Detailed information for compound 1003229

Basic information

Technical information
  • TDR Targets ID: 1003229
  • Name: [(2R,3R,4R,5R,6R)-6-[(2E)-3,7-dimethylocta-2, 6-dienoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S ,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2 -yl]oxyoxan-3-yl] (E)-3-(4-hydroxyphenyl)prop -2-enoate
  • MW: 608.674 | Formula: C31H44O12
  • H donors: 6 H acceptors: 7 LogP: 1.96 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@H]1O[C@@H](OC/C=C(/CCC=C(C)C)\C)[C@@H]([C@H]([C@@H]1OC(=O)/C=C/c1ccc(cc1)O)O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O)O
  • InChi: 1S/C31H44O12/c1-17(2)6-5-7-18(3)14-15-39-30-27(38)29(43-31-26(37)25(36)24(35)19(4)40-31)28(22(16-32)41-30)42-23(34)13-10-20-8-11-21(33)12-9-20/h6,8-14,19,22,24-33,35-38H,5,7,15-16H2,1-4H3/b13-10+,18-14+/t19-,22+,24-,25+,26+,27+,28+,29+,30+,31-/m0/s1
  • InChiKey: SWJOMZRFHWDJCX-FNGLMVHISA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2R,3R,4R,5R,6R)-6-[(2E)-3,7-dimethylocta-2,6-dienoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-tetrahydropyran-3-yl] (E)-3-(4-hydroxyphenyl)prop-2-enoate
  • (E)-3-(4-hydroxyphenyl)prop-2-enoic acid [(2R,3R,4R,5R,6R)-6-[(2E)-3,7-dimethylocta-2,6-dienoxy]-5-hydroxy-2-(hydroxymethyl)-4-[[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-2-tetrahydropyranyl]oxy]-3-tetrahydropyranyl] ester
  • (E)-3-(4-hydroxyphenyl)acrylic acid [(2R,3R,4R,5R,6R)-6-[(2E)-3,7-dimethylocta-2,6-dienoxy]-5-hydroxy-2-methylol-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-tetrahydropyran-3-yl] ester
  • [(2R,3R,4R,5R,6R)-6-[(2E)-3,7-dimethylocta-2,6-dienoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-oxan-3-yl] (E)-3-(4-hydroxyphenyl)prop-2-enoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0198 0.4128 1
Echinococcus granulosus cpg binding protein 0.0035 0.0549 0.0537
Loa Loa (eye worm) hypothetical protein 0.0021 0.0247 0.0459
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0198 0.4128 0.3979
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0044 0.0757 0.1459
Brugia malayi hypothetical protein 0.0021 0.0247 0.0464
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0757 0.0523
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0021 0.0247 0.0234
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0419 0.0801
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0247 0.0234
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.5113 0.5107
Schistosoma mansoni jun-related protein 0.0066 0.1235 0.1013
Brugia malayi nuclear receptor NHR-67 0.0021 0.0247 0.0464
Brugia malayi Telomerase reverse transcriptase 0.0219 0.4579 0.8954
Schistosoma mansoni hypothetical protein 0.0466 1 1
Leishmania major telomerase reverse transcriptase, putative 0.0082 0.1591 1
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0301 0.6379 1
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0159 0.3272 0.3263
Toxoplasma gondii hypothetical protein 0.0118 0.237 0.614
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0159 0.3272 0.7928
Toxoplasma gondii hypothetical protein 0.0041 0.0694 0.1796
Brugia malayi hypothetical protein 0.0021 0.0247 0.0464
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0757 0.0745
Brugia malayi hypothetical protein 0.0243 0.5113 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0118 0.237 0.5741
Echinococcus multilocularis jun protein 0.0081 0.1568 0.1557
Schistosoma mansoni cpg binding protein 0.0035 0.0549 0.031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0247 0.0459
Loa Loa (eye worm) hypothetical protein 0.0159 0.3272 0.639
Loa Loa (eye worm) hypothetical protein 0.0021 0.0247 0.0459
Echinococcus granulosus ecdysone induced protein 78C 0.0044 0.0757 0.0745
Loa Loa (eye worm) hypothetical protein 0.0021 0.0247 0.0459
Echinococcus multilocularis thyroid hormone receptor alpha 0.0044 0.0757 0.0745
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0694 0.2137
Brugia malayi hypothetical protein 0.0023 0.0302 0.0571
Onchocerca volvulus 0.0033 0.0508 0.0426
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0044 0.0757 0.1464
Brugia malayi steroid hormone receptor 0.0044 0.0757 0.1464
Loa Loa (eye worm) hypothetical protein 0.0021 0.0247 0.0459
Echinococcus multilocularis nuclear receptor nhr 48 0.0021 0.0247 0.0234
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.003 0.045 0.1091
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0419 0.0796
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0021 0.0247 0.0459
Brugia malayi tailless protein 0.0021 0.0247 0.0464
Loa Loa (eye worm) nuclear receptor NHR-67 0.0021 0.0247 0.0459
Entamoeba histolytica hypothetical protein 0.0075 0.1439 0.3486
Brugia malayi hypothetical protein 0.0064 0.1187 0.2305
Schistosoma mansoni hypothetical protein 0.0066 0.1235 0.1013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0757 0.1464
Brugia malayi nuclear hormone receptor 0.0044 0.0757 0.1464
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0247 0.0234
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0247 0.0234
Loa Loa (eye worm) hypothetical protein 0.0243 0.5113 1
Echinococcus granulosus lamin 0.0029 0.0419 0.0407
Toxoplasma gondii hypothetical protein 0.0186 0.3859 1
Giardia lamblia Rab geranylgeranyltransferase 0.0041 0.0694 0.2118
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0082 0.1591 1
Plasmodium falciparum telomerase reverse transcriptase 0.0082 0.1591 0.4042
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0877 0.1698
Entamoeba histolytica hypothetical protein 0.0075 0.1439 0.3486
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0095 0.0081
Brugia malayi nuclear receptor RXR 0.0021 0.0247 0.0464
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.1568 0.1557
Schistosoma mansoni cpg binding protein 0.0033 0.0508 0.0268
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.0694 0.2137
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0186 0.3859 0.754
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0302 0.0571
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.115 0.2977
Echinococcus granulosus protein farnesyltransferase subunit beta 0.003 0.045 0.0438
Loa Loa (eye worm) hypothetical protein 0.0044 0.0757 0.1459
Giardia lamblia Rab geranylgeranyltransferase 0.0159 0.3272 1
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.003 0.045 0.1091
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0302 0.0566
Loa Loa (eye worm) hypothetical protein 0.0021 0.0247 0.0459
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0159 0.3272 0.7928
Trichomonas vaginalis MYB, putative 0.001 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0044 0.0757 0.1459
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0247 0.0234
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0302 0.0289
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.003 0.045 0.1165
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0044 0.0757 0.0523
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0198 0.4128 0.412
Loa Loa (eye worm) hypothetical protein 0.0013 0.0083 0.0137
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0041 0.0694 0.1339
Schistosoma mansoni steroid hormone receptor ad4bp 0.0044 0.0757 0.0523
Loa Loa (eye worm) hypothetical protein 0.003 0.045 0.0857
Loa Loa (eye worm) nuclear hormone receptor 0.0021 0.0247 0.0459
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0044 0.0757 0.1464
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0044 0.0757 0.0745
Giardia lamblia Telomerase catalytic subunit 0.0082 0.1591 0.486
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0044 0.0757 0.0745
Echinococcus multilocularis FTZ F1 alpha 0.0044 0.0757 0.0745
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0041 0.0694 0.0682
Loa Loa (eye worm) hypothetical protein 0.0044 0.0757 0.1459
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0044 0.0757 0.0745
Plasmodium vivax telomerase reverse transcriptase, putative 0.0082 0.1591 0.4042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0247 0.0459
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0247 0.0464
Brugia malayi hypothetical protein 0.0075 0.1439 0.2799
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0044 0.0757 0.0523
Loa Loa (eye worm) hypothetical protein 0.0021 0.0247 0.0459
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0757 0.0523
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0044 0.0757 0.1459
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0159 0.3272 0.3263
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0021 0.0247 0.0234
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.003 0.045 0.0862
Entamoeba histolytica hypothetical protein 0.0075 0.1439 0.3486
Loa Loa (eye worm) hypothetical protein 0.0023 0.0302 0.0566
Brugia malayi nuclear receptor RXR 0.0023 0.0302 0.0571
Schistosoma mansoni lamin 0.0029 0.0419 0.0177
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.5113 0.5107
Loa Loa (eye worm) hypothetical protein 0.0186 0.3859 0.754
Echinococcus granulosus intermediate filament protein 0.0029 0.0419 0.0407
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0044 0.0757 0.0832
Loa Loa (eye worm) hypothetical protein 0.0021 0.0247 0.0459
Loa Loa (eye worm) hypothetical protein 0.0044 0.0757 0.1459
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0044 0.0757 0.0745
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0159 0.3272 0.7928
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0044 0.0757 0.0745
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.1439 0.1222
Echinococcus multilocularis lamin 0.0029 0.0419 0.0407
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.0694 0.2137
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0041 0.0694 0.2137
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0044 0.0757 0.1464
Loa Loa (eye worm) hypothetical protein 0.0044 0.0757 0.1459
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.003 0.045 0.1091
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0041 0.0694 0.2137
Echinococcus granulosus FTZ F1 alpha 0.0044 0.0757 0.0745
Loa Loa (eye worm) hypothetical protein 0.0021 0.0247 0.0459
Loa Loa (eye worm) hypothetical protein 0.0021 0.0247 0.0459
Schistosoma mansoni protein farnesyltransferase subunit beta 0.003 0.045 0.0208
Onchocerca volvulus 0.0029 0.0419 0.0281
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0041 0.0694 0.2137
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0247 0.0234
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0044 0.0757 0.0745
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0044 0.0757 0.0745
Schistosoma mansoni coup transcription factor 0.0044 0.0757 0.0523
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0757 0.1464
Onchocerca volvulus 0.0029 0.0419 0.0281
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0302 0.0056
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0128 0.023
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0128 0.0225
Brugia malayi photoreceptor-specific nuclear receptor 0.0044 0.0757 0.1464
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0044 0.0757 0.1464
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0041 0.0694 0.2137
Echinococcus multilocularis cpg binding protein 0.0035 0.0549 0.0537
Schistosoma mansoni lamin 0.0029 0.0419 0.0177
Brugia malayi conserved hypotetical protein 0.0021 0.0247 0.0464
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0757 0.0745
Brugia malayi CXXC zinc finger family protein 0.0033 0.0508 0.0976
Echinococcus multilocularis ecdysone induced protein 78C 0.0044 0.0757 0.0745
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.1439 0.1427
Loa Loa (eye worm) hypothetical protein 0.0044 0.0757 0.1459
Onchocerca volvulus 0.0064 0.1187 0.1532
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.003 0.045 0.1091
Loa Loa (eye worm) hypothetical protein 0.0186 0.3859 0.754
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0198 0.4128 0.3979
Brugia malayi nuclear hormone receptor 0.0021 0.0247 0.0464
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0044 0.0757 0.0523
Echinococcus granulosus lamin dm0 0.0029 0.0419 0.0407
Brugia malayi bZIP transcription factor family protein 0.0081 0.1568 0.3052
Schistosoma mansoni retinoic acid receptor RXR 0.0044 0.0757 0.0523
Loa Loa (eye worm) hypothetical protein 0.0021 0.0247 0.0459
Loa Loa (eye worm) hypothetical protein 0.0186 0.3859 0.754
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.003 0.045 0.1091
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.003 0.045 0.1165
Brugia malayi intermediate filament protein 0.0029 0.0419 0.0801
Echinococcus granulosus nuclear receptor nhr 48 0.0021 0.0247 0.0234
Onchocerca volvulus 0.0044 0.0757 0.0832
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.003 0.045 0.1091
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0159 0.3272 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0408 0.0774
Schistosoma mansoni hypothetical protein 0.0075 0.1439 0.1222
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0694 0.0458
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0041 0.0694 0.0864
Echinococcus multilocularis musashi 0.0029 0.0419 0.0407
Onchocerca volvulus 0.005 0.0877 0.1027
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0001 0.0002
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0001 0.0002
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.003 0.045 0.1091
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0694 0.2137
Schistosoma mansoni RAR-like nuclear receptor 0.0044 0.0757 0.0523
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0757 0.1464
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0159 0.3272 0.639
Loa Loa (eye worm) hypothetical protein 0.0023 0.0302 0.0566
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0247 0.0234
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0041 0.0694 0.1335
Echinococcus multilocularis dnaJ subfamily B 0.0466 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0247 0.0459
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0159 0.3272 0.6392
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.1568 0.1557
Schistosoma mansoni hypothetical protein 0.005 0.0877 0.0646
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0095 0.0081
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0302 0.0571
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0044 0.0757 0.0523
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.003 0.045 0.0208
Trypanosoma brucei telomerase reverse transcriptase 0.0082 0.1591 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0757 0.0745
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0757 0.1464
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0302 0.0056
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0757 0.1464
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0757 0.1464
Loa Loa (eye worm) hypothetical protein 0.0013 0.0083 0.0137
Schistosoma mansoni intermediate filament proteins 0.0029 0.0419 0.0177
Loa Loa (eye worm) hypothetical protein 0.0023 0.0302 0.0566
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0044 0.0757 0.1464
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0757 0.1464
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0041 0.0694 0.0682
Schistosoma mansoni survival motor neuron protein 0.005 0.0877 0.0646
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0044 0.0757 0.0745
Brugia malayi nuclear hormone receptor family member odr-7 0.0021 0.0247 0.0464
Brugia malayi nuclear receptor NHR-88 0.0021 0.0247 0.0464
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0419 0.0796
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0159 0.3272 0.3102
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0508 0.0971
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0044 0.0757 0.1459
Loa Loa (eye worm) hypothetical protein 0.0079 0.1519 0.2953
Brugia malayi Steroid receptor seven-up type 2 0.0044 0.0757 0.1464
Brugia malayi nuclear receptor NHR-88 0.0044 0.0757 0.1464
Loa Loa (eye worm) hypothetical protein 0.003 0.045 0.0857
Brugia malayi nuclear hormone receptor family member nhr-6 0.0021 0.0247 0.0464
Entamoeba histolytica hypothetical protein 0.0075 0.1439 0.3486
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0044 0.0757 0.0745
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0247 0.0464
Loa Loa (eye worm) steroid hormone receptor 0.0044 0.0757 0.1459
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0302 0.0289
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0044 0.0757 0.0523
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.003 0.045 0.5
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0021 0.0247 0.0234
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0041 0.0694 0.1681
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0041 0.0694 0.0682
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.0694 0.2137
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0757 0.0745
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.003 0.045 0.0857
Echinococcus multilocularis lamin dm0 0.0029 0.0419 0.0407
Echinococcus granulosus jun protein 0.0081 0.1568 0.1557
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.003 0.045 0.1165
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0041 0.0694 0.0682
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0757 0.0523
Loa Loa (eye worm) hypothetical protein 0.0023 0.0302 0.0566
Brugia malayi hypothetical protein 0.0023 0.0302 0.0571
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0694 0.2137
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0044 0.0757 0.1459
Loa Loa (eye worm) DR-78 0.0021 0.0247 0.0459
Loa Loa (eye worm) hypothetical protein 0.0023 0.0302 0.0566
Loa Loa (eye worm) hypothetical protein 0.0044 0.0757 0.1459
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0082 0.1591 1
Schistosoma mansoni cpg binding protein 0.0035 0.0549 0.031
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0198 0.4128 0.8067
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0044 0.0757 0.1464
Giardia lamblia Prenyltransferase 0.003 0.045 0.1373
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.003 0.045 0.1091
Loa Loa (eye worm) hypothetical protein 0.0014 0.0095 0.0159
Onchocerca volvulus Bile acid receptor homolog 0.0044 0.0757 0.0832
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0041 0.0694 0.1681
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0041 0.0694 0.0864
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0044 0.0757 0.1464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0044 0.0757 0.1459
Toxoplasma gondii RNA-directed DNA polymerase 0.0082 0.1591 0.4121
Brugia malayi orphan nuclear receptor NR2E1 0.0021 0.0247 0.0464
Onchocerca volvulus 0.0041 0.0694 0.0729
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0198 0.4128 0.412
Brugia malayi ecdysteroid receptor 0.0044 0.0757 0.1464
Echinococcus granulosus thyroid hormone receptor alpha 0.0021 0.0247 0.0234
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.003 0.045 0.0438
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0757 0.0523
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.1439 0.1427
Loa Loa (eye worm) hypothetical protein 0.0029 0.0419 0.0796
Giardia lamblia Rab geranylgeranyltransferase 0.003 0.045 0.1373
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.003 0.045 0.0438
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0021 0.0247 0.0464
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.003 0.045 0.1091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0044 0.0757 0.1459
Brugia malayi ecdysone receptor 0.0021 0.0247 0.0464
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.1312 0.1092
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0198 0.4128 1
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.003 0.045 0.0862
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.003 0.045 0.1091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0044 0.0757 0.1459
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0198 0.4128 0.8068
Onchocerca volvulus Protein ultraspiracle homolog 0.0044 0.0757 0.0832
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0159 0.3272 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0159 0.3272 0.7928
Loa Loa (eye worm) hypothetical protein 0.0044 0.0757 0.1459

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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