Detailed information for compound 1035776

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 405.509 | Formula: C24H23NO3S
  • H donors: 0 H acceptors: 1 LogP: 5.34 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(ccc2c1OC(C)(C)C=C2)CN(C(=O)c1cccs1)c1ccccc1
  • InChi: 1S/C24H23NO3S/c1-24(2)14-13-17-11-12-18(21(27-3)22(17)28-24)16-25(19-8-5-4-6-9-19)23(26)20-10-7-15-29-20/h4-15H,16H2,1-3H3
  • InChiKey: HTJGPJGFRUHDQW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1317 0.1294
Echinococcus multilocularis dna polymerase eta 0.0019 0.006 0.0052
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0032 0.0008
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0253 0.0845
Trypanosoma cruzi Aph-1 protein, putative 0.0381 0.3815 1
Leishmania major kinesin, putative 0.0029 0.0163 0.0292
Brugia malayi CXXC zinc finger family protein 0.0062 0.0512 0.0489
Echinococcus granulosus pyruvate kinase 0.0035 0.023 0.0222
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0357 0.3562 0.3546
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0061 0.05 0.0492
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0061 0.05 0.0492
Mycobacterium ulcerans lipase LipD 0.0037 0.0253 0.6178
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0137 0.1282 0.3255
Trypanosoma brucei calpain-like protein, putative 0.0041 0.029 0.076
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.0333 1
Loa Loa (eye worm) hypothetical protein 0.0357 0.3562 0.356
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0253 0.7487
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.006 0.0036
Loa Loa (eye worm) pyruvate kinase 0.0035 0.023 0.0227
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.006 0.0052
Echinococcus granulosus calpain 0.0041 0.029 0.0282
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0041 0.029 0.0656
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0019 0.0063 0.0055
Schistosoma mansoni lamin 0.0028 0.0161 0.0135
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0026 0.0018
Echinococcus multilocularis lamin 0.0028 0.0161 0.0153
Onchocerca volvulus 0.0186 0.1789 0.317
Echinococcus granulosus dna polymerase eta 0.0019 0.006 0.0052
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0161 0.0158
Echinococcus granulosus inhibitor of apoptosis protein 0.0525 0.5296 0.5293
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.006 0.0158
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0049 0.0372 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.006 0.0158
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0389 0.0366
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.006 0.0034
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0029
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0161 0.0137
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0253 0.0245
Echinococcus multilocularis inhibitor of apoptosis protein 0.0525 0.5296 0.5293
Echinococcus multilocularis gamma secretase subunit aph 1 0.0979 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0253 0.6178
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0303 0.3005 0.3003
Loa Loa (eye worm) glutamate receptor 1 0.0052 0.0399 0.0396
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.006 0.0158
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0066 0.0057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.1317 0.1315
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0041 0.029 0.0656
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.023 0.0207
Giardia lamblia Cathepsin B precursor 0.0045 0.0333 1
Schistosoma mansoni hypothetical protein 0.0344 0.3426 0.3409
Schistosoma mansoni hypothetical protein 0.0035 0.0224 0.0198
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.012 0.2778
Onchocerca volvulus Cell death protein 3 homolog 0.0186 0.1789 0.317
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0032 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1317 0.1294
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0041 0.029 0.0612
Echinococcus multilocularis pyruvate kinase 0.0035 0.023 0.0222
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1317 0.131
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.023 0.0746
Onchocerca volvulus 0.0037 0.0253 0.0179
Loa Loa (eye worm) inositol-1 0.004 0.0275 0.0272
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.006 0.0158
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0019 0.0063 0.0055
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0137 0.1282 0.1259
Mycobacterium ulcerans hypothetical protein 0.0037 0.0253 0.6178
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0045 0.0333 0.078
Loa Loa (eye worm) hypothetical protein 0.0035 0.0224 0.0221
Loa Loa (eye worm) hypothetical protein 0.0068 0.0566 0.0563
Schistosoma mansoni calpain-7 (C02 family) 0.0044 0.0321 0.0295
Onchocerca volvulus 0.0037 0.0253 0.0179
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0005
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.029 0.0612
Loa Loa (eye worm) calpain family protein 1 0.0109 0.099 0.0987
Mycobacterium tuberculosis Conserved protein 0.0037 0.0253 0.0845
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0253 0.0845
Loa Loa (eye worm) hypothetical protein 0.0525 0.5296 0.5295
Brugia malayi calpain 7 0.0041 0.029 0.0267
Echinococcus multilocularis pyruvate kinase 0.0035 0.023 0.0222
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0253 0.0227
Echinococcus multilocularis geminin 0.0344 0.3426 0.3421
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.1236 0.1213
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.023 0.6785
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0357 0.3562 0.9327
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0232 0.0864
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0137 0.1282 0.1259
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.029 0.0612
Giardia lamblia Cathepsin B precursor 0.0045 0.0333 1
Echinococcus granulosus lamin 0.0028 0.0161 0.0153
Echinococcus multilocularis calpain 5 0.0041 0.029 0.0282
Echinococcus granulosus sodium channel protein 0.004 0.0279 0.0271
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.029 0.0612
Echinococcus granulosus pyruvate kinase 0.0018 0.0053 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0253 0.0512
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0253 0.0245
Brugia malayi intermediate filament protein 0.0028 0.0161 0.0137
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0389 0.0366
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0158
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.006 0.0158
Schistosoma mansoni glutamate receptor NMDA 0.0052 0.0399 0.0374
Schistosoma mansoni pyruvate kinase 0.0035 0.023 0.0204
Leishmania major calcium channel protein, putative,ion transporter, putative 0.004 0.0279 0.0624
Echinococcus granulosus glutamate receptor 2 0.0061 0.05 0.0492
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.029 0.0612
Mycobacterium leprae Probable lipase LipE 0.0037 0.0253 1
Echinococcus multilocularis NMDA receptor 0.0019 0.0063 0.0055
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0275 0.0267
Loa Loa (eye worm) pyruvate kinase 0.0035 0.023 0.0227
Mycobacterium tuberculosis Conserved protein 0.0037 0.0253 0.0845
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0066 0.0063
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0109 0.099 0.0966
Schistosoma mansoni calpain (C02 family) 0.0041 0.029 0.0264
Echinococcus granulosus calpain A 0.0113 0.1041 0.1034
Schistosoma mansoni hypothetical protein 0.0019 0.0063 0.0037
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0113 0.1041 0.1034
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0525 0.5296 0.5284
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0303 0.3005 0.2988
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1317 0.1294
Echinococcus multilocularis dna polymerase kappa 0.0019 0.006 0.0052
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.023 0.0452
Schistosoma mansoni glutamate receptor kainate 0.0052 0.0399 0.0374
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0224 0.02
Brugia malayi calpain family protein 1 0.0109 0.099 0.0968
Trypanosoma brucei C-8 sterol isomerase, putative 0.0357 0.3562 0.9337
Loa Loa (eye worm) hypothetical protein 0.0051 0.0389 0.0387
Echinococcus multilocularis pyruvate kinase 0.0028 0.0153 0.0145
Brugia malayi Glutamate receptor 1 precursor 0.0052 0.0399 0.0376
Loa Loa (eye worm) hypothetical protein 0.0037 0.0253 0.025
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.2337 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0113 0.1041 0.1017
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0061 0.05 0.0492
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0275 0.0267
Echinococcus granulosus pyruvate kinase 0.0018 0.0053 0.0045
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0019 0.0063 0.0055
Echinococcus multilocularis glutamate receptor 2 0.0052 0.0399 0.0391
Loa Loa (eye worm) calpain 5 0.0029 0.0163 0.016
Toxoplasma gondii ABC1 family protein 0.0037 0.0253 0.1928
Trypanosoma cruzi kinesin, putative 0.0029 0.0163 0.0272
Loa Loa (eye worm) hypothetical protein 0.0096 0.0863 0.086
Echinococcus multilocularis musashi 0.0028 0.0161 0.0153
Echinococcus multilocularis caspase 2 0.0186 0.1789 0.1782
Brugia malayi calpain family protein 1 0.0109 0.099 0.0968
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0041 0.029 0.076
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0253 0.0845
Echinococcus multilocularis glutamate receptor 2 0.0042 0.0303 0.0295
Loa Loa (eye worm) calpain family protein 1 0.008 0.0694 0.0691
Echinococcus granulosus intermediate filament protein 0.0028 0.0161 0.0153
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1317 0.131
Schistosoma mansoni glutamate receptor AMPA 0.0052 0.0399 0.0374
Trypanosoma brucei unspecified product 0.0019 0.006 0.0158
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0253 0.7487
Echinococcus granulosus calpain 7 C02 family 0.0041 0.029 0.0282
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0063 0.0039
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.006 0.0052
Loa Loa (eye worm) cathepsin B 0.0045 0.0333 0.0331
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.1317 0.1296
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0512 0.0509
Brugia malayi cathepsin B-like cysteine proteinase 0.0137 0.1282 0.1261
Loa Loa (eye worm) hypothetical protein 0.0025 0.012 0.0117
Onchocerca volvulus 0.0062 0.0512 0.0683
Schistosoma mansoni inositol monophosphatase 0.004 0.0275 0.0249
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.006 0.0158
Echinococcus multilocularis calpain 7 (C02 family) 0.0041 0.029 0.0282
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0389 0.0387
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0026 0.0018
Trypanosoma cruzi kinesin, putative 0.0029 0.0163 0.0272
Echinococcus granulosus calpain 5 0.0041 0.029 0.0282
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.029 0.0612
Echinococcus multilocularis hypothetical protein 0.0041 0.029 0.0282
Schistosoma mansoni hypothetical protein 0.0344 0.3426 0.3409
Echinococcus granulosus pyruvate kinase 0.0018 0.0053 0.0045
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0303 0.3005 0.2986
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0032 0.0023
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.029 0.0612
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.029 0.0612
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0253 0.025
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0275 0.0572
Schistosoma mansoni pyruvate kinase 0.0035 0.023 0.0204
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0052 0.0399 0.0391
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.023 0.0135
Trypanosoma brucei antigen, putative 0.0041 0.029 0.076
Giardia lamblia DINP protein human, muc B family 0.0019 0.006 0.0265
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.006 0.0158
Loa Loa (eye worm) hypothetical protein 0.0109 0.099 0.0987
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0906 0.9248 0.9247
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0253 0.7487
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.006 0.0158
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0253 1
Schistosoma mansoni lamin 0.0028 0.0161 0.0135
Loa Loa (eye worm) hypothetical protein 0.0525 0.5296 0.5295
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0045 0.0333 0.0727
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0049 0.0372 0.5
Onchocerca volvulus 0.0037 0.0253 0.0179
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0057
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0253 0.0229
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0275 0.6893
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0019 0.0063 0.0055
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0232 0.0755
Echinococcus multilocularis sodium channel protein 0.004 0.0279 0.0271
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.023 0.0603
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0061 0.05 0.0492
Loa Loa (eye worm) hypothetical protein 0.0037 0.0253 0.025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.006 0.0158
Echinococcus multilocularis calpain family protein 1, d 0.008 0.0694 0.0686
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0525 0.5296 0.5293
Brugia malayi hypothetical protein 0.0186 0.1789 0.1769
Leishmania major pyruvate kinase 0.0035 0.023 0.0485
Leishmania major pyruvate kinase 0.0035 0.023 0.0485
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.012 0.0117
Toxoplasma gondii cathepsin B 0.0045 0.0333 0.2706
Schistosoma mansoni intermediate filament proteins 0.0028 0.0161 0.0135
Echinococcus granulosus geminin 0.0344 0.3426 0.3421
Mycobacterium tuberculosis Conserved protein 0.0037 0.0253 0.0845
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.029 0.0612
Echinococcus granulosus gamma secretase subunit aph 1 0.0979 1 1
Echinococcus granulosus apoptotic protease activating factor 1 0.0186 0.1789 0.1782
Schistosoma mansoni ATP-binding cassette transporter 0.0052 0.0399 0.0374
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.004 0.0279 0.0271
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0275 0.818
Chlamydia trachomatis glutamine binding protein 0.0049 0.0372 1
Echinococcus multilocularis calpain A 0.0113 0.1041 0.1034
Schistosoma mansoni hypothetical protein 0.0186 0.1789 0.1767
Echinococcus multilocularis pyruvate kinase 0.0018 0.0053 0.0045
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0253 0.6178
Trypanosoma brucei pyruvate kinase 1 0.0035 0.023 0.0603
Schistosoma mansoni glutamate receptor kainate 0.0052 0.0399 0.0374
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0253 0.0845
Plasmodium vivax pyruvate kinase, putative 0.0035 0.023 0.7475
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0049 0.0372 0.5
Leishmania major C-8 sterol isomerase-like protein 0.0357 0.3562 1
Echinococcus multilocularis glutamate receptor 2 0.0061 0.05 0.0492
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0032 0.0023
Giardia lamblia Cathepsin B precursor 0.0045 0.0333 1
Leishmania major hypothetical protein, conserved 0.0037 0.0253 0.0549
Mycobacterium ulcerans beta-lactamase 0.0037 0.0253 0.6178
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0253 0.0227
Echinococcus granulosus GPCR family 2 0.0016 0.0032 0.0023
Schistosoma mansoni calpain-7 (C02 family) 0.0044 0.0321 0.0295
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0275 0.5
Echinococcus granulosus lamin dm0 0.0028 0.0161 0.0153
Brugia malayi Inositol-1 0.004 0.0275 0.0252
Schistosoma mansoni cpg binding protein 0.0062 0.0512 0.0487
Plasmodium vivax calpain, putative 0.0041 0.029 1
Schistosoma mansoni hypothetical protein 0.0525 0.5296 0.5284
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0525 0.5296 0.5285
Loa Loa (eye worm) hypothetical protein 0.008 0.0694 0.0691
Schistosoma mansoni cpg binding protein 0.0066 0.0549 0.0524
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0005
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0113 0.1041 0.1034
Schistosoma mansoni calpain C (C02 family) 0.0041 0.029 0.0264
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0275 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0041 0.029 0.076
Brugia malayi Glutamate receptor 2 precursor 0.0052 0.0399 0.0376
Giardia lamblia Pyruvate kinase 0.0035 0.023 0.6319
Loa Loa (eye worm) calpain 0.0041 0.029 0.0287
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.006 0.0158
Loa Loa (eye worm) hypothetical protein 0.0037 0.0253 0.025
Brugia malayi beta-lactamase 0.0037 0.0253 0.0229
Loa Loa (eye worm) hypothetical protein 0.0186 0.1789 0.1787
Entamoeba histolytica protein kinase, putative 0.0029 0.0163 0.4762
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0049 0.0372 0.1368
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0005
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0032 0.0023
Trypanosoma brucei Aph-1 protein, putative 0.0381 0.3815 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0061 0.05 0.0492
Schistosoma mansoni caspase-7 (C14 family) 0.0186 0.1789 0.1767
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.006 0.1496
Brugia malayi beta-lactamase family protein 0.0037 0.0253 0.0229
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.029 0.0612
Trypanosoma brucei calpain-like protein, putative 0.0041 0.029 0.076
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.006 0.0036
Trypanosoma brucei calpain-like protein, putative 0.0041 0.029 0.076
Echinococcus granulosus glutamate NMDA receptor subunit 0.0052 0.0399 0.0391
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0253 0.0845
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0137 0.1282 0.1259
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0333 0.0308
Loa Loa (eye worm) hypothetical protein 0.0186 0.1789 0.1787
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0253 0.8426
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.1089 1
Echinococcus granulosus cpg binding protein 0.0066 0.0549 0.0541
Echinococcus multilocularis lamin dm0 0.0028 0.0161 0.0153
Echinococcus multilocularis calpain 0.0041 0.029 0.0282
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0253 0.7487
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0253 0.0512
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.006 0.0158
Brugia malayi beta-lactamase family protein 0.0037 0.0253 0.0229
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0275 0.818
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0253 0.0662
Loa Loa (eye worm) hypothetical protein 0.0037 0.0253 0.025
Schistosoma mansoni Mername-AA248 (C02 family) 0.0041 0.029 0.0264
Loa Loa (eye worm) hypothetical protein 0.0137 0.1282 0.128
Echinococcus multilocularis pyruvate kinase 0.0018 0.0053 0.0045
Trypanosoma cruzi Aph-1 protein, putative 0.0381 0.3815 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0275 0.818
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1317 0.131
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1317 0.131
Mycobacterium ulcerans pyruvate kinase 0.0035 0.023 0.5454
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0005
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0061 0.05 0.0492
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0525 0.5296 0.5293
Loa Loa (eye worm) glutamate receptor 2 0.0052 0.0399 0.0396
Schistosoma mansoni glutamate receptor NMDA 0.0061 0.05 0.0475
Brugia malayi Cell death protein 3 precursor 0.0186 0.1789 0.1769
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.023 0.171
Trypanosoma brucei cysteine peptidase C (CPC) 0.0045 0.0333 0.0874
Schistosoma mansoni inhibitor of apoptosis protein 0.0525 0.5296 0.5284
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0161 0.0158
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0061 0.05 0.0492
Schistosoma mansoni glutamate receptor kainate 0.0052 0.0399 0.0374
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0049 0.0372 1
Schistosoma mansoni pyruvate kinase 0.0018 0.0053 0.0027
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0019 0.0063 0.0055
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0137 0.1282 0.1259
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0041 0.029 0.0656
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.006 0.0158
Trypanosoma brucei kinesin, putative 0.0029 0.0163 0.0426
Echinococcus granulosus cathepsin b 0.0137 0.1282 0.1275
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.023 0.0135
Brugia malayi calpain 5 0.0029 0.0163 0.0139
Plasmodium falciparum pyruvate kinase 0.0035 0.023 1
Schistosoma mansoni gamma-secretase subunit aph-1 0.0979 1 1
Echinococcus multilocularis pyruvate kinase 0.0018 0.0053 0.0045
Loa Loa (eye worm) hypothetical protein 0.0182 0.1755 0.1753
Schistosoma mansoni inositol monophosphatase 0.004 0.0275 0.0249
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0275 0.0721
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0113 0.1041 0.1017
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0253 0.0845
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0068 0.0569 0.0561
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.006 0.0158
Onchocerca volvulus 0.0525 0.5296 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.006 0.0034
Onchocerca volvulus Deterin homolog 0.0525 0.5296 1
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0253 0.0845
Echinococcus granulosus calpain A 0.0041 0.029 0.0282
Loa Loa (eye worm) hypothetical protein 0.0035 0.023 0.0227
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.006 0.0057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0253 0.025
Trypanosoma brucei calpain-like protein, putative 0.0041 0.029 0.076
Entamoeba histolytica calpain large subunit domain III containing protein 0.0029 0.0163 0.4762
Schistosoma mansoni glutamate receptor AMPA 0.0052 0.0399 0.0374
Echinococcus granulosus nmda type glutamate receptor 0.0068 0.0569 0.0561
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0061 0.05 0.0492
Echinococcus granulosus glutamate receptor 2 0.0042 0.0303 0.0295
Echinococcus multilocularis nmda type glutamate receptor 0.0068 0.0569 0.0561
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.006 0.1496
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.006 0.0158
Echinococcus multilocularis apoptotic protease activating factor 1 0.0186 0.1789 0.1782
Echinococcus multilocularis max protein X 0.0303 0.3005 0.2999
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0525 0.5296 0.5285
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0253 0.7487
Echinococcus multilocularis cathepsin b 0.0137 0.1282 0.1275
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0275 0.0613
Echinococcus multilocularis GPCR, family 2 0.0016 0.0032 0.0023
Echinococcus multilocularis cpg binding protein 0.0066 0.0549 0.0541
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0026 0.0018
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0026 0.0018
Echinococcus granulosus glutamate receptor subunit protein glur 0.0019 0.0063 0.0055
Echinococcus multilocularis cathepsin b 0.0137 0.1282 0.1275
Schistosoma mansoni cpg binding protein 0.0066 0.0549 0.0524
Onchocerca volvulus 0.0068 0.0566 0.0789
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.023 0.6785
Loa Loa (eye worm) hypothetical protein 0.0037 0.0253 0.025
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0275 0.0572
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0019 0.0063 0.0055
Echinococcus granulosus dna polymerase kappa 0.0019 0.006 0.0052
Loa Loa (eye worm) beta-lactamase 0.0037 0.0253 0.025
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0028 0.0156 0.0153
Trichomonas vaginalis esterase, putative 0.0037 0.0253 0.7487
Echinococcus granulosus caspase 2 0.0186 0.1789 0.1782
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0303 0.3005 0.2986
Echinococcus granulosus pyruvate kinase 0.0035 0.023 0.0222
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0032 0.0023
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.023 0.0452
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0032 0.0029
Loa Loa (eye worm) pyruvate kinase 0.0035 0.023 0.0227
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.023 0.0135
Echinococcus granulosus cathepsin b 0.0137 0.1282 0.1275
Echinococcus granulosus max protein X 0.0303 0.3005 0.2999
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.006 0.0034
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0275 0.2142
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0979 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0066 0.0057
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.023 0.0207

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.