TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 419.902 | Formula: C21H26ClN3O4
H donors: 1 H acceptors: 3 LogP: 3.76 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+](=O)c1ccc2c(c1)[C@@H](N1CCN(CC1)c1ccccc1)[C@@H](C(O2)(C)C)O.Cl
InChi: 1S/C21H25N3O4.ClH/c1-21(2)20(25)19(17-14-16(24(26)27)8-9-18(17)28-21)23-12-10-22(11-13-23)15-6-4-3-5-7-15;/h3-9,14,19-20,25H,10-13H2,1-2H3;1H/t19-,20+;/m1./s1
InChiKey: IOZDQEOJBIVZDL-FDOHDBATSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0171	0.0502
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.1278	0.3751
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Brugia malayi	MH2 domain containing protein	0.012	0.5256	0.9208
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.08	0.1171
Brugia malayi	Cathepsin L-like precursor	0.0033	0.1205	0.2054
Trypanosoma cruzi	cysteine proteinase, putative	0.0017	0.0456	0.053
Brugia malayi	hypothetical protein	0.0016	0.0396	0.0626
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0017	0.0456	0.1337
Echinococcus multilocularis	cathepsin L	0.0017	0.0456	0.1337
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0033	0.1205	0.3535
Onchocerca volvulus		0.0033	0.1205	0.1019
Mycobacterium leprae	Probable lipase LipE	0.0035	0.1278	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0033	0.1205	0.2538
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0084	0.0245
Brugia malayi	cathepsin L-like precursor	0.0022	0.0694	0.1153
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.5546	1
Schistosoma mansoni	ubiquitin conjugating enzyme 13	0.0081	0.3407	1
Leishmania major	cathepsin L-like protease	0.0033	0.1205	0.0853
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0081	0.3407	0.5943
Trypanosoma cruzi	cysteine peptidase, putative	0.0033	0.1205	0.1924
Trypanosoma cruzi	major cysteine proteinase, putative	0.01	0.4286	0.7656
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0033	0.1205	0.2538
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1205	0.2054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Leishmania major	cathepsin L-like protease	0.0127	0.5546	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0694	0.0807
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0456	0.053
Onchocerca volvulus		0.0035	0.1278	0.1166
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Onchocerca volvulus	Huntingtin homolog	0.013	0.5705	1
Schistosoma mansoni	hypothetical protein	0.0011	0.0171	0.0502
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0033	0.1205	0.2538
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.1278	0.2184
Loa Loa (eye worm)	hypothetical protein	0.0011	0.017	0.0228
Echinococcus granulosus	Smad4	0.0008	0.0041	0.012
Loa Loa (eye worm)	hypothetical protein	0.013	0.5705	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Echinococcus granulosus	smad	0.0008	0.0041	0.012
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.2255	0.558
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.5256	0.9208
Toxoplasma gondii	cathepsin CPL	0.0033	0.1205	0.1552
Onchocerca volvulus		0.0033	0.1205	0.1019
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0033	0.1205	0.3535
Brugia malayi	ubiquitin conjugating enzyme protein 13	0.0081	0.3407	0.5943
Plasmodium vivax	vivapain-3	0.0017	0.0456	0.0881
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0033	0.1205	0.3535
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0041	0.012
Loa Loa (eye worm)	ctsf protein	0.0033	0.1205	0.2054
Brugia malayi	Cathepsin L-like precursor	0.0033	0.1205	0.2054
Loa Loa (eye worm)	beta-lactamase	0.0035	0.1278	0.2184
Plasmodium vivax	vivapain-2	0.0033	0.1205	0.3195
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1278	0.2184
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.1205	0.2538
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0127	0.5546	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1278	0.2787
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Leishmania major	cathepsin L-like protease	0.0033	0.1205	0.0853
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0081	0.3407	0.6022
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.1205	0.2054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.08	0.1167
Echinococcus granulosus	cathepsin L cysteine protease	0.0017	0.0456	0.1337
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0081	0.3407	0.5943
Brugia malayi	hypothetical protein	0.0025	0.08	0.134
Leishmania major	hypothetical protein, conserved	0.0035	0.1278	0.1008
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0694	0.2036
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0041	0.012
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0041	0.012
Brugia malayi	Cathepsin L-like precursor	0.0033	0.1205	0.2054
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0081	0.3407	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.017	0.0228
Echinococcus granulosus	cathepsin l1	0.0022	0.0694	0.2036
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.1278	0.3751
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0694	0.1153
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0171	0.0502
Plasmodium vivax	unspecified product	0.0017	0.0456	0.0881
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0033	0.1205	0.2538
Loa Loa (eye worm)	hypothetical protein	0.0011	0.017	0.0228
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.1205	0.3535
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0081	0.3407	0.6022
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Plasmodium vivax	vivapain-2	0.0033	0.1205	0.3195
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.08	0.0677
Mycobacterium ulcerans	beta-lactamase	0.0035	0.1278	0.5
Brugia malayi	CXXC zinc finger family protein	0.0029	0.103	0.1745
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0041	0.012
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.1205	0.2538
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0022	0.0694	0.1153
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0011	0.017	0.0228
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0033	0.1205	0.2054
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.1278	0.3751
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.5256	0.9208
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0116	0.5035	0.905
Toxoplasma gondii	ABC1 family protein	0.0035	0.1278	0.1834
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0081	0.3407	1
Brugia malayi	Cathepsin L-like precursor	0.0033	0.1205	0.2054
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.1278	0.2061
Schistosoma mansoni	cathepsin s	0.0011	0.017	0.05
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.0694	0.0807
Brugia malayi	Cathepsin L-like precursor	0.0033	0.1205	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1278	0.2184
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.08	0.1167
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0033	0.1205	0.3535
Leishmania major	cathepsin L-like protease	0.0033	0.1205	0.0853
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.1278	0.3422
Brugia malayi	cathepsin F-like cysteine proteinase	0.0011	0.017	0.0228
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0694	0.1153
Echinococcus multilocularis	cathepsin L cysteine protease	0.0033	0.1205	0.3535
Loa Loa (eye worm)	cysteine protease	0.0033	0.1205	0.2054
Echinococcus multilocularis	cysteine protease	0.0033	0.1205	0.3535
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0694	0.0807
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1278	0.2787
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1278	0.2787
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0017	0.0456	0.1337
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.1205	0.3535
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.2565	0.7529
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Echinococcus multilocularis	smad	0.0008	0.0041	0.012
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0041	0.012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0033	0.1205	0.2538
Echinococcus granulosus	cathepsin l1	0.0033	0.1205	0.3535
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Onchocerca volvulus		0.0033	0.1205	0.1019
Echinococcus multilocularis	cathepsin L cysteine protease	0.0033	0.1205	0.3535
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.1278	0.2787
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.1278	0.5
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.08	0.1945
Echinococcus multilocularis	cpg binding protein	0.0031	0.1108	0.3251
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0694	0.1153
Schistosoma mansoni	cpg binding protein	0.0031	0.1108	0.3251
Trypanosoma cruzi	cysteine proteinase, putative	0.0017	0.0456	0.053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Onchocerca volvulus	Cathepsin L homolog	0.0033	0.1205	0.1019
Trypanosoma brucei	ubiquitin-protein ligase, putative	0.0081	0.3407	0.5799
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1278	0.2184
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.5546	1
Onchocerca volvulus		0.0035	0.1278	0.1166
Onchocerca volvulus		0.0035	0.1278	0.1166
Mycobacterium ulcerans	hypothetical protein	0.0035	0.1278	0.5
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0033	0.1205	0.2054
Echinococcus granulosus	cathepsin L	0.0017	0.0456	0.1337
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0041	0.012
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0017	0.0456	0.053
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.1278	0.1616
Onchocerca volvulus	Cathepsin F homolog	0.0033	0.1205	0.1019
Toxoplasma gondii	ubiquitin-conjugating enzyme subfamily protein	0.0081	0.3407	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.1278	0.2061
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Leishmania major	cathepsin L-like protease	0.0127	0.5546	1
Brugia malayi	beta-lactamase family protein	0.0035	0.1278	0.2184
Loa Loa (eye worm)	hypothetical protein	0.013	0.5705	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1278	0.2184
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0041	0.012
Mycobacterium ulcerans	lipase LipD	0.0035	0.1278	0.5
Brugia malayi	Ubiquitin conjugating enzyme protein 13	0.0081	0.3407	0.5943
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.1278	0.2184
Trypanosoma cruzi	cysteine protease, putative	0.0017	0.0456	0.053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Onchocerca volvulus		0.0033	0.1205	0.1019
Schistosoma mansoni	smad	0.0008	0.0041	0.012
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.1278	0.2787
Onchocerca volvulus		0.0033	0.1205	0.1019
Echinococcus multilocularis	Smad4	0.0008	0.0041	0.012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.08	0.134
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0084	0.0245
Leishmania major	cathepsin L-like protease	0.0033	0.1205	0.0853
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0694	0.1153
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.1278	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.08	0.1171
Onchocerca volvulus	Cathepsin L homolog	0.0033	0.1205	0.1019
Echinococcus multilocularis	cysteine protease	0.0033	0.1205	0.3535
Leishmania major	cathepsin L-like protease	0.0033	0.1205	0.0853
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.103	0.1745
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.1278	0.3751
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1278	0.2184
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0011	0.017	0.0228
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	0.0081	0.3407	1
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.1278	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.5546	1
Echinococcus granulosus	ubiquitin conjugating enzyme E2 N	0.0081	0.3407	1
Entamoeba histolytica	cysteine protease, putative	0.0033	0.1205	0.2538
Onchocerca volvulus		0.0033	0.1205	0.1019
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0017	0.0456	0.1337
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Onchocerca volvulus		0.0033	0.1205	0.1019
Plasmodium vivax	vivapain-1	0.0017	0.0456	0.0881
Echinococcus multilocularis	ubiquitin conjugating enzyme E2 N	0.0081	0.3407	1
Schistosoma mansoni	cpg binding protein	0.0029	0.103	0.3022
Onchocerca volvulus		0.0029	0.103	0.067
Leishmania major	cysteine peptidase A (CPA)	0.0033	0.1205	0.0853
Trichomonas vaginalis	esterase, putative	0.0035	0.1278	0.2787
Schistosoma mansoni	cpg binding protein	0.0031	0.1108	0.3251
Echinococcus granulosus	cpg binding protein	0.0031	0.1108	0.3251
Schistosoma mansoni	Smad4	0.0008	0.0041	0.012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Plasmodium vivax	ubiquitin-conjugating enzyme E2 N, putative	0.0081	0.3407	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0694	0.1153
Loa Loa (eye worm)	fibroinase	0.0033	0.1205	0.2054
Echinococcus granulosus	cysteine protease	0.0017	0.0456	0.1337
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0084	0.0075
Onchocerca volvulus	Huntingtin homolog	0.013	0.5705	1
Brugia malayi	beta-lactamase	0.0035	0.1278	0.2184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0078	0.0065
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0456	0.0732
Leishmania major	ubiquitin-conjugating enzyme e2, putative	0.0081	0.3407	0.5494
Brugia malayi	beta-lactamase family protein	0.0035	0.1278	0.2184
Brugia malayi	Cathepsin L-like precursor	0.0011	0.017	0.0228
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0041	0.012
Brugia malayi	hypothetical protein	0.013	0.5705	1
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0456	0.0732
Plasmodium falciparum	ubiquitin-conjugating enzyme E2 N, putative	0.0081	0.3407	1
Leishmania major	cathepsin L-like protease	0.0127	0.5546	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1278	0.2184
Brugia malayi	Cathepsin L-like precursor	0.0033	0.1205	0.2054

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL544719

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1039142