Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | renin | Starlite/ChEMBL | References |
Callithrix jacchus | Renin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | hypothetical protein | Renin | 400 aa | 352 aa | 21.9 % |
Candida albicans | secretory aspartyl proteinase SAP7p | Renin | 400 aa | 374 aa | 25.4 % |
Plasmodium yoelii | Eukaryotic aspartyl protease, putative | Renin | 400 aa | 338 aa | 26.3 % |
Candida albicans | secretory aspartyl proteinase SAP6p | Renin | 400 aa | 355 aa | 26.8 % |
Plasmodium berghei | plasmepsin X | Renin | 400 aa | 383 aa | 25.3 % |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | Renin | 400 aa | 400 aa | 26.8 % |
Candida albicans | secretory aspartyl proteinase SAP7p | Renin | 400 aa | 374 aa | 25.4 % |
Neospora caninum | Cathepsin D enzyme (EC 3.4.23.5), related | Renin | 400 aa | 364 aa | 31.0 % |
Plasmodium falciparum | plasmepsin VII | Renin | 400 aa | 426 aa | 23.7 % |
Plasmodium berghei | plasmepsin VII | Renin | 400 aa | 389 aa | 26.0 % |
Babesia bovis | aspartyl protease, putative | Renin | 400 aa | 354 aa | 25.7 % |
Candida albicans | secretory aspartyl proteinase SAP4p | Renin | 400 aa | 372 aa | 25.5 % |
Candida albicans | secretory aspartyl proteinase SAP5p | Renin | 400 aa | 347 aa | 24.5 % |
Cryptosporidium parvum | secreted pepsinogen like aspartyl protease having a signal peptide | Renin | 400 aa | 407 aa | 23.1 % |
Candida albicans | secretory aspartyl proteinase SAP8p | Renin | 400 aa | 342 aa | 26.3 % |
Candida albicans | secretory aspartyl proteinase SAP10p, related to SAP9p | Renin | 400 aa | 356 aa | 21.6 % |
Schistosoma japonicum | Lysosomal aspartic protease precursor, putative | Renin | 400 aa | 326 aa | 32.8 % |
Plasmodium knowlesi | aspartyl protease, putative | Renin | 400 aa | 375 aa | 25.9 % |
Candida albicans | secretory aspartyl proteinase SAP6p | Renin | 400 aa | 355 aa | 26.8 % |
Plasmodium vivax | aspartyl protease, putative | Renin | 400 aa | 374 aa | 25.4 % |
Dictyostelium discoideum | hypothetical protein | Renin | 400 aa | 363 aa | 22.0 % |
Plasmodium falciparum | plasmepsin X | renin | 406 aa | 352 aa | 26.4 % |
Candida albicans | secretory aspartyl proteinase SAP5p | Renin | 400 aa | 347 aa | 24.5 % |
Candida albicans | secretory aspartyl proteinase SAP8p | Renin | 400 aa | 342 aa | 26.3 % |
Plasmodium knowlesi | eukaryotic aspartyl protease, putative | Renin | 400 aa | 352 aa | 28.7 % |
Cryptosporidium parvum | AT hook motif protein, putative | Renin | 400 aa | 399 aa | 21.8 % |
Babesia bovis | aspartyl protease, putative | Renin | 400 aa | 398 aa | 23.9 % |
Toxoplasma gondii | aspartyl protease ASP3 | Renin | 400 aa | 335 aa | 32.8 % |
Candida albicans | secretory aspartyl proteinase SAP10p, related to SAP9p | Renin | 400 aa | 356 aa | 21.6 % |
Plasmodium falciparum | plasmepsin X | Renin | 400 aa | 338 aa | 26.6 % |
Candida albicans | secretory aspartyl proteinase SAP4p | Renin | 400 aa | 372 aa | 25.5 % |
Toxoplasma gondii | aspartyl protease | Renin | 400 aa | 417 aa | 29.5 % |
Onchocerca volvulus | Renin | 400 aa | 385 aa | 27.3 % | |
Plasmodium vivax | aspartyl protease, putative | Renin | 400 aa | 349 aa | 28.1 % |
Onchocerca volvulus | Sphingomyelin phosphodiesterase 1 homolog | Renin | 400 aa | 398 aa | 37.2 % |
Plasmodium falciparum | plasmepsin III | Renin | 400 aa | 336 aa | 29.8 % |
Neospora caninum | hypothetical protein | Renin | 400 aa | 340 aa | 32.6 % |
Drosophila melanogaster | CG31926 gene product from transcript CG31926-RB | Renin | 400 aa | 388 aa | 31.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.2983 | 0.5022 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0118 | 0.2766 | 0.8923 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0128 | 0.3096 | 0.5214 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0128 | 0.3096 | 0.3071 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0128 | 0.3096 | 0.0807 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0128 | 0.3096 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0128 | 0.3096 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.3096 | 0.5214 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0128 | 0.3096 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0128 | 0.3096 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0128 | 0.3096 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.2983 | 0.5022 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0118 | 0.2766 | 0.8935 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0128 | 0.3096 | 0.449 |
Plasmodium vivax | plasmepsin IV, putative | 0.0118 | 0.2766 | 0.8923 |
Brugia malayi | Pre-SET motif family protein | 0.0218 | 0.5904 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0128 | 0.3096 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0248 | 0.685 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0128 | 0.3096 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0128 | 0.3096 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0118 | 0.2766 | 0.4653 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0128 | 0.3096 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0128 | 0.3096 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0128 | 0.3096 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0128 | 0.3096 | 0.0807 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0128 | 0.3096 | 0.3071 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.2766 | 0.4653 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0128 | 0.3096 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0128 | 0.3096 | 0.0807 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0218 | 0.5904 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0118 | 0.2766 | 0.8923 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0128 | 0.3096 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0036 | 0.0117 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0128 | 0.3096 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0128 | 0.3096 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0118 | 0.2766 | 0.8923 |
Plasmodium vivax | RNA helicase-1, putative | 0.0128 | 0.3096 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0118 | 0.2766 | 0.274 |
Onchocerca volvulus | 0.0248 | 0.685 | 1 | |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0118 | 0.2766 | 0.8923 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0348 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.2983 | 0.5022 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.