Detailed information for compound 1015148

Basic information

Technical information
  • TDR Targets ID: 1015148
  • Name: 2-[4,5-dihydroxy-2,3-bis(3-methylbut-2-enyl)p henyl]-3,5,7-trihydroxy-8-(3-methylbut-2-enyl )chromen-4-one
  • MW: 506.587 | Formula: C30H34O7
  • H donors: 5 H acceptors: 6 LogP: 7.94 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=CCc1c(CC=C(C)C)c(O)c(cc1c1oc2c(CC=C(C)C)c(O)cc(c2c(=O)c1O)O)O)C
  • InChi: 1S/C30H34O7/c1-15(2)7-10-18-19(11-8-16(3)4)26(34)24(33)13-21(18)30-28(36)27(35)25-23(32)14-22(31)20(29(25)37-30)12-9-17(5)6/h7-9,13-14,31-34,36H,10-12H2,1-6H3
  • InChiKey: XYNNBNIJZARIJF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4,5-dihydroxy-2,3-bis(3-methylbut-2-enyl)phenyl]-3,5,7-trihydroxy-8-(3-methylbut-2-enyl)-4-chromenone
  • 2-[4,5-dihydroxy-2,3-bis(3-methylbut-2-enyl)phenyl]-3,5,7-trihydroxy-8-(3-methylbut-2-enyl)chromone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni DNA polymerase eta 0.0016 0.0124 0.4533
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0445 0.7652
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0253 0.9407
Entamoeba histolytica cell division protein kinase 2, putative 0.0017 0.0144 0.1543
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0182 0.2122
Entamoeba histolytica hypothetical protein 0.0021 0.0253 1
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0253 0.432
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0253 0.1535
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0856 1
Brugia malayi PXA domain containing protein 0.0021 0.0253 0.432
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0253 0.025
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0856 1
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0253 0.025
Echinococcus granulosus serine:threonine protein kinase haspin 0.0016 0.0128 0.0124
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0253 0.432
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0161 0.1884
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0253 0.9407
Brugia malayi hypothetical protein 0.0016 0.0128 0.2155
Schistosoma mansoni hypothetical protein 0.0016 0.0128 0.4692
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0253 0.1535
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0269 1
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0124 0.1445
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0253 0.025
Echinococcus multilocularis cyclin dependent kinase 9 0.0017 0.0144 0.014
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0017 0.0144 0.0272
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.432
Echinococcus multilocularis dna polymerase eta 0.0016 0.0124 0.012
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0161 0.0513
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0253 0.9407
Loa Loa (eye worm) hypothetical protein 0.0016 0.0124 0.2082
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0305 0.3568
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0161 0.2733
Entamoeba histolytica hypothetical protein 0.0021 0.0253 1
Loa Loa (eye worm) haspin protein kinase 0.0017 0.0144 0.2427
Trichomonas vaginalis DNA polymerase eta, putative 0.0046 0.0856 1
Brugia malayi Cytochrome P450 family protein 0.0018 0.0161 0.2733
Loa Loa (eye worm) hypothetical protein 0.0035 0.0581 1
Entamoeba histolytica hypothetical protein 0.0021 0.0253 1
Echinococcus granulosus serine:threonine protein kinase haspin 0.0016 0.0128 0.0124
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0253 0.025
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0253 0.025
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0253 0.432
Echinococcus multilocularis dna polymerase kappa 0.0046 0.0856 0.0852
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0253 0.9407
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0253 0.1535
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0161 0.2733
Brugia malayi Cytochrome P450 family protein 0.0029 0.0445 0.7652
Brugia malayi PXA domain containing protein 0.0021 0.0253 0.432
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0856 1
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0674 0.7878
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0253 0.432
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0017 0.0144 0.0272
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.432
Echinococcus granulosus Pfam-B_8186 domain containing protein 0.0016 0.0128 0.0124
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0253 0.025
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0161 0.2733
Echinococcus multilocularis hypothetical protein 0.0016 0.0128 0.0124
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0124 0.4533
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0017 0.0144 0.2427
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0016 0.0128 0.0124
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0161 0.0513
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0305 1
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0253 0.025
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0253 0.432
Trypanosoma brucei unspecified product 0.0038 0.0674 0.7878
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0253 0.432
Loa Loa (eye worm) haspin protein kinase 0.0016 0.0128 0.2155
Loa Loa (eye worm) haspin protein kinase 0.0016 0.0128 0.2155
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0182 0.2122
Mycobacterium ulcerans DNA polymerase IV 0.0046 0.0856 1
Brugia malayi Protein kinase domain containing protein 0.0017 0.0144 0.2427
Leishmania major cytochrome p450-like protein 0.0018 0.0161 0.2069
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0017 0.0144 0.014
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0124 0.4533
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0046 0.0856 1
Echinococcus granulosus mitogen activated protein kinase 15 0.0017 0.0144 0.014
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0003 0.5
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0253 0.9407
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0269 0.0265
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0182 0.2122
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0253 0.9407
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0017 0.0144 0.1098
Echinococcus granulosus cyclin dependent kinase 9 0.0017 0.0144 0.014
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0253 0.025
Echinococcus granulosus serine:threonine protein kinase haspin 0.0016 0.0128 0.0124
Brugia malayi GSG2 0.0016 0.0128 0.2155
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0856 1
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0253 0.9407
Schistosoma mansoni serine/threonine kinase 0.0017 0.0144 0.5286
Mycobacterium ulcerans DNA polymerase IV 0.0046 0.0856 1
Brugia malayi polk-prov protein 0.0035 0.0581 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0856 1
Onchocerca volvulus 0.0011 0.0003 0.5
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0253 0.432
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0124 0.2082
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0856 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.432
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0253 0.025
Trypanosoma brucei protein kinase, putative 0.0017 0.0144 0.1678
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0253 0.025
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0124 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0581 0.6789
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0253 0.9407
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0247 0.5837 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0856 1
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0253 0.9407
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0305 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0269 0.4593
Giardia lamblia DINP protein human, muc B family 0.0023 0.0305 1
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0269 1
Echinococcus granulosus dna polymerase kappa 0.0046 0.0856 0.0852
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0253 0.432
Brugia malayi hypothetical protein 0.0021 0.0253 0.432
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.432
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0144 0.5286
Brugia malayi Cell division protein kinase 2 0.0017 0.0144 0.2427
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0253 0.9407
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0856 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0856 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0124 0.012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0856 1
Plasmodium falciparum MO15-related protein kinase 0.0247 0.5837 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0003 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0253 0.1535
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.023 0.5434 1
Leishmania major serine/threonine kinase-like protein, putative 0.0017 0.0144 0.1098
Schistosoma mansoni hypothetical protein 0.0016 0.0128 0.4692
Brugia malayi Cytochrome P450 family protein 0.0018 0.0161 0.2733
Schistosoma mansoni protein kinase 0.0017 0.0144 0.5286
Leishmania major DNA polymerase kappa, putative 0.0023 0.0305 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.432
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0253 0.025
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0017 0.0144 0.0272
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0124 0.2082
Entamoeba histolytica protein kinase domain containing protein 0.0017 0.0144 0.1543
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0269 0.0265
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0253 0.025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.432
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0017 0.0144 0.014
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0017 0.0144 0.2427
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0581 0.6789
Brugia malayi hypothetical protein 0.0021 0.0253 0.432
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0253 0.9407
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0124 0.2082
Echinococcus multilocularis expressed protein 0.0415 1 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0269 0.4593
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0253 0.025
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0856 1
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0269 1
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0016 0.0128 0.0124
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0856 1
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0253 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0253 0.1535
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0856 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0253 0.025
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0003 0.5
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0269 0.4593
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0856 1
Echinococcus granulosus dna polymerase eta 0.0016 0.0124 0.012
Echinococcus granulosus serine:threonine protein kinase NLK 0.0017 0.0144 0.014
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0253 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0253 0.1535
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0253 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0253 0.1535
Brugia malayi cyclin-dependent kinase 7 homolog 0.0017 0.0144 0.2427
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0017 0.0144 0.014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0856 1
Entamoeba histolytica hypothetical protein 0.0016 0.0128 0.0326
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0017 0.0144 0.1678

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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