TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 211.233 | Formula: C11H14FNO2
H donors: 1 H acceptors: 0 LogP: 1.12 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OC)[C@@]1(F)C[C@H]1N
InChi: 1S/C11H14FNO2/c1-14-8-4-3-7(5-9(8)15-2)11(12)6-10(11)13/h3-5,10H,6,13H2,1-2H3/t10-,11+/m1/s1
InChiKey: YEAOSCFPRGAUHT-MNOVXSKESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nuclear receptor	0.0031	0.0769	0.2804
Entamoeba histolytica	hypothetical protein	0.0029	0.0669	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1059	0.1085
Trichomonas vaginalis	rheb, putative	0.0235	0.9767	1
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0172	0.0109
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.234	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0031	0.0769	0.0788
Brugia malayi	nuclear receptor RXR	0.0035	0.0934	0.0894
Brugia malayi	hypothetical protein	0.0035	0.0934	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0769	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0235	0.9767	1
Echinococcus granulosus	FTZ F1 alpha	0.0066	0.2303	0.2358
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0031	0.0769	0.0788
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.1059	0.1085
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0445	0.3082
Brugia malayi	intermediate filament protein	0.0028	0.0643	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0769	0.0788
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0066	0.2303	0.2306
Loa Loa (eye worm)	ctsf protein	0.0017	0.0172	0.0176
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.1059	0.4093
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.1059	0.0814
Brugia malayi	hypothetical protein	0.0035	0.0934	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0934	0.0956
Mycobacterium tuberculosis	Conserved protein	0.0038	0.1059	0.0814
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0267	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.234	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0035	0.0934	0.0956
Echinococcus multilocularis	cysteine protease	0.0017	0.0172	0.0176
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0066	0.2303	0.2358
Toxoplasma gondii	ABC1 family protein	0.0038	0.1059	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2303	0.2358
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0066	0.2303	0.2306
Leishmania major	hypothetical protein, conserved	0.0038	0.1059	0.4093
Echinococcus granulosus	cathepsin l1	0.0017	0.0172	0.0176
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0031	0.0769	0.0788
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0066	0.2303	0.2306
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0066	0.2303	0.2358
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0066	0.2303	0.2306
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0172	0.0109
Loa Loa (eye worm)	CYP4Cod1	0.002	0.0293	0.03
Schistosoma mansoni	transcription factor LCR-F1	0.0029	0.0669	0.2333
Leishmania major	cytochrome p450-like protein	0.002	0.0293	0.056
Brugia malayi	ecdysteroid receptor	0.0066	0.2303	0.2306
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.1059	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0643	0.0658
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0035	0.0934	0.0956
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0172	0.0176
Schistosoma mansoni	lamin	0.0028	0.0643	0.2211
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0038	0.1059	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0066	0.2303	0.2306
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0172	0.0109
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0066	0.2303	0.2358
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0066	0.2303	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.002	0.0293	0.03
Brugia malayi	hypothetical protein	0.0024	0.0445	0.0391
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.1059	0.0814
Schistosoma mansoni	nuclear hormone receptor	0.0066	0.2303	1
Trichomonas vaginalis	ral, putative	0.0235	0.9767	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0066	0.2303	0.2358
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.234	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.1059	0.0925
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0066	0.2303	0.2306
Schistosoma mansoni	thyroid hormone receptor	0.0066	0.2303	1
Brugia malayi	nuclear receptor NHR-88	0.0066	0.2303	0.2306
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0066	0.2303	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1059	0.1085
Brugia malayi	nuclear receptor NHR-88	0.0031	0.0769	0.0725
Echinococcus multilocularis	cysteine protease	0.0017	0.0172	0.0176
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0172	0.0176
Loa Loa (eye worm)	beta-lactamase	0.0038	0.1059	0.1085
Schistosoma mansoni	hypothetical protein	0.0027	0.0602	0.2018
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0172	0.0176
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.1059	0.0925
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0445	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0934	0.0956
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0031	0.0769	0.0788
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0643	0.0658
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0061	0.2085	0.8824
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0031	0.0769	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0934	0.0956
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0066	0.2303	0.2358
Echinococcus granulosus	intermediate filament protein	0.0028	0.0643	0.0658
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1059	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0769	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0769	0.0788
Loa Loa (eye worm)	cytochrome P450 family protein	0.002	0.0293	0.03
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0031	0.0769	0.0788
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0029	0.0669	0.0685
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0267	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.0066	0.2303	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.234	1
Onchocerca volvulus		0.0028	0.0643	0.2211
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0445	0.0456
Schistosoma mansoni	ap endonuclease	0.002	0.0267	0.0446
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.234	1
Trypanosoma cruzi	cytochrome P450, putative	0.002	0.0293	0.056
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0066	0.2303	0.2358
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.1059	0.0925
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.1059	0.0814
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0066	0.2303	0.2358
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0031	0.0769	0.0725
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0643	0.0658
Mycobacterium ulcerans	hypothetical protein	0.0038	0.1059	1
Leishmania major	cathepsin L-like protease	0.0067	0.234	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0066	0.2303	0.2358
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0769	0.0788
Schistosoma mansoni	nuclear hormone receptor	0.0031	0.0769	0.2804
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0445	1
Mycobacterium leprae	Probable lipase LipE	0.0038	0.1059	0.5
Echinococcus granulosus	thyroid hormone receptor alpha	0.0031	0.0769	0.0788
Brugia malayi	latrophilin 2 splice variant baaae	0.0027	0.0602	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1059	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2303	0.2358
Brugia malayi	beta-lactamase	0.0038	0.1059	0.1024
Schistosoma mansoni	nuclear receptor	0.0031	0.0769	0.2804
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0643	0.0595
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0172	0.0176
Echinococcus multilocularis	FTZ F1 alpha	0.0066	0.2303	0.2358
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.1059	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.234	1
Brugia malayi	Steroid receptor seven-up type 2	0.0066	0.2303	0.2306
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1059	0.1085
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0445	0.1262
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0066	0.2303	0.2358
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0066	0.2303	0.2358
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2303	0.2358
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.1059	0.1085
Brugia malayi	Cytochrome P450 family protein	0.002	0.0293	0.0234
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.1059	0.5
Mycobacterium tuberculosis	Conserved protein	0.0038	0.1059	0.0814
Mycobacterium ulcerans	lipase LipD	0.0038	0.1059	1
Trichomonas vaginalis	GTP-binding protein rit, putative	0.0235	0.9767	1
Entamoeba histolytica	Ras family GTPase	0.0235	0.9767	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0267	0.0273
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0031	0.0769	0.2804
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0031	0.0769	0.0788
Echinococcus granulosus	ras gtpase	0.0235	0.9767	1
Onchocerca volvulus		0.0031	0.0769	0.2804
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.1059	0.4165
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0643	0.2211
Loa Loa (eye worm)	cysteine protease	0.0017	0.0172	0.0176
Schistosoma mansoni	RAR-like nuclear receptor	0.0066	0.2303	1
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0172	0.0109
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0172	0.0109
Onchocerca volvulus		0.0028	0.0643	0.2211
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0066	0.2303	0.2358
Trypanosoma cruzi	cruzipain precursor, putative	0.0067	0.234	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0267	0.0438
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0066	0.2303	0.2306
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0066	0.2303	0.2358
Brugia malayi	orphan nuclear receptor NR2E1	0.0031	0.0769	0.0725
Loa Loa (eye worm)	hypothetical protein	0.004	0.1158	0.1186
Leishmania major	cathepsin L-like protease	0.0067	0.234	1
Brugia malayi	Cytochrome P450 family protein	0.0051	0.1648	0.1631
Brugia malayi	Cytochrome P450 family protein	0.002	0.0293	0.0234
Brugia malayi	hypothetical protein	0.0031	0.0769	0.0725
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.234	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1059	0.1085
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0035	0.0934	0.3575
Brugia malayi	nuclear receptor RXR	0.0031	0.0769	0.0725
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0172	0.0109
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0445	0.0861
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0267	0.0273
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0066	0.2303	1
Brugia malayi	steroid hormone receptor	0.0066	0.2303	0.2306
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2303	0.2358
Trypanosoma cruzi	cytochrome P450, putative	0.002	0.0293	0.056
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.002	0.0293	0.0332
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0267	0.0099
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0031	0.0769	0.2804
Echinococcus multilocularis	ras gtpase	0.0235	0.9767	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.234	1
Brugia malayi	nuclear hormone receptor	0.0066	0.2303	0.2306
Brugia malayi	nuclear hormone receptor family member odr-7	0.0031	0.0769	0.0725
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0066	0.2303	0.2306
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0267	0.1071
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0031	0.0769	0.2804
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0172	0.0176
Brugia malayi	Nuclear hormone receptor E75	0.0031	0.0769	0.0725
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0066	0.2303	0.2306
Schistosoma mansoni	nuclear hormone receptor	0.0031	0.0769	0.2804
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0066	0.2303	0.2358
Onchocerca volvulus		0.0038	0.1059	0.4165
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.1059	0.4165
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0066	0.2303	0.2358
Onchocerca volvulus	Protein ultraspiracle homolog	0.0066	0.2303	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.004	0.1158	0.1186
Trichomonas vaginalis	rap1 and, putative	0.0235	0.9767	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.234	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2303	0.2358
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0066	0.2303	0.2358
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0031	0.0769	0.0725
Brugia malayi	ecdysone receptor	0.0031	0.0769	0.0725
Brugia malayi	photoreceptor-specific nuclear receptor	0.0066	0.2303	0.2306
Trichomonas vaginalis	ras-dva small GTPase, putative	0.0235	0.9767	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0066	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0769	0.0788
Brugia malayi	Nuclear hormone receptor E75	0.0031	0.0769	0.0725
Toxoplasma gondii	exonuclease III APE	0.002	0.0267	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0934	0.0956
Echinococcus granulosus	nuclear receptor nhr 48	0.0031	0.0769	0.0788
Trichomonas vaginalis	dexras1, putative	0.0235	0.9767	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0267	0.0438
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0267	0.0099
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0066	0.2303	1
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0267	0.0099
Schistosoma mansoni	lamin	0.0028	0.0643	0.2211
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0066	0.2303	0.2306
Brugia malayi	Ras-related protein R-Ras2	0.0235	0.9767	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0066	0.2303	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0031	0.0769	0.0788
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0031	0.0769	0.2804
Echinococcus multilocularis	ecdysone induced protein 78C	0.0066	0.2303	0.2358
Onchocerca volvulus		0.0038	0.1059	0.4165
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.1059	0.0814
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0267	0.3475
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0172	0.0176
Brugia malayi	Nuclear hormone receptor-like 1	0.0035	0.0934	0.0894
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0066	0.2303	0.2358
Leishmania major	hypothetical protein, conserved	0.0024	0.0445	0.1262
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0066	0.2303	0.2358
Echinococcus granulosus	ecdysone induced protein 78C	0.0066	0.2303	0.2358
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0769	0.0788
Onchocerca volvulus		0.0038	0.1059	0.4165
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.234	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.004	0.1158	0.1126
Echinococcus multilocularis	lamin dm0	0.0028	0.0643	0.0658
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0066	0.2303	0.2306
Onchocerca volvulus		0.0066	0.2303	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0172	0.0176
Brugia malayi	Ras protein let-60	0.0235	0.9767	1
Trichomonas vaginalis	esterase, putative	0.0038	0.1059	0.0925
Schistosoma mansoni	thyroid hormone receptor	0.0066	0.2303	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0066	0.2303	0.2358
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.1059	0.1085
Loa Loa (eye worm)	steroid hormone receptor	0.0066	0.2303	0.2358
Echinococcus granulosus	lamin	0.0028	0.0643	0.0658
Echinococcus granulosus	lamin dm0	0.0028	0.0643	0.0658
Schistosoma mansoni	nuclear receptor nhr-48	0.0031	0.0769	0.2804
Schistosoma mansoni	hypothetical protein	0.0029	0.0669	0.2333
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.1059	0.0814
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0066	0.2303	0.2306
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0172	0.0109
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0035	0.0934	0.3575
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0066	0.2303	0.2358
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.234	1
Brugia malayi	hypothetical protein	0.0031	0.0769	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0769	0.0788
Echinococcus multilocularis	lamin	0.0028	0.0643	0.0658
Brugia malayi	Nuclear hormone receptor-like 1	0.0035	0.0934	0.0894
Entamoeba histolytica	hypothetical protein	0.0029	0.0669	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0934	0.0956
Mycobacterium ulcerans	beta-lactamase	0.0038	0.1059	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0769	0.0788
Brugia malayi	hypothetical protein	0.0029	0.0669	0.0621
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.1059	0.0814
Echinococcus multilocularis	nuclear receptor nhr 48	0.0031	0.0769	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0769	0.0788
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0066	0.2303	1
Brugia malayi	tailless protein	0.0031	0.0769	0.0725
Trypanosoma brucei	cytochrome P450, putative	0.002	0.0293	0.0127
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0029	0.0669	0.0685
Brugia malayi	hypothetical protein	0.0015	0.0075	0.0009
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0267	0.0207
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0031	0.0769	0.0788
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0066	0.2303	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0051	0.1648	0.1687
Leishmania major	cathepsin L-like protease	0.0067	0.234	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0038	0.1059	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0066	0.2303	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0031	0.0769	0.0788
Schistosoma mansoni	zinc finger protein	0.0031	0.0769	0.2804
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2303	0.2358
Onchocerca volvulus	Bile acid receptor homolog	0.0066	0.2303	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.234	1
Entamoeba histolytica	ras-1, putative	0.0235	0.9767	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0066	0.2303	0.2358
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0035	0.0934	0.0956
Echinococcus multilocularis	musashi	0.0028	0.0643	0.0658
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.004	0.1158	0.1126
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0267	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2303	0.2358
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.1059	0.0925
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.234	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0602	0.0616
Brugia malayi	beta-lactamase family protein	0.0038	0.1059	0.1024
Entamoeba histolytica	hypothetical protein	0.0029	0.0669	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0028	0.062	0.0635
Brugia malayi	conserved hypotetical protein	0.0031	0.0769	0.0725
Mycobacterium tuberculosis	Conserved protein	0.0038	0.1059	0.0814
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0172	0.0176
Brugia malayi	nuclear hormone receptor	0.0031	0.0769	0.0725
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0066	0.2303	0.2306
Loa Loa (eye worm)	Ras protein let-60	0.0235	0.9767	1
Brugia malayi	beta-lactamase family protein	0.0038	0.1059	0.1024
Onchocerca volvulus		0.0031	0.0769	0.2804
Schistosoma mansoni	coup transcription factor	0.0066	0.2303	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.1059	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0769	0.0788
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.1059	0.0925
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0769	0.0788
Brugia malayi	Nuclear hormone receptor-like 1	0.0066	0.2303	0.2306
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0031	0.0769	0.0788
Entamoeba histolytica	Ras family GTPase	0.0235	0.9767	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0066	0.2303	0.2358
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2303	0.2358
Brugia malayi	nuclear receptor NHR-67	0.0031	0.0769	0.0725
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0445	0.1262
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0445	0.3082
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0267	0.0438
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.234	1
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.1059	0.3823
Loa Loa (eye worm)	fibroinase	0.0017	0.0172	0.0176
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.1059	0.0814
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0031	0.0769	0.0788
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0267	0.0273
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0172	0.0176
Loa Loa (eye worm)	DR-78	0.0031	0.0769	0.0788
Entamoeba histolytica	hypothetical protein	0.0029	0.0669	0.0518
Schistosoma mansoni	ap endonuclease	0.002	0.0267	0.0446
Trypanosoma cruzi	major cysteine proteinase, putative	0.0052	0.1711	0.7098
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0769	0.0788

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of human recombinant MAOA	ChEMBL.	18640844
IC50 (binding)	= 470 uM	Inhibition of human recombinant MAOB	ChEMBL.	18640844

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL500248

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1006182