Detailed information for compound 100981

Basic information

Technical information
  • TDR Targets ID: 100981
  • Name: 2-bromo-N-(diaminomethylidene)-4-methyl-5-met hylsulfonylbenzamide
  • MW: 334.19 | Formula: C10H12BrN3O3S
  • H donors: 2 H acceptors: 3 LogP: 1.13 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=NC(=O)c1cc(c(cc1Br)C)S(=O)(=O)C)N
  • InChi: 1S/C10H12BrN3O3S/c1-5-3-7(11)6(9(15)14-10(12)13)4-8(5)18(2,16)17/h3-4H,1-2H3,(H4,12,13,14,15)
  • InChiKey: GWBBYTKOSOBENT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-bromo-N-(diaminomethylene)-4-methyl-5-methylsulfonyl-benzamide
  • 2-bromo-N-(diaminomethylene)-4-methyl-5-methylsulfonylbenzamide
  • N-[bis(azanyl)methylidene]-2-bromo-4-methyl-5-methylsulfonyl-benzamide
  • 2-bromo-N-(diaminomethylene)-5-mesyl-4-methyl-benzamide
  • 2-bromo-N-(diaminomethylidene)-4-methyl-5-methylsulfonyl-benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Oryctolagus cuniculus Sodium/hydrogen exchanger Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma japonicum Sodium/hydrogen exchanger 2, putative Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) sodium/hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma mansoni sodium/hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 Get druggable targets OG5_127664 All targets in OG5_127664
Onchocerca volvulus Sodium\/hydrogen exchanger homolog Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) NHE-3 Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma japonicum Sodium/hydrogen exchanger 2, putative Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127664 All targets in OG5_127664
Onchocerca volvulus Sodium\/hydrogen exchanger homolog Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma japonicum ko:K03316 monovalent cation:H+ antiporter, CPA1 family, putative Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 Get druggable targets OG5_127664 All targets in OG5_127664
Giardia lamblia Sodium/hydrogen exchanger 3 Get druggable targets OG5_127664 All targets in OG5_127664
Onchocerca volvulus Sodium\/hydrogen exchanger homolog Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Brugia malayi sodium/hydrogen exchanger 3 family protein Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0063 0.0597 0.2648
Loa Loa (eye worm) hypothetical protein 0.0062 0.0582 0.2583
Echinococcus multilocularis solute carrier family 22 0.0029 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0201 0.0894
Giardia lamblia Hexose transporter 0.0029 0.0201 0.1973
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0076 0.3786
Schistosoma mansoni sugar transporter 0.0029 0.0201 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0206 0.2253 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0076 0.0338
Echinococcus granulosus General substrate transporter 0.0177 0.1918 0.851
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0072 0.0701 0.106
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0201 0.5052
Plasmodium vivax CDK-related protein kinase 6, putative 0.0874 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0201 0.0894
Leishmania major hypothetical protein, conserved 0.0029 0.0201 0.2874
Schistosoma mansoni sodium/hydrogen exchanger 0.01 0.1021 0.4529
Onchocerca volvulus 0.0029 0.0201 0.1235
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0201 0.0201
Loa Loa (eye worm) sugar transporter 0.0206 0.2253 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0201 0.0894
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0201 0.0894
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0201 0.0894
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.0019 0.0086 0.1226
Toxoplasma gondii facilitative glucose transporter GT1 0.0206 0.2253 0.3408
Schistosoma mansoni hypothetical protein 0.0019 0.0086 0.0381
Onchocerca volvulus 0.0029 0.0201 0.1235
Schistosoma mansoni sugar transporter 0.0029 0.0201 0.0894
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0701 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0076 0.1088
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0606 0.8651
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0063 0.0597 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Loa Loa (eye worm) sodium-hydrogen exchanger NHE1 0.0019 0.0086 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0606 0.269
Toxoplasma gondii sodium/hydrogen exchanger NHE2 0.0019 0.0086 0.013
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.004 0.0333 0.1477
Giardia lamblia Lysyl-tRNA synthetase 0.0046 0.0399 0.3906
Loa Loa (eye worm) hypothetical protein 0.0029 0.0201 0.0894
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0333 0.3724 0.3724
Loa Loa (eye worm) hypothetical protein 0.0029 0.0201 0.0894
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.038 0.1686
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.038 0.1686
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.0019 0.0086 0.1226
Toxoplasma gondii exonuclease III APE 0.0018 0.0076 0.0115
Onchocerca volvulus 0.0029 0.0201 0.1235
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0076 0.1913
Onchocerca volvulus 0.0029 0.0201 0.1235
Chlamydia trachomatis lysine--tRNA ligase 0.0046 0.0399 1
Loa Loa (eye worm) NHE-3 0.01 0.1021 0.4529
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0597 0.2648
Schistosoma mansoni sugar transporter 0.0029 0.0201 0.0894
Echinococcus granulosus sodium:hydrogen exchanger 0.01 0.1021 0.4529
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Onchocerca volvulus 0.0029 0.0201 0.1235
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0318 1
Leishmania major glucose transporter, lmgt1 0.0064 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0201 0.2874
Plasmodium falciparum calcium-dependent protein kinase 2 0.0063 0.0597 0.0597
Schistosoma mansoni protein kinase 0.0063 0.0597 0.2648
Brugia malayi Cam kinase protein 1 0.0063 0.0597 0.2648
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0201 0.6328
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0063 0.0597 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0029 0.0201 0.0894
Onchocerca volvulus 0.0029 0.0201 0.1235
Trypanosoma brucei glucose transporter, putative 0.0064 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0062 0.0582 0.2583
Plasmodium falciparum calcium-dependent protein kinase 3 0.0063 0.0597 0.0597
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0063 0.0597 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0076 0.0338
Echinococcus granulosus lysyl tRNA synthetase 0.0046 0.0399 0.1769
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0076 0.2396
Onchocerca volvulus 0.0029 0.0201 0.1235
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Plasmodium falciparum calcium-dependent protein kinase 1 0.0063 0.0597 0.0597
Echinococcus multilocularis mitochondrial sodium:hydrogen exchanger 9B2 0.0019 0.0086 0.0381
Schistosoma mansoni glucose transporter 0.0029 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0201 0.0894
Plasmodium vivax proline--tRNA ligase, putative 0.0072 0.0701 0.0701
Plasmodium vivax lysine--tRNA ligase, putative 0.0046 0.0399 0.0399
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) 0.0081 0.08 0.3552
Schistosoma mansoni sugar transporter 0.0029 0.0201 0.0894
Onchocerca volvulus 0.0029 0.0201 0.1235
Loa Loa (eye worm) sodium/hydrogen exchanger 0.01 0.1021 0.4529
Echinococcus multilocularis General substrate transporter 0.0177 0.1918 0.851
Leishmania major lysyl-tRNA synthetase, putative 0.0046 0.0399 0.5689
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.038 0.1686
Mycobacterium tuberculosis Probable conserved integral membrane transport protein YjcE 0.0019 0.0086 0.27
Loa Loa (eye worm) hypothetical protein 0.0029 0.0201 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0206 0.2253 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0597 0.2648
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0025 0.016 0.0709
Trypanosoma brucei glucose transporter, putative 0.0064 0.0606 0.8651
Plasmodium falciparum mitogen-activated protein kinase 2 0.0333 0.3724 0.3724
Loa Loa (eye worm) hypothetical protein 0.01 0.1021 0.4529
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0206 0.2253 1
Onchocerca volvulus 0.0029 0.0201 0.1235
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.0399 0.1769
Onchocerca volvulus 0.0029 0.0201 0.1235
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0119 0.2978
Loa Loa (eye worm) hypothetical protein 0.0046 0.0399 0.1769
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0062 0.0582 0.2583
Mycobacterium ulcerans sugar transporter 0.0029 0.0201 0.5052
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0062 0.0582 0.9752
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0019 0.0086 0.27
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0029 0.0201 0.0894
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0076 0.6424
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0606 0.269
Schistosoma mansoni Slc9a7 protein 0.0019 0.0086 0.0381
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0076 0.0338
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0606 0.269
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0076 0.1088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0076 0.0076
Toxoplasma gondii protein kinase, putative 0.0582 0.6612 1
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.1021 0.4529
Onchocerca volvulus 0.0029 0.0201 0.1235
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0399 0.1769
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0201 0.0894
Brugia malayi Sugar transporter family protein 0.0029 0.0201 0.0894
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.0019 0.0086 0.0381
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0606 0.269
Loa Loa (eye worm) hypothetical protein 0.0029 0.0201 0.0894
Schistosoma mansoni glucose transport protein 0.0206 0.2253 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0399 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0076 0.0338
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0333 0.3724 0.5632
Echinococcus granulosus sodium:hydrogen exchanger 7 0.0019 0.0086 0.0381
Echinococcus multilocularis solute carrier family 22 0.0029 0.0201 0.0894
Echinococcus multilocularis sodium:hydrogen exchanger 0.01 0.1021 0.4529
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0081 0.08 0.3552
Leishmania major glucose transporter/membrane transporter D2, putative 0.0064 0.0606 0.8651
Brugia malayi hypothetical protein 0.0029 0.0201 0.0894
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0046 0.0399 0.6849
Loa Loa (eye worm) hypothetical protein 0.0029 0.0201 0.0894
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0606 0.269
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0063 0.0597 0.0597
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0076 0.1278
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Echinococcus granulosus sodium:hydrogen exchanger 0.01 0.1021 0.4529
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0201 0.0305
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0201 0.2874
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0318 0.5469
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.038 0.1686
Trypanosoma brucei glucose transporter, putative 0.0064 0.0606 0.8651
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.1021 0.4529
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein 0.01 0.1021 0.4529
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0062 0.0582 0.2583
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0063 0.0597 0.8517
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0062 0.0582 0.2583
Mycobacterium ulcerans ion antiporter, NhaP 0.0019 0.0086 0.2156
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0062 0.0582 0.2583
Toxoplasma gondii sodium/hydrogen exchanger 3 protein 0.0019 0.0086 0.013
Mycobacterium ulcerans potassium/proton antiporter 0.0019 0.0086 0.2156
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0062 0.0582 0.2583
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0029 0.0201 0.0894
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.1021 0.4529
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0029 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.01 0.1021 0.4529
Plasmodium vivax calcium-dependent protein kinase, putative 0.0063 0.0597 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Entamoeba histolytica sodium/proton antiporter, putative 0.0019 0.0086 0.144
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0201 0.2874
Toxoplasma gondii sugar transporter ST3 0.0029 0.0201 0.0305
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0063 0.0597 0.0597
Trypanosoma brucei sugar transporter, putative 0.0029 0.0201 0.2874
Trypanosoma brucei glucose transporter, putative 0.0064 0.0606 0.8651
Trypanosoma brucei glucose transporter 2A 0.0064 0.0606 0.8651
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0201 0.0894
Leishmania major glucose transporter, lmgt3 0.0064 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0029 0.0201 0.0894
Echinococcus granulosus calcium dependent protein kinase 0.0059 0.0552 0.2448
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0399 1
Echinococcus granulosus solute carrier family 22 0.0029 0.0201 0.0894
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0039 0.0318 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.038 0.1686
Entamoeba histolytica sodium/proton antiporter, putative 0.0019 0.0086 0.144
Schistosoma mansoni hypothetical protein 0.0206 0.2253 1
Loa Loa (eye worm) hypothetical protein 0.01 0.1021 0.4529
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0072 0.0701 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0063 0.0597 0.0597
Leishmania major Na/H antiporter-like protein 0.0019 0.0086 0.1226
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0701 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Plasmodium falciparum proline--tRNA ligase 0.0072 0.0701 0.0701
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Toxoplasma gondii sugar transporter ST2 0.0029 0.0201 0.0305
Echinococcus multilocularis solute carrier family 22 0.0029 0.0201 0.0894
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.0019 0.0086 0.1226
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0201 0.0894
Onchocerca volvulus 0.0029 0.0201 0.1235
Giardia lamblia Prolyl-tRNA synthetase 0.0062 0.0582 0.5702
Echinococcus granulosus solute carrier family 22 0.0029 0.0201 0.0894
Echinococcus granulosus solute carrier family 22 0.0029 0.0201 0.0894
Echinococcus granulosus solute carrier family 22 0.0029 0.0201 0.0894
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0701 1
Plasmodium vivax sodium/hydrogen exchanger 1, putative 0.0019 0.0086 0.0086
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0582 0.2583
Echinococcus multilocularis calcium dependent protein kinase 0.0059 0.0552 0.2448
Echinococcus multilocularis sodium:hydrogen exchanger 7 0.0019 0.0086 0.0381
Loa Loa (eye worm) hypothetical protein 0.005 0.0448 0.1987
Wolbachia endosymbiont of Brugia malayi Kef-type K+ transport system, membrane component 0.0019 0.0086 0.4267
Onchocerca volvulus 0.0029 0.0201 0.1235
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0597 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0063 0.0597 0.0903
Toxoplasma gondii lysine-tRNA ligase 0.0046 0.0399 0.0603
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0201 0.2874
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0597 0.2648
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0597 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0119 1
Schistosoma mansoni protein kinase 0.0063 0.0597 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Plasmodium falciparum lysine--tRNA ligase 0.0046 0.0399 0.0399
Loa Loa (eye worm) sugar transporter 0.0029 0.0201 0.0894
Brugia malayi lysyl-tRNA synthetase 0.0046 0.0399 0.1769
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Trypanosoma cruzi hexose transporter 0.0064 0.0606 0.8651
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0606 0.8651
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0206 0.2253 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.038 0.1686
Echinococcus multilocularis solute carrier family 22 0.0029 0.0201 0.0894
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0119 0.2978
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0399 0.1769
Plasmodium falciparum sodium/hydrogen exchanger, Na+, H+ antiporter 0.0019 0.0086 0.0086
Toxoplasma gondii Na+/H+ exchanger NHE1 0.0019 0.0086 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0606 0.269
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0201 0.0894
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.1021 1
Trypanosoma cruzi hexose transporter, putative 0.0035 0.027 0.386
Brugia malayi Sugar transporter family protein 0.0029 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Onchocerca volvulus 0.0029 0.0201 0.1235
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0201 0.0894
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0597 0.2648
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0076 0.0747
Schistosoma mansoni ap endonuclease 0.0018 0.0076 0.0338
Brugia malayi hypothetical protein 0.0029 0.0201 0.0894
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) 0.01 0.1021 0.4529
Brugia malayi hypothetical protein 0.0029 0.0201 0.0894
Onchocerca volvulus 0.0029 0.0201 0.1235
Schistosoma mansoni hypothetical protein 0.0019 0.0086 0.0381
Schistosoma mansoni glucose transport protein 0.0206 0.2253 1
Brugia malayi Sugar transporter family protein 0.0206 0.2253 1
Mycobacterium leprae probable conserved integral membrane transport protein 0.0019 0.0086 0.1477
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.1021 0.4529
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0606 0.8651
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0201 0.5052
Echinococcus granulosus mitochondrial sodium:hydrogen exchanger 9B2 0.0019 0.0086 0.0381
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0201 0.5052
Mycobacterium ulcerans membrane transporter 0.0019 0.0086 0.2156
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.1021 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0072 0.0701 1
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.1021 0.4529
Plasmodium falciparum protein kinase 7 0.0582 0.6612 0.6612
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0206 0.2253 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0063 0.0597 0.2648
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0206 0.2253 1
Trypanosoma brucei glucose transporter, putative 0.0064 0.0606 0.8651
Schistosoma mansoni ap endonuclease 0.0018 0.0076 0.0338
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0019 0.0086 0.0381
Giardia lamblia Sugar-proton symporter 0.0029 0.0201 0.1973
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Onchocerca volvulus 0.0029 0.0201 0.1235
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.1021 0.4529
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0046 0.0399 0.5689
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0046 0.0399 0.5689
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0206 0.2253 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0201 0.2874
Trypanosoma brucei glucose transporter, putative 0.0064 0.0606 0.8651
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0582 0.2583
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0597 0.2648
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0606 0.8651
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.038 0.1686
Brugia malayi major facilitator superfamily protein 0.0029 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.2253 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0606 0.8651
Trypanosoma brucei glucose transporter 1E 0.0064 0.0606 0.8651
Leishmania major hypothetical protein, conserved 0.0019 0.0086 0.1226
Echinococcus multilocularis lysyl tRNA synthetase 0.0046 0.0399 0.1769
Loa Loa (eye worm) hypothetical protein 0.0029 0.0201 0.0894
Toxoplasma gondii sugar transporter ST1 0.0029 0.0201 0.0305
Leishmania major glucose transporter, lmgt2 0.0064 0.0606 0.8651
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0063 0.0597 0.0597
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0201 1
Onchocerca volvulus Putative transporter 0.0029 0.0201 0.1235
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.038 0.1686
Loa Loa (eye worm) hypothetical protein 0.0029 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Plasmodium vivax sugar transporter, putative 0.0029 0.0201 0.0201
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0076 0.0076
Schistosoma mansoni protein kinase 0.0063 0.0597 0.2648
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0076 0.1088
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.1021 1
Plasmodium vivax hexose transporter 0.0206 0.2253 0.2253
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Schistosoma mansoni glucose transport protein 0.0206 0.2253 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Schistosoma mansoni sodium/hydrogen exchanger 3 (nhe3) 0.0019 0.0086 0.0381
Plasmodium falciparum hexose transporter 0.0206 0.2253 0.2253
Brugia malayi Sodium/hydrogen exchanger 8 0.0019 0.0086 0.0381
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0063 0.0597 0.0903
Echinococcus multilocularis sodium:hydrogen exchanger 0.01 0.1021 0.4529
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.038 0.1686
Toxoplasma gondii Na+/H+ exchanger NHE3 0.0019 0.0086 0.013
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0062 0.0582 1
Leishmania major protein kinase, putative 0.0063 0.0597 0.8517
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0019 0.0086 0.0381
Loa Loa (eye worm) hypothetical protein 0.0029 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0076 0.0338
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.01 0.1021 0.4529
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0201 0.6328
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0201 0.0894
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0201 0.0894
Brugia malayi major facilitator superfamily protein 0.0029 0.0201 0.0894
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0076 0.1088
Entamoeba histolytica hypothetical protein 0.0046 0.0399 0.6679
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0206 0.2253 1
Brugia malayi hypothetical protein 0.0019 0.0086 0.0381
Trypanosoma brucei glucose transporter, putative 0.0064 0.0606 0.8651
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0076 0.0338
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0597 0.2648
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0606 0.8651
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0597 0.2648
Plasmodium falciparum calcium-dependent protein kinase 5 0.0063 0.0597 0.0597
Entamoeba histolytica protein kinase, putative 0.0063 0.0597 1
Giardia lamblia Sodium/hydrogen exchanger 3 0.01 0.1021 1
Trypanosoma brucei glucose transporter, putative 0.0064 0.0606 0.8651
Entamoeba histolytica protein kinase, putative 0.0063 0.0597 1
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0606 0.269
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0063 0.0597 0.0903
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.0019 0.0086 0.1226

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 70 nM Inhibition of 5-N-(ethyl isopropyl)-amiloride[EIPA]-sensitive Na+ uptake into acidified rabbit erythrocytes. ChEMBL. 9207943
IC50 (functional) = 70 nM Inhibition of 5-N-(ethyl isopropyl)-amiloride[EIPA]-sensitive Na+ uptake into acidified rabbit erythrocytes. ChEMBL. 9207943

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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