TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 354.298 | Formula: C14H19N4O5P
H donors: 3 H acceptors: 6 LogP: -0.41 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(Oc1ccccc1)C)NC(CP(=O)(O)O)Cn1cncn1
InChi: 1S/C14H19N4O5P/c1-11(23-13-5-3-2-4-6-13)14(19)17-12(8-24(20,21)22)7-18-10-15-9-16-18/h2-6,9-12H,7-8H2,1H3,(H,17,19)(H2,20,21,22)
InChiKey: BBHUTOXJVLSIDF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Cryptococcus neoformans var. neoformans B-3501A	Imidazoleglycerol-phosphate dehydratase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	Imidazole glycerol phosphate dehydratase	Get druggable targets OG5_129258	All targets in OG5_129258
Candida albicans	Imidazole glycerol phosphate dehydratase	Get druggable targets OG5_129258	All targets in OG5_129258
Mycobacterium leprae	Probable imidazole glycerol-phosphate dehydratase HisB	Get druggable targets OG5_129258	All targets in OG5_129258
Mycobacterium tuberculosis	Probable imidazole glycerol-phosphate dehydratase HisB	Get druggable targets OG5_129258	All targets in OG5_129258
Mycobacterium ulcerans	imidazoleglycerol-phosphate dehydratase	Get druggable targets OG5_129258	All targets in OG5_129258

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus	Nanchung homolog	Imidazoleglycerol-phosphate dehydratase	202 aa	162 aa	19.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0168	0.201	0.9053
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0121	0.5
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0305	0.0933
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0196	0.0232
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0123	0.1439	0.1439
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0025	0.0076
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0025	0.0025
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0121	0.0143
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0196	0.4702
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0418	0.0418
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0025	0.0025
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0025	0.0076
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0264	0.3213	0.379
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0196	0.0232
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0025	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0121	0.037
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0121	0.037
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0121	0.037
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.0418	0.1011
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0025	0.0112
Mycobacterium ulcerans	imidazoleglycerol-phosphate dehydratase	0.0683	0.8477	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0545	0.1666
Echinococcus multilocularis	survival motor neuron protein 1	0.0269	0.3274	0.3274
Brugia malayi	hypothetical protein	0.0269	0.3274	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0545	0.2457
Brugia malayi	beta-lactamase family protein	0.0041	0.0418	0.1276
Onchocerca volvulus		0.0267	0.3247	1
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0025	0.0112
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0545	0.2457
Loa Loa (eye worm)	hypothetical protein	0.001	0.0025	0.0076
Schistosoma mansoni	survival motor neuron protein	0.0055	0.0587	0.2646
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0121	0.037
Entamoeba histolytica	hypothetical protein	0.0123	0.1439	1
Plasmodium vivax	SET domain protein, putative	0.0034	0.0321	0.6736
Echinococcus granulosus	intestinal type alkaline phosphatase 1	0.0185	0.222	0.6781
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0418	0.1276
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0121	0.0143
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0025	0.0076
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0025	0.0076
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0109	0.0129
Echinococcus granulosus	geminin	0.0168	0.201	0.6139
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.0272	0.0832
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0025	0.0076
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0196	0.0232
Echinococcus granulosus	intestinal type alkaline phosphatase	0.0185	0.222	0.6781
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0025	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0196	0.06
Loa Loa (eye worm)	hypothetical protein	0.001	0.0025	0.0076
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0418	0.0493
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0418	0.0493
Echinococcus multilocularis	geminin	0.0168	0.201	0.201
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0545	0.0545
Onchocerca volvulus		0.0011	0.0036	0.0033
Entamoeba histolytica	hypothetical protein	0.0123	0.1439	1
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0418	0.0493
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0418	0.1276
Loa Loa (eye worm)	hypothetical protein	0.001	0.0025	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0418	0.1276
Schistosoma mansoni	alkaline phosphatase	0.0185	0.222	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0025	0.0025
Brugia malayi	ecdysteroid receptor	0.001	0.0025	0.0076
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0109	0.0129
Brugia malayi	Pre-SET motif family protein	0.0034	0.0321	0.098
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0025	0.0025
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0418	0.1276
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0025	0.0076
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0418	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0025	0.0112
Echinococcus multilocularis	alkaline phosphatase	0.0185	0.222	0.222
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0025	0.0112
Loa Loa (eye worm)	hypothetical protein	0.001	0.0025	0.0076
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0196	0.0232
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0025	0.0076
Loa Loa (eye worm)	hypothetical protein	0.001	0.0025	0.0076
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0025	0.0076
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0055	0.0587	0.1794
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0025	0.0076
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0025	0.0076
Loa Loa (eye worm)	hypothetical protein	0.001	0.0025	0.0076
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0418	0.0493
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0196	0.0232
Brugia malayi	steroid hormone receptor	0.001	0.0025	0.0076
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0025	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0121	0.037
Brugia malayi	beta-lactamase family protein	0.0041	0.0418	0.1276
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0025	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0196	0.06
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	0.0185	0.222	0.222
Schistosoma mansoni	hypothetical protein	0.0055	0.0587	0.2646
Echinococcus multilocularis	intestinal type alkaline phosphatase	0.0185	0.222	0.222
Trichomonas vaginalis	set domain proteins, putative	0.0267	0.3247	1
Onchocerca volvulus		0.0041	0.0418	0.1219
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.0418	0.0493
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0025	0.0076
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0321	0.0321
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.0418	0.0493
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0025	0.0076
Entamoeba histolytica	hypothetical protein	0.0123	0.1439	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0545	0.0545
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0025	0.0076
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0025	0.0076
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0321	0.1445
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0025	0.0076
Mycobacterium leprae	Probable lipase LipE	0.0041	0.0418	0.1011
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0418	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3274	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0545	0.1666
Brugia malayi	beta-lactamase	0.0041	0.0418	0.1276
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0025	0.0076
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0196	0.0232
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0321	0.098
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.0418	0.0493
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0196	0.0232
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	0.0185	0.222	0.222
Loa Loa (eye worm)	hypothetical protein	0.001	0.0025	0.0076
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0025	0.0076
Toxoplasma gondii	ABC1 family protein	0.0041	0.0418	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0025	0.0025
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0025	0.0076
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0418	0.1881
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0234	0.2841	0.8676
Brugia malayi	hypothetical protein	0.0123	0.1439	0.4396
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0196	0.0232
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0418	1
Onchocerca volvulus		0.0041	0.0418	0.1219
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0418	0.0493
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0025	0.0076
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0196	0.0232
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0025	0.0076
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.0418	0.0493
Onchocerca volvulus		0.0055	0.0587	0.1746
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0321	0.1445
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0418	0.0493
Mycobacterium tuberculosis	Probable imidazole glycerol-phosphate dehydratase HisB	0.0683	0.8477	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.0418	0.0493
Schistosoma mansoni	hypothetical protein	0.0168	0.201	0.9053
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0196	0.0476
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0418	0.0493
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0196	0.4702
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0121	0.5
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0196	0.06
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0321	0.1445
Onchocerca volvulus		0.0024	0.0196	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0418	0.1276
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0025	0.0112
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0025	0.0025
Leishmania major	hypothetical protein, conserved	0.0041	0.0418	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0025	0.0076
Brugia malayi	Cytochrome P450 family protein	0.003	0.0272	0.0832
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0025	0.0112
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0025	0.0076
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0196	0.06
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0025	0.0076
Echinococcus granulosus	alkaline phosphatase	0.0185	0.222	0.6781
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0025	0.0076
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0025	0.0112
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0196	0.4702
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0025	0.0076
Onchocerca volvulus		0.0041	0.0418	0.1219
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0418	0.1276
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0109	0.0129
Schistosoma mansoni	alkaline phosphatase	0.0185	0.222	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.0321	0.1445
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0545	0.1666
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0545	0.2457
Schistosoma mansoni	hypothetical protein	0.0096	0.1105	0.4977
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0025	0.0076
Schistosoma mansoni	transcription factor LCR-F1	0.0123	0.1439	0.6483
Loa Loa (eye worm)	hypothetical protein	0.001	0.0025	0.0076
Mycobacterium leprae	Probable imidazole glycerol-phosphate dehydratase HisB	0.0337	0.413	1
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	0.0185	0.222	0.6781
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0109	0.0129
Mycobacterium ulcerans	lipase LipD	0.0041	0.0418	0.0493
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0025	0.0112
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0025	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0321	0.098
Schistosoma mansoni	hypothetical protein	0.0123	0.1439	0.6483
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0196	0.0232
Brugia malayi	nuclear hormone receptor	0.001	0.0025	0.0076
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0025	0.0076
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0418	1
Echinococcus granulosus	survival motor neuron protein 1	0.0269	0.3274	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.0418	0.0493
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0025	0.0076
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0025	0.0112
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0196	0.0476
Brugia malayi	nuclear receptor NHR-88	0.001	0.0025	0.0076
Onchocerca volvulus		0.0034	0.0321	0.0919
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0321	0.7683
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0025	0.0076
Entamoeba histolytica	hypothetical protein	0.0123	0.1439	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0025	0.0025
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0025	0.0025
Schistosoma mansoni	coup transcription factor	0.001	0.0025	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0418	0.1276
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0418	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0196	0.06
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0025	0.0076
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0418	0.1881
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0196	0.06
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0025	0.0112
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0321	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0418	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0418	0.1276
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.0418	0.0493
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0025	0.0025
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0545	0.1666
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0123	0.1439	0.4396
Brugia malayi	Pre-SET motif family protein	0.0234	0.2841	0.8676

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.5 uM	Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans	ChEMBL.	10450980
IC50 (binding)	= 1.5 uM	Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans	ChEMBL.	10450980
Ki (binding)	= 0.23 uM	Binding affinity imidazole glycerol phosphate dehydratase (IGPD) obtained from Cryptococcus neoformans	ChEMBL.	10450980
Ki (binding)	= 0.23 uM	Binding affinity imidazole glycerol phosphate dehydratase (IGPD) obtained from Cryptococcus neoformans	ChEMBL.	10450980
Kis (binding)	= 1.22 uM	Kinetic constant for the inhibition of imidazole glycerol phosphate dehydratase (IGPD)	ChEMBL.	10450980
Kis (binding)	= 1.22 uM	Kinetic constant for the inhibition of imidazole glycerol phosphate dehydratase (IGPD)	ChEMBL.	10450980

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL418642

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 103430