Detailed information for compound 889005

Basic information

Technical information
  • TDR Targets ID: 889005
  • Name: Oprea1_724596
  • MW: 325.405 | Formula: C19H23N3O2
  • H donors: 1 H acceptors: 1 LogP: 3.04 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N1CCN(CC1)C(=O)Nc1cccc(c1)C
  • InChi: 1S/C19H23N3O2/c1-15-4-3-5-16(14-15)20-19(23)22-12-10-21(11-13-22)17-6-8-18(24-2)9-7-17/h3-9,14H,10-13H2,1-2H3,(H,20,23)
  • InChiKey: CZYHFMIHQFUQQO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AQ-360/43018896
  • ZINC00386879

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0093 0.1365 1
Schistosoma mansoni protein kinase 0.0174 0.3292 0.4904
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1214 0.7192
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0039 0.0072 0.0069
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.187 0.2784
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.004 0.008 0.0409
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.029 0.1716
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0037 0.0025 0.0022
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0121 0.2029 0.2062
Brugia malayi hypothetical protein 0.019 0.3685 0.3744
Echinococcus multilocularis cyclin dependent kinase 5 0.0048 0.029 0.0287
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0059 0.0555 0.3954
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0025 0.0033
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0047 0.0249 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0279 0.0413
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Trypanosoma cruzi cdc2-related kinase 3 0.0048 0.029 0.1977
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.004 0.008 0.0115
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0078 0.0991 0.1007
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0048 0.029 0.0294
Onchocerca volvulus 0.0059 0.0555 0.0793
Giardia lamblia Kinase, STE STE20 0.0043 0.0161 0.0819
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0025 0.0033
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0059 0.0555 0.0824
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0174 0.3292 0.3346
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0025 0.0022
Trichomonas vaginalis STE family protein kinase 0.0043 0.0161 0.0953
Brugia malayi hypothetical protein 0.0037 0.0025 0.0023
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0025 0.0022
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.004 0.008 0.0081
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0037 0.0025 0.0023
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.004 0.008 0.0115
Brugia malayi Protein kinase domain containing protein 0.0162 0.3003 0.305
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0025 0.0022
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.004 0.008 0.0077
Trypanosoma brucei rac serine-threonine kinase, putative 0.0087 0.1214 0.8871
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Echinococcus multilocularis 0.0065 0.0688 0.0686
Giardia lamblia Kinase, CMGC CDK 0.0048 0.029 0.1593
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0025 0.0033
Schistosoma mansoni protein kinase 0.0161 0.2976 0.4433
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0025 0.0025
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0025 0.0022
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0048 0.029 0.1307
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0048 0.0279 0.0284
Giardia lamblia Kinase, NEK 0.0107 0.1688 1
Plasmodium falciparum protein kinase 5 0.0048 0.029 0.1307
Entamoeba histolytica cell division protein kinase 2, putative 0.0048 0.029 0.2108
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0125 0.2117 0.2116
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0025 0.0022
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0025 0.0022
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1214 0.7192
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0025 0.0033
Schistosoma mansoni rap gtpase-activating protein 0.0059 0.0555 0.0824
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Trypanosoma cruzi cdc2-related kinase 3 0.0048 0.029 0.1977
Entamoeba histolytica protein kinase, putative 0.0087 0.1214 0.889
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.041 0.8937 0.9083
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0037 0.0025 0.0033
Trypanosoma cruzi Protein kinase B 0.0057 0.0505 0.3586
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0448 0.9839 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0025 0.0022
Brugia malayi Serine/threonine-protein kinase SULU 0.019 0.3685 0.3744
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0025 0.0022
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0066 0.0716 0.0713
Echinococcus granulosus cyclin dependent kinase 1 0.0048 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0059 0.0555 0.0564
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0025 0.0033
Brugia malayi p70 ribosomal S6 kinase beta 0.0083 0.1118 0.1134
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.2117 0.3153
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.3485 0.5192
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0037 0.0025 0.0033
Schistosoma mansoni protein kinase 0.0161 0.2976 0.4433
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0043 0.0161 0.0159
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0037 0.0025 0.0164
Loa Loa (eye worm) hypothetical protein 0.0059 0.0555 0.0564
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0208 0.412 0.4188
Trichomonas vaginalis STE family protein kinase 0.0043 0.0161 0.0953
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0182 0.3485 0.3542
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0048 0.0279 0.0277
Entamoeba histolytica protein kinase 2, putative 0.0053 0.041 0.2988
Trypanosoma cruzi SNF1-related protein kinases, putative 0.004 0.008 0.0409
Trypanosoma cruzi cdc2-related kinase 1 0.0048 0.029 0.1977
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Echinococcus granulosus serine threonine protein kinase nrc 0.0053 0.041 0.0407
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.1365 0.2032
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0043 0.0161 0.0159
Loa Loa (eye worm) AGC/NDR protein kinase 0.0036 0.0002 0.0002
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0037 0.0025 0.0025
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Brugia malayi hypothetical protein 0.0037 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0002 0.0002
Brugia malayi Protein kinase domain containing protein 0.0087 0.1214 0.1232
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0059 0.0555 0.0553
Schistosoma mansoni protein kinase 0.0124 0.211 0.3142
Onchocerca volvulus 0.0148 0.2683 0.3977
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0037 0.0025 0.0022
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0059 0.0555 0.3954
Schistosoma mansoni serine/threonine protein kinase 0.004 0.008 0.0115
Brugia malayi map kinase activated protein kinase protein 2 0.0182 0.3485 0.354
Entamoeba histolytica protein kinase, putative 0.0087 0.1214 0.889
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0025 0.0025
Brugia malayi Protein kinase domain containing protein 0.0317 0.671 0.6818
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0025 0.0025
Schistosoma mansoni protein kinase 0.0043 0.0161 0.0236
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0039 0.0072 0.0069
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0037 0.0025 0.0023
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0048 0.029 0.0294
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0025 0.0022
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0182 0.3485 0.3483
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Brugia malayi hypothetical protein 0.0037 0.0025 0.0023
Schistosoma mansoni pcd6 interacting protein-related 0.0037 0.0025 0.0033
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0048 0.029 0.1977
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0025 0.0025
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.004 0.008 0.0081
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0059 0.0555 0.0553
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1214 0.7192
Schistosoma mansoni vam6/vps39 related 0.0059 0.0555 0.0824
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0317 0.671 0.6818
Echinococcus multilocularis rac serine:threonine kinase 0.0057 0.0505 0.0503
Loa Loa (eye worm) hypothetical protein 0.0059 0.0553 0.0562
Echinococcus multilocularis cyclin dependent kinase 1 0.0048 0.029 0.0287
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0025 0.0022
Echinococcus multilocularis protein kinase c iota type 0.0048 0.0279 0.0277
Echinococcus multilocularis protein kinase c epsilon type 0.0048 0.0279 0.0277
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0025 0.0022
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0037 0.0025 0.0033
Schistosoma mansoni atypical protein kinase C 0.0048 0.0279 0.0413
Echinococcus granulosus nervana 2 0.0047 0.0249 0.0246
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0048 0.029 0.0294
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0002 0.0014
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0025 0.0022
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0025 0.0033
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0037 0.0025 0.0022
Echinococcus granulosus nervana 2 0.0047 0.0249 0.0246
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Entamoeba histolytica serine/threonine protein kinase, putative 0.004 0.008 0.0566
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0025 0.0025
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0047 0.0249 0.0246
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0002 0.0014
Schistosoma mansoni serine/threonine-protein kinase 0.0057 0.0505 0.075
Onchocerca volvulus 0.0142 0.2523 0.3737
Brugia malayi Protein-tyrosine phosphatase 0.0037 0.0025 0.0023
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0066 0.0716 0.0713
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0025 0.0022
Echinococcus multilocularis nervana 2 0.0047 0.0249 0.0246
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0036 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0093 0.1365 1
Schistosoma mansoni protein kinase 0.0065 0.0688 0.1022
Echinococcus multilocularis Glutaredoxin protein 5 0.0047 0.0249 0.0246
Echinococcus multilocularis hypothetical protein 0.0037 0.0025 0.0022
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0025 0.0022
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0037 0.0025 0.0022
Echinococcus multilocularis 0.0037 0.0025 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.2117 0.3153
Trichomonas vaginalis AGC family protein kinase 0.004 0.0098 0.0581
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0025 0.0025
Loa Loa (eye worm) protein tyrosine phosphatase 0.0037 0.0025 0.0025
Brugia malayi hypothetical protein 0.0037 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0448 0.9839 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0926 0.0941
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Brugia malayi hypothetical protein 0.0037 0.0025 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.029 0.0428
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0025 0.0025
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0162 0.3003 0.3052
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0037 0.0025 0.0033
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0025 0.0025
Echinococcus multilocularis dual specificity 0.0093 0.1365 0.1363
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0066 0.0714 0.0726
Schistosoma mansoni protein kinase 0.0162 0.3003 0.4473
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0317 0.671 1
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0118 0.1949 0.1947
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0025 0.0025
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0059 0.0555 0.3954
Schistosoma mansoni serine/threonine-protein kinase 0.0057 0.0505 0.075
Echinococcus multilocularis cyclin dependent kinase 0.0048 0.029 0.0287
Loa Loa (eye worm) hypothetical protein 0.0042 0.0129 0.0131
Schistosoma mansoni hypothetical protein 0.0059 0.0555 0.0824
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.2683 0.3997
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0037 0.0025 0.0025
Echinococcus multilocularis nervana 2 0.0047 0.0249 0.0246
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0025 0.0022
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0037 0.0025 0.0022
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.004 0.008 0.0077
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Echinococcus granulosus cyclin dependent kinase 5 0.0048 0.029 0.0287
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.029 0.1716
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0083 0.1118 0.1137
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0078 0.0991 0.1005
Entamoeba histolytica protein kinase, putative 0.0093 0.1365 1
Brugia malayi Protein kinase domain containing protein 0.0134 0.2331 0.2367
Onchocerca volvulus 0.0075 0.0926 0.1348
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0093 0.1365 1
Giardia lamblia Kinase, NEK 0.0107 0.1688 1
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0037 0.0025 0.0033
Entamoeba histolytica protein kinase, putative 0.0043 0.0161 0.1163
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1214 0.7192
Echinococcus granulosus Glutaredoxin protein 5 0.0047 0.0249 0.0246
Brugia malayi Doublecortin family protein 0.0121 0.2029 0.206
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0048 0.029 0.1977
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0039 0.0072 0.0073
Echinococcus granulosus rho-associated protein kinase 1 0.0148 0.2683 0.2682
Echinococcus multilocularis rho associated protein kinase 0.0148 0.2683 0.2682
Brugia malayi Protein kinase domain containing protein 0.0093 0.1365 0.1386
Echinococcus granulosus serine:threonine kinase SAD 1 0.004 0.008 0.0077
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0025 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0025 0.0022
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0037 0.0025 0.0033
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0174 0.3292 0.329
Echinococcus granulosus Protein kinase C brain isozyme 0.0048 0.0279 0.0277
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0025 0.0022
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0043 0.0161 0.0159
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Brugia malayi hypothetical protein 0.0059 0.0555 0.0562
Onchocerca volvulus 0.0059 0.0553 0.0791
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0093 0.1365 1
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.0081
Brugia malayi C1-like domain containing protein 0.0078 0.0991 0.1005
Trichomonas vaginalis pten, drome, putative 0.0037 0.0025 0.0146
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0115 0.1893 0.1924
Loa Loa (eye worm) AGC/AKT protein kinase 0.0087 0.1214 0.1234
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0037 0.0025 0.0164
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0043 0.0161 0.0159
Brugia malayi Protein kinase domain containing protein 0.0174 0.3292 0.3344
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0037 0.0025 0.0033
Echinococcus granulosus Vam6:Vps39 protein 0.0059 0.0555 0.0553
Echinococcus granulosus serine:threonine protein kinase TAO1 0.019 0.3685 0.3683
Entamoeba histolytica p21-activated kinase 0.0047 0.0257 0.1865
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0053 0.041 0.2872
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0053 0.041 0.0407
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Echinococcus granulosus serine/threonine protein kinase 0.0057 0.0505 0.0503
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0279 0.0413
Giardia lamblia Kinase, AGC PKA 0.0053 0.041 0.2315
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Giardia lamblia Kinase, CAMK CAMKL 0.004 0.008 0.033
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0025 0.0022
Loa Loa (eye worm) AGC/PKN protein kinase 0.0036 0.0002 0.0002
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0053 0.041 0.2052
Brugia malayi Temporarily assigned gene name protein 59 0.0059 0.0555 0.0562
Echinococcus granulosus cyclin dependent kinase 0.0048 0.029 0.0287
Trypanosoma brucei cdc2-related kinase 1 0.0048 0.029 0.1977
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Brugia malayi Protein kinase domain containing protein 0.0448 0.9839 1
Entamoeba histolytica protein kinase, putative 0.0093 0.1365 1
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1214 0.7192
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0454 1 1
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0025 0.0033
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0036 0.0002 0.0002
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0317 0.671 0.6819
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0161 0.2976 0.2974
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0025 0.0025
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0161 0.2976 0.2974
Onchocerca volvulus 0.0071 0.083 0.1205
Schistosoma mansoni protein kinase 0.0043 0.0161 0.0236
Brugia malayi Temporarily assigned gene name protein 59 0.0125 0.2126 0.2159
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Entamoeba histolytica protein kinase, putative 0.0083 0.1118 0.8187
Brugia malayi Protein-tyrosine phosphatase 1 0.0039 0.0072 0.007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Plasmodium falciparum NIMA related kinase 1 0.0107 0.1688 1
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.029 0.1716
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1214 0.7192
Brugia malayi putative serine/threonine kinase SADA gamma 0.004 0.008 0.0078
Entamoeba histolytica cell division protein kinase 2, putative 0.0048 0.029 0.2108
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0059 0.0553 0.0562
Brugia malayi Protein kinase domain 0.0043 0.0161 0.0161
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0107 0.1688 1
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0059 0.0555 0.0824
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0048 0.029 0.0287
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.019 0.3685 0.3745
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.004 0.008 0.0409
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0037 0.0025 0.0022
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0025 0.0022
Echinococcus granulosus protein kinase 0.0065 0.0688 0.0686
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0037 0.0025 0.0025
Trypanosoma brucei cdc2-related kinase 3 0.0048 0.029 0.1977
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Echinococcus granulosus dual specificity 0.0093 0.1365 0.1363
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0025 0.0022
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0093 0.1365 0.1388
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0043 0.0161 0.0159
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0025 0.0025
Entamoeba histolytica PH domain containing protein kinase, putative 0.0057 0.0505 0.3691
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0025 0.0022
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0025 0.0025
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0065 0.0688 0.0699
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0125 0.2117 0.2116
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Plasmodium vivax protein kinase Crk2 0.0048 0.029 0.1307
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0037 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.0087 0.1204 0.1224
Trichomonas vaginalis STE family protein kinase 0.0043 0.0161 0.0953
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.019 0.3685 0.3683
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1214 0.7192
Schistosoma mansoni serine/threonine protein kinase 0.0317 0.671 1
Giardia lamblia Kinase, CMGC CDK 0.0048 0.029 0.1593
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0037 0.0025 0.0164
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0037 0.0025 0.0022
Toxoplasma gondii AGC kinase 0.0083 0.1118 0.6458
Trichomonas vaginalis STE family protein kinase 0.0043 0.0161 0.0953
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0002 0.0014
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0174 0.3292 0.329
Echinococcus granulosus protein kinase c iota type 0.0048 0.0279 0.0277
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.0071 0.083 0.0844
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0093 0.1365 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Echinococcus granulosus protein tyrosine phosphatase n9 0.0037 0.0025 0.0022
Brugia malayi Protein kinase domain containing protein 0.041 0.8937 0.9082
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0118 0.1949 0.1981
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0037 0.0025 0.0033
Echinococcus granulosus protein kinase c epsilon type 0.0048 0.0279 0.0277
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.004 0.008 0.0409
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0043 0.0161 0.0159
Schistosoma mansoni serine/threonine protein kinase 0.019 0.3685 0.549
Trichomonas vaginalis AGC family protein kinase 0.0107 0.1688 1
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0037 0.0025 0.0033
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0053 0.041 0.2052
Schistosoma mansoni serine/threonine protein kinase 0.004 0.008 0.0115
Trypanosoma brucei SNF1-related protein kinases, putative 0.004 0.008 0.0409
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Brugia malayi probable protein kinase 0.0124 0.211 0.2143
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0025 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.029 0.0428
Entamoeba histolytica protein kinase domain containing protein 0.0093 0.1365 1
Giardia lamblia Kinase, CAMK CAMKL 0.004 0.008 0.033
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.0087 0.1204 0.1224
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0037 0.0025 0.0022
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0037 0.0025 0.0033
Brugia malayi Protein kinase domain containing protein 0.0048 0.029 0.0292
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Schistosoma mansoni protein kinase C mu 0.0078 0.0991 0.1474
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0057 0.0505 0.3586
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0317 0.671 0.6709
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0025 0.0022
Brugia malayi cell division control protein 2 homolog 0.0048 0.029 0.0292
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Brugia malayi protein kinase C II. 0.0048 0.0279 0.0282
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0025 0.0023
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.004 0.008 0.0409
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0317 0.671 0.6709
Echinococcus multilocularis cyclin dependent kinase 1 0.0048 0.029 0.0287
Trichomonas vaginalis CAMK family protein kinase 0.004 0.008 0.0471
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0107 0.1688 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0182 0.3485 0.3483
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0037 0.0025 0.0022
Giardia lamblia Kinase, NEK 0.0107 0.1688 1
Schistosoma mansoni serine/threonine protein kinase 0.004 0.008 0.0115
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0053 0.041 0.0407
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0037 0.0025 0.0022
Brugia malayi Protein-tyrosine phosphatase 0.0037 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0059 0.0555 0.0564
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.004 0.008 0.0078
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0317 0.671 0.6819
Echinococcus multilocularis serine:threonine kinase SAD 1 0.004 0.008 0.0077
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0279 0.0413
Trypanosoma cruzi cdc2-related kinase 1 0.0048 0.029 0.1977
Entamoeba histolytica PH domain containing protein kinase, putative 0.0057 0.0505 0.3691
Trichomonas vaginalis STE family protein kinase 0.0107 0.1688 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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