Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | importin-beta 2, putative | 0.0033 | 0.0192 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0094 | 0.2061 | 0.6925 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0036 | 0.0289 | 0.321 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0289 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0192 | 0.0128 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0118 | 0.2779 | 0.2638 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0036 | 0.0289 | 0.0827 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0056 | 0.0899 | 0.084 |
Brugia malayi | Cytochrome P450 family protein | 0.0123 | 0.2947 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0036 | 0.0289 | 0.2266 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0068 | 0.1273 | 0.4454 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0033 | 0.0192 | 0.047 |
Schistosoma mansoni | hypothetical protein | 0.0353 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 0.1273 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0056 | 0.0899 | 0.6198 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0036 | 0.0289 | 0.0099 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0118 | 0.2779 | 0.2638 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0036 | 0.0289 | 0.2688 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0123 | 0.2947 | 0.2902 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0078 | 0.1579 | 0.1415 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0036 | 0.0289 | 0.2266 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.1273 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.1273 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0056 | 0.0899 | 0.7059 |
Brugia malayi | cytochrome P450 | 0.0036 | 0.0289 | 0.0778 |
Echinococcus multilocularis | 0.0036 | 0.0289 | 0.0099 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.1273 | 0.1103 |
Toxoplasma gondii | melibiase subfamily protein | 0.0118 | 0.2779 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0036 | 0.0289 | 0.0099 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.1273 | 0.1103 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0056 | 0.0899 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0056 | 0.0899 | 1 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0036 | 0.0289 | 0.321 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0033 | 0.0192 | 0.1528 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0064 | 0.0504 |
Brugia malayi | Melibiase family protein | 0.0078 | 0.1579 | 0.5255 |
Mycobacterium leprae | putative cytochrome p450 | 0.0036 | 0.0289 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0056 | 0.0899 | 0.2896 |
Brugia malayi | Cytochrome P450 family protein | 0.0056 | 0.0899 | 0.2896 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0118 | 0.2779 | 0.2638 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0068 | 0.1273 | 0.1103 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0118 | 0.2779 | 0.2638 |
Plasmodium falciparum | importin beta, putative | 0.0033 | 0.0192 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0056 | 0.0899 | 0.084 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.1273 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0118 | 0.2779 | 0.2638 |
Trypanosoma brucei | cytochrome P450, putative | 0.0056 | 0.0899 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0064 | 0.0714 |
Brugia malayi | Importin beta-1 subunit | 0.0033 | 0.0192 | 0.0442 |
Leishmania major | cytochrome p450-like protein | 0.0036 | 0.0289 | 0.2266 |
Echinococcus multilocularis | snurportin 1 | 0.0353 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 | 0.0036 | 0.0289 | 0.0226 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0036 | 0.0289 | 0.321 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0118 | 0.2779 | 0.2638 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1579 | 0.1525 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0118 | 0.2779 | 0.2638 |
Brugia malayi | Cytochrome P450 family protein | 0.0036 | 0.0289 | 0.0778 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0353 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0036 | 0.0289 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0056 | 0.0899 | 0.084 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0064 | 0.0714 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0033 | 0.0192 | 0.1528 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0068 | 0.1273 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0078 | 0.1579 | 0.1415 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0078 | 0.1579 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 0.1273 | 0.1103 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.