027 0.4747 0.4742
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0037 0.0037
Plasmodium falciparum pyruvate kinase 0.0034 0.0397 0.2426
Toxoplasma gondii hypothetical protein 0.0087 0.1364 1
Onchocerca volvulus 0.0511 0.9203 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0018 0.0094 0.0085
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0311 0.175
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0062 0.0053
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0009
Leishmania major mitochondrial DNA polymerase beta 0.0312 0.5521 1
Loa Loa (eye worm) hypothetical protein 0.0511 0.9203 0.921
Schistosoma mansoni pyruvate kinase 0.0034 0.0397 0.0391
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0062 0.0053
Treponema pallidum sodium- and chloride- dependent transporter 0.0511 0.9203 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0634 0.0625
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0312 0.5521 1
Entamoeba histolytica hypothetical protein 0.0028 0.0281 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0397 0.0419
Echinococcus granulosus tyrosine protein kinase Btk29A 0.015 0.2524 0.2516
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0012 0.0012
Echinococcus granulosus tyrosine protein kinase shark 0.027 0.4747 0.4742
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0712 0.0761
Plasmodium vivax amine transporter, putative 0.0087 0.1364 1
Leishmania major pyruvate kinase 0.0034 0.0397 0.0432
Echinococcus multilocularis pyruvate kinase 0.0018 0.0088 0.0078
Loa Loa (eye worm) hypothetical protein 0.0511 0.9203 0.921
Entamoeba histolytica Ran family GTPase 0.0022 0.0166 0.5714
Schistosoma mansoni tyrosine kinase 0.027 0.4747 0.5137
Loa Loa (eye worm) hypothetical protein 0.0024 0.0205 0.0205
Echinococcus multilocularis tyrosine protein kinase Srms 0.0014 0.0012 0.0003
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0397 0.2426
Echinococcus granulosus pyruvate kinase 0.0018 0.0088 0.0078
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0087 0.1364 0.1356
Schistosoma mansoni hypothetical protein 0.0016 0.0062 0.0025
Loa Loa (eye worm) TK protein kinase 0.0014 0.0012 0.0012
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0571 0.0757
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0281 0.0265
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0039 0.0029
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.015 0.2524 0.2516
Schistosoma mansoni lamin 0.0028 0.0276 0.0258
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0281 0.1517
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0276 0.0276
Schistosoma mansoni sodium-dependent amino acid transporter 0.0087 0.1364 0.1446
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0281 0.0272
Echinococcus multilocularis sodium and chloride dependent glycine 0.0087 0.1364 0.1356
Brugia malayi RNA, U transporter 1 0.0085 0.1325 0.1428
Brugia malayi Sex muscle abnormal protein 5 0.0015 0.0039 0.0029
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0397 0.0432
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0311 0.0271
Toxoplasma gondii hypothetical protein 0.0087 0.1364 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0712 0.0712
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0034 0.0397 0.0398
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0166 0.0157
Schistosoma mansoni tyrosine kinase 0.0259 0.4551 0.4923
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0397 0.0398
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0166 0.2525
Echinococcus granulosus tyrosine protein kinase Fyn 0.0018 0.0094 0.0085
Echinococcus granulosus tyrosine protein kinase Blk 0.0014 0.0012 0.0003
Schistosoma mansoni tyrosine kinase 0.0018 0.0094 0.006
Echinococcus granulosus geminin 0.0175 0.2993 0.2986
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0087 0.1364 0.1356
Schistosoma mansoni hypothetical protein 0.0175 0.2993 0.3223
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0087 0.1364 0.1356
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0015 0.0039 0.0039
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0087 0.1364 0.1446
Echinococcus granulosus intermediate filament protein 0.0028 0.0276 0.0266
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0014 0.0012 0.0003
Echinococcus granulosus pyruvate kinase 0.0018 0.0088 0.0078
Leishmania major importin beta-1 subunit, putative 0.0024 0.0207 0.0077
Schistosoma mansoni hypothetical protein 0.0318 0.5632 0.6103
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0087 0.1364 0.1446
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0397 0.0419
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0018 0.0094 0.0085
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0217 0.2217
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0207 0.1779
Onchocerca volvulus 0.0028 0.0276 0.0287
Schistosoma mansoni hypothetical protein 0.0016 0.0062 0.0025

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Binding affinity to human EPHA4 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human AKT3 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human JNK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human PIM1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human ACTR2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human ADCK3 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human MST3 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human JAK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human PLK3 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human LIMK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human PAK6 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human PKCA at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human CK1gamma1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human NEK9 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human FGFR2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human NEK6 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human KDR at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human FUSED at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human AMPKA2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human RSK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human CDK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human ERK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human PIM2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human NLK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human ALK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human P38B at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human YANK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human TRKC at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human EPHB3 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human NEK7 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human GSK3A at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human TLK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human PCTAIRE1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human YANK3 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human CAMK1G at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human JNK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human AMPKA1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human LIMK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human ZAP70 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human RSK4 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human YSK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human CAMK2G at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human P38A at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human TIE2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human EPHA6 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human EPHA2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human MAP3K5 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human ADCK4 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human AKT2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human TGFBR1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human TYRO3 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human PRKX at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human CAMK2A at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human PAK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human PAK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human PAK3 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human TRKA at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human RIPK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human CLK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human FGFR3 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human P38G at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human MARK4 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human NEK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human ROS at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human ALK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human GAK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human IRR at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human BMPR1A at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human EPHB4 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human BRSK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human FLT1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human MSK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human ALK4 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human AKT1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human DMPK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human FGFR1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human CLK4 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human CLK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human PKACB at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human BRAF at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human MARK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human CSK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human PYK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human TLK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human BTK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human CAMK2D at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human MARK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human NDR2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human MSK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human RSK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human RAF1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human CAMK2B at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human EPHB2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human CLK3 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human TESK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human ERK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) Binding affinity to human FGFR4 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 0.1 % Binding affinity to human SLK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 0.1 % Binding affinity to human LOK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 0.1 % Binding affinity to human ARG at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 0.1 % Binding affinity to human FLT3 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 0.2 % Binding affinity to human AAK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 0.2 % Binding affinity to human EPHB1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 0.3 % Binding affinity to human MER at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 0.3 % Binding affinity to human SYK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 0.4 % Binding affinity to human PDGFRB at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 0.6 % Binding affinity to human PLK4 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 0.7 % Binding affinity to human DRAK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 0.9 % Binding affinity to human FMS at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 1 % Binding affinity to human SRC at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 1.1 % Binding affinity to human HPK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 1.1 % Binding affinity to human AXL at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 1.2 % Binding affinity to human DRAK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 1.3 % Binding affinity to human PHKG2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 1.4 % Binding affinity to human LKB1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 1.6 % Binding affinity to human TNIK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 1.8 % Binding affinity to human DAPK3 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 1.8 % Binding affinity to human BIKE at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 2 % Binding affinity to human AURC at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 2.2 % Binding affinity to human RET at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 2.2 % Binding affinity to human ALK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 2.4 % Binding affinity to human CK2A1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 2.6 % Binding affinity to human STK33 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 2.7 % Binding affinity to human FGR at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 2.8 % Binding affinity to human CAMKK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 2.8 % Binding affinity to human BLK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 3.1 % Binding affinity to human DAPK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 3.1 % Binding affinity to human SRPK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 3.2 % Binding affinity to human HCK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 3.4 % Binding affinity to human TXK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 3.5 % Binding affinity to human KIT at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 3.8 % Binding affinity to human ABL at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 3.9 % Binding affinity to human GCN2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 4.2 % Binding affinity to human EPHA1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 5.2 % Binding affinity to human FYN at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 5.5 % Binding affinity to human LCK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 5.9 % Binding affinity to human FAK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 6.1 % Binding affinity to human TNK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 6.2 % Binding affinity to human JAK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 6.8 % Binding affinity to human EPHA5 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 6.9 % Binding affinity to human ERBB2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 8.1 % Binding affinity to human LTK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 8.2 % Binding affinity to human MLK3 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 8.5 % Binding affinity to human MNK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 9.1 % Binding affinity to human CK1d at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 9.9 % Binding affinity to human MPSK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 10.1 % Binding affinity to human MST2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 10.4 % Binding affinity to human FER at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 10.6 % Binding affinity to human EPHA8 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 10.8 % Binding affinity to human QIK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 11 % Binding affinity to human BRK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 11.5 % Binding affinity to human EPHA3 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 11.7 % Binding affinity to human ULK3 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 11.7 % Binding affinity to human YES at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 12.8 % Binding affinity to human EPHA7 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 13.8 % Binding affinity to human LYN at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 15.8 % Binding affinity to human MET at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 15.9 % Binding affinity to human CAMKK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 15.9 % Binding affinity to human EGFR at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 16 % Binding affinity to human TTK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 16.5 % Binding affinity to human FRK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 16.9 % Binding affinity to human CAMK1D at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 17.7 % Binding affinity to human CK2A2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 20.3 % Binding affinity to human FLT4 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 20.4 % Binding affinity to human MYT1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 22.2 % Binding affinity to human ITK at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 22.8 % Binding affinity to human CK1e at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 22.9 % Binding affinity to human PAK4 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 23.2 % Binding affinity to human FES at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 23.65 % Binding affinity to human PKN2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 24.4 % Binding affinity to human KHS1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 24.4 % Binding affinity to human MST1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 24.6 % Binding affinity to human PDK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 24.9 % Binding affinity to human TYK2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 25.5 % Binding affinity to human PHKG1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 26.7 % Binding affinity to human AURB at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 27.2 % Binding affinity to human PDGFRA at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 27.8 % Binding affinity to human ERBB4 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 29.15 % Binding affinity to human TRKB at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 29.3 % Binding affinity to human BMX at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 29.9 % Binding affinity to human PAK5 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 30.3 % Binding affinity to human CAMK1A at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 30.9 % Binding affinity to human PLK1 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 32.4 % Binding affinity to human CK1a2 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 32.7 % Binding affinity to human AURA at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 32.9 % Binding affinity to human INSR at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 33.2 % Binding affinity to human JNK3 at 10 uM relative to control ChEMBL. 19035792
Activity (binding) = 34.1 % Binding affinity to human IGF1R at 10 uM relative to control ChEMBL. 19035792
IC50 (binding) = 19 nM Inhibition of recombinant Syk ChEMBL. 19254842
IC50 (binding) = 34 nM Inhibition of SYK ChEMBL. 19035792
IC50 (binding) = 0.019 uM Inhibitory activity against spleen tyrosine kinase (SYK) ChEMBL. 12668002
IC50 (binding) = 0.019 uM Inhibitory activity against spleen tyrosine kinase (SYK) ChEMBL. 12668002
IC50 (binding) = 0.019 uM Inhibition of SYK ChEMBL. 22257213
Kd (binding) = 395 nM Binding affinity to human TXK ChEMBL. 19035792
Kd (binding) = 623 nM Binding affinity to human SLK ChEMBL. 19035792

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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