Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2312 | 0.0883 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2312 | 0.0883 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 1.7312 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 1.7312 | 1 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2312 | 0.0883 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0859 | 0 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.4283 | 0.2081 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2312 | 0.0883 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2312 | 0.0883 | 0.4245 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2312 | 0.0883 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2312 | 0.0883 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.4283 | 0.2081 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2312 | 0.0883 | 1 |
Onchocerca volvulus | 0.3155 | 0.1396 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2312 | 0.0883 | 0.4245 |
Schistosoma mansoni | carbonic anhydrase | 0.4283 | 0.2081 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2312 | 0.0883 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.3155 | 0.1396 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.5929 | 0.3081 | 0.3016 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.3644 | 0.1693 | 0.1263 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 1.5028 | 0.8612 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.4283 | 0.2081 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.2312 | 0.0883 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0859 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2 | ChEMBL. | 19569717 | |
Inhibition (binding) | = -17 % | Displacement of [3H]PSB-11 from human recombinant adenosine A3 receptor expressed in CHO cells at 1 uM | ChEMBL. | 19569717 |
Inhibition (binding) | = 56 % | Displacement of [3H]MSX-2 from rat brain striatum adenosine A2A receptor at 1 uM | ChEMBL. | 19569717 |
Ki (binding) | Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 19569717 | |
Ki (binding) | Displacement of [3H]MSX-2 from human recombinant adenosine A2A receptor expressed in CHO cells | ChEMBL. | 19569717 | |
Ki (binding) | = 7.49 nM | Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells | ChEMBL. | 19569717 |
Ki (binding) | = 86.8 nM | Displacement of [3H]CCPA from rat brain cortex adenosine A1 receptor | ChEMBL. | 19569717 |
Ki (binding) | = 1000 nM | Displacement of [3H]MSX-2 from rat brain striatum adenosine A2A receptor | ChEMBL. | 19569717 |
Ki (binding) | > 1000 nM | Displacement of [3H]PSB-11 from human recombinant adenosine A3 receptor expressed in CHO cells | ChEMBL. | 19569717 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.