Detailed information for compound 954194

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 533.483 | Formula: C28H23NO10
  • H donors: 2 H acceptors: 5 LogP: 2.84 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC1=CC(=CC(=O)C1=O)[C@H]1[C@H]2C(=O)OC[C@@H]2[C@@H](c2c1cc1OCOc1c2)Nc1ccc(c(c1)O)C(=O)OC
  • InChi: 1S/C28H23NO10/c1-35-22-6-12(5-19(31)26(22)32)23-15-8-20-21(39-11-38-20)9-16(15)25(17-10-37-28(34)24(17)23)29-13-3-4-14(18(30)7-13)27(33)36-2/h3-9,17,23-25,29-30H,10-11H2,1-2H3/t17-,23+,24-,25+/m0/s1
  • InChiKey: OVWVVNWVCLLSAB-AKEHSPCASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.0031 0.005 0.0245
Schistosoma mansoni tyrosine kinase 0.0365 0.5473 1
Schistosoma mansoni tyrosine kinase 0.0035 0.0106 0.0192
Schistosoma mansoni tyrosine kinase 0.0046 0.0295 0.0537
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0072 0.0129
Giardia lamblia Kinase, CMGC MAPK 0.0068 0.0656 0.3252
Entamoeba histolytica protein kinase, putative 0.0029 0.0012 0.0055
Schistosoma mansoni tyrosine kinase 0.0223 0.3163 0.5777
Giardia lamblia Kinase, CMGC GSK 0.0065 0.0602 0.2981
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0487 0.2402
Toxoplasma gondii aurora kinase 0.0138 0.1788 0.898
Trypanosoma brucei cdc2-related kinase 1 0.0151 0.1991 0.4574
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0033 0.0072 0.0087
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.1461 0.732
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0087
Schistosoma mansoni tyrosine kinase 0.0223 0.3163 0.5777
Brugia malayi Tyrosine-protein kinase abl-1 0.0136 0.175 0.212
Echinococcus granulosus mitogen activated protein kinase 3 0.0068 0.0656 0.0655
Echinococcus granulosus NDR protein kinase 0.0033 0.0072 0.007
Brugia malayi Furin-like cysteine rich region family protein 0.0318 0.4712 0.5734
Loa Loa (eye worm) hypothetical protein 0.0073 0.0734 0.0894
Echinococcus granulosus tyrosine kinase 0.0035 0.0106 0.0105
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0151 0.1991 0.4574
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0041 0.0214 0.0389
Loa Loa (eye worm) hypothetical protein 0.0041 0.0214 0.0261
Toxoplasma gondii AGC kinase 0.0056 0.0459 0.2299
Schistosoma mansoni tyrosine kinase 0.024 0.3439 0.6283
Echinococcus multilocularis growth factor receptor bound protein 2 0.0029 0.0019 0.0021
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0029 0.0012 0.0013
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0073 0.0734 0.1683
Trypanosoma brucei cdc2-related kinase 3 0.0151 0.1991 0.4574
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0056 0.0459 0.1051
Trypanosoma cruzi polo-like protein kinase, putative 0.0118 0.1461 0.3355
Brugia malayi Variant SH3 domain containing protein 0.0029 0.0019 0.0008
Echinococcus granulosus growth factor receptor bound protein 2 0.0029 0.0019 0.0017
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0151 0.1991 0.2426
Schistosoma mansoni protein kinase 0.0191 0.2656 0.4852
Loa Loa (eye worm) TK/INSR protein kinase 0.0365 0.5473 0.6668
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.0734 0.088
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.0734 0.088
Loa Loa (eye worm) cyclin C 0.0091 0.1027 0.1251
Echinococcus granulosus cyclins 0.0045 0.0276 0.0275
Loa Loa (eye worm) TK protein kinase 0.0138 0.179 0.2181
Loa Loa (eye worm) hypothetical protein 0.0058 0.0493 0.0601
Brugia malayi Protein kinase domain containing protein 0.0191 0.2656 0.3226
Echinococcus granulosus protein kinase c iota type 0.0039 0.0183 0.0182
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0045 0.0269 0.0328
Loa Loa (eye worm) AUR protein kinase 0.0138 0.1788 0.2178
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0072 0.0129
Entamoeba histolytica protein kinase, putative 0.0058 0.0487 0.2443
Echinococcus multilocularis mitogen activated protein kinase 3 0.0068 0.0656 0.08
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.02 0.2801 0.3421
Leishmania major cyclin 0.0073 0.0734 0.1683
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0459 0.0836
Trypanosoma brucei mitotic cyclin 6 0.0073 0.0734 0.1683
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.1991 0.3637
Echinococcus multilocularis insulin receptor 0.0365 0.5473 0.6685
Plasmodium falciparum protein kinase 5 0.0151 0.1991 1
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0072 0.0129
Chlamydia trachomatis serine/threonine protein kinase 0.0245 0.3526 0.5
Schistosoma mansoni tyrosine kinase 0.0035 0.0106 0.0191
Echinococcus granulosus cyclin B 0.0073 0.0734 0.0732
Echinococcus multilocularis cyclin dependent kinase 5 0.0151 0.1991 0.2431
Echinococcus granulosus cyclin dependent kinase 5 0.0151 0.1991 0.199
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.1991 1
Brugia malayi serine/threonine-protein kinase PAK 7 0.0218 0.3089 0.3754
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0614 0.3042
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0118 0.1461 0.1783
Brugia malayi protein kinase C II. 0.0041 0.0206 0.0237
Brugia malayi Serine/threonine-protein kinase Nek7 0.0245 0.3526 0.4287
Onchocerca volvulus Tyrosine kinase homolog 0.0379 0.5699 0.6903
Echinococcus multilocularis Immunoglobulin 0.0041 0.0214 0.026
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0072 0.0129
Trichomonas vaginalis cyclin D, putative 0.0045 0.0276 0.1332
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0296 0.4352 1
Echinococcus granulosus protein kinase shaggy 0.0065 0.0602 0.0601
Loa Loa (eye worm) hypothetical protein 0.0073 0.0734 0.0894
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0033 0.0072 0.007
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0365 0.5473 0.5473
Schistosoma mansoni tyrosine kinase 0.0046 0.0295 0.0537
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0215 0.3037 0.3709
Giardia lamblia Aurora kinase 0.0138 0.1788 0.8974
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0072 0.03
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.1461 0.732
Plasmodium vivax glycogen synthase kinase 3, putative 0.0065 0.0602 0.2645
Schistosoma mansoni tyrosine kinase 0.0046 0.0295 0.0537
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0035 0.0106 0.0105
Trypanosoma brucei polo-like protein kinase 0.0118 0.1461 0.3355
Trypanosoma cruzi aurora B kinase, putative 0.0138 0.1788 0.4107
Entamoeba histolytica protein kinase, putative 0.0138 0.1788 0.898
Entamoeba histolytica protein kinase domain containing protein 0.0065 0.0602 0.302
Echinococcus multilocularis cyclins 0.0045 0.0276 0.0335
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0029 0.0012 0.0013
Echinococcus granulosus defective proboscis extension response 0.0041 0.0214 0.0213
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0034 0.0102 0.0124
Loa Loa (eye worm) hypothetical protein 0.0045 0.0269 0.0328
Giardia lamblia Kinase, CMGC CDK 0.0151 0.1991 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0163 0.2195 0.2674
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0035 0.0106 0.0526
Echinococcus granulosus cyclin dependent kinase 7 0.0098 0.1136 0.1135
Loa Loa (eye worm) CDC7 protein kinase 0.0075 0.0766 0.0933
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0487 0.2402
Brugia malayi Cyclin, N-terminal domain containing protein 0.0045 0.0276 0.0322
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.1991 1
Echinococcus multilocularis epidermal growth factor receptor 0.024 0.3439 0.42
Trichomonas vaginalis cyclins, putative 0.0043 0.0237 0.1136
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0072 0.03
Entamoeba histolytica p21-activated kinase 0.0031 0.005 0.0245
Brugia malayi serine/threonine kinase 12 0.0138 0.1788 0.2167
Echinococcus granulosus Protein kinase C brain isozyme 0.0086 0.0933 0.0932
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0045 0.0276 0.0275
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.0106 0.0129
Echinococcus multilocularis CDC7 cell division cycle 7 0.0075 0.0766 0.0935
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0151 0.1991 0.199
Schistosoma mansoni protein kinase 0.0029 0.0012 0.002
Echinococcus multilocularis tyrosine protein kinase shark 0.0275 0.4022 0.4912
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.024 0.3439 0.3438
Onchocerca volvulus 0.0073 0.0734 0.0775
Brugia malayi intracellular kinase 0.0065 0.0602 0.072
Brugia malayi Protein kinase domain containing protein 0.0179 0.2452 0.2977
Entamoeba histolytica cyclin family protein 0.0045 0.0276 0.1379
Echinococcus granulosus aurora kinase A 0.0138 0.1788 0.1787
Onchocerca volvulus 0.0065 0.0602 0.0613
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0028 0.0004 0.0005
Trichomonas vaginalis cyclins, putative 0.0073 0.0734 0.3645
Brugia malayi SRC-1 0.0046 0.0295 0.0346
Loa Loa (eye worm) hypothetical protein 0.0049 0.034 0.0414
Brugia malayi cell division control protein 2 homolog 0.0151 0.1991 0.2415
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0656 0.3252
Loa Loa (eye worm) hypothetical protein 0.0162 0.2175 0.265
Trichomonas vaginalis cyclins, putative 0.0073 0.0734 0.3645
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0033 0.0072 0.0087
Brugia malayi MAP kinase sur-1 0.0068 0.0656 0.0785
Schistosoma mansoni serine/threonine-protein kinase 0.0037 0.014 0.0254
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.1136 0.2074
Echinococcus multilocularis mitogen activated protein kinase 11 0.0296 0.4352 0.5315
Loa Loa (eye worm) hypothetical protein 0.0058 0.0493 0.0601
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0098 0.1136 0.1384
Entamoeba histolytica protein kinase 2, putative 0.0034 0.0102 0.0509
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0033 0.0072 0.007
Trypanosoma brucei protein kinase, putative 0.0065 0.0602 0.1381
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0766 0.3811
Echinococcus multilocularis cyclin B3 1 0.0045 0.0276 0.0335
Schistosoma mansoni tyrosine kinase 0.0275 0.4022 0.7347
Brugia malayi hypothetical protein 0.0139 0.1801 0.2183
Brugia malayi protein-tyrosine kinase 0.0035 0.0106 0.0114
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.02 0.2802 0.3413
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0034 0.0102 0.0509
Schistosoma mansoni tyrosine kinase 0.024 0.3439 0.6283
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0056 0.0459 0.0559
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0109 0.0492
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.1461 0.732
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0296 0.0539
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0037 0.014 0.032
Echinococcus multilocularis cyclin dependent kinase 1 0.0151 0.1991 0.2431
Schistosoma mansoni cyclin B3 0.0045 0.0276 0.0502
Echinococcus granulosus serine:threonine protein kinase N2 0.0033 0.0072 0.007
Leishmania major protein kinase A catalytic subunit 0.0056 0.0459 0.1051
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0532 0.8187 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0046 0.0295 0.0359
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0046 0.0295 0.0294
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0068 0.0656 0.1504
Echinococcus multilocularis serine:threonine protein kinase N2 0.0033 0.0072 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0459 0.0836
Echinococcus multilocularis serine:threonine protein kinase N2 0.0033 0.0072 0.0086
Giardia lamblia Kinase, AGC PKA 0.0034 0.0102 0.0457
Brugia malayi Protein kinase domain containing protein 0.0033 0.0072 0.0073
Echinococcus multilocularis serine threonine protein kinase 0.0079 0.0822 0.1003
Giardia lamblia Kinase, CMGC GSK 0.0065 0.0602 0.2981
Brugia malayi Protein kinase domain containing protein 0.0035 0.0106 0.0114
Brugia malayi Protein kinase domain containing protein 0.0075 0.0766 0.092
Loa Loa (eye worm) AGC/AKT protein kinase 0.0058 0.0487 0.0594
Brugia malayi Variant SH3 domain containing protein 0.0029 0.0019 0.0008
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0056 0.0459 0.0458
Loa Loa (eye worm) TK/ABL protein kinase 0.0269 0.391 0.4763
Loa Loa (eye worm) AUR protein kinase 0.0138 0.1788 0.2178
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.02 0.2801 0.28
Echinococcus multilocularis cyclins 0.0045 0.0276 0.0335
Trichomonas vaginalis cyclin D, putative 0.0045 0.0276 0.1332
Echinococcus granulosus CDC7 cell division cycle 7 0.0075 0.0766 0.0765
Echinococcus granulosus tyrosine protein kinase Src64B 0.0046 0.0295 0.0294
Echinococcus multilocularis roundabout 2 0.0058 0.0493 0.0601
Trypanosoma cruzi cdc2-related kinase 3 0.0151 0.1991 0.4574
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.1991 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.1809 0.2204
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0365 0.5473 0.6685
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0056 0.0459 0.1051
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.1136 0.2074
Echinococcus multilocularis cyclin b3 0.0045 0.0276 0.0335
Loa Loa (eye worm) TK protein kinase 0.0035 0.0106 0.0129
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0214 0.0247
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.0295 0.0294
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0029 0.0012 0.0011
Echinococcus multilocularis cyclin 0.0091 0.1027 0.1253
Brugia malayi SH2 domain containing protein 0.0035 0.0106 0.0114
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0138 0.1788 0.898
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0065 0.0602 0.1381
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0029 0.0012 0.0011
Plasmodium falciparum cyclin 0.0045 0.0276 0.1379
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0766 0.3811
Echinococcus granulosus cyclin dependent kinase 0.0151 0.1991 0.199
Schistosoma mansoni tyrosine kinase 0.0046 0.0295 0.0537
Echinococcus multilocularis tyrosine protein kinase Abl 0.0136 0.175 0.2136
Schistosoma mansoni tyrosine kinase 0.0129 0.1637 0.2989
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0066 0.0614 0.0748
Schistosoma mansoni cell adhesion molecule 0.0049 0.034 0.0619
Brugia malayi Fibronectin type III domain containing protein 0.0041 0.0214 0.0247
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0295 0.0359
Entamoeba histolytica cyclin, putative 0.0045 0.0276 0.1379
Entamoeba histolytica cyclin family protein 0.0045 0.0276 0.1379
Brugia malayi Protein kinase domain containing protein 0.0058 0.0487 0.058
Schistosoma mansoni serine/threonine protein kinase 0.0245 0.3526 0.6441
Echinococcus granulosus cyclin B3 1 0.0045 0.0276 0.0275
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0046 0.0295 0.0359
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0296 0.4352 1
Echinococcus multilocularis epidermal growth factor receptor 0.0318 0.4712 0.5755
Loa Loa (eye worm) hypothetical protein 0.0041 0.0214 0.0261
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0459 0.2256
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.029 0.4262 0.5205
Trichomonas vaginalis CMGC family protein kinase 0.0065 0.0602 0.2981
Echinococcus multilocularis 0.0091 0.1024 0.125
Loa Loa (eye worm) hypothetical protein 0.0139 0.1801 0.2195
Loa Loa (eye worm) hypothetical protein 0.0056 0.0459 0.0559
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0029 0.0019 0.0032
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0532 0.8187 0.8187
Entamoeba histolytica protein kinase, putative 0.0031 0.005 0.0245
Echinococcus granulosus cyclins 0.0045 0.0276 0.0275
Trypanosoma brucei aurora B kinase 0.0138 0.1788 0.4107
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0068 0.0656 0.3289
Echinococcus multilocularis mitogen activated protein kinase 14 0.0296 0.4352 0.5315
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0766 0.1398
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0206 0.0375
Entamoeba histolytica cyclin, putative 0.0073 0.0734 0.368
Trichomonas vaginalis AGC family protein kinase 0.0138 0.1788 0.8974
Schistosoma mansoni tyrosine kinase 0.0365 0.5473 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0065 0.0602 0.1098
Loa Loa (eye worm) hypothetical protein 0.029 0.4262 0.5192
Entamoeba histolytica protein kinase, putative 0.0029 0.0011 0.0051
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0487 0.2402
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0035 0.0106 0.0128
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0118 0.1461 0.178
Loa Loa (eye worm) hypothetical protein 0.0041 0.0214 0.0261
Brugia malayi Hr1 repeat family protein 0.0033 0.0072 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.1461 0.2667
Echinococcus multilocularis Immunoglobulin 0.0041 0.0214 0.026
Entamoeba histolytica cell division protein kinase 2, putative 0.0151 0.1991 1
Trypanosoma brucei protein kinase, putative 0.0068 0.0656 0.1504
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0056 0.0459 0.1051
Brugia malayi Protein kinase domain containing protein 0.0035 0.0106 0.0114
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0487 0.2402
Giardia lamblia Kinase, CMGC CDK 0.0151 0.1991 1
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0091 0.1027 0.1253
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0218 0.3089 0.3763
Entamoeba histolytica PH domain containing protein kinase, putative 0.0037 0.014 0.0699
Trichomonas vaginalis cyclin B3, putative 0.0045 0.0276 0.1332
Onchocerca volvulus Serine\/threonine kinase homolog 0.0118 0.1461 0.1672
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0766 0.3811
Leishmania major protein kinase, putative 0.0138 0.1788 0.4107
Giardia lamblia Cyclin A 0.0045 0.0276 0.1332
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0656 0.3252
Echinococcus multilocularis mitogen activated protein kinase 11 0.0296 0.4352 0.5315
Trichomonas vaginalis cyclins, putative 0.0045 0.0276 0.1332
Echinococcus multilocularis mitogen activated protein kinase 14 0.0296 0.4352 0.5315
Trichomonas vaginalis AGC family protein kinase 0.0138 0.1788 0.8974
Echinococcus multilocularis tyrosine kinase 0.0035 0.0106 0.0128
Onchocerca volvulus 0.0075 0.0766 0.0815
Echinococcus multilocularis protein kinase c iota type 0.0039 0.0183 0.0222
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0045 0.0276 0.0335
Entamoeba histolytica PH domain containing protein kinase, putative 0.0059 0.0497 0.2489
Schistosoma mansoni tyrosine kinase 0.0223 0.3163 0.5777
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0296 0.4352 0.5302
Brugia malayi Protein kinase domain containing protein 0.02 0.2802 0.3404
Echinococcus multilocularis protein kinase c epsilon type 0.0041 0.0206 0.025
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.1991 0.3637
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0295 0.0359
Brugia malayi SH2 domain containing protein 0.0035 0.0106 0.0114
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0035 0.0106 0.0128
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0068 0.0656 0.1504
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0046 0.0295 0.0537
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0056 0.0459 0.2299
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0034 0.0102 0.0101
Schistosoma mansoni protein kinase 0.0138 0.1788 0.3266
Trypanosoma cruzi cyclin 6, putative 0.0073 0.0734 0.1683
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0933 0.1703
Echinococcus granulosus epidermal growth factor receptor 0.024 0.3439 0.3438
Brugia malayi cyclin-dependent kinase 7 homolog 0.0098 0.1136 0.1371
Trichomonas vaginalis cyclin B, putative 0.0073 0.0734 0.3645
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0091 0.1027 0.1025
Brugia malayi serine/threonine-protein kinase plk-2 0.0118 0.1461 0.1767
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0056 0.0459 0.2299
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0056 0.0459 0.1051
Echinococcus multilocularis mitogen activated protein kinase 0.0068 0.0656 0.08
Trypanosoma cruzi polo-like protein kinase, putative 0.0118 0.1461 0.3355
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0056 0.0459 0.1886
Trypanosoma brucei rac serine-threonine kinase, putative 0.0058 0.0487 0.1117
Brugia malayi Immunoglobulin I-set domain containing protein 0.0418 0.6344 0.7725
Entamoeba histolytica protein kinase, putative 0.0033 0.0072 0.0353
Echinococcus granulosus RNA directed DNA polymerase 0.0045 0.0269 0.0268
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0418 0.6344 0.7728
Giardia lamblia G2/mitotic-specific cyclin B 0.0073 0.0734 0.3645
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.1788 0.3266
Entamoeba histolytica protein kinase , putative 0.0138 0.1788 0.898
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0046 0.0295 0.0294
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.3037 0.5548
Echinococcus multilocularis aurora kinase A 0.0138 0.1788 0.2183
Entamoeba histolytica PH domain containing protein kinase, putative 0.0059 0.0497 0.2489
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0056 0.0459 0.1051
Plasmodium falciparum glycogen synthase kinase 3 0.0065 0.0602 0.302
Loa Loa (eye worm) hypothetical protein 0.052 0.8005 0.9751
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0049 0.034 0.0339
Brugia malayi Cyclin, N-terminal domain containing protein 0.0163 0.2195 0.2663
Schistosoma mansoni cyclins 0.0045 0.0276 0.0502
Toxoplasma gondii AGC kinase 0.0056 0.045 0.2253
Schistosoma mansoni protein kinase 0.0029 0.0012 0.002
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0056 0.0459 0.1051
Echinococcus granulosus Immunoglobulin 0.0041 0.0214 0.0213
Brugia malayi Immunoglobulin I-set domain containing protein 0.0138 0.179 0.2169
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0296 0.4352 1
Echinococcus multilocularis PAK box P21 Rho binding 0.0029 0.0012 0.0013
Echinococcus granulosus cyclins 0.0045 0.0276 0.0275
Echinococcus granulosus c src tyrosine kinase 0.0046 0.0295 0.0294
Schistosoma mansoni atypical protein kinase C 0.0039 0.0183 0.0332
Loa Loa (eye worm) NEK/NEK6 protein kinase 0.0245 0.3526 0.4295
Echinococcus multilocularis cyclins 0.0045 0.0276 0.0335
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0656 0.3252
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0068 0.0656 0.1504
Echinococcus multilocularis c src tyrosine kinase 0.0046 0.0295 0.0359
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0656 0.3252
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.0106 0.0129
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0215 0.3037 0.37
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0046 0.0295 0.0359
Echinococcus multilocularis cyclin B 0.0073 0.0734 0.0895
Echinococcus granulosus protein kinase c epsilon type 0.0041 0.0206 0.0205
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0033 0.0072 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0581 0.2875
Brugia malayi Protein kinase domain containing protein 0.0151 0.1991 0.2415
Trichomonas vaginalis CMGC family protein kinase 0.0065 0.0602 0.2981
Trichomonas vaginalis cyclin H, putative 0.0072 0.0711 0.353
Loa Loa (eye worm) hypothetical protein 0.0106 0.1273 0.1551
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.0295 0.0294
Trypanosoma cruzi cdc2-related kinase 1 0.0151 0.1991 0.4574
Schistosoma mansoni tyrosine kinase 0.0318 0.4712 0.8608
Schistosoma mansoni growth factor receptor-bound protein 0.0029 0.0019 0.0032
Entamoeba histolytica PH domain containing protein kinase, putative 0.0037 0.014 0.0699
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0065 0.0602 0.0734
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.1461 0.732
Echinococcus multilocularis cyclin dependent kinase 7 0.0098 0.1136 0.1387
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0066 0.0614 0.0749
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.0106 0.0129
Entamoeba histolytica hypothetical protein 0.0072 0.0711 0.3565
Brugia malayi p70 ribosomal S6 kinase beta 0.0056 0.045 0.0534
Schistosoma mansoni adapter molecule crk 0.0029 0.0019 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0072 0.03
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0065 0.0602 0.302
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.029 0.4262 0.4261
Echinococcus granulosus tyrosine kinase 0.0035 0.0106 0.0105
Schistosoma mansoni protein kinase 0.0029 0.0012 0.002
Echinococcus granulosus fibroblast growth factor receptor 4 0.0129 0.1637 0.1636
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0065 0.0602 0.1381
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0068 0.0656 0.1504
Echinococcus granulosus tyrosine protein kinase Srms 0.0035 0.0106 0.0105
Loa Loa (eye worm) hypothetical protein 0.0139 0.1801 0.2195
Echinococcus granulosus mitogen activated protein kinase 0.0068 0.0656 0.0655
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0138 0.1788 0.898
Echinococcus multilocularis RNA directed DNA polymerase 0.0045 0.0269 0.0328
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.0106 0.0129
Loa Loa (eye worm) AUR protein kinase 0.0138 0.1788 0.2178
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0614 0.3042
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0056 0.0459 0.0559
Echinococcus multilocularis serine:threonine protein kinase 38 0.0033 0.0072 0.0086
Onchocerca volvulus 0.0533 0.8209 1
Entamoeba histolytica protein kinase, putative 0.0056 0.045 0.2253
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0581 0.2875
Trypanosoma cruzi cyclin, putative 0.0073 0.0734 0.1683
Brugia malayi Protein kinase domain containing protein 0.0533 0.8209 1
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.1461 0.732
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0276 0.1332
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0656 0.1196
Entamoeba histolytica protein kinase, putative 0.0029 0.0012 0.0055
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.0106 0.0129
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0056 0.0459 0.0559
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0296 0.4352 1
Trichomonas vaginalis cyclin A, putative 0.0073 0.0734 0.3645
Echinococcus granulosus epidermal growth factor receptor 0.0318 0.4712 0.4711
Entamoeba histolytica protein kinase domain containing protein 0.0138 0.1788 0.898
Plasmodium falciparum serine/threonine protein kinase, putative 0.0138 0.1788 0.898
Echinococcus granulosus serine threonine protein kinase nrc 0.0034 0.0102 0.0101
Brugia malayi Cyclin C 0.0091 0.1027 0.1238
Entamoeba histolytica protein kinase, putative 0.0066 0.0614 0.3081
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.029 0.4262 0.7786
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0191 0.2656 0.3236
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0151 0.1991 0.4574
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0269 0.391 0.4775
Brugia malayi map kinase activated protein kinase protein 2 0.0215 0.3037 0.369
Echinococcus multilocularis cyclin dependent kinase 0.0151 0.1991 0.2431
Echinococcus multilocularis cyclins 0.0045 0.0276 0.0335
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0138 0.1788 0.2183
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0029 0.0012 0.0013
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0035 0.0106 0.0105
Giardia lamblia Kinase, AGC PKA 0.0056 0.0459 0.2256
Entamoeba histolytica protein kinase, putative 0.0058 0.0487 0.2443
Schistosoma mansoni serine/threonine kinase 0.0033 0.0072 0.0129
Schistosoma mansoni serine/threonine protein kinase 0.02 0.2802 0.5118
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0023
Schistosoma mansoni nephrin 0.0051 0.0368 0.0669
Trichomonas vaginalis cyclins, putative 0.0073 0.0734 0.3645
Echinococcus granulosus NCK adaptor protein 0.0029 0.0019 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0614 0.112
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0065 0.0602 0.0734
Trichomonas vaginalis cyclin B, putative 0.0073 0.0734 0.3645
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0045 0.0276 0.0275
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0138 0.1788 0.898
Trichomonas vaginalis AGC family protein kinase 0.0138 0.1788 0.8974
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0066 0.0614 0.0748
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0046 0.0295 0.0359
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0041 0.0214 0.0389
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0151 0.1991 0.2426
Loa Loa (eye worm) AGC/PKN protein kinase 0.0033 0.0072 0.0087
Loa Loa (eye worm) hypothetical protein 0.0035 0.0106 0.0129
Echinococcus granulosus insulin receptor 0.0365 0.5473 0.5473
Echinococcus granulosus mitogen activated protein kinase 14 0.0296 0.4352 0.4352
Entamoeba histolytica cell division protein kinase 2, putative 0.0151 0.1991 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0118 0.1461 0.7334
Entamoeba histolytica protein kinase domain containing protein 0.0065 0.0602 0.302
Trypanosoma cruzi CYC2-like cyclin, putative 0.0073 0.0734 0.1683
Trichomonas vaginalis cyclin B, putative 0.0073 0.0734 0.3645
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0056 0.0459 0.1051
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0029 0.0019 0.0023
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0045 0.0276 0.0336
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0129 0.1637 0.1998
Toxoplasma gondii AGC kinase 0.0056 0.0459 0.2299
Echinococcus granulosus cyclin b3 0.0045 0.0276 0.0275
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0056 0.0459 0.0545
Brugia malayi Protein kinase domain containing protein 0.0033 0.0072 0.0073
Echinococcus granulosus mitogen activated protein kinase 11 0.0296 0.4352 0.4352
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0041 0.0206 0.0251
Schistosoma mansoni tyrosine kinase 0.0034 0.0098 0.0177
Loa Loa (eye worm) AGC/NDR protein kinase 0.0033 0.0072 0.0087
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0068 0.0656 0.1504
Schistosoma mansoni serine/threonine-protein kinase 0.0037 0.014 0.0254
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0046 0.0295 0.0359
Echinococcus granulosus cyclins 0.0045 0.0276 0.0275
Onchocerca volvulus 0.0075 0.0766 0.0815
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0614 0.3042
Echinococcus granulosus roundabout 2 0.0058 0.0493 0.0492
Brugia malayi phosphoinositide-dependent protein kinase I 0.0066 0.0614 0.0735
Echinococcus multilocularis tyrosine protein kinase Blk 0.0035 0.0106 0.0128
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0068 0.0656 0.1504
Schistosoma mansoni tyrosine kinase 0.0251 0.3623 0.6618
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0065 0.0602 0.0734
Echinococcus multilocularis cyclins 0.0045 0.0276 0.0335
Brugia malayi Protein kinase c protein 2 0.0064 0.0586 0.0701
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0029 0.0019 0.0023
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0151 0.1991 0.2426
Trichomonas vaginalis AGC family protein kinase 0.0138 0.1788 0.8974
Trichomonas vaginalis cyclin B, putative 0.0073 0.0734 0.3645
Trypanosoma cruzi Protein kinase B 0.0037 0.014 0.032
Brugia malayi serine/threonine-protein kinase 6 0.0138 0.1788 0.2167
Echinococcus granulosus tyrosine protein kinase Blk 0.0035 0.0106 0.0105
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0057 0.0475 0.0578
Echinococcus granulosus serine/threonine protein kinase 0.0037 0.014 0.0139
Brugia malayi hypothetical protein 0.0041 0.0214 0.0247
Giardia lamblia Kinase, CDC7 0.0075 0.0766 0.3811
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0066 0.0614 0.0613
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.0106 0.0129
Echinococcus multilocularis cyclins 0.0045 0.0276 0.0335
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0046 0.0295 0.0294
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0033 0.0072 0.0087
Echinococcus granulosus cyclin 0.0091 0.1027 0.1025
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0118 0.1461 0.146
Toxoplasma gondii hypothetical protein 0.0031 0.0039 0.0189
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0129 0.1637 0.1998
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.1461 0.732
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0056 0.045 0.0548
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0215 0.3037 0.3036
Echinococcus granulosus cyclins 0.0045 0.0276 0.0275
Schistosoma mansoni growth factor receptor-bound protein 0.0029 0.0019 0.0032
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0046 0.0295 0.0359
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0056 0.0459 0.0458
Loa Loa (eye worm) SRC-1 0.0046 0.0295 0.036
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0138 0.1788 0.1787
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.0295 0.0294
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0033 0.0072 0.007
Echinococcus granulosus tyrosine protein kinase Src42A 0.0046 0.0295 0.0294
Trichomonas vaginalis cyclins, putative 0.0073 0.0734 0.3645
Leishmania major protein kinase A catalytic subunit isoform 1 0.0056 0.0459 0.1051
Loa Loa (eye worm) TK/EGFR protein kinase 0.0318 0.4712 0.574
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0056 0.0459 0.0559
Echinococcus granulosus tyrosine protein kinase shark 0.0275 0.4022 0.4021
Brugia malayi Tyrosine-protein kinase abl-1 0.0144 0.1892 0.2293
Loa Loa (eye worm) hypothetical protein 0.0041 0.0216 0.0264
Brugia malayi Protein kinase domain containing protein 0.0365 0.5473 0.6663
Plasmodium vivax protein kinase Crk2 0.0151 0.1991 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0068 0.0656 0.1504
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0138 0.1788 0.8925
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0065 0.0602 0.0601
Echinococcus multilocularis cyclin dependent kinase 1 0.0151 0.1991 0.2431
Loa Loa (eye worm) cyclin domain-containing protein 0.0045 0.0276 0.0336
Brugia malayi P38 map kinase family protein 2 0.0296 0.4352 0.5295
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0151 0.1991 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0269 0.391 0.3909
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0487 0.2402
Trichomonas vaginalis cyclin B, putative 0.0045 0.0276 0.1332
Loa Loa (eye worm) hypothetical protein 0.0041 0.0214 0.0261
Loa Loa (eye worm) IKK protein kinase 0.0533 0.8209 1
Schistosoma mansoni nck2/grb4 0.0029 0.0019 0.0032
Trypanosoma cruzi cyclin, putative 0.0073 0.0734 0.1683
Entamoeba histolytica protein kinase, putative 0.0065 0.0602 0.302
Brugia malayi serine/threonine protein kinase 6 0.0138 0.1788 0.2167
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0933 0.1703
Echinococcus multilocularis neuroglian 0.0051 0.0368 0.0448
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0041 0.0214 0.026
Echinococcus granulosus neuroglian 0.0051 0.0368 0.0366
Giardia lamblia Kinase, PLK 0.0118 0.1461 0.732
Echinococcus granulosus twitchin 0.0062 0.055 0.0549
Schistosoma mansoni vesicular amine transporter 0.0041 0.0214 0.0389
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.0106 0.0129
Echinococcus multilocularis tyrosine protein kinase Srms 0.0035 0.0106 0.0128
Trypanosoma cruzi cdc2-related kinase 3 0.0151 0.1991 0.4574
Entamoeba histolytica protein kinase, putative 0.0138 0.1788 0.898
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0129 0.1637 0.1636
Schistosoma mansoni g1/s-specific cyclin C 0.0091 0.1027 0.1874
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.0106 0.0129
Schistosoma mansoni kinase 0.0065 0.0604 0.1102
Echinococcus granulosus cyclin dependent kinase 1 0.0151 0.1991 0.199
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0459 0.0836
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.0106 0.0129
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0033 0.0072 0.0086
Schistosoma mansoni tyrosine kinase 0.0258 0.3735 0.6823
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0034 0.0102 0.0233
Leishmania major protein kinase A catalytic subunit isoform 2 0.0056 0.0459 0.1051
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.0106 0.0129
Echinococcus multilocularis cyclins 0.0045 0.0276 0.0335
Brugia malayi Protein kinase domain containing protein 0.0035 0.0106 0.0114
Loa Loa (eye worm) hypothetical protein 0.0041 0.0214 0.0261
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0487 0.2402
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0029 0.0012 0.0011
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0295 0.0359
Trypanosoma cruzi cdc2-related kinase 1 0.0151 0.1991 0.4574
Echinococcus multilocularis rac serine:threonine kinase 0.0037 0.014 0.017
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0056 0.0459 0.0458
Echinococcus multilocularis protein kinase shaggy 0.0065 0.0602 0.0734
Giardia lamblia Hypothetical protein 0.0045 0.0276 0.1332
Loa Loa (eye worm) AGC/PKA protein kinase 0.0056 0.0459 0.0559
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0068 0.0656 0.0799
Brugia malayi hypothetical protein 0.0035 0.0106 0.0114
Brugia malayi Protein kinase domain containing protein 0.0035 0.0106 0.0114
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0046 0.0295 0.0359
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0487 0.2402
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0029 0.0011 0.0051
Loa Loa (eye worm) hypothetical protein 0.0052 0.0381 0.0464
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.1461 0.732
Schistosoma mansoni cyclin B 0.0073 0.0734 0.1338
Brugia malayi Protein kinase domain containing protein 0.0035 0.0106 0.0114
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0033 0.0072 0.0086
Loa Loa (eye worm) AGC/PKA protein kinase 0.0056 0.0459 0.0559
Brugia malayi Protein kinase domain containing protein 0.0066 0.0614 0.0735
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0086 0.0933 0.1139
Echinococcus granulosus protein kinase C gamma type 0.0079 0.0822 0.0821
Brugia malayi Sex muscle abnormal protein 5 0.0029 0.0019 0.0008
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0118 0.1461 0.3355
Echinococcus granulosus tyrosine protein kinase Lyn 0.0058 0.0478 0.0477
Onchocerca volvulus 0.0352 0.5269 0.6372
Echinococcus multilocularis NCK adaptor protein 0.0029 0.0019 0.0021

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 47 % Inhibition of strand rejoining activity of human DNA topoisomerase 2 assessed as protein-DNA complex formation at 20 uM by cell-based assay ChEMBL. 1331331
ID50 (functional) = 1.9 uM Cytotoxicity against human KB cells assessed as reduction in cell number after 3 days ChEMBL. 1331331
ID50 (binding) = 100 uM Inhibition of human DNA topoisomerase 2 ChEMBL. 1331331

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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