Detailed information for compound 1041752

Basic information

Technical information
  • TDR Targets ID: 1041752
  • Name: 3-(1-phenylethoxy)benzo[c]isochromen-6-one
  • MW: 316.35 | Formula: C21H16O3
  • H donors: 0 H acceptors: 1 LogP: 4.9 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1ccccc1)Oc1ccc2c(c1)oc(=O)c1c2cccc1
  • InChi: 1S/C21H16O3/c1-14(15-7-3-2-4-8-15)23-16-11-12-18-17-9-5-6-10-19(17)21(22)24-20(18)13-16/h2-14H,1H3
  • InChiKey: USIQBZCKWWHMJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(1-phenylethoxy)-6-benzo[c]isochromenone
  • AE-641/12195128
  • STOCK2S-14569
  • 3-(1-Phenyl-ethoxy)-benzo[c]chromen-6-one
  • BAS 00872364
  • Oprea1_197184
  • Oprea1_615007

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0457 0.0269
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0453 0.1526
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0457 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1234 0.6991
Onchocerca volvulus 0.0061 0.2348 1
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0406 0.1235
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0457 0.0152
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0453 0.0149
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.4406 0.425
Leishmania major DNA polymerase kappa, putative 0.0019 0.0453 0.0899
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.4865 0.4701
Echinococcus granulosus GPCR family 2 0.0032 0.1033 0.0768
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0453 0.1567
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0406 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.5452 0.5307
Schistosoma mansoni cpg binding protein 0.0064 0.2504 0.3599
Schistosoma mansoni hypothetical protein 0.0032 0.1033 0.1484
Brugia malayi MH2 domain containing protein 0.0116 0.4822 0.473
Loa Loa (eye worm) hypothetical protein 0.0036 0.1234 0.0956
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0309 0.0118
Trypanosoma brucei trypanothione reductase 0.0051 0.1912 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0453 0.0899
Schistosoma mansoni hypothetical protein 0.0044 0.1592 0.2288
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0457 0.0919
Loa Loa (eye worm) hypothetical protein 0.0036 0.1234 0.0956
Leishmania major trypanothione reductase 0.0051 0.1912 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0406 0.0601
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.1234 0.0954
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.1234 0.0954
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0453 0.1526
Trypanosoma brucei unspecified product 0.0019 0.0453 0.1526
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0453 0.1526
Loa Loa (eye worm) hypothetical protein 0.0036 0.1234 0.0956
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0406 0.0601
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0455 0.0172
Plasmodium vivax hypothetical protein, conserved 0.0036 0.1234 0.5767
Brugia malayi glutathione reductase 0.0051 0.1912 0.1756
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0406 0.0601
Loa Loa (eye worm) hypothetical protein 0.0046 0.1667 0.1404
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0406 0.1249
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.1234 0.5767
Echinococcus multilocularis dna polymerase eta 0.0019 0.0453 0.0171
Schistosoma mansoni survival motor neuron protein 0.0047 0.1723 0.2476
Leishmania major DNA polymerase eta, putative 0.0019 0.0453 0.0899
Entamoeba histolytica hypothetical protein 0.0073 0.2887 0.6155
Brugia malayi beta-lactamase 0.0036 0.1234 0.1063
Brugia malayi CHE-14 protein 0.0046 0.1667 0.1505
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.1234 0.0954
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0406 0.1235
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0406 0.0601
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.48 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0309 0.0022
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0453 0.0171
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.9979 1
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.1912 0.1657
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.4481 0.6439
Echinococcus granulosus cpg binding protein 0.0064 0.2504 0.2287
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0406 0.0601
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0457 0.0008
Plasmodium vivax glutathione reductase, putative 0.0051 0.1912 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0453 0.0171
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0453 0.0652
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.1033 0.0768
Brugia malayi beta-lactamase family protein 0.0036 0.1234 0.1063
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0453 0.1526
Echinococcus multilocularis cpg binding protein 0.0064 0.2504 0.2287
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0457 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0453 0.0149
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0406 0.0217
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.1667 0.1404
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0406 0.0601
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.1033 0.0857
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0406 0.0601
Leishmania major hypothetical protein, conserved 0.0036 0.1234 0.5767
Trichomonas vaginalis esterase, putative 0.0036 0.1234 0.6991
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0453 0.0577
Schistosoma mansoni hypothetical protein 0.0032 0.1033 0.1484
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.1723 0.1562
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0453 0.0265
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0406 0.0601
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0309 0.0689
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.1667 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.1234 0.6059
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.1033 0.0768
Schistosoma mansoni DNA polymerase eta 0.0019 0.0453 0.0652
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0455 0.0151
Loa Loa (eye worm) beta-lactamase 0.0036 0.1234 0.0956
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.4113 0.4005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0453 0.1526
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0457 0.0919
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.1234 0.0954
Schistosoma mansoni cpg binding protein 0.0064 0.2504 0.3599
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0309 0.0022
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0453 0.0652
Schistosoma mansoni hypothetical protein 0.0047 0.1723 0.2476
Loa Loa (eye worm) hypothetical protein 0.0056 0.213 0.1883
Plasmodium falciparum thioredoxin reductase 0.0051 0.1912 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0288 0.0414
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0453 0.1526
Schistosoma mansoni ap endonuclease 0.0019 0.0457 0.0656
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.4865 0.4701
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1234 0.6991
Mycobacterium tuberculosis Probable reductase 0.0117 0.4865 0.4701
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.4406 0.4305
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1234 0.6991
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.1234 0.5767
Echinococcus granulosus expressed conserved protein 0.01 0.4115 0.3949
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0453 0.0899
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0457 0.0919
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0457 0.1545
Echinococcus multilocularis protein dispatched 1 0.0052 0.1958 0.1723
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0309 0.0444
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.1234 0.6991
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0453 0.0899
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0457 0.0174
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0453 0.1567
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.1234 0.1063
Schistosoma mansoni hypothetical protein 0.0073 0.2887 0.4148
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.1234 0.0976
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.5421 0.7791
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.1234 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0406 0.0601
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0453 0.1526
Brugia malayi beta-lactamase family protein 0.0036 0.1234 0.1063
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0453 0.0899
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0453 0.0577
Entamoeba histolytica hypothetical protein 0.0073 0.2887 0.6155
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0457 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.4865 0.8609
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.1234 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0453 0.1526
Mycobacterium ulcerans hypothetical protein 0.0036 0.1234 1
Schistosoma mansoni ap endonuclease 0.0019 0.0457 0.0656
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.1234 0.0954
Toxoplasma gondii ABC1 family protein 0.0036 0.1234 0.2058
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0406 0.0601
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0406 0.0601
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0453 0.1526
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0453 0.0265
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0309 0.0022
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0406 0.0215
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0406 0.1249
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0457 0.0919
Loa Loa (eye worm) hypothetical protein 0.0106 0.4406 0.4237
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0309 0.0022
Schistosoma mansoni patched 1 0.0046 0.1667 0.2395
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.1234 0.1773
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0457 0.0152
Echinococcus granulosus survival motor neuron protein 1 0.023 0.9979 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.2887 0.2681
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.4406 0.425
Schistosoma mansoni hypothetical protein 0.0068 0.2687 0.3862
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0455 0.0172
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.4113 0.3933
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0406 0.0122
Echinococcus multilocularis Niemann Pick C1 protein 0.0152 0.6466 0.6375
Brugia malayi hypothetical protein 0.0073 0.2887 0.2752
Loa Loa (eye worm) hypothetical protein 0.0068 0.2687 0.2459
Schistosoma mansoni hypothetical protein 0.0044 0.1592 0.2288
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0453 0.0149
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.4865 0.4701
Echinococcus multilocularis GPCR, family 2 0.0032 0.1033 0.0768
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0406 0.0601
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.1234 0.1773
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0309 0.0022
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.5452 0.5307
Giardia lamblia DINP protein human, muc B family 0.0019 0.0453 0.937
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0309 0.0689
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.5452 1
Loa Loa (eye worm) hypothetical protein 0.023 0.9979 1
Plasmodium falciparum glutathione reductase 0.0051 0.1912 1
Brugia malayi hypothetical protein 0.023 0.9979 1
Echinococcus multilocularis expressed conserved protein 0.01 0.4115 0.3949
Loa Loa (eye worm) hypothetical protein 0.0036 0.1234 0.0956
Brugia malayi isocitrate dehydrogenase 0.0016 0.0309 0.0118
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0406 0.0601
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.1234 0.0954
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0453 0.0899
Loa Loa (eye worm) hypothetical protein 0.01 0.4113 0.3933
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0453 0.1526
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0406 0.0601
Entamoeba histolytica hypothetical protein 0.0073 0.2887 0.6155
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.1912 1
Schistosoma mansoni hypothetical protein 0.0032 0.1033 0.1484
Plasmodium falciparum thioredoxin reductase 0.0018 0.0406 0.0601
Entamoeba histolytica hypothetical protein 0.0073 0.2887 0.6155
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.4822 0.4667
Loa Loa (eye worm) glutathione reductase 0.0051 0.1912 0.1657
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0453 0.0899
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.2687 0.2548
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.4822 0.4667
Loa Loa (eye worm) hypothetical protein 0.0019 0.0453 0.0149
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0406 0.1249
Brugia malayi Thioredoxin reductase 0.0051 0.1912 0.1756
Toxoplasma gondii thioredoxin reductase 0.0051 0.1912 0.3569
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.1912 0.1676
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.1912 0.1654
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.1234 0.0954
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0406 0.0122
Brugia malayi Latrophilin receptor protein 2 0.0032 0.1033 0.0857
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0406 0.1249
Echinococcus granulosus Niemann Pick C1 protein 0.0152 0.6466 0.6375
Schistosoma mansoni cpg binding protein 0.0061 0.2348 0.3375
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.1912 0.1676
Plasmodium falciparum glutathione reductase 0.0018 0.0406 0.0601
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0406 0.0215
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.4113 0.4005
Schistosoma mansoni hypothetical protein 0.0032 0.1033 0.1484
Loa Loa (eye worm) hypothetical protein 0.0036 0.1234 0.0956
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0406 0.0601
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0453 0.1526
Brugia malayi CXXC zinc finger family protein 0.0061 0.2348 0.2202
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0406 0.0601
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.4865 0.4701
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0453 0.0171
Echinococcus granulosus dna polymerase kappa 0.0019 0.0453 0.0171
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.5452 0.5307
Loa Loa (eye worm) hypothetical protein 0.0036 0.1234 0.0956
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.1667 0.1423
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.1234 0.0976
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0457 0.1589
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.2887 0.2681
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0309 0.0022
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.1033 0.0768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0457 0.0919
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.1912 1
Mycobacterium ulcerans lipase LipD 0.0036 0.1234 1
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.2887 0.4148
Mycobacterium tuberculosis Conserved protein 0.0036 0.1234 0.0954
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0444 0.0256
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.1033 0.0768
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.4865 0.4701
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0453 0.1526
Echinococcus granulosus Protein patched homolog 1 0.0046 0.1667 0.1423
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0406 0.0601
Schistosoma mansoni hypothetical protein 0.0044 0.1592 0.2288
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.1234 0.0956
Mycobacterium ulcerans beta-lactamase 0.0036 0.1234 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0453 0.1526
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0457 0.1589
Onchocerca volvulus 0.0047 0.1723 0.4387
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0406 0.0099
Toxoplasma gondii exonuclease III APE 0.0019 0.0457 0.0328
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.1033 0.0748
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0453 0.1526
Schistosoma mansoni hypothetical protein 0.0044 0.1592 0.2288
Echinococcus granulosus dna polymerase eta 0.0019 0.0453 0.0171
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.2348 0.2108
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.4406 1
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.1667 0.1423
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0457 0.0615
Loa Loa (eye worm) hypothetical protein 0.0032 0.1033 0.0748
Mycobacterium tuberculosis Conserved protein 0.0036 0.1234 0.0954
Mycobacterium tuberculosis Conserved protein 0.0036 0.1234 0.0954
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0457 0.0174
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.1234 0.6991
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0406 0.0583
Echinococcus multilocularis protein patched 0.0046 0.1667 0.1423

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 40 uM Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid scintillation counting ChEMBL. 19574055
Ki (binding) > 40 uM Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs by scintillation counting ChEMBL. 19574055

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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