Detailed information for compound 1060008

Basic information

Technical information
  • TDR Targets ID: 1060008
  • Name: N,1,4,4-tetramethyl-8-[[4-(4-methylpiperazin- 1-yl)phenyl]amino]-5H-pyrazolo[4,5-h]quinazol ine-3-carboxamide
  • MW: 460.575 | Formula: C25H32N8O
  • H donors: 2 H acceptors: 4 LogP: 2.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)c1nn(c2c1C(C)(C)Cc1c2nc(nc1)Nc1ccc(cc1)N1CCN(CC1)C)C
  • InChi: 1S/C25H32N8O/c1-25(2)14-16-15-27-24(29-20(16)22-19(25)21(23(34)26-3)30-32(22)5)28-17-6-8-18(9-7-17)33-12-10-31(4)11-13-33/h6-9,15H,10-14H2,1-5H3,(H,26,34)(H,27,28,29)
  • InChiKey: RXZMYLDMFYNEIM-UHFFFAOYSA-N  


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Synonyms

  • N,1,4,4-tetramethyl-8-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5H-pyrazolo[4,5-h]quinazoline-3-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon Starlite/ChEMBL References
Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Starlite/ChEMBL References
Homo sapiens cell division cycle 7 Starlite/ChEMBL References
Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 Starlite/ChEMBL References
Homo sapiens protein kinase C, beta Starlite/ChEMBL References
Homo sapiens fibroblast growth factor receptor 1 Starlite/ChEMBL References
Homo sapiens aurora kinase B Starlite/ChEMBL References
Homo sapiens ret proto-oncogene Starlite/ChEMBL References
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References
Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 4 Starlite/ChEMBL References
Homo sapiens cyclin H References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens v-akt murine thymoma viral oncogene homolog 1 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 7 Starlite/ChEMBL References
Homo sapiens LYN proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens polo-like kinase 1 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 4 Starlite/ChEMBL References
Homo sapiens insulin-like growth factor 1 receptor Starlite/ChEMBL References
Homo sapiens mitogen-activated protein kinase 14 Starlite/ChEMBL References
Homo sapiens cyclin B1 References
Homo sapiens 3-phosphoinositide dependent protein kinase 1 Starlite/ChEMBL References
Homo sapiens insulin receptor Starlite/ChEMBL References
Homo sapiens NIMA-related kinase 6 Starlite/ChEMBL References
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL References
Homo sapiens mitogen-activated protein kinase 11 Starlite/ChEMBL References
Homo sapiens mitogen-activated protein kinase-activated protein kinase 2 Starlite/ChEMBL References
Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta Starlite/ChEMBL References
Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens STE20-like kinase Starlite/ChEMBL References
Homo sapiens zeta-chain (TCR) associated protein kinase 70kDa Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens cyclin D1 References
Homo sapiens checkpoint kinase 1 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References
Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha Starlite/ChEMBL References
Homo sapiens MET proto-oncogene, receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens fms-related tyrosine kinase 4 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References
Homo sapiens aurora kinase A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Candida albicans cyclin Get druggable targets OG5_129254 All targets in OG5_129254
Schistosoma japonicum ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative Get druggable targets OG5_129857 All targets in OG5_129857
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) STE/STE20/SLK protein kinase Get druggable targets OG5_130670 All targets in OG5_130670
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus macrophage colony stimulating factor 1 receptor Get druggable targets OG5_132967 All targets in OG5_132967
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130670 All targets in OG5_130670
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi map kinase activated protein kinase protein 2 Get druggable targets OG5_131483 All targets in OG5_131483
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129224 All targets in OG5_129224
Plasmodium yoelii kinase Akt/PKB-related Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative Get druggable targets OG5_131483 All targets in OG5_131483
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K06276 3-phosphoinositide dependent protein kinase-1, putative Get druggable targets OG5_128785 All targets in OG5_128785
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum cyclin domain protein, possible cyclin H Get druggable targets OG5_129254 All targets in OG5_129254
Echinococcus granulosus fibroblast growth factor receptor 4 Get druggable targets OG5_128769 All targets in OG5_128769
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase Get druggable targets OG5_130454 All targets in OG5_130454
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi serine/threonine-protein kinase PAK 7 Get druggable targets OG5_131977 All targets in OG5_131977
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase 2, putative Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) AGC/RSK/P70 protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni protein kinase Get druggable targets OG5_130670 All targets in OG5_130670
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Tyrosine-protein kinase abl-1 Get druggable targets OG5_131234 All targets in OG5_131234
Giardia lamblia Kinase, CDC7 Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Loa Loa (eye worm) NEK/NEK6 protein kinase Get druggable targets OG5_131134 All targets in OG5_131134
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_128769 All targets in OG5_128769
Schistosoma japonicum ko:K07390 monothiol glutaredoxin, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Leishmania major protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Fibroblast growth factor receptor precursor, putative Get druggable targets OG5_128769 All targets in OG5_128769
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_128785 All targets in OG5_128785
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04456 RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131234 All targets in OG5_131234
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase Chk1, putative Get druggable targets OG5_130454 All targets in OG5_130454
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_132247 All targets in OG5_132247
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum expressed protein Get druggable targets OG5_129224 All targets in OG5_129224
Echinococcus multilocularis MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine-threonine kinase, subunit of RNA Pol TFIIK. Get druggable targets OG5_129224 All targets in OG5_129224
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130454 All targets in OG5_130454
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128769 All targets in OG5_128769
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130454 All targets in OG5_130454
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K04527 insulin receptor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans Serine-threonine kinase, subunit of RNA Pol TFIIK. Get druggable targets OG5_129224 All targets in OG5_129224
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trichomonas vaginalis cyclin H, putative Get druggable targets OG5_129254 All targets in OG5_129254
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Serine/threonine-protein kinase Nek7 Get druggable targets OG5_131134 All targets in OG5_131134
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_128769 All targets in OG5_128769
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) STE/STE20/PAKB protein kinase Get druggable targets OG5_131977 All targets in OG5_131977
Chlamydia trachomatis serine/threonine protein kinase Get druggable targets OG5_131134 All targets in OG5_131134
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K08837 serine/threonine kinase 10, putative Get druggable targets OG5_130670 All targets in OG5_130670
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Entamoeba histolytica hypothetical protein Get druggable targets OG5_129254 All targets in OG5_129254
Schistosoma japonicum ko:K08792 serum/glucocorticoid regulated kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) TK/ABL protein kinase Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Cryptosporidium parvum protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129254 All targets in OG5_129254
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai Get druggable targets OG5_128769 All targets in OG5_128769
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 7 Get druggable targets OG5_129224 All targets in OG5_129224
Echinococcus granulosus basic fibroblast growth factor receptor 1 A Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) CDC7 protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129224 All targets in OG5_129224
Trypanosoma cruzi Protein kinase B Get druggable targets OG5_126635 All targets in OG5_126635
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 Get druggable targets OG5_128785 All targets in OG5_128785
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 Get druggable targets OG5_128785 All targets in OG5_128785
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) TK/INSR protein kinase Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase Get druggable targets OG5_129224 All targets in OG5_129224
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade Get druggable targets OG5_128785 All targets in OG5_128785
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Theileria parva cAMP-dependent protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/PDK1 protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus serine threonine protein kinase nrc Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi phosphoinositide-dependent protein kinase I Get druggable targets OG5_128785 All targets in OG5_128785
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis STE20 serine:threonine protein kinase Get druggable targets OG5_130670 All targets in OG5_130670
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02214 cell division control protein CDC7, putative Get druggable targets OG5_129189 All targets in OG5_129189
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis rac serine:threonine kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis tyrosine protein kinase Abl Get druggable targets OG5_131234 All targets in OG5_131234
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Schistosoma japonicum IPR008957,Fibronectin, type III-like fold,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08857 NIMA (never in mitosis gene a)-related kinase, putative Get druggable targets OG5_131134 All targets in OG5_131134
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Loa Loa (eye worm) IKK protein kinase Get druggable targets OG5_132247 All targets in OG5_132247
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii AGC kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/PDK1 protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium knowlesi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi p70 ribosomal S6 kinase beta Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/AKT protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129189 All targets in OG5_129189
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A Get druggable targets OG5_128769 All targets in OG5_128769
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis fibroblast growth factor receptor 4 Get druggable targets OG5_128769 All targets in OG5_128769
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Theileria parva cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade Get druggable targets OG5_128785 All targets in OG5_128785
Schistosoma japonicum ko:K05855 spleen tyrosine kinase, putative Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Protein kinase DC2, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Neospora caninum Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130670 All targets in OG5_130670
Trypanosoma brucei gambiense protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum expressed protein Get druggable targets OG5_130670 All targets in OG5_130670
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_129254 All targets in OG5_129254
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Serine/threonine-protein kinase Nek6, putative Get druggable targets OG5_131134 All targets in OG5_131134
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_132247 All targets in OG5_132247
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei protein kinase A catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania braziliensis protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_128785 All targets in OG5_128785
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Plasmodium berghei rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania donovani protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Trypanosoma brucei gambiense rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus cyclin dependent kinase 7 Get druggable targets OG5_129224 All targets in OG5_129224
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_129254 All targets in OG5_129254
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Brugia malayi cyclin-dependent kinase 7 homolog Get druggable targets OG5_129224 All targets in OG5_129224
Echinococcus multilocularis insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative Get druggable targets OG5_131855 All targets in OG5_131855
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131134 All targets in OG5_131134
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus calcium:calmodulin dependent protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania major protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131234 All targets in OG5_131234
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase ABL1, putative Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans cyclin Get druggable targets OG5_129254 All targets in OG5_129254
Candida albicans protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus STE20 serine:threonine protein kinase Get druggable targets OG5_130670 All targets in OG5_130670
Candida albicans likely protein kinase similar to S. cerevisiae YPK2 (YMR104C) Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania major protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 7 346 aa 311 aa 32.5 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 11 364 aa 361 aa 33.0 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase-activated protein kinase 2 370 aa 303 aa 26.4 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 4 303 aa 312 aa 29.8 %
Plasmodium falciparum cyclin cyclin H 270 aa 253 aa 22.1 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 14 360 aa 336 aa 33.3 %
Trypanosoma cruzi Wee1-like protein kinase, putative NIMA-related kinase 6 347 aa 301 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0594 0.0724
Schistosoma mansoni tyrosine kinase 0.0237 0.3203 0.5823
Schistosoma mansoni tyrosine kinase 0.0049 0.0353 0.0641
Brugia malayi Fibronectin type III domain containing protein 0.0044 0.0272 0.0331
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0147 0.1829 1
Echinococcus granulosus cyclins 0.0048 0.0333 0.0333
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0314 0.4378 1
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0213 0.2836 0.2836
Loa Loa (eye worm) SRC-1 0.0049 0.0353 0.043
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.006 0.0508 0.0508
Giardia lamblia Kinase, CMGC MAPK 0.0072 0.0703 0.3623
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0164 0.02
Echinococcus granulosus neuroglian 0.0054 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.0044 0.0272 0.0331
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0028 0.0032 0.0039
Entamoeba histolytica PH domain containing protein kinase, putative 0.0039 0.0191 0.0778
Entamoeba histolytica protein kinase, putative 0.003 0.0064 0.0061
Giardia lamblia G2/mitotic-specific cyclin B 0.0078 0.0788 0.4104
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0137 0.1686 0.2059
Schistosoma mansoni tyrosine kinase 0.0255 0.3478 0.6324
Echinococcus granulosus Protein kinase C brain isozyme 0.0091 0.098 0.098
Schistosoma mansoni tyrosine kinase 0.0049 0.0353 0.0641
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0813 0.1479
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1504 0.8157
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.1343 0.2442
Echinococcus granulosus mitogen activated protein kinase 11 0.0314 0.4378 0.4378
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0049 0.0353 0.0431
Loa Loa (eye worm) cyclin domain-containing protein 0.0048 0.0333 0.0406
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0072 0.0703 0.1504
Trichomonas vaginalis CMGC family protein kinase 0.008 0.0813 0.4246
Echinococcus multilocularis protein kinase c epsilon type 0.0043 0.0257 0.0313
Onchocerca volvulus Serine\/threonine kinase homolog 0.0125 0.1504 0.1665
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0314 0.4378 0.5332
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0115 0.1343 0.1635
Trichomonas vaginalis cyclin B3, putative 0.0048 0.0333 0.1526
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0115 0.1343 0.2982
Echinococcus granulosus tyrosine protein kinase Blk 0.0037 0.0164 0.0164
Echinococcus granulosus serine:threonine protein kinase N2 0.0034 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0309 0.4296 0.5231
Plasmodium falciparum glycogen synthase kinase 3 0.0069 0.065 0.3363
Schistosoma mansoni atypical protein kinase C 0.0041 0.0234 0.0425
Entamoeba histolytica PH domain containing protein kinase, putative 0.0062 0.0545 0.2772
Trichomonas vaginalis cyclin B, putative 0.0048 0.0333 0.1526
Echinococcus multilocularis mitogen activated protein kinase 3 0.0072 0.0703 0.0859
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.1829 0.3326
Brugia malayi Immunoglobulin I-set domain containing protein 0.0147 0.1839 0.2239
Trypanosoma brucei rac serine-threonine kinase, putative 0.0061 0.0536 0.1117
Loa Loa (eye worm) hypothetical protein 0.0062 0.055 0.0669
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0037 0.0164 0.0627
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0232 0.3122 0.3802
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0044 0.0272 0.0332
Schistosoma mansoni g1/s-specific cyclin C 0.0097 0.108 0.1963
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0069 0.065 0.0792
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.4296 0.781
Echinococcus multilocularis tyrosine protein kinase Abl 0.0145 0.1799 0.2196
Echinococcus multilocularis cyclin 0.0097 0.108 0.1318
Echinococcus granulosus epidermal growth factor receptor 0.0339 0.4743 0.4743
Entamoeba histolytica protein kinase, putative 0.0061 0.0536 0.2721
Echinococcus granulosus Immunoglobulin 0.0044 0.0272 0.0272
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1504 0.8157
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0703 0.3623
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0048 0.0334 0.0334
Brugia malayi Protein kinase domain containing protein 0.0061 0.0536 0.0653
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0566 0.819 1
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0137 0.0167
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0123 0.015
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0314 0.4378 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0333 0.1526
Onchocerca volvulus 0.008 0.0813 0.0807
Brugia malayi Protein kinase domain containing protein 0.0388 0.55 0.6698
Schistosoma mansoni tyrosine kinase 0.0137 0.1686 0.3066
Entamoeba histolytica cyclin, putative 0.0078 0.0788 0.414
Leishmania major protein kinase, putative 0.0147 0.1829 0.4107
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0123 0.0335
Trichomonas vaginalis CMGC family protein kinase 0.008 0.0813 0.4246
Entamoeba histolytica cyclin, putative 0.0048 0.0333 0.1578
Schistosoma mansoni protein kinase 0.003 0.0053 0.0096
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0049 0.0353 0.0431
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0115 0.1343 0.1635
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0059 0.0499 0.0607
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0353 0.0353
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0594 0.0724
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0049 0.0353 0.0353
Brugia malayi Protein kinase domain containing protein 0.007 0.0662 0.0807
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.006 0.0508 0.256
Entamoeba histolytica cell division protein kinase 2, putative 0.0115 0.1343 0.7262
Giardia lamblia Cyclin A 0.0048 0.0333 0.1526
Loa Loa (eye worm) hypothetical protein 0.0052 0.0397 0.0484
Echinococcus granulosus c src tyrosine kinase 0.0049 0.0353 0.0353
Echinococcus granulosus mitogen activated protein kinase 14 0.0314 0.4378 0.4378
Schistosoma mansoni nck2/grb4 0.0031 0.0078 0.0141
Schistosoma mansoni serine/threonine protein kinase 0.026 0.3556 0.6466
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.006 0.0508 0.2113
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0388 0.55 0.55
Trichomonas vaginalis AGC family protein kinase 0.0147 0.1829 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.2221 0.2705
Toxoplasma gondii Erv1 / Alr family protein 0.0038 0.018 0.0715
Echinococcus multilocularis cyclins 0.0048 0.0333 0.0407
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.0327 0.0327
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0353 0.0431
Echinococcus multilocularis serine:threonine protein kinase 38 0.0034 0.0123 0.015
Echinococcus granulosus cyclin dependent kinase 7 0.0104 0.1181 0.1181
Brugia malayi Cyclin C 0.0097 0.108 0.1315
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0038 0.018 0.0157
Entamoeba histolytica protein kinase, putative 0.0069 0.065 0.3363
Echinococcus granulosus fibroblast growth factor receptor 4 0.0137 0.1686 0.1686
Echinococcus granulosus tyrosine protein kinase Srms 0.0037 0.0164 0.0164
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0164 0.02
Echinococcus granulosus protein kinase C gamma type 0.0083 0.0869 0.0869
Echinococcus granulosus NDR protein kinase 0.0034 0.0123 0.0123
Echinococcus granulosus tar DNA binding protein 0.0065 0.0594 0.0594
Echinococcus granulosus protein kinase c iota type 0.0041 0.0234 0.0234
Onchocerca volvulus 0.0069 0.065 0.0604
Echinococcus multilocularis CDC7 cell division cycle 7 0.008 0.0813 0.0993
Trichomonas vaginalis CMGC family protein kinase 0.008 0.0813 0.4246
Loa Loa (eye worm) hypothetical protein 0.0048 0.0327 0.0398
Echinococcus multilocularis cyclin b3 0.0048 0.0333 0.0407
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0213 0.2836 0.3463
Echinococcus multilocularis aurora kinase A 0.0147 0.1829 0.2234
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0353 0.0431
Brugia malayi TAR-binding protein 0.0065 0.0594 0.0724
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0536 0.2676
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1504 0.8157
Echinococcus granulosus tyrosine protein kinase ABL1 0.0286 0.3946 0.3946
Echinococcus granulosus tyrosine protein kinase Src64B 0.0049 0.0353 0.0353
Entamoeba histolytica protein kinase, putative 0.0147 0.1829 1
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0566 0.819 0.819
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.006 0.0508 0.1051
Loa Loa (eye worm) TK protein kinase 0.0037 0.0164 0.02
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0508 0.0923
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0049 0.0353 0.0431
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0536 0.2676
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0164 0.02
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0703 0.3623
Trichomonas vaginalis AGC family protein kinase 0.0037 0.016 0.0548
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0353 0.0353
Echinococcus granulosus CDC7 cell division cycle 7 0.008 0.0813 0.0813
Echinococcus granulosus tyrosine protein kinase shark 0.0293 0.4057 0.4057
Brugia malayi serine/threonine kinase 12 0.0147 0.1829 0.2228
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0104 0.1181 0.1438
Loa Loa (eye worm) hypothetical protein 0.0037 0.0164 0.02
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0069 0.065 0.1381
Brugia malayi hypothetical protein 0.0037 0.0164 0.02
Echinococcus multilocularis epidermal growth factor receptor 0.0255 0.3478 0.4247
Brugia malayi Variant SH3 domain containing protein 0.0031 0.0078 0.0095
Schistosoma mansoni tyrosine kinase 0.0037 0.0165 0.03
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0043 0.0257 0.0313
Brugia malayi Protein kinase domain containing protein 0.0213 0.2837 0.3455
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.006 0.0508 0.0508
Leishmania major hypothetical protein, conserved 0.0038 0.018 0.0294
Leishmania major protein kinase A catalytic subunit isoform 1 0.006 0.0508 0.1051
Trypanosoma cruzi cdc2-related kinase 3 0.0115 0.1343 0.2982
Loa Loa (eye worm) hypothetical protein 0.0044 0.0272 0.0331
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.003 0.0064 0.0064
Entamoeba histolytica protein kinase, putative 0.0034 0.0123 0.0394
Echinococcus multilocularis tyrosine protein kinase shark 0.0293 0.4057 0.4953
Schistosoma mansoni tyrosine kinase 0.0255 0.3478 0.6324
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.003 0.0064 0.0078
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0147 0.1829 0.1829
Loa Loa (eye worm) CDC7 protein kinase 0.008 0.0813 0.0991
Echinococcus multilocularis protein kinase shaggy 0.0069 0.065 0.0794
Trichomonas vaginalis cyclin A, putative 0.0078 0.0788 0.4104
Brugia malayi Protein kinase domain containing protein 0.0191 0.2497 0.304
Echinococcus granulosus aurora kinase A 0.0147 0.1829 0.1829
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0072 0.0703 0.0857
Loa Loa (eye worm) AGC/PKA protein kinase 0.006 0.0508 0.0618
Loa Loa (eye worm) cyclin domain-containing protein 0.0174 0.2241 0.2729
Loa Loa (eye worm) hypothetical protein 0.0078 0.0788 0.096
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0069 0.065 0.0792
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0137 0.1686 0.1686
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0034 0.0123 0.015
Echinococcus multilocularis cyclins 0.0048 0.0333 0.0407
Trypanosoma brucei mitotic cyclin 6 0.0078 0.0788 0.17
Toxoplasma gondii AGC kinase 0.0059 0.0499 0.2509
Echinococcus multilocularis Immunoglobulin 0.0044 0.0272 0.0332
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0594 0.1081
Echinococcus multilocularis mitogen activated protein kinase 11 0.0314 0.4378 0.5346
Brugia malayi cyclin-dependent kinase 7 homolog 0.0104 0.1181 0.1438
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0164 0.02
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0072 0.0703 0.1504
Echinococcus multilocularis roundabout 2 0.0062 0.055 0.0671
Giardia lamblia Kinase, CDC7 0.008 0.0813 0.4246
Brugia malayi hypothetical protein 0.0148 0.185 0.2253
Brugia malayi Protein kinase domain containing protein 0.0037 0.0164 0.02
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0167
Echinococcus multilocularis cyclins 0.0048 0.0333 0.0407
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0255 0.3478 0.3478
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0049 0.0353 0.0431
Giardia lamblia Kinase, CMGC CDK 0.0115 0.1343 0.7245
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.098 0.1781
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.003 0.0055 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0257 0.0467
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0048 0.0333 0.0333
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.1343 0.7245
Entamoeba histolytica serine/threonine protein kinase, putative 0.0125 0.1504 0.8168
Echinococcus multilocularis cyclins 0.0048 0.0333 0.0407
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0034 0.0123 0.0123
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0069 0.065 0.065
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0069 0.065 0.1381
Trypanosoma brucei cdc2-related kinase 3 0.0115 0.1343 0.2982
Toxoplasma gondii Erv1 / Alr family protein 0.0038 0.018 0.0715
Echinococcus multilocularis c src tyrosine kinase 0.0049 0.0353 0.0431
Brugia malayi hypothetical protein 0.0044 0.0272 0.0331
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0164 0.02
Schistosoma mansoni metabotropic glutamate receptor 0.0176 0.2273 0.4132
Loa Loa (eye worm) hypothetical protein 0.0031 0.0078 0.0095
Loa Loa (eye worm) AUR protein kinase 0.0147 0.1829 0.2228
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.003 0.0064 0.0064
Brugia malayi SRC-1 0.0049 0.0353 0.043
Schistosoma mansoni protein kinase 0.003 0.0064 0.0116
Brugia malayi protein kinase C II. 0.0043 0.0257 0.0313
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.1181 0.2148
Loa Loa (eye worm) hypothetical protein 0.0148 0.185 0.2253
Chlamydia trachomatis serine/threonine protein kinase 0.026 0.3556 0.5
Echinococcus multilocularis cyclins 0.0048 0.0333 0.0407
Brugia malayi serine/threonine-protein kinase PAK 7 0.0232 0.3122 0.3802
Trypanosoma cruzi cdc2-related kinase 3 0.0115 0.1343 0.2982
Trypanosoma cruzi aurora B kinase, putative 0.0147 0.1829 0.4107
Trichomonas vaginalis AGC family protein kinase 0.007 0.0662 0.339
Brugia malayi Cyclin, N-terminal domain containing protein 0.0078 0.0788 0.096
Echinococcus multilocularis tyrosine protein kinase Srms 0.0037 0.0164 0.0201
Trichomonas vaginalis AGC family protein kinase 0.0147 0.1829 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0314 0.4378 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0069 0.065 0.1182
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0164 0.0201
Onchocerca volvulus Tyrosine kinase homolog 0.0403 0.5725 0.6909
Entamoeba histolytica cyclin family protein 0.0048 0.0333 0.1578
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.0327 0.0399
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0164 0.02
Echinococcus multilocularis insulin receptor 0.0388 0.55 0.6716
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0228 0.3071 0.3071
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0125 0.1504 0.1836
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0049 0.0353 0.0431
Loa Loa (eye worm) hypothetical protein 0.0078 0.0788 0.096
Brugia malayi Protein kinase domain containing protein 0.0037 0.0164 0.02
Echinococcus granulosus cyclin dependent kinase 1 0.0115 0.1343 0.1343
Echinococcus granulosus tyrosine protein kinase Src42A 0.0049 0.0353 0.0353
Schistosoma mansoni vesicular amine transporter 0.0044 0.0272 0.0495
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0037 0.0164 0.0201
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1504 0.8157
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.003 0.0064 0.0064
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0203 0.2692 0.3278
Trypanosoma cruzi CYC2-like cyclin, putative 0.0078 0.0788 0.17
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.2837 0.5158
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0536 0.2676
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0594 0.0724
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0703 0.1279
Loa Loa (eye worm) TK/INSR protein kinase 0.0388 0.55 0.6698
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1829 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.185 0.2253
Trichomonas vaginalis cyclins, putative 0.0078 0.0788 0.4104
Schistosoma mansoni tyrosine kinase 0.0037 0.0164 0.0299
Brugia malayi Serine/threonine-protein kinase Nek7 0.026 0.3556 0.4331
Echinococcus granulosus epidermal growth factor receptor 0.0255 0.3478 0.3478
Echinococcus granulosus tyrosine protein kinase Lyn 0.0061 0.0527 0.0527
Entamoeba histolytica protein kinase, putative 0.0033 0.0101 0.0273
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0272 0.0331
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0044 0.0272 0.0495
Giardia lamblia Hypothetical protein 0.0048 0.0333 0.1526
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0147 0.1829 1
Trichomonas vaginalis cyclin B, putative 0.0078 0.0788 0.4104
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0123 0.0223
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.015
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0508 0.0923
Loa Loa (eye worm) AUR protein kinase 0.0147 0.1829 0.2228
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.194 0.2362
Brugia malayi Protein kinase domain containing protein 0.0203 0.2692 0.3278
Brugia malayi Protein kinase domain containing protein 0.0034 0.0123 0.015
Schistosoma mansoni hypothetical protein 0.0035 0.0137 0.0249
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0115 0.1343 0.7262
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0125 0.1504 0.1831
Loa Loa (eye worm) RNA binding protein 0.0065 0.0594 0.0724
Onchocerca volvulus 0.008 0.0813 0.0807
Schistosoma mansoni tyrosine kinase 0.0388 0.55 1
Loa Loa (eye worm) cyclin C 0.0097 0.108 0.1315
Echinococcus granulosus cyclins 0.0048 0.0333 0.0333
Echinococcus multilocularis cyclin B 0.0078 0.0788 0.0963
Loa Loa (eye worm) AGC/NDR protein kinase 0.0034 0.0123 0.015
Schistosoma mansoni tyrosine kinase 0.0237 0.3203 0.5823
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0164 0.02
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0388 0.55 0.6716
Giardia lamblia Kinase, AGC PKA 0.0036 0.0154 0.0509
Echinococcus multilocularis mitogen activated protein kinase 0.0072 0.0703 0.0859
Loa Loa (eye worm) hypothetical protein 0.0051 0.0383 0.0467
Echinococcus granulosus serine threonine protein kinase nrc 0.0036 0.0154 0.0154
Brugia malayi RNA binding protein 0.0065 0.0594 0.0724
Toxoplasma gondii aurora kinase 0.0147 0.1829 1
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1504 0.8157
Brugia malayi intracellular kinase 0.0069 0.065 0.0792
Schistosoma mansoni tyrosine kinase 0.0237 0.3203 0.5823
Echinococcus multilocularis cyclin dependent kinase 1 0.0115 0.1343 0.164
Plasmodium vivax protein kinase Crk2 0.0115 0.1343 0.7097
Echinococcus granulosus tyrosine kinase 0.0037 0.0164 0.0164
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0164 0.02
Echinococcus granulosus dual specificity testis-specific protein kinase 0.003 0.0053 0.0053
Trichomonas vaginalis cyclins, putative 0.0078 0.0788 0.4104
Loa Loa (eye worm) hypothetical protein 0.003 0.0059 0.0072
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0072 0.0703 0.1504
Echinococcus multilocularis epidermal growth factor receptor 0.0339 0.4743 0.5791
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0037 0.0164 0.0164
Onchocerca volvulus 0.0078 0.0788 0.0776
Brugia malayi Protein kinase domain containing protein 0.0115 0.1343 0.1635
Brugia malayi Protein kinase domain containing protein 0.0034 0.0123 0.015
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.006 0.0508 0.0508
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0536 0.2676
Trichomonas vaginalis AGC family protein kinase 0.007 0.0662 0.339
Brugia malayi Sex muscle abnormal protein 5 0.0031 0.0078 0.0095
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0036 0.0154 0.0233
Schistosoma mansoni serine/threonine-protein kinase 0.0039 0.0191 0.0348
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0123 0.0223
Schistosoma mansoni protein kinase 0.003 0.0053 0.0096
Echinococcus multilocularis cyclin dependent kinase 5 0.0115 0.1343 0.164
Echinococcus multilocularis NCK adaptor protein 0.0031 0.0078 0.0095
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.098 0.1781
Echinococcus granulosus cyclin 0.0097 0.108 0.108
Echinococcus granulosus activin receptor type 0.003 0.0053 0.0053
Echinococcus granulosus roundabout 2 0.0062 0.055 0.055
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0123 0.0335
Onchocerca volvulus 0.0375 0.5297 0.6378
Echinococcus multilocularis cyclins 0.0048 0.0333 0.0407
Trypanosoma cruzi Protein kinase B 0.0039 0.0191 0.032
Brugia malayi Augmenter of liver regeneration 0.0038 0.018 0.0219
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0594 0.1081
Trichomonas vaginalis cyclins, putative 0.0048 0.0333 0.1526
Loa Loa (eye worm) hypothetical protein 0.006 0.0508 0.0618
Loa Loa (eye worm) hypothetical protein 0.0044 0.0272 0.0331
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0034 0.0123 0.0123
Loa Loa (eye worm) TK protein kinase 0.0147 0.1839 0.2239
Loa Loa (eye worm) hypothetical protein 0.0055 0.0438 0.0533
Echinococcus granulosus growth factor receptor bound protein 2 0.0031 0.0078 0.0078
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0508 0.0923
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0072 0.0703 0.1504
Entamoeba histolytica protein kinase domain containing protein 0.0069 0.065 0.3363
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.006 0.0508 0.1051
Schistosoma mansoni growth factor receptor-bound protein 0.0031 0.0078 0.0141
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0031 0.0078 0.0095
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0353 0.0643
Schistosoma mansoni protein kinase 0.003 0.0064 0.0116
Loa Loa (eye worm) hypothetical protein 0.0062 0.055 0.0669
Schistosoma mansoni growth factor receptor-bound protein 0.0031 0.0078 0.0141
Brugia malayi p70 ribosomal S6 kinase beta 0.0059 0.0499 0.0607
Entamoeba histolytica PH domain containing protein kinase, putative 0.0039 0.0191 0.0778
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0038 0.018 0.0294
Schistosoma mansoni protein kinase 0.003 0.0064 0.0116
Echinococcus multilocularis growth factor receptor bound protein 2 0.0031 0.0078 0.0095
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.006 0.0508 0.1051
Trypanosoma brucei cdc2-related kinase 1 0.0115 0.1343 0.2982
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0038 0.018 0.0715
Trichomonas vaginalis AGC family protein kinase 0.0147 0.1829 1
Brugia malayi Protein kinase c protein 2 0.0068 0.0635 0.0773
Echinococcus multilocularis tyrosine protein kinase Blk 0.0037 0.0164 0.0201
Loa Loa (eye worm) hypothetical protein 0.0044 0.0274 0.0334
Echinococcus granulosus cyclin dependent kinase 0.0115 0.1343 0.1343
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0137 0.1686 0.2059
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0061 0.0524 0.0638
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0069 0.065 0.0794
Schistosoma mansoni protein kinase 0.0147 0.1829 0.3326
Schistosoma mansoni tyrosine kinase 0.0275 0.3772 0.6857
Echinococcus granulosus tyrosine kinase 0.0037 0.0164 0.0164
Loa Loa (eye worm) hepatopoietin HPO2 0.0038 0.018 0.0219
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0036 0.0154 0.0188
Echinococcus multilocularis 0.0097 0.1078 0.1316
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0039 0.0191 0.032
Loa Loa (eye worm) TK/ABL protein kinase 0.0286 0.3946 0.4805
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0147 0.1829 1
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0314 0.4378 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0594 0.1081
Entamoeba histolytica p21-activated kinase 0.0033 0.0101 0.0273
Schistosoma mansoni tyrosine kinase 0.0049 0.0353 0.0641
Entamoeba histolytica protein kinase, putative 0.0147 0.1829 1
Trichomonas vaginalis cyclin D, putative 0.0048 0.0333 0.1526
Loa Loa (eye worm) IKK protein kinase 0.0567 0.8212 1
Echinococcus granulosus cyclins 0.0048 0.0333 0.0333
Loa Loa (eye worm) TK/ROR protein kinase 0.0028 0.0032 0.0038
Trypanosoma cruzi cyclin 6, putative 0.0078 0.0788 0.17
Entamoeba histolytica protein kinase domain containing protein 0.0069 0.065 0.3363
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0091 0.098 0.1196
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.1343 0.7245
Echinococcus granulosus metabotropic glutamate receptor 5 0.0026 0.0001 0.0001
Brugia malayi Hr1 repeat family protein 0.0034 0.0123 0.015
Trichomonas vaginalis cyclins, putative 0.0045 0.0295 0.1308
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.006 0.0508 0.062
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0123 0.015
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.006 0.0508 0.1051
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0031 0.0078 0.0095
Schistosoma mansoni cyclin B3 0.0048 0.0333 0.0606
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.006 0.0508 0.0618
Entamoeba histolytica protein kinase, putative 0.0059 0.0499 0.2509
Toxoplasma gondii hypothetical protein 0.0033 0.0098 0.0252
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.3071 0.5583
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0049 0.0353 0.0431
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0125 0.1504 0.1504
Schistosoma mansoni tyrosine kinase 0.0036 0.0157 0.0285
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0049 0.0353 0.0431
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0536 0.2676
Brugia malayi Furin-like cysteine rich region family protein 0.0339 0.4743 0.5776
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.006 0.0508 0.1051
Schistosoma mansoni cyclin B 0.0078 0.0788 0.1433
Schistosoma mansoni tyrosine kinase 0.0388 0.55 1
Entamoeba histolytica protein kinase , putative 0.0147 0.1829 1
Plasmodium falciparum cyclin 0.0048 0.0333 0.1578
Trypanosoma brucei polo-like protein kinase 0.0125 0.1504 0.3355
Plasmodium vivax glycogen synthase kinase 3, putative 0.0069 0.065 0.2964
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0072 0.0703 0.1504
Schistosoma mansoni tyrosine kinase 0.0293 0.4057 0.7376
Loa Loa (eye worm) hypothetical protein 0.0026 0.0001 0.0002
Brugia malayi Variant SH3 domain containing protein 0.0031 0.0078 0.0095
Trypanosoma brucei aurora B kinase 0.0147 0.1829 0.4107
Trypanosoma cruzi polo-like protein kinase, putative 0.0125 0.1504 0.3355
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0044 0.0272 0.0495
Trichomonas vaginalis cyclin B, putative 0.0078 0.0788 0.4104
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1504 0.8157
Echinococcus multilocularis Immunoglobulin 0.0044 0.0272 0.0332
Entamoeba histolytica PH domain containing protein kinase, putative 0.0062 0.0545 0.2772
Echinococcus granulosus protein kinase c epsilon type 0.0043 0.0257 0.0257
Echinococcus multilocularis cyclin B3 1 0.0048 0.0333 0.0407
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0383 0.0467
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0038 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0103 0.1169 0.1424
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0164 0.02
Trichomonas vaginalis cyclin D, putative 0.0048 0.0333 0.1526
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.007 0.0662 0.0809
Echinococcus multilocularis serine threonine protein kinase 0.0083 0.0869 0.1061
Echinococcus granulosus cyclin dependent kinase 5 0.0115 0.1343 0.1343
Trypanosoma cruzi cdc2-related kinase 1 0.0115 0.1343 0.2982
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0536 0.2676
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0115 0.1343 0.2982
Entamoeba histolytica protein kinase 2, putative 0.0036 0.0154 0.0567
Brugia malayi Cyclin, N-terminal domain containing protein 0.0048 0.0333 0.0406
Brugia malayi Protein kinase domain containing protein 0.008 0.0813 0.0991
Loa Loa (eye worm) hypothetical protein 0.0044 0.0272 0.0331
Echinococcus multilocularis neuroglian 0.0054 0.0425 0.0518
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0703 0.3623
Trichomonas vaginalis AGC family protein kinase 0.007 0.0662 0.339
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0662 0.1204
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0594 0.0726
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0072 0.0703 0.3662
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0049 0.0353 0.0353
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0629 0.3204
Schistosoma mansoni tyrosine kinase 0.0267 0.3661 0.6655
Trichomonas vaginalis CMGC family protein kinase 0.0069 0.065 0.3322
Schistosoma mansoni serine/threonine-protein kinase 0.0039 0.0191 0.0348
Trichomonas vaginalis AGC family protein kinase 0.0147 0.1829 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0034 0.0123 0.015
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0115 0.1343 0.1343
Echinococcus granulosus cyclin b3 0.0048 0.0333 0.0333
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.006 0.0508 0.062
Leishmania major protein kinase A catalytic subunit isoform 2 0.006 0.0508 0.1051
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0034 0.0123 0.0123
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0036 0.0154 0.0154
Trichomonas vaginalis AGC family protein kinase 0.006 0.0508 0.2514
Echinococcus granulosus cyclin B3 1 0.0048 0.0333 0.0333
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.003 0.0064 0.0078
Echinococcus multilocularis activin receptor type 0.003 0.0053 0.0065
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0164 0.02
Brugia malayi SH2 domain containing protein 0.0037 0.0164 0.02
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0028 0.0032 0.0032
Echinococcus multilocularis mitogen activated protein kinase 14 0.0314 0.4378 0.5346
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0048 0.0333 0.0407
Entamoeba histolytica protein kinase, putative 0.007 0.0662 0.3431
Schistosoma mansoni nephrin 0.0054 0.0425 0.0772
Trichomonas vaginalis cyclin B, putative 0.0078 0.0788 0.4104
Echinococcus granulosus cyclins 0.0048 0.0333 0.0333
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.1504 0.2734
Brugia malayi serine/threonine-protein kinase plk-2 0.0125 0.1504 0.1831
Echinococcus multilocularis rac serine:threonine kinase 0.0039 0.0191 0.0233
Echinococcus multilocularis mitogen activated protein kinase 11 0.0314 0.4378 0.5346
Echinococcus granulosus insulin receptor 0.0388 0.55 0.55
Brugia malayi Protein kinase domain containing protein 0.0037 0.0164 0.02
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0147 0.1829 0.2234
Schistosoma mansoni cyclins 0.0048 0.0333 0.0606
Echinococcus multilocularis dual specificity testis specific protein kinase 0.003 0.0053 0.0065
Loa Loa (eye worm) AUR protein kinase 0.0147 0.1829 0.2228
Echinococcus multilocularis cyclin dependent kinase 1 0.0115 0.1343 0.164
Trichomonas vaginalis cyclin B, putative 0.0078 0.0788 0.4104
Trichomonas vaginalis cyclins, putative 0.0078 0.0788 0.4104
Entamoeba histolytica protein kinase, putative 0.0033 0.0101 0.0273
Brugia malayi phosphoinositide-dependent protein kinase I 0.007 0.0662 0.0807
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.4296 0.5245
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0097 0.108 0.1318
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.007 0.0662 0.0662
Brugia malayi map kinase activated protein kinase protein 2 0.0228 0.3071 0.3739
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0147 0.1829 1
Schistosoma mansoni protein kinase 0.0203 0.2692 0.4895
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0286 0.3946 0.4818
Brugia malayi serine/threonine-protein kinase 6 0.0147 0.1829 0.2228
Brugia malayi metabotropic glutamate receptor type 2 0.0026 0.0001 0.0002
Echinococcus multilocularis protein kinase c iota type 0.0041 0.0234 0.0285
Trypanosoma cruzi polo-like protein kinase, putative 0.0125 0.1504 0.3355
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0049 0.0353 0.0353
Loa Loa (eye worm) AGC/PKN protein kinase 0.0034 0.0123 0.015
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.007 0.0662 0.0807
Trichomonas vaginalis cyclins, putative 0.0078 0.0788 0.4104
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.006 0.0508 0.1051
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0123 0.0335
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0123 0.0223
Trypanosoma brucei protein kinase, putative 0.0069 0.065 0.1381
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.006 0.0508 0.1051
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0213 0.2837 0.3455
Brugia malayi Protein kinase domain containing protein 0.0037 0.0164 0.02
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0594 0.1081
Echinococcus multilocularis mitogen activated protein kinase 14 0.0314 0.4378 0.5346
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0038 0.018 0.0294
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.006 0.0508 0.062
Echinococcus granulosus cyclin B 0.0078 0.0788 0.0788
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.1343 0.2442
Echinococcus granulosus NCK adaptor protein 0.0031 0.0078 0.0078
Schistosoma mansoni tyrosine kinase 0.0339 0.4743 0.8624
Entamoeba histolytica protein kinase, putative 0.003 0.0063 0.0057
Echinococcus multilocularis tyrosine kinase 0.0037 0.0164 0.0201
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0125 0.1504 0.3355
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0353 0.0353
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0038 0.018 0.0294
Echinococcus granulosus mitogen activated protein kinase 3 0.0072 0.0703 0.0703
Entamoeba histolytica cell division protein kinase 2, putative 0.0115 0.1343 0.7262
Toxoplasma gondii AGC kinase 0.006 0.0508 0.256
Giardia lamblia Kinase, PLK 0.0125 0.1504 0.8157
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.007 0.0662 0.0807
Leishmania major cyclin 0.0078 0.0788 0.17
Entamoeba histolytica SH2-protein kinase domain containing protein 0.003 0.0063 0.0057
Brugia malayi Protein kinase domain containing protein 0.0567 0.8212 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0037 0.0164 0.0164
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0031 0.0078 0.0141
Schistosoma mansoni kinase 0.0069 0.0652 0.1186
Giardia lamblia Kinase, AGC PKA 0.006 0.0508 0.2514
Onchocerca volvulus 0.0567 0.8212 1
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0034 0.0123 0.015
Echinococcus granulosus mitogen activated protein kinase 0.0072 0.0703 0.0703
Echinococcus granulosus cyclins 0.0048 0.0333 0.0333
Brugia malayi cell division control protein 2 homolog 0.0115 0.1343 0.1635
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0034 0.0123 0.015
Loa Loa (eye worm) AGC/PKA protein kinase 0.006 0.0508 0.0618
Entamoeba histolytica hypothetical protein 0.0077 0.0766 0.4012
Echinococcus granulosus serine/threonine protein kinase 0.0039 0.0191 0.0191
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.4296 0.4296
Brugia malayi SH2 domain containing protein 0.0037 0.0164 0.02
Giardia lamblia Kinase, CMGC GSK 0.0069 0.065 0.3322
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0115 0.1343 0.1635
Schistosoma mansoni serine/threonine kinase 0.0034 0.0123 0.0223
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0038 0.018 0.022
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0038 0.018 0.0294
Brugia malayi serine/threonine protein kinase 6 0.0147 0.1829 0.2228
Echinococcus granulosus protein kinase shaggy 0.0069 0.065 0.065
Trypanosoma brucei protein kinase, putative 0.0072 0.0703 0.1504
Giardia lamblia Aurora kinase 0.0147 0.1829 1
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0069 0.065 0.3363
Schistosoma mansoni cell adhesion molecule 0.0052 0.0397 0.0722
Brugia malayi protein-tyrosine kinase 0.0037 0.0164 0.02
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0629 0.3204
Echinococcus multilocularis cyclins 0.0048 0.0333 0.0407
Brugia malayi Cyclin, N-terminal domain containing protein 0.0078 0.0788 0.096
Trypanosoma cruzi cyclin, putative 0.0078 0.0788 0.17
Plasmodium falciparum serine/threonine protein kinase, putative 0.0147 0.1829 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0383 0.0467
Loa Loa (eye worm) hypothetical protein 0.0113 0.1325 0.1613
Plasmodium falciparum protein kinase 5 0.0115 0.1343 0.7262
Loa Loa (eye worm) TK/EGFR protein kinase 0.0339 0.4743 0.5776
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0034 0.0123 0.015
Trichomonas vaginalis CMGC family protein kinase 0.0069 0.065 0.3322
Loa Loa (eye worm) hypothetical protein 0.0044 0.0272 0.0331
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.1181 0.2148
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0703 0.3623
Brugia malayi Protein kinase domain 0.003 0.0064 0.0078
Loa Loa (eye worm) hypothetical protein 0.0554 0.8016 0.9762
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.006 0.0508 0.256
Giardia lamblia Kinase, CMGC GSK 0.0069 0.065 0.3322
Entamoeba histolytica protein kinase, putative 0.0061 0.0536 0.2721
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.003 0.0064 0.0078
Schistosoma mansoni tyrosine kinase 0.0049 0.0353 0.0641
Brugia malayi Cyclin, N-terminal domain containing protein 0.0174 0.2241 0.2729
Brugia malayi P38 map kinase family protein 2 0.0314 0.4378 0.5332
Giardia lamblia Kinase, CMGC CDK 0.0115 0.1343 0.7245
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0123 0.0223
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.0327 0.0399
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0026 0.0001 0.0002
Entamoeba histolytica cyclin family protein 0.0048 0.0333 0.1578
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0034 0.0123 0.015
Loa Loa (eye worm) AGC/AKT protein kinase 0.0061 0.0536 0.0653
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0049 0.0353 0.0641
Brugia malayi MAP kinase sur-1 0.0072 0.0703 0.0857
Loa Loa (eye worm) NEK/NEK6 protein kinase 0.026 0.3556 0.4331
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0383 0.0467
Echinococcus granulosus defective proboscis extension response 0.0044 0.0272 0.0272
Brugia malayi Protein kinase domain containing protein 0.0037 0.0164 0.02
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0072 0.0703 0.1504
Trichomonas vaginalis cyclin H, putative 0.0077 0.0766 0.3975
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0052 0.0397 0.0397
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0228 0.3071 0.3749
Entamoeba histolytica protein kinase, putative 0.003 0.0064 0.0061
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.006 0.0508 0.062
Schistosoma mansoni vav2 0.0029 0.0038 0.0068
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0072 0.0703 0.1504
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0078 0.0788 0.17
Echinococcus multilocularis cyclin dependent kinase 7 0.0104 0.1181 0.1442
Toxoplasma gondii AGC kinase 0.006 0.0508 0.256
Trypanosoma cruzi cdc2-related kinase 1 0.0115 0.1343 0.2982
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0097 0.108 0.108
Schistosoma mansoni adapter molecule crk 0.0031 0.0078 0.0141
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0048 0.0334 0.0408
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0036 0.0154 0.0567
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0445 0.6365 0.7751
Echinococcus multilocularis cyclin dependent kinase 0.0115 0.1343 0.164
Echinococcus multilocularis PAK box P21 Rho binding 0.003 0.0064 0.0078
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0594 0.1081
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0536 0.2676
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1504 0.8157
Brugia malayi Immunoglobulin I-set domain containing protein 0.0445 0.6365 0.7751
Trypanosoma cruzi cyclin, putative 0.0078 0.0788 0.17
Schistosoma mansoni protein kinase 0.003 0.0053 0.0096
Leishmania major protein kinase A catalytic subunit 0.006 0.0508 0.1051
Brugia malayi Tyrosine-protein kinase abl-1 0.0145 0.1799 0.219
Echinococcus granulosus twitchin 0.0066 0.0598 0.0598
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0228 0.3071 0.3739
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0353 0.0431
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.1343 0.7245

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of CDK2 in human A2780 cells assessed as reduction of hyperphosphorylated form of retinoblastoma protein at 3 uM relative to control ChEMBL. 19603809
Activity (binding) Inhibition of CDK2 in human A2780 cells assessed as accumulation of hypophosphorylated form of retinoblastoma protein at 3 uM relative to control ChEMBL. 19603809
Activity (binding) Inhibition of CDK2 in human A2780 cells assessed as accumulation of hypophosphorylated form of retinoblastoma protein at 1 uM relative to control ChEMBL. 19603809
Activity (binding) Inhibition of CDK2 in human A2780 cells assessed as reduction of hyperphosphorylated form of retinoblastoma protein at 1 uM relative to control ChEMBL. 19603809
Activity (functional) = 40 % Effect on cell cycle progression in human A2780 cells assessed as decrease in accumulation at G2/M phase at 1 uM after 24 hrs by flow cytometry ChEMBL. 19603809
Activity (functional) = 49 % Effect on cell cycle progression in human A2780 cells assessed as increase in accumulation at G/G1 phase at 1 uM after 24 hrs by flow cytometry ChEMBL. 19603809
Activity (functional) = 53 % Antitumor activity against human A2780 cells xenografted in nude mouse assessed as tumor growth inhibition at 20 mg/kg, po BID for 10 consecutive days ChEMBL. 19603809
Activity (functional) = 68 % Effect on cell cycle progression in human A2780 cells assessed as decrease in accumulation at S phase at 1 uM after 24 hrs by flow cytometry ChEMBL. 19603809
Activity (functional) = 75 % Inhibition of DNA synthesis in human A2780 cells assessed as decrease in GrdU incorporation at 1 uM after 24 hrs by flow cytometry ChEMBL. 19603809
Activity (functional) = 76 % Antitumor activity against human A2780 cells xenografted in nude mouse assessed as tumor growth inhibition at 30 mg/kg, po BID for 10 consecutive days ChEMBL. 19603809
Activity (functional) = 91 % Antitumor activity against human A2780 cells xenografted in nude mouse assessed as tumor growth inhibition at 40 mg/kg, po BID for 10 consecutive days ChEMBL. 19603809
CC50 (functional) = 1.1 uM MRC5 CC50 (uM) Cytotoxicity ChEMBL. No reference
IC50 (binding) = 0.045 uM Inhibition of CDK2/Cyclin A ChEMBL. 19603809
IC50 (binding) = 0.053 uM Inhibition of TRKA ChEMBL. 19603809
IC50 (functional) < 0.13 uM AntiTrypanosoma brucei activity T. b. brucei IC50 (uM) ChEMBL. No reference
IC50 (functional) < 0.13 uM AntiTrypanosoma brucei activity T. b. rhodesiense IC50 (uM) ChEMBL. No reference
IC50 (binding) = 0.15 uM Inhibition of CDK7/Cyclin H ChEMBL. 19603809
IC50 (binding) = 0.16 uM Inhibition of CDK4/Cyclin D1 ChEMBL. 19603809
IC50 (functional) = 0.2 uM Antiproliferative activity against human A2780 cells after 72 hrs by cell Titer_Glo assay ChEMBL. 19603809
IC50 (binding) = 0.209 uM Inhibition of LCK ChEMBL. 19603809
IC50 (binding) = 0.265 uM Inhibition of CDK5/p35 ChEMBL. 19603809
IC50 (binding) = 0.363 uM Inhibition of CDK2/Cyclin E ChEMBL. 19603809
IC50 (binding) = 0.398 uM Inhibition of CDK1/Cyclin B ChEMBL. 19603809
IC50 (binding) = 0.478 uM Inhibition of c-ABL ChEMBL. 19603809
IC50 (binding) = 0.668 uM Inhibition of C-KIT ChEMBL. 19603809
IC50 (functional) = 0.85 uM AntiLeishmania activity L. infantum (macrophages) IC50 (uM) ChEMBL. No reference
IC50 (binding) = 0.92 uM Inhibition of VEGFR3 ChEMBL. 19603809
IC50 (functional) = 1.05 uM AntiTrypanosoma cruzi activity IC50 (uM) ChEMBL. No reference
IC50 (binding) = 1.051 uM Inhibition of Aurora A ChEMBL. 19603809
IC50 (binding) = 1.065 uM Inhibition of NEK6 ChEMBL. 19603809
IC50 (binding) = 1.207 uM Inhibition of FGFR1 ChEMBL. 19603809
IC50 (binding) = 1.933 uM Inhibition of RET ChEMBL. 19603809
IC50 (binding) = 3.069 uM Inhibition of EGFR ChEMBL. 19603809
IC50 (binding) = 4.175 uM Inhibition of Aurora B ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of ZAP-70 ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of AKT1 ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of CDC7 ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of CHK1 ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of ERK2 ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of GSK3-beta ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of IGF1R ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of IKKi ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of IKK2 ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of IR ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of LYN ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of MAPKAPK2 ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of MET ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of PAK4 ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of PDK1 ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of PKAalpha ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of PKCbeta ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of PLK1 ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of P38alpha ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of P38beta ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of STLK2 ChEMBL. 19603809
IC50 (binding) > 10 uM Inhibition of VEGFR2 ChEMBL. 19603809
Inhibition (binding) Compound was evaluated for the inhibition of human FECH at 10uM MMV_PBOX. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei ChEMBL23
Homo sapiens ChEMBL23 19603809
Trypanosoma brucei gambiense
Leishmania infantum ChEMBL23
Trypanosoma cruzi ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.