Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | P38 map kinase family protein 2 | 0.0138 | 0.191 | 0.4748 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0245 | 0.0455 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0035 | 0.0126 | 0.066 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0138 | 0.191 | 0.191 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0111 | 0.1438 | 0.4155 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0184 | 0.2706 | 0.7708 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0245 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0146 | 0.2048 | 0.6541 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0035 | 0.0126 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0138 | 0.191 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0206 | 0.3072 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0041 | 0.0245 | 0.0455 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0138 | 0.191 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0098 | 0.1218 | 0.5682 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0859 | 0.2446 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0102 | 0.0291 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0089 | 0.1068 | 0.4903 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0206 | 0.3072 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0099 | 0.1233 | 0.3791 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0138 | 0.1901 | 0.6044 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0138 | 0.191 | 0.191 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0042 | 0.026 | 0.0505 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0138 | 0.1901 | 0.6023 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0248 | 0.3802 | 1 |
Onchocerca volvulus | 0.0151 | 0.2138 | 0.1911 | |
Echinococcus granulosus | roundabout 2 | 0.0033 | 0.0102 | 0.0102 |
Schistosoma mansoni | 3-oxoacyl-[ACP] synthase | 0.0035 | 0.0126 | 0.5143 |
Loa Loa (eye worm) | fatty acid synthase | 0.0136 | 0.1869 | 0.5323 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0138 | 0.191 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0035 | 0.0126 | 0.5 |
Loa Loa (eye worm) | beta-ketoacyl synthase domain-containing protein | 0.0035 | 0.0126 | 0.0359 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0133 | 0.1828 | 0.5799 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0115 | 0.1506 | 0.4398 |
Echinococcus granulosus | neuroglian | 0.003 | 0.0045 | 0.0045 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0146 | 0.2048 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0138 | 0.191 | 0.5439 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.3511 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0138 | 0.1901 | 0.6044 |
Loa Loa (eye worm) | acyl carrier protein | 0.0063 | 0.0621 | 0.1768 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0138 | 0.1901 | 0.6023 |
Mycobacterium ulcerans | thioesterase TesA | 0.0115 | 0.1506 | 0.4682 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0138 | 0.1901 | 0.6023 |
Schistosoma mansoni | cell adhesion molecule | 0.0031 | 0.0057 | 0.2337 |
Schistosoma mansoni | methyltransferase-related | 0.0041 | 0.0245 | 1 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0042 | 0.026 | 0.0454 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0146 | 0.2048 | 0.6522 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0261 | 0.4022 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0091 | 0.1098 | 0.2941 |
Mycobacterium ulcerans | thioesterase | 0.0115 | 0.1506 | 0.4682 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0206 | 0.3072 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0057 | 0.0163 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0245 | 0.0667 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0078 | 0.0878 | 0.2593 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0041 | 0.0245 | 0.0609 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0112 | 0.1469 | 0.4587 |
Echinococcus multilocularis | neuroglian | 0.003 | 0.0045 | 0.0235 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0128 | 0.1745 | 0.5519 |
Giardia lamblia | Methyltransferase like 2 | 0.0041 | 0.0245 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0056 | 0.0489 | 0.128 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0146 | 0.2048 | 0.6541 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0047 | 0.0346 | 0.0795 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0138 | 0.1901 | 0.4726 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0138 | 0.191 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0146 | 0.2048 | 0.6337 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0138 | 0.191 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0138 | 0.191 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0091 | 0.1098 | 0.3299 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0031 | 0.0057 | 0.0057 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0115 | 0.1506 | 0.4711 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0128 | 0.1745 | 0.4969 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0091 | 0.1098 | 0.3299 |
Mycobacterium ulcerans | polyketide synthase | 0.0138 | 0.1901 | 0.6023 |
Onchocerca volvulus | 0.0239 | 0.3655 | 0.9285 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0138 | 0.1901 | 0.581 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0156 | 0.2225 | 0.2336 |
Mycobacterium ulcerans | polyketide synthase | 0.0146 | 0.2048 | 0.6522 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0138 | 0.191 | 1 |
Echinococcus granulosus | twitchin | 0.003 | 0.0054 | 0.0054 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0043 | 0.0276 | 0.0558 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0133 | 0.1828 | 0.5799 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0146 | 0.2048 | 0.6337 |
Brugia malayi | AMP-binding enzyme family protein | 0.0128 | 0.1745 | 0.4338 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0035 | 0.0126 | 0.0126 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0138 | 0.191 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0184 | 0.2706 | 0.6729 |
Schistosoma mansoni | nephrin | 0.003 | 0.0045 | 0.1831 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0146 | 0.2048 | 0.6522 |
Brugia malayi | AMP-binding enzyme family protein | 0.0042 | 0.026 | 0.0646 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0138 | 0.1901 | 0.6044 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0035 | 0.0126 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0138 | 0.1901 | 0.6023 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0111 | 0.1438 | 0.4452 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0102 | 0.0291 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0146 | 0.2048 | 0.6337 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0035 | 0.0126 | 0.0313 |
Echinococcus multilocularis | roundabout 2 | 0.0033 | 0.0102 | 0.0535 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0111 | 0.1438 | 0.4452 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0146 | 0.2048 | 0.6541 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0206 | 0.3072 | 1 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0043 | 0.0276 | 0.0508 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0138 | 0.1901 | 0.581 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.007 | 0.0729 | 0.3136 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0035 | 0.0126 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.