TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 419.902 | Formula: C21H26ClN3O4
H donors: 1 H acceptors: 3 LogP: 3.76 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+](=O)c1ccc2c(c1)[C@@H](N1CCN(CC1)c1ccccc1)[C@@H](C(O2)(C)C)O.Cl
InChi: 1S/C21H25N3O4.ClH/c1-21(2)20(25)19(17-14-16(24(26)27)8-9-18(17)28-21)23-12-10-22(11-13-23)15-6-4-3-5-7-15;/h3-9,14,19-20,25H,10-13H2,1-2H3;1H/t19-,20+;/m1./s1
InChiKey: IOZDQEOJBIVZDL-FDOHDBATSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	hypothetical protein, conserved	0.0035	0.1278	0.1008
Onchocerca volvulus		0.0029	0.103	0.067
Trypanosoma cruzi	cysteine peptidase, putative	0.0033	0.1205	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1278	0.2184
Trypanosoma brucei	ubiquitin-protein ligase, putative	0.0081	0.3407	0.5799
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0694	0.1153
Leishmania major	cysteine peptidase A (CPA)	0.0033	0.1205	0.0853
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0041	0.012
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0017	0.0456	0.053
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0694	0.1153
Plasmodium vivax	ubiquitin-conjugating enzyme E2 N, putative	0.0081	0.3407	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.1205	0.2538
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0017	0.0456	0.1337
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0041	0.012
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.08	0.1945
Echinococcus multilocularis	cathepsin L cysteine protease	0.0033	0.1205	0.3535
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.08	0.0677
Onchocerca volvulus	Huntingtin homolog	0.013	0.5705	1
Loa Loa (eye worm)	ctsf protein	0.0033	0.1205	0.2054
Echinococcus granulosus	smad	0.0008	0.0041	0.012
Onchocerca volvulus		0.0033	0.1205	0.1019
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.2565	0.7529
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.1278	0.2184
Echinococcus multilocularis	smad	0.0008	0.0041	0.012
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.1278	0.2787
Leishmania major	cathepsin L-like protease	0.0127	0.5546	1
Schistosoma mansoni	Smad4	0.0008	0.0041	0.012
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0033	0.1205	0.2538
Echinococcus granulosus	cathepsin L	0.0017	0.0456	0.1337
Onchocerca volvulus		0.0033	0.1205	0.1019
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.2255	0.558
Mycobacterium leprae	Probable lipase LipE	0.0035	0.1278	0.5
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0033	0.1205	0.3535
Toxoplasma gondii	ABC1 family protein	0.0035	0.1278	0.1834
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Plasmodium falciparum	ubiquitin-conjugating enzyme E2 N, putative	0.0081	0.3407	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0011	0.017	0.0228
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.0694	0.0807
Mycobacterium ulcerans	hypothetical protein	0.0035	0.1278	0.5
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0084	0.0245
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0171	0.0502
Leishmania major	cathepsin L-like protease	0.0127	0.5546	1
Trypanosoma cruzi	cysteine protease, putative	0.0017	0.0456	0.053
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0033	0.1205	0.2538
Leishmania major	cathepsin L-like protease	0.0033	0.1205	0.0853
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0033	0.1205	0.2538
Brugia malayi	cathepsin L-like precursor	0.0022	0.0694	0.1153
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.1278	0.3751
Onchocerca volvulus		0.0035	0.1278	0.1166
Brugia malayi	beta-lactamase	0.0035	0.1278	0.2184
Loa Loa (eye worm)	cysteine protease	0.0033	0.1205	0.2054
Echinococcus multilocularis	cathepsin L cysteine protease	0.0033	0.1205	0.3535
Onchocerca volvulus		0.0035	0.1278	0.1166
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.1278	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.08	0.134
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Onchocerca volvulus	Cathepsin L homolog	0.0033	0.1205	0.1019
Echinococcus multilocularis	cathepsin L	0.0017	0.0456	0.1337
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Loa Loa (eye worm)	hypothetical protein	0.013	0.5705	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.1278	0.2787
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0022	0.0694	0.1153
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Schistosoma mansoni	cpg binding protein	0.0031	0.1108	0.3251
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.1205	0.3535
Loa Loa (eye worm)	hypothetical protein	0.0011	0.017	0.0228
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0041	0.012
Brugia malayi	cathepsin F-like cysteine proteinase	0.0011	0.017	0.0228
Brugia malayi	Cathepsin L-like precursor	0.0033	0.1205	0.2054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Plasmodium vivax	vivapain-1	0.0017	0.0456	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0011	0.017	0.0228
Brugia malayi	Cathepsin L-like precursor	0.0011	0.017	0.0228
Leishmania major	cathepsin L-like protease	0.0033	0.1205	0.0853
Schistosoma mansoni	smad	0.0008	0.0041	0.012
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.1278	0.5
Brugia malayi	hypothetical protein	0.0025	0.08	0.134
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0011	0.017	0.0228
Brugia malayi	MH2 domain containing protein	0.012	0.5256	0.9208
Echinococcus multilocularis	ubiquitin conjugating enzyme E2 N	0.0081	0.3407	1
Echinococcus granulosus	cathepsin l1	0.0022	0.0694	0.2036
Schistosoma mansoni	ubiquitin conjugating enzyme 13	0.0081	0.3407	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0033	0.1205	0.3535
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.5546	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Plasmodium vivax	vivapain-3	0.0017	0.0456	0.0881
Echinococcus granulosus	cysteine protease	0.0017	0.0456	0.1337
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0041	0.012
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0456	0.0732
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.1205	0.2538
Schistosoma mansoni	cpg binding protein	0.0031	0.1108	0.3251
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.1278	0.3751
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0081	0.3407	0.6022
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0127	0.5546	1
Onchocerca volvulus		0.0033	0.1205	0.1019
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0456	0.0732
Onchocerca volvulus		0.0033	0.1205	0.1019
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0017	0.0456	0.1337
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.1205	0.2054
Loa Loa (eye worm)	beta-lactamase	0.0035	0.1278	0.2184
Onchocerca volvulus	Huntingtin homolog	0.013	0.5705	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.08	0.1171
Onchocerca volvulus		0.0033	0.1205	0.1019
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0041	0.012
Loa Loa (eye worm)	fibroinase	0.0033	0.1205	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1278	0.2184
Onchocerca volvulus		0.0033	0.1205	0.1019
Brugia malayi	hypothetical protein	0.013	0.5705	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0017	0.0456	0.1337
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0041	0.012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Brugia malayi	Cathepsin L-like precursor	0.0033	0.1205	0.2054
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0084	0.0245
Brugia malayi	Cathepsin L-like precursor	0.0033	0.1205	0.2054
Plasmodium vivax	unspecified product	0.0017	0.0456	0.0881
Plasmodium vivax	vivapain-2	0.0033	0.1205	0.3195
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1278	0.2184
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0033	0.1205	0.2054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.1278	0.3422
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.1278	0.5
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0033	0.1205	0.3535
Onchocerca volvulus	Cathepsin L homolog	0.0033	0.1205	0.1019
Trypanosoma cruzi	major cysteine proteinase, putative	0.01	0.4286	0.7656
Onchocerca volvulus		0.0033	0.1205	0.1019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Echinococcus granulosus	cathepsin l1	0.0033	0.1205	0.3535
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Echinococcus granulosus	Smad4	0.0008	0.0041	0.012
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.1278	0.2184
Mycobacterium ulcerans	lipase LipD	0.0035	0.1278	0.5
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0081	0.3407	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1278	0.2184
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1278	0.2184
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0694	0.1153
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.5256	0.9208
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0694	0.0807
Onchocerca volvulus	Cathepsin F homolog	0.0033	0.1205	0.1019
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0041	0.012
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1278	0.2184
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1278	0.2787
Plasmodium vivax	vivapain-2	0.0033	0.1205	0.3195
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.5546	1
Leishmania major	cathepsin L-like protease	0.0033	0.1205	0.0853
Trypanosoma cruzi	cysteine proteinase, putative	0.0017	0.0456	0.053
Leishmania major	ubiquitin-conjugating enzyme e2, putative	0.0081	0.3407	0.5494
Brugia malayi	CXXC zinc finger family protein	0.0029	0.103	0.1745
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1205	0.2054
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0081	0.3407	0.5943
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.1278	0.3751
Echinococcus granulosus	cpg binding protein	0.0031	0.1108	0.3251
Trypanosoma cruzi	cysteine proteinase, putative	0.0017	0.0456	0.053
Brugia malayi	beta-lactamase family protein	0.0035	0.1278	0.2184
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0017	0.0456	0.1337
Leishmania major	cathepsin L-like protease	0.0033	0.1205	0.0853
Echinococcus multilocularis	Smad4	0.0008	0.0041	0.012
Leishmania major	cathepsin L-like protease	0.0033	0.1205	0.0853
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.5546	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0694	0.1153
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0694	0.1153
Echinococcus multilocularis	cysteine protease	0.0033	0.1205	0.3535
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.1278	0.1616
Onchocerca volvulus		0.0035	0.1278	0.1166
Loa Loa (eye worm)	hypothetical protein	0.013	0.5705	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Leishmania major	cathepsin L-like protease	0.0127	0.5546	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.08	0.1171
Echinococcus granulosus	ubiquitin conjugating enzyme E2 N	0.0081	0.3407	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.1278	0.2061
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0694	0.0807
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.1278	0.3751
Toxoplasma gondii	ubiquitin-conjugating enzyme subfamily protein	0.0081	0.3407	1
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0081	0.3407	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1278	0.2787
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0116	0.5035	0.905
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Schistosoma mansoni	cpg binding protein	0.0029	0.103	0.3022
Loa Loa (eye worm)	hypothetical protein	0.0011	0.017	0.0228
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.1278	0.2061
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0081	0.3407	0.6022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Trichomonas vaginalis	esterase, putative	0.0035	0.1278	0.2787
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.5256	0.9208
Mycobacterium ulcerans	beta-lactamase	0.0035	0.1278	0.5
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.08	0.1167
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1278	0.2787
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.08	0.1167
Brugia malayi	beta-lactamase family protein	0.0035	0.1278	0.2184
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.1205	0.3535
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0041	0.012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Brugia malayi	Cathepsin L-like precursor	0.0033	0.1205	0.2054
Brugia malayi	ubiquitin conjugating enzyme protein 13	0.0081	0.3407	0.5943
Echinococcus multilocularis	cpg binding protein	0.0031	0.1108	0.3251
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0033	0.1205	0.2054
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0456	0.053
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0033	0.1205	0.3535
Toxoplasma gondii	cathepsin CPL	0.0033	0.1205	0.1552
Brugia malayi	Ubiquitin conjugating enzyme protein 13	0.0081	0.3407	0.5943
Echinococcus multilocularis	cysteine protease	0.0033	0.1205	0.3535
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1205	0.2538
Brugia malayi	Cathepsin L-like precursor	0.0033	0.1205	0.2054
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0171	0.0502
Schistosoma mansoni	hypothetical protein	0.0011	0.0171	0.0502
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.1205	0.2538
Brugia malayi	hypothetical protein	0.0016	0.0396	0.0626
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	0.0081	0.3407	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.103	0.1745
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0081	0.3407	0.5943
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0033	0.1205	0.2538
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0694	0.2036
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0078	0.0065
Brugia malayi	Cathepsin L-like precursor	0.0033	0.1205	0.2054
Schistosoma mansoni	cathepsin s	0.0011	0.017	0.05
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.5546	1
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0084	0.0075
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0033	0.1205	0.2538
Entamoeba histolytica	cysteine protease, putative	0.0033	0.1205	0.2538

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL544719

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1039142