Detailed information for compound 1010971

Basic information

Technical information
  • TDR Targets ID: 1010971
  • Name: 1,3-dimethyl-5-[[1-(phenylmethyl)indol-3-yl]m ethylidene]-1,3-diazinane-2,4,6-trione
  • MW: 373.405 | Formula: C22H19N3O3
  • H donors: 0 H acceptors: 3 LogP: 3 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(C)C(=O)C(=Cc2cn(c3c2cccc3)Cc2ccccc2)C(=O)N1C
  • InChi: 1S/C22H19N3O3/c1-23-20(26)18(21(27)24(2)22(23)28)12-16-14-25(13-15-8-4-3-5-9-15)19-11-7-6-10-17(16)19/h3-12,14H,13H2,1-2H3
  • InChiKey: VLNKFANNJDIHFV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3-dimethyl-5-[[1-(phenylmethyl)indol-3-yl]methylene]hexahydropyrimidine-2,4,6-trione
  • 1,3-dimethyl-5-[[1-(phenylmethyl)-3-indolyl]methylene]hexahydropyrimidine-2,4,6-trione
  • 5-[[1-(benzyl)indol-3-yl]methylene]-1,3-dimethyl-barbituric acid
  • 5-(1-Benzyl-1H-indol-3-ylmethylene)-1,3-dimethyl-pyrimidine-2,4,6-trione
  • BAS 00652786
  • STK325130
  • ZINC04797619

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0153 0.139 0.2326
Echinococcus granulosus 7tm_1 domain containing protein 0.0089 0.063 0.0816
Echinococcus multilocularis neuropeptide s receptor 0.0089 0.063 0.0816
Schistosoma mansoni opsin-like receptor 0.0089 0.063 0.1047
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0089 0.063 0.1047
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0266 0.2708 0.2702
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0082 0.0555 0.1788
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.063 0.0816
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.0571 0.0948
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0749 0.097
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0174 0.163 0.5307
Onchocerca volvulus 0.0089 0.063 0.1191
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0749 0.1247
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.1419 0.3024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0887 1 1
Onchocerca volvulus 0.0061 0.0299 0.0557
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.3065 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0266 0.2708 0.4545
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0273 0.0353
Brugia malayi larval opioid receptor 0.0089 0.063 0.1047
Brugia malayi hypothetical protein 0.0089 0.063 0.1047
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0266 0.2708 0.2702
Echinococcus multilocularis fmrfamide receptor 0.0089 0.063 0.0816
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0089 0.063 0.1047
Echinococcus granulosus 7TM GPCR rhodopsin 0.0089 0.063 0.0816
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.063 0.1047
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0266 0.2708 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.063 0.1047
Schistosoma mansoni opsin-like receptor 0.0089 0.063 0.1047
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0266 0.2708 0.8832
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0266 0.2708 0.8832
Schistosoma mansoni biogenic amine receptor 0.0089 0.063 0.1047
Schistosoma mansoni amine GPCR 0.0089 0.063 0.1047
Schistosoma mansoni histamine h1 receptor 0.0089 0.063 0.1047
Schistosoma mansoni neuropeptide receptor 0.0089 0.063 0.1047
Echinococcus granulosus neuropeptide Y receptor 0.0089 0.063 0.0816
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.063 0.0816
Treponema pallidum fructose-bisphosphate aldolase 0.0887 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.063 0.0816
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0266 0.2708 0.3508
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0233 0.0481
Echinococcus multilocularis muscleblind protein 1 0.0153 0.139 0.18
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0082 0.0555 0.1788
Mycobacterium ulcerans hypothetical protein 0.0156 0.1419 0.2376
Schistosoma mansoni biogenic amine receptor 0.0089 0.063 0.1047
Loa Loa (eye worm) TYRA-2 protein 0.0089 0.063 0.1047
Echinococcus granulosus G protein coupled receptor 139 0.0089 0.063 0.0816
Brugia malayi Melatonin receptor type 1A 0.0089 0.063 0.1047
Echinococcus multilocularis g protein coupled receptor 0.0089 0.063 0.0816
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0184 0.0575
Onchocerca volvulus 0.0101 0.0778 0.1475
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0092 0.0666 0.1409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0749 0.1247
Echinococcus granulosus serotonin receptor 0.0089 0.063 0.0816
Echinococcus granulosus neuropeptide receptor 0.0089 0.063 0.0816
Schistosoma mansoni hypothetical protein 0.0089 0.063 0.1047
Brugia malayi Dopamine receptor protein 1 0.0089 0.063 0.1047
Onchocerca volvulus 0.0089 0.063 0.1191
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0266 0.2708 0.2702
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.063 0.0816
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0089 0.063 0.1047
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0266 0.2708 0.8832
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0266 0.2708 0.8832
Echinococcus multilocularis g-protein coupled receptor 0.0089 0.063 0.0816
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.0745 0.0965
Schistosoma mansoni glutaminase 0.0542 0.5948 1
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0745 0.0737
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0266 0.2708 0.2266
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0089 0.063 0.1047
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.0778 0.1297
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0089 0.063 0.1047
Loa Loa (eye worm) glutaminase 0.0542 0.5948 1
Brugia malayi Bromodomain containing protein 0.0037 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Brugia malayi Muscleblind-like protein 0.0153 0.139 0.2326
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0069 0.0399 0.0658
Brugia malayi Bromodomain containing protein 0.0073 0.0448 0.074
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0887 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0089 0.063 0.0816
Brugia malayi GnHR receptor homolog 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Echinococcus granulosus alpha 1A adrenergic receptor 0.0089 0.063 0.0816
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Schistosoma mansoni neuropeptide receptor 0.0089 0.063 0.1047
Onchocerca volvulus 0.0089 0.063 0.1191
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Mycobacterium ulcerans glutaminase 0.0542 0.5948 1
Plasmodium vivax SET domain protein, putative 0.0061 0.0299 0.1078
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0089 0.063 0.1047
Schistosoma mansoni opsin-like receptor 0.0089 0.063 0.1047
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0266 0.2708 0.8832
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0089 0.063 0.1047
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0089 0.063 0.1047
Echinococcus granulosus neuropeptide FF receptor 2 0.0089 0.063 0.0816
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0266 0.2708 0.2646
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0887 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0223 0.2207 0.7194
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0089 0.063 0.0816
Brugia malayi Pre-SET motif family protein 0.0061 0.0299 0.049
Echinococcus multilocularis G-protein coupled receptor, putative 0.0089 0.063 0.0816
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0745 0.1241
Echinococcus multilocularis somatostatin receptor 0.0089 0.063 0.0816
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0089 0.063 0.0816
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Echinococcus multilocularis serotonin receptor 0.0089 0.063 0.0816
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0266 0.2708 0.3508
Brugia malayi Dopamine receptor 0.0089 0.063 0.1047
Schistosoma mansoni neuropeptide receptor 0.0089 0.063 0.1047
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0089 0.063 0.0816
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0266 0.2708 0.3508
Onchocerca volvulus 0.048 0.5229 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0749 0.097
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0089 0.063 0.0816
Schistosoma mansoni amine GPCR 0.0089 0.063 0.1047
Schistosoma mansoni biogenic amine (5HT) receptor 0.0089 0.063 0.1047
Loa Loa (eye worm) melatonin receptor type 1A 0.0089 0.063 0.1047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0494 0.0819
Echinococcus granulosus neuropeptide Y receptor 0.0089 0.063 0.0816
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1233 0.4009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0028 0.0033
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Echinococcus multilocularis dro:myosuppressin receptor 0.0089 0.063 0.0816
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0084 0.0127
Echinococcus multilocularis muscleblind protein 0.0153 0.139 0.18
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0174 0.163 0.5307
Loa Loa (eye worm) glutaminase 2 0.0542 0.5948 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0887 1 1
Echinococcus granulosus neuropeptide s receptor 0.0089 0.063 0.0816
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0174 0.1632 0.2114
Brugia malayi Probable ClpP-like protease 0.0084 0.0571 0.0948
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Onchocerca volvulus 0.0089 0.063 0.1191
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0266 0.2708 0.4545
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0266 0.2708 1
Leishmania major hypothetical protein, conserved 0.0223 0.2207 0.7194
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0089 0.063 0.1047
Echinococcus granulosus dro:myosuppressin receptor 0.0089 0.063 0.0816
Echinococcus multilocularis g protein coupled receptor 0.0089 0.063 0.0816
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.063 0.0816
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0153 0.139 0.2326
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0266 0.2708 0.8832
Trichomonas vaginalis set domain proteins, putative 0.048 0.5229 0.5225
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0089 0.063 0.0816
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0089 0.063 0.0816
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0089 0.063 0.0816
Loa Loa (eye worm) hypothetical protein 0.0049 0.016 0.0255
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0089 0.063 0.1191
Loa Loa (eye worm) neuropeptide F receptor 0.0089 0.063 0.1047
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.063 0.0816
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0089 0.063 0.1047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0749 0.097
Onchocerca volvulus Neuropeptide F receptor homolog 0.0089 0.063 0.1191
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0494 0.0819
Loa Loa (eye worm) G-protein coupled receptor 0.0089 0.063 0.1047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0887 1 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0266 0.2708 0.4545
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0174 0.163 0.5307
Echinococcus granulosus peptide allatostatin:somatostatin 0.0089 0.063 0.0816
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0089 0.063 0.1047
Schistosoma mansoni hypothetical protein 0.0042 0.0084 0.0127
Schistosoma mansoni neuropeptide receptor 0.0089 0.063 0.1047
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0311 0.3243 0.5446
Brugia malayi hypothetical protein 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Brugia malayi Serotonin receptor 0.0089 0.063 0.1047
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0008 0.001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0749 0.1247
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.063 0.0816
Echinococcus multilocularis neuropeptide receptor 0.0089 0.063 0.0816
Schistosoma mansoni neuropeptide F-like receptor 0.0089 0.063 0.1047
Brugia malayi hypothetical protein 0.0089 0.063 0.1047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.063 0.0816
Echinococcus multilocularis orexin receptor type 2 0.0089 0.063 0.0816
Schistosoma mansoni biogenic amine (5HT) receptor 0.0089 0.063 0.1047
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.0745 0.1241
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0089 0.063 0.0816
Loa Loa (eye worm) G-protein coupled receptor 0.0089 0.063 0.1047
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0749 0.1247
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.063 0.1047
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0745 0.0737
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0433 0.4674 1
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0092 0.0666 0.1409
Schistosoma mansoni neuropeptide f receptor 76f 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0089 0.063 0.0816
Echinococcus granulosus g-protein coupled receptor 0.0089 0.063 0.0816
Echinococcus multilocularis neuropeptide receptor 0.0089 0.063 0.0816
Loa Loa (eye worm) neuropeptide F receptor 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.063 0.1047
Brugia malayi hypothetical protein 0.0089 0.063 0.1047
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0089 0.063 0.0816
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0571 0.2087
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0266 0.2708 0.2702
Giardia lamblia Fructose-bisphosphate aldolase 0.0887 1 1
Onchocerca volvulus 0.0089 0.063 0.1191
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0089 0.063 0.0816
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0183 0.1741 0.2918
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0077 0.0494 0.0641
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0092 0.0664 0.1104
Echinococcus multilocularis allatostatin A receptor 0.0089 0.063 0.0816
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0571 0.0948
Trypanosoma brucei polo-like protein kinase 0.0099 0.0745 0.2411
Echinococcus multilocularis fmrfamide receptor 0.0089 0.063 0.0816
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0266 0.2708 0.2702
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.0555 0.1788
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.063 0.0816
Echinococcus granulosus muscleblind protein 0.0153 0.139 0.18
Echinococcus multilocularis sex peptide receptor 0.0089 0.063 0.0816
Brugia malayi Serotonin receptor 0.0089 0.063 0.1047
Echinococcus granulosus histone lysine methyltransferase setb 0.0077 0.0494 0.0641
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0749 0.097
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0272 0.0353
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Echinococcus granulosus biogenic amine 5HT receptor 0.0089 0.063 0.0816
Onchocerca volvulus 0.0089 0.063 0.1191
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Echinococcus multilocularis g protein coupled receptor 0.0089 0.063 0.0816
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0084 0.0108
Schistosoma mansoni hypothetical protein 0.0089 0.063 0.1047
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0089 0.063 0.1047
Echinococcus granulosus tm gpcr rhodopsin 0.0089 0.063 0.0816
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.3065 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0494 0.0819
Onchocerca volvulus 0.0089 0.063 0.1191
Loa Loa (eye worm) hypothetical protein 0.0042 0.0077 0.0116
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.0571 0.074
Brugia malayi putative neuropeptide receptor NPR1 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0084 0.0571 0.0948
Echinococcus granulosus g protein coupled receptor 0.0089 0.063 0.0816
Echinococcus granulosus hypothetical protein 0.0089 0.063 0.0816
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0266 0.2708 0.2121
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0272 0.0353
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1233 0.4009
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0266 0.2708 0.8832
Brugia malayi Dopamine receptor protein 2 0.0089 0.063 0.1047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.063 0.0816
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0299 0.049
Echinococcus multilocularis neuropeptide Y receptor 0.0089 0.063 0.0816
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Echinococcus granulosus tumor protein p63 0.0692 0.7719 1
Brugia malayi hypothetical protein 0.0089 0.063 0.1047
Echinococcus granulosus sex peptide receptor 0.0089 0.063 0.0816
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0299 0.0387
Toxoplasma gondii hypothetical protein 0.0048 0.0149 0.0522
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.3065 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.0571 0.074
Onchocerca volvulus 0.0089 0.063 0.1191
Onchocerca volvulus 0.0089 0.063 0.1191
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.063 0.0816
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0887 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.016 0.0255
Echinococcus granulosus orexin receptor type 2 0.0089 0.063 0.0816
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0174 0.1632 0.2734
Onchocerca volvulus 0.0089 0.063 0.1191
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0089 0.063 0.0816
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0089 0.063 0.1047
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0082 0.0555 0.092
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.0745 0.0965
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.063 0.1047
Schistosoma mansoni alpha-1 adrenergic receptor 0.0089 0.063 0.1047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0749 0.1247
Brugia malayi AKH receptor 0.0089 0.063 0.1047
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0089 0.063 0.1047
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0299 0.1078
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0745 0.0737
Brugia malayi Tachykinin-like peptides receptor 99D 0.0089 0.063 0.1047
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0233 0.0481
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Schistosoma mansoni amine GPCR 0.0089 0.063 0.1047
Onchocerca volvulus 0.0089 0.063 0.1191
Echinococcus multilocularis neuropeptides capa receptor 0.0089 0.063 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0745 0.0737
Echinococcus multilocularis serotonin receptor 0.0089 0.063 0.0816
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0174 0.1632 0.2114
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0233 0.0481
Onchocerca volvulus 0.0089 0.063 0.1191
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0077 0.0226
Echinococcus granulosus fmrfamide receptor 0.0089 0.063 0.0816
Echinococcus multilocularis neuropeptide FF receptor 2 0.0089 0.063 0.0816
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0571 0.2087
Onchocerca volvulus 0.0089 0.063 0.1191
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0089 0.063 0.0816
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0089 0.063 0.0816
Brugia malayi RE15519p 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Echinococcus granulosus somatostatin receptor 0.0089 0.063 0.0816
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Brugia malayi G protein-coupled receptor F59B2.13 0.0089 0.063 0.1047
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.0745 0.2411
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0089 0.063 0.1047
Brugia malayi hypothetical protein 0.0089 0.063 0.1047
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0571 0.2087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.063 0.0816
Echinococcus granulosus neuropeptides capa receptor 0.0089 0.063 0.0816
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0174 0.1632 0.2734
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0266 0.2708 0.4545
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0174 0.1632 0.1625
Brugia malayi neuropeptide F receptor 0.0089 0.063 0.1047
Schistosoma mansoni amine GPCR 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0174 0.1632 0.1625
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Trichomonas vaginalis CAMK family protein kinase 0.005 0.017 0.0162
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Brugia malayi G protein-coupled receptor 0.0089 0.063 0.1047
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.0745 0.0667
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0266 0.2708 0.2646
Brugia malayi hypothetical protein 0.0089 0.063 0.1047
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0183 0.1741 0.2918
Echinococcus granulosus allatostatin A receptor 0.0089 0.063 0.0816
Trypanosoma brucei hypothetical protein, conserved 0.0223 0.2207 0.7194
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0089 0.063 0.1047
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0571 0.0948
Schistosoma mansoni growth hormone secretagogue receptor 0.0089 0.063 0.1047
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0745 0.2411
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0266 0.2708 0.4545
Echinococcus granulosus tm gpcr rhodopsin 0.0089 0.063 0.0816
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0266 0.2708 0.2646
Echinococcus multilocularis tumor protein p63 0.0692 0.7719 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.0745 0.1241
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0433 0.4674 0.7856
Loa Loa (eye worm) hypothetical protein 0.0174 0.1632 0.2734
Loa Loa (eye worm) hypothetical protein 0.0101 0.0778 0.1297
Trypanosoma cruzi hypothetical protein, conserved 0.0223 0.2207 0.7194
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0266 0.2708 0.3508
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0745 0.2411
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Brugia malayi hypothetical protein 0.0089 0.063 0.1047
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0266 0.2708 0.8832
Brugia malayi hypothetical protein 0.0089 0.063 0.1047
Echinococcus granulosus g protein coupled receptor 0.0089 0.063 0.0816
Echinococcus multilocularis neuropeptides capa receptor 0.0089 0.063 0.0816
Echinococcus multilocularis neuropeptide Y receptor 0.0089 0.063 0.0816
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Schistosoma mansoni hypothetical protein 0.0089 0.063 0.1047
Schistosoma mansoni bromodomain containing protein 0.0062 0.0313 0.0514
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0174 0.163 0.5307
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Schistosoma mansoni adenoreceptor 0.0089 0.063 0.1047
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0089 0.063 0.0816
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0077 0.0226
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0266 0.2708 0.4545
Schistosoma mansoni myosin xvIII 0.0089 0.063 0.1047
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0008 0.001
Brugia malayi hypothetical protein 0.0089 0.063 0.1047
Onchocerca volvulus 0.0089 0.063 0.1191
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.3065 1
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0266 0.2708 0.8832
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0266 0.2708 0.8832
Echinococcus granulosus neuropeptide receptor 0.0089 0.063 0.0816
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.0571 0.1207
Trichomonas vaginalis CAMK family protein kinase 0.005 0.017 0.0162
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.2271 0.4849
Brugia malayi follicle stimulating hormone receptor 0.0311 0.3243 0.5446
Schistosoma mansoni neuropeptide F-like receptor 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0089 0.063 0.1047
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0422 0.4544 0.7637
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.063 0.1047
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0266 0.2708 0.8832
Brugia malayi hypothetical protein 0.0042 0.0084 0.0127
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.0555 0.1788
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0077 0.0226
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0174 0.163 0.0957
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0089 0.063 0.0816
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Onchocerca volvulus 0.0089 0.063 0.1191
Brugia malayi glutaminase DH11.1 0.0542 0.5948 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0089 0.063 0.0816
Onchocerca volvulus 0.0089 0.063 0.1191
Echinococcus granulosus tachykinin peptides receptor 99D 0.0089 0.063 0.0816
Echinococcus granulosus neuropeptide receptor A26 0.0089 0.063 0.0816
Schistosoma mansoni biogenic amine receptor 0.0089 0.063 0.1047
Schistosoma mansoni amine GPCR 0.0089 0.063 0.1047
Brugia malayi G-protein coupled receptor 0.0089 0.063 0.1047
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0089 0.063 0.0816
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.016 0.0255
Echinococcus granulosus g protein coupled receptor 0.0089 0.063 0.0816
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0266 0.2708 1
Brugia malayi ORL1-like opioid receptor 0.0089 0.063 0.1047
Brugia malayi G-protein coupled receptor 0.0089 0.063 0.1047
Echinococcus granulosus neuropeptides capa receptor 0.0089 0.063 0.0816
Echinococcus multilocularis neuropeptide receptor A26 0.0089 0.063 0.0816
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0089 0.063 0.0816
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0266 0.2708 0.8832
Trichomonas vaginalis glutaminase, putative 0.0542 0.5948 0.5944
Brugia malayi sulfakinin receptor protein 0.0089 0.063 0.1047
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1233 0.4009
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0266 0.2708 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0077 0.0226
Echinococcus multilocularis G protein coupled receptor 139 0.0089 0.063 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0745 0.0737
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0433 0.4674 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0089 0.063 0.1047
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0745 0.0737
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.063 0.0816
Brugia malayi Pre-SET motif family protein 0.0422 0.4544 0.7637
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0089 0.063 0.1047
Onchocerca volvulus 0.0089 0.063 0.1191
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0266 0.2708 1
Schistosoma mansoni kinase 0.0051 0.0185 0.0297
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0299 0.049
Loa Loa (eye worm) hypothetical protein 0.004 0.0055 0.0079
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0266 0.2708 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.063 0.0816
Brugia malayi neuropeptide F receptor 0.0089 0.063 0.1047
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0745 0.0737
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0233 0.0301
Schistosoma mansoni hypothetical protein 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.0555 0.1788
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.0745 0.1411
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.016 0.0255
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0092 0.0664 0.0656
Echinococcus granulosus biogenic amine 5HT receptor 0.0089 0.063 0.0816
Echinococcus granulosus tm gpcr rhodopsin 0.0089 0.063 0.0816
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0887 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0887 1 1
Brugia malayi putative neuropeptide receptor 0.0089 0.063 0.1047
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.063 0.0816
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0089 0.063 0.1047
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0233 0.0301
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0084 0.0108
Loa Loa (eye worm) hypothetical protein 0.0089 0.063 0.1047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0887 1 1

Activities

Activity type Activity value Assay description Source Reference
GI (functional) = 36 % Growth inhibition of human UO31 cells at 10 uM ChEMBL. 19398334
GI (functional) = 43 % Growth inhibition of human RXF393 cells at 10 uM ChEMBL. 19398334
GI (functional) = 95 % Growth inhibition of human TK10 cells at 10 uM ChEMBL. 19398334
GI50 (functional) = 0.02 uM Growth inhibition of human MDA-MB-468 cells ChEMBL. 19398334
GI50 (functional) = 0.06 uM Growth inhibition of human IGROV1 cells ChEMBL. 19398334
GI50 (functional) = 0.1 uM Growth inhibition of human OVCAR5 cells ChEMBL. 19398334
GI50 (functional) = 0.2 uM Growth inhibition of human A498 cells ChEMBL. 19398334
GI50 (functional) = 0.5 uM Growth inhibition of human Caki1 cells ChEMBL. 19398334
GI50 (functional) = 0.7 uM Growth inhibition of human COLO205 cells ChEMBL. 19398334
GI50 (functional) = 1 uM Growth inhibition of human UACC62 cells ChEMBL. 19398334
GI50 (functional) = 1.1 uM Growth inhibition of human SF295 cells ChEMBL. 19398334
GI50 (functional) = 3 uM Growth inhibition of human SK-MEL-2 cells ChEMBL. 19398334
GI50 (functional) = 3.1 uM Growth inhibition of human TK10 cells ChEMBL. 19398334
GI50 (functional) = 3.4 uM Growth inhibition of human NCI-H226 cells ChEMBL. 19398334
GI50 (functional) = 4.1 uM Growth inhibition of human NCI-H460 cells ChEMBL. 19398334
GI50 (functional) = 4.3 uM Growth inhibition of human K562 cells ChEMBL. 19398334
GI50 (functional) = 5 uM Growth inhibition of human T47D cells ChEMBL. 19398334
GI50 (functional) = 6.1 uM Growth inhibition of human OVCAR4 cells ChEMBL. 19398334
GI50 (functional) = 8.3 uM Growth inhibition of human HOP92 cells ChEMBL. 19398334
LC50 (functional) = 0.69 uM Growth inhibition of human MDA-MB-468 cells ChEMBL. 19398334
LC50 (functional) = 0.85 uM Growth inhibition of human IGROV1 cells ChEMBL. 19398334
LC50 (functional) = 2.29 uM Growth inhibition of human A498 cells ChEMBL. 19398334
LC50 (functional) > 100 uM Growth inhibition of human K562 cells ChEMBL. 19398334
LC50 (functional) > 100 uM Growth inhibition of human HOP92 cells ChEMBL. 19398334
LC50 (functional) > 100 uM Growth inhibition of human NCI-H226 cells ChEMBL. 19398334
LC50 (functional) > 100 uM Growth inhibition of human NCI-H460 cells ChEMBL. 19398334
LC50 (functional) > 100 uM Growth inhibition of human COLO205 cells ChEMBL. 19398334
LC50 (functional) > 100 uM Growth inhibition of human SF295 cells ChEMBL. 19398334
LC50 (functional) > 100 uM Growth inhibition of human SK-MEL-2 cells ChEMBL. 19398334
LC50 (functional) > 100 uM Growth inhibition of human UACC62 cells ChEMBL. 19398334
LC50 (functional) > 100 uM Growth inhibition of human OVCAR4 cells ChEMBL. 19398334
LC50 (functional) > 100 uM Growth inhibition of human OVCAR5 cells ChEMBL. 19398334
LC50 (functional) > 100 uM Growth inhibition of human Caki1 cells ChEMBL. 19398334
LC50 (functional) > 100 uM Growth inhibition of human TK10 cells ChEMBL. 19398334
LC50 (functional) > 100 uM Growth inhibition of human T47D cells ChEMBL. 19398334
MTD (ADMET) = 400 mg kg-1 Toxicity in mouse assessed as mouse survival administered intraperitoneally once daily measured after 19 days ChEMBL. 20810192
TGI (functional) = 0.06 uM Growth inhibition of human MDA-MB-468 cells ChEMBL. 19398334
TGI (functional) = 0.26 uM Growth inhibition of human IGROV1 cells ChEMBL. 19398334
TGI (functional) = 0.64 uM Growth inhibition of human A498 cells ChEMBL. 19398334
TGI (functional) = 0.67 uM Growth inhibition of human OVCAR5 cells ChEMBL. 19398334
TGI (functional) = 6.4 uM Growth inhibition of human Caki1 cells ChEMBL. 19398334
TGI (functional) = 9.1 uM Growth inhibition of human COLO205 cells ChEMBL. 19398334
TGI (functional) = 12.5 uM Growth inhibition of human UACC62 cells ChEMBL. 19398334
TGI (functional) = 27 uM Growth inhibition of human NCI-H226 cells ChEMBL. 19398334
TGI (functional) = 45.7 uM Growth inhibition of human SK-MEL-2 cells ChEMBL. 19398334
TGI (functional) = 50 uM Growth inhibition of human HOP92 cells ChEMBL. 19398334
TGI (functional) = 57.5 uM Growth inhibition of human TK10 cells ChEMBL. 19398334
TGI (functional) > 100 uM Growth inhibition of human K562 cells ChEMBL. 19398334
TGI (functional) > 100 uM Growth inhibition of human NCI-H460 cells ChEMBL. 19398334
TGI (functional) > 100 uM Growth inhibition of human SF295 cells ChEMBL. 19398334
TGI (functional) > 100 uM Growth inhibition of human OVCAR4 cells ChEMBL. 19398334
TGI (functional) > 100 uM Growth inhibition of human T47D cells ChEMBL. 19398334

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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