Detailed information for compound 1012928

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 457.956 | Formula: C20H16ClN5O2S2
  • H donors: 0 H acceptors: 5 LogP: 3.46 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cc(ccc1N1CCc2c1nccc2n1ccc(n1)c1nccs1)S(=O)(=O)C
  • InChi: 1S/C20H16ClN5O2S2/c1-30(27,28)13-2-3-18(15(21)12-13)25-9-5-14-17(4-7-22-19(14)25)26-10-6-16(24-26)20-23-8-11-29-20/h2-4,6-8,10-12H,5,9H2,1H3
  • InChiKey: ARKSLNIFOGBPCH-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens corticotropin releasing hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 1 444 aa 445 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0077 0.0082 0.0302
Schistosoma mansoni sulfate transporter 0.0007 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0077 0.0082 0.0302
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0016 0.003
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0016 0.0016
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0012 0.0042
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0125 0.0434
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0016 0.0027
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0012 0.0042
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0016 0.0136
Brugia malayi Animal haem peroxidase family protein 0.0077 0.0082 0.0302
Onchocerca volvulus Peroxidasin homolog 0.0077 0.0082 0.0413
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0125 0.0464
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0028 0.0028
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0028 0.0559
Schistosoma mansoni carbonic anhydrase 0.0658 0.0751 0.2796
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0273 0.0307 0.2299
Schistosoma mansoni ran 0.0022 0.0018 0.0068
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0016 0.0016
Schistosoma mansoni carbonic anhydrase-related 0.1163 0.1333 0.4961
Brugia malayi MH2 domain containing protein 0.0126 0.0138 0.0512
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0066 0.0069
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0004 0.0013
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0004 0.0012
Brugia malayi MH1 domain containing protein 0.0009 0.0002 0.0008
Entamoeba histolytica carbonic anhydrase, putative 0.0658 0.0751 1
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0012 0.0082
Schistosoma mansoni hypothetical protein 0.0324 0.0366 0.1362
Echinococcus multilocularis dna polymerase eta 0.002 0.0016 0.0058
Brugia malayi Animal haem peroxidase family protein 0.0077 0.0082 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0027
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0016 0.0057
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0016 0.0027
Echinococcus multilocularis carbonic anhydrase 0.1163 0.1333 0.496
Loa Loa (eye worm) carbonic anhydrase 3 0.2338 0.2687 1
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0004 0.0012
Schistosoma mansoni regulator of G protein signaling 0.001 0.0004 0.0013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0016 0.0057
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0018 0.0067
Echinococcus multilocularis carbonic anhydrase 0.1163 0.1333 0.496
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0159 0.0592
Schistosoma mansoni hypothetical protein 0.0053 0.0053 0.0199
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0028 0.0559
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0139 0.0153 0.0161
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0012 0.0042
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0004 0.0012
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.0125 0.0464
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.0125 0.0109
Onchocerca volvulus Chorion peroxidase homolog 0.0077 0.0082 0.0413
Onchocerca volvulus Peroxidase homolog 0.0077 0.0082 0.0413
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.0125 0.0462
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0058
Loa Loa (eye worm) hypothetical protein 0.0077 0.0082 0.0302
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0001 0.0004
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0021 0.0021
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0273 0.0307 0.0292
Chlamydia trachomatis sulfate transporter 0.0273 0.0307 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0077 0.0082 0.0302
Brugia malayi MH1 domain containing protein 0.0009 0.0002 0.0008
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0028 0.0206
Loa Loa (eye worm) hypothetical protein 0.0077 0.0082 0.0302
Mycobacterium leprae Probable transmembrane transport protein 0.1979 0.2274 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0077 0.0082 0.0302
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0273 0.0307 0.2236
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0002 0.0008
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1163 0.1333 0.496
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0016 0.0058
Echinococcus granulosus dna polymerase kappa 0.002 0.0016 0.0058
Echinococcus granulosus solute carrier family 26 prestin 0.0007 0.0001 0.0002
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0004 0.0012
Brugia malayi Animal haem peroxidase family protein 0.0077 0.0082 0.0302
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0066 0.0246
Schistosoma mansoni microtubule-associated protein tau 0.0729 0.0833 0.31
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0012 0.0012
Onchocerca volvulus Peroxidase homolog 0.0077 0.0082 0.0413
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0053 0.0197
Echinococcus multilocularis Smad4 0.0009 0.0002 0.0008
Schistosoma mansoni importin beta-1 0.003 0.0028 0.0102
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0002 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0159 0.0592
Echinococcus granulosus carbonic anhydrase 0.1163 0.1333 0.496
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0028 0.1145
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0016 0.0058
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0016 0.0056
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0016 0.0059
Onchocerca volvulus 0.0077 0.0082 0.0413
Echinococcus multilocularis GPCR, family 2 0.0053 0.0053 0.0197
Loa Loa (eye worm) hypothetical protein 0.0077 0.0082 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0027
Schistosoma mansoni ap endonuclease 0.002 0.0016 0.0059
Brugia malayi Peroxidasin 0.0077 0.0082 0.0302
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0002
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.0125 0.0464
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0025 0.0021 0.0273
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0028 0.0103
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0016 0.0058
Schistosoma mansoni DNA polymerase eta 0.002 0.0016 0.0059
Trypanosoma brucei carbonic anhydrase-like protein 0.2338 0.2687 1
Brugia malayi RNA, U transporter 1 0.0086 0.0092 0.0341
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0028 1
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.0082 0.0302
Echinococcus multilocularis peroxidasin 0.0077 0.0082 0.0302
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.0082 0.0302
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0012 0.0012
Echinococcus granulosus peroxidasin 0.0077 0.0082 0.0302
Brugia malayi hypothetical protein 0.001 0.0004 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0066 0.0246
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0016 0.0058
Trypanosoma brucei unspecified product 0.002 0.0016 0.0027
Entamoeba histolytica Ran family GTPase 0.0022 0.0018 0.0238
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0066 0.005
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0012 0.0042
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0016 0.0058
Echinococcus granulosus carbonic anhydrase 0.1163 0.1333 0.496
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0016 0.0056
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0016 0.0057
Schistosoma mansoni cpg binding protein 0.0033 0.003 0.0112
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0159 0.0592
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0016 0.0206
Brugia malayi N-terminal motif family protein 0.0194 0.0216 0.0802
Trichomonas vaginalis conserved hypothetical protein 0.8681 1 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0012 0.0042
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0016 0.5
Schistosoma mansoni dishevelled 0.001 0.0004 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0068 0.0253
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0125 0.0125
Echinococcus granulosus dna polymerase eta 0.002 0.0016 0.0058
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0021 0.0021
Leishmania major carbonic anhydrase family protein, putative 0.0658 0.0751 0.2794
Echinococcus multilocularis solute carrier family 26, (prestin) 0.0007 0.0001 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0159 0.0592
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0016 0.0058
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0012 0.0042
Plasmodium falciparum carbonic anhydrase 0.1163 0.1333 1
Echinococcus multilocularis microtubule associated protein 2 0.0729 0.0833 0.3099
Schistosoma mansoni cpg binding protein 0.0033 0.003 0.0112
Loa Loa (eye worm) hypothetical protein 0.0077 0.0082 0.0302
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0194 0.0216 0.1096
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0018 0.022
Echinococcus multilocularis solute carrier family 26 0.0007 0.0001 0.0002
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0001 0.0004
Echinococcus granulosus cpg binding protein 0.0033 0.003 0.0111
Brugia malayi MH2 domain containing protein 0.0009 0.0002 0.0008
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0125 0.0465
Brugia malayi Blistered cuticle protein 3 0.0077 0.0082 0.0302
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0012 0.0044
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0053 0.0197
Brugia malayi CXXC zinc finger family protein 0.0031 0.0028 0.0103
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0018 0.0067
Brugia malayi hypothetical protein 0.0077 0.0082 0.0302
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0238 0.0267 0.0992
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0001 0.0005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0066 0.005
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.8162 0.9401 1
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0125 0.0125
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0018 0.0131
Echinococcus multilocularis snurportin 1 0.0324 0.0366 0.1361
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0016 0.0027
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0012
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.2499 0.2873 0.3055
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0012
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.006 0.0443
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0027
Toxoplasma gondii hypothetical protein 0.1163 0.1333 1
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0016 0.0058
Echinococcus granulosus microtubule associated protein 2 0.0729 0.0833 0.3099
Loa Loa (eye worm) phosphofructokinase 0.0115 0.0125 0.0464
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0053 0.0197
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.0082 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0027
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0012 0.0042
Brugia malayi Smad1 0.0009 0.0002 0.0008
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0053 0.0053 0.0197
Leishmania major importin beta-1 subunit, putative 0.0025 0.0021 0.0075
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0028 0.0101
Schistosoma mansoni hypothetical protein 0.0053 0.0053 0.0199
Schistosoma mansoni smad1 5 8 and 0.0009 0.0002 0.0009
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0028 0.0125
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.2338 0.2687 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0077 0.0082 0.0302
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0125 0.1659
Brugia malayi Animal haem peroxidase family protein 0.0077 0.0082 0.0302
Onchocerca volvulus Peroxidasin homolog 0.0077 0.0082 0.0413
Schistosoma mansoni hypothetical protein 0.0114 0.0124 0.0462
Brugia malayi 6-phosphofructokinase 0.0115 0.0125 0.0464
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0016 0.0015
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0018 0.0067
Loa Loa (eye worm) hypothetical protein 0.0114 0.0124 0.046
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0028 0.0028
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0016 0.0027
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0028 0.007
Schistosoma mansoni sulfate transporter 0.0007 0.0001 0.0003
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0012 0.0012
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0125 0.1659
Toxoplasma gondii hypothetical protein 0.001 0.0004 0.002
Brugia malayi MH2 domain containing protein 0.0009 0.0002 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0027
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0012 0.0042
Onchocerca volvulus 0.1714 0.1968 1
Onchocerca volvulus 0.0077 0.0082 0.0413
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0016 0.0058
Loa Loa (eye worm) hypothetical protein 0.0077 0.0082 0.0302
Plasmodium vivax importin-beta 2, putative 0.003 0.0028 0.0533
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0004 0.0012
Echinococcus multilocularis smad 0.0009 0.0002 0.0008
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0273 0.0307 0.1142
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0 0.0001
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0004 0.0012
Echinococcus multilocularis importin subunit beta 1 0.003 0.0028 0.0101
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0012 0.0042
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0028 0.02
Plasmodium falciparum importin beta, putative 0.003 0.0028 0.0119
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.1979 0.2274 0.2418
Brugia malayi phosphofructokinase 0.0115 0.0125 0.0464
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1163 0.1333 0.496
Loa Loa (eye worm) hypothetical protein 0.0194 0.0216 0.0802
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.0125 1
Brugia malayi isocitrate dehydrogenase 0.0017 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.1163 0.1333 0.496
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0004 0.0012
Toxoplasma gondii exonuclease III APE 0.002 0.0016 0.0112
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0053 0.0197
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0004 0.0012
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0018 0.0049
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0003 0.0011
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0238 0.0267 0.0992
Schistosoma mansoni smad1 5 8 and 0.0009 0.0002 0.0009
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0053 0.0197
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0018 0.1978
Schistosoma mansoni carbonic anhydrase 0.1163 0.1333 0.4961
Schistosoma mansoni ran 0.0022 0.0018 0.0068
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0004 0.0012
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0066 0.0245
Plasmodium vivax sulfate transporter, putative 0.0273 0.0307 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0028 0.0372
Echinococcus multilocularis cpg binding protein 0.0033 0.003 0.0111
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0002
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0016 0.0027
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0018 0.0036
Leishmania major GTP-binding protein, putative 0.0022 0.0018 0.0065
Schistosoma mansoni smad1 5 8 and 0.0009 0.0002 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0159 0.0593
Loa Loa (eye worm) hypothetical protein 0.1163 0.1333 0.496
Schistosoma mansoni ap endonuclease 0.002 0.0016 0.0059
Onchocerca volvulus 0.0031 0.0028 0.0141
Schistosoma mansoni Smad4 0.0009 0.0002 0.0009
Mycobacterium ulcerans integral membrane transporter 0.0273 0.0307 0.0292
Echinococcus granulosus carbonic anhydrase 0.1163 0.1333 0.496
Brugia malayi sulfate permease family protein 0.0007 0.0001 0.0002
Onchocerca volvulus 0.0077 0.0082 0.0413
Schistosoma mansoni hypothetical protein 0.0053 0.0053 0.0199
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0016 0.0016
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1163 0.1333 0.496
Loa Loa (eye worm) histone methyltransferase 0.001 0.0004 0.0012
Schistosoma mansoni peroxidasin 0.0077 0.0082 0.0304
Loa Loa (eye worm) hypothetical protein 0.0077 0.0082 0.0302
Echinococcus granulosus snurportin 1 0.0324 0.0366 0.1361
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.2338 0.2687 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0021 0.0021
Echinococcus granulosus carbonic anhydrase II 0.2338 0.2687 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0001 0.0004
Echinococcus multilocularis dna polymerase kappa 0.002 0.0016 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0027
Brugia malayi Putative carbonic anhydrase 5 precursor 0.2338 0.2687 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0016 0.0059
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0125 0.0465
Onchocerca volvulus Dual oxidase homolog 0.0077 0.0082 0.0413
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0159 0.0593
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0004 0.0012
Loa Loa (eye worm) Smad1 0.0009 0.0002 0.0008
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0273 0.0307 0.0292
Schistosoma mansoni dep domain containing protein 0.001 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0352 0.0398 0.1481
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1163 0.1333 0.496
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.0125 0.0132
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0016 0.0207
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0066 0.0243
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0016 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0028 0.0028
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.0159 0.0592
Trichomonas vaginalis ran, putative 0.0022 0.0018 0.0018
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0018 0.0067
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0012 0.0041
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1163 0.1333 0.496
Leishmania major carbonic anhydrase-like protein 0.2338 0.2687 1
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0125 0.0125
Echinococcus granulosus importin subunit beta 1 0.003 0.0028 0.0101
Echinococcus granulosus GPCR family 2 0.0053 0.0053 0.0197
Onchocerca volvulus Putative sulfate transporter 0.1714 0.1968 1
Loa Loa (eye worm) sulfate permease 0.0007 0.0001 0.0002
Brugia malayi Importin beta-1 subunit 0.003 0.0028 0.0101
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0066 0.0245
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0658 0.0751 0.2915
Schistosoma mansoni dishevelled 0.001 0.0004 0.0013
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0273 0.0307 0.1114
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0028 0.0206
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0352 0.0398 0.1481
Brugia malayi Animal haem peroxidase family protein 0.0077 0.0082 0.0302
Brugia malayi Calcitonin receptor-like protein seb-1 0.0167 0.0185 0.0687
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0002 0.0008
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0028 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0027
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0018 0.0067
Schistosoma mansoni cpg binding protein 0.0031 0.0028 0.0105
Schistosoma mansoni peroxidasin 0.0077 0.0082 0.0304
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.2338 0.2687 1
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0138 0.0512
Schistosoma mansoni ras GTP exchange factor 0.0007 0 0.0001
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0 0.0001
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0016 0.0016
Mycobacterium ulcerans carbonic anhydrase 0.0658 0.0751 0.0737
Schistosoma mansoni carbonic anhydrase-related 0.1163 0.1333 0.4961
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0016 0.0016
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0028 0.0206
Loa Loa (eye worm) hypothetical protein 0.0077 0.0082 0.0302
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0012
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0016 0.0057
Leishmania major DNA polymerase kappa, putative 0.002 0.0016 0.0056
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0004 0.0013
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1163 0.1333 0.496
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0167 0.0185 0.0687
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.0159 0.0592
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0002 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.8681 1 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0004 0.0012
Echinococcus granulosus solute carrier family 26 0.0007 0.0001 0.0002
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0125 0.1659
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0125 0.0125
Brugia malayi 6-phosphofructokinase 0.0115 0.0125 0.0464
Schistosoma mansoni hypothetical protein 0.0053 0.0053 0.0199
Loa Loa (eye worm) hypothetical protein 0.0077 0.0082 0.0302
Giardia lamblia DINP protein human, muc B family 0.002 0.0016 0.0112
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0002 0.0008
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0012 0.0042
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0016 0.0058
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0066 0.049
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0125 0.0464
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0027
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0125 0.0464
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0004 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0028 0.0028
Echinococcus multilocularis carbonic anhydrase II 0.2338 0.2687 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0082 0.0302
Brugia malayi latrophilin 2 splice variant baaae 0.0114 0.0124 0.046
Echinococcus granulosus smad 0.0009 0.0002 0.0008
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0004 0.0012
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.0082 0.0302
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.2338 0.2687 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0027
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0273 0.0307 0.1142
Brugia malayi DIX domain containing protein 0.001 0.0004 0.0012
Schistosoma mansoni smad 0.0009 0.0002 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0016 0.0057
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0004 0.0012
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0012 0.0082
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0004 0.0012
Echinococcus multilocularis carbonic anhydrase 0.1163 0.1333 0.496
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0016 0.0058
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0004 0.0012
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.2338 0.2687 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0028 0.007
Loa Loa (eye worm) hypothetical protein 0.0077 0.0082 0.0302
Brugia malayi hypothetical protein 0.001 0.0004 0.0012
Schistosoma mansoni carbonic anhydrase-related 0.1163 0.1333 0.4961
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0016 0.0057
Echinococcus granulosus Smad4 0.0009 0.0002 0.0008
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0021 0.0076
Leishmania major DNA polymerase eta, putative 0.002 0.0016 0.0056
Schistosoma mansoni hypothetical protein 0.1163 0.1333 0.4961
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0018 0.0067
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.0366 0.1361
Loa Loa (eye worm) hypothetical protein 0.1163 0.1333 0.496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0159 0.0593
Onchocerca volvulus 0.001 0.0004 0.0016
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.2338 0.2687 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0066 0.005
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0138 0.0512

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.63 Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells by SPA ChEMBL. 18975927

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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