Detailed information for compound 1046067

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 368.753 | Formula: C14H20Cl3N3S
  • H donors: 2 H acceptors: 0 LogP: 4.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(Nc1c(Cl)cccc1Cl)NCCN1CCCCC1.Cl
  • InChi: 1S/C14H19Cl2N3S.ClH/c15-11-5-4-6-12(16)13(11)18-14(20)17-7-10-19-8-2-1-3-9-19;/h4-6H,1-3,7-10H2,(H2,17,18,20);1H
  • InChiKey: WSVNNUSIZSDBJF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/KIN16 protein kinase 0.379 1 1
Loa Loa (eye worm) TK protein kinase 0.0271 0.0447 0.0447
Toxoplasma gondii CBS domain-containing protein 0.0157 0.0139 0.1315
Brugia malayi Immunoglobulin I-set domain containing protein 0.0134 0.0074 0.0033
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.1516 0.3827 1
Echinococcus granulosus neuroglian 0.0146 0.0108 0.0069
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0157 0.0139 0.036
Loa Loa (eye worm) hypothetical protein 0.0146 0.0108 0.0108
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0157 0.0139 0.0124
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.1491 0.3759 0.6615
Schistosoma mansoni cell adhesion molecule 0.0349 0.0659 0.1709
Onchocerca volvulus Alicorn homolog 0.0734 0.1703 0.1776
Echinococcus multilocularis ephrin type A receptor 4 A 0.038 0.0744 0.1209
Loa Loa (eye worm) hypothetical protein 0.0134 0.0074 0.0074
Brugia malayi Voltage gated chloride channel family protein 0.0157 0.0139 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0298 0.0521 0.1351
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Echinococcus granulosus hemicentin 1 0.0134 0.0074 0.0008
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0157 0.0139 0.0124
Schistosoma mansoni roundabout 0.0134 0.0074 0.0192
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0271 0.0447 0.0676
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0298 0.0521 0.2616
Schistosoma mansoni titin 0.0134 0.0074 0.0192
Schistosoma mansoni vesicular amine transporter 0.0262 0.0422 0.1094
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0298 0.0521 0.2616
Leishmania major hypothetical protein, conserved 0.0157 0.0139 0.0698
Loa Loa (eye worm) hypothetical protein 0.0337 0.0625 0.0625
Echinococcus multilocularis neuroglian 0.032 0.0581 0.0917
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0157 0.0139 0.036
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Loa Loa (eye worm) hypothetical protein 0.0157 0.0139 0.0139
Onchocerca volvulus 0.0157 0.0139 0.0071
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0783 0.1837 0.1837
Echinococcus multilocularis lachesin 0.0134 0.0074 0.0008
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0042 0.0042
Wolbachia endosymbiont of Brugia malayi Mg/Co/Ni transporter MgtE 0.0157 0.0139 0.5
Echinococcus granulosus tyrosine protein kinase Lyn 0.0323 0.0589 0.0931
Brugia malayi Immunoglobulin I-set domain containing protein 0.0134 0.0074 0.0033
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0157 0.0139 0.0698
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0298 0.0521 0.0521
Echinococcus granulosus tyrosine protein kinase Fyn 0.0313 0.0561 0.0881
Loa Loa (eye worm) hypothetical protein 0.0298 0.0521 0.0521
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0313 0.0561 0.0881
Echinococcus multilocularis tyrosine protein kinase HCK 0.0228 0.033 0.0467
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0448 0.0929 0.4664
Toxoplasma gondii IMP dehydrogenas 0.0157 0.0139 0.1315
Echinococcus granulosus tyrosine protein kinase Fyn 0.0313 0.0561 0.0881
Loa Loa (eye worm) hypothetical protein 0.0395 0.0785 0.0785
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0313 0.0561 0.0881
Mycobacterium ulcerans hypothetical protein 0.0157 0.0139 0.5
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0298 0.0521 0.2616
Echinococcus multilocularis hemicentin 1 0.0134 0.0074 0.0008
Schistosoma mansoni neuroglian 0.0146 0.0108 0.028
Leishmania major inosine-5-monophosphate dehydrogenase 0.0157 0.0139 0.0698
Echinococcus granulosus roundabout 2 0.0146 0.0108 0.0069
Brugia malayi Immunoglobulin I-set domain containing protein 0.0134 0.0074 0.0033
Echinococcus granulosus defective proboscis extension response 0.0262 0.0422 0.0632
Mycobacterium ulcerans hypothetical protein 0.0157 0.0139 0.5
Echinococcus multilocularis hemicentin 1 0.0134 0.0074 0.0008
Echinococcus granulosus tyrosine protein kinase Blk 0.0271 0.0447 0.0676
Brugia malayi putative serine/threonine kinase SADA gamma 0.0298 0.0521 0.0481
Brugia malayi CBS domain containing protein 0.0157 0.0139 0.0098
Echinococcus granulosus H:Cl exchange transporter 3 0.0157 0.0139 0.0124
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0157 0.0139 0.0124
Loa Loa (eye worm) hypothetical protein 0.0157 0.0139 0.0139
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.1128 0.2774 0.2774
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0262 0.0422 0.1094
Loa Loa (eye worm) hypothetical protein 0.0262 0.0422 0.0422
Trypanosoma brucei GMP reductase 0.0157 0.0139 0.0698
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0521 0.1127 0.1896
Schistosoma mansoni cell adhesion molecule 0.0146 0.0108 0.028
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0313 0.0561 0.0881
Schistosoma mansoni chloride channel protein 0.0157 0.0139 0.036
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.159 0.4027 0.4027
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0157 0.0139 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.1516 0.3827 0.6736
Schistosoma mansoni protein kinase subunit gamma 0.1516 0.3827 0.992
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0146 0.0108 0.0108
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0042 0.0042
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0521 0.1127 0.1896
Schistosoma mansoni protein kinase subunit beta 0.084 0.1991 0.5162
Schistosoma mansoni serine/threonine protein kinase 0.0298 0.0521 0.1351
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Echinococcus multilocularis tyrosine protein kinase otk 0.0134 0.0074 0.0008
Echinococcus multilocularis Immunoglobulin 0.0262 0.0422 0.0632
Brugia malayi Fibronectin type III domain containing protein 0.0274 0.0456 0.0416
Echinococcus granulosus H:Cl exchange transporter 4 0.0157 0.0139 0.0124
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Echinococcus granulosus tyrosine kinase 0.0271 0.0447 0.0676
Chlamydia trachomatis Mg++ transporter 0.0157 0.0139 0.5
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0146 0.0108 0.0069
Brugia malayi Protein kinase domain containing protein 0.159 0.4027 0.4002
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Mycobacterium ulcerans transcriptional regulator 0.0157 0.0139 0.5
Loa Loa (eye worm) hypothetical protein 0.0134 0.0074 0.0074
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.1527 0.3858 0.6792
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0157 0.0139 0.0698
Giardia lamblia 5-AMP-activated protein kinase, beta-1 subunit 0.084 0.1991 0.5023
Loa Loa (eye worm) TK protein kinase 0.0228 0.033 0.033
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.0108 0.0067
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.1527 0.3858 0.3832
Trypanosoma cruzi chloride channel protein, putative 0.0157 0.0139 0.0698
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0157 0.0139 0.0698
Echinococcus multilocularis neuroglian 0.0146 0.0108 0.0069
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0448 0.0929 0.0891
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Loa Loa (eye worm) 5'-AMP-activated protein kinase 0.084 0.1991 0.1991
Schistosoma mansoni cell adhesion molecule 0.0134 0.0074 0.0192
Echinococcus granulosus tyrosine protein kinase Fyn 0.0313 0.0561 0.0881
Brugia malayi bone morphogenetic protein type 1 receptor 0.1128 0.2774 0.2744
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.1527 0.3858 0.6792
Brugia malayi Peroxidasin 0.0134 0.0074 0.0033
Echinococcus granulosus tyrosine protein kinase Src64B 0.0313 0.0561 0.0881
Toxoplasma gondii CBS domain-containing protein 0.0157 0.0139 0.1315
Schistosoma mansoni protein kinase subunit beta 0.0451 0.0935 0.2423
Loa Loa (eye worm) hypothetical protein 0.0134 0.0074 0.0074
Echinococcus multilocularis peroxidasin 0.0134 0.0074 0.0008
Loa Loa (eye worm) chloride channel protein 7 0.0157 0.0139 0.0139
Loa Loa (eye worm) IMP dehydrogenase 1 0.0157 0.0139 0.0139
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0157 0.0139 0.0698
Trypanosoma cruzi chloride channel protein, putative 0.0157 0.0139 0.0698
Giardia lamblia Kinase, CAMK CAMKL 0.0298 0.0521 0.1036
Brugia malayi Immunoglobulin I-set domain containing protein 0.0134 0.0074 0.0033
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0298 0.0521 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Echinococcus granulosus neuroglian 0.032 0.0581 0.0917
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0157 0.0139 0.0124
Leishmania major CBS domain protein, conserved 0.0157 0.0139 0.0698
Schistosoma mansoni cell adhesion molecule 0.0146 0.0108 0.028
Echinococcus multilocularis Immunoglobulin 0.0262 0.0422 0.0632
Schistosoma mansoni tyrosine kinase 0.018 0.0201 0.0522
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0521 0.1127 0.1127
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0224 0.032 0.0448
Brugia malayi CLC chloride channel protein 0.0157 0.0139 0.0098
Loa Loa (eye worm) hypothetical protein 0.0134 0.0074 0.0074
Echinococcus multilocularis TGF beta receptor type 1 0.1092 0.2675 0.4671
Plasmodium falciparum serine/threonine protein kinase KIN 0.0298 0.0521 1
Echinococcus granulosus 5' AMP activated protein kinase subunit beta 1 0.0451 0.0935 0.1551
Onchocerca volvulus 0.0333 0.0617 0.0592
Leishmania major guanosine monophosphate reductase 0.0157 0.0139 0.0698
Brugia malayi ephrin receptor 1 precursor 0.0204 0.0265 0.0225
Echinococcus granulosus tyrosine protein kinase Src42A 0.0313 0.0561 0.0881
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0157 0.0139 0.036
Leishmania major chloride channel protein, putative 0.0157 0.0139 0.0698
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0271 0.0447 0.0676
Wolbachia endosymbiont of Brugia malayi Mg2+/Co2+ transporter 0.0157 0.0139 0.5
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0157 0.0139 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0526 0.1139 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0146 0.0108 0.028
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0313 0.0561 0.0881
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0313 0.0561 0.0881
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0157 0.0139 0.0124
Loa Loa (eye worm) hypothetical protein 0.0274 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0262 0.0422 0.0422
Loa Loa (eye worm) chloride channel 3 0.0157 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0333 0.0617 0.0617
Brugia malayi hypothetical protein 0.0288 0.0493 0.0453
Giardia lamblia Kinase, AGC AKT 0.0448 0.0929 0.2142
Echinococcus granulosus contactin 0.0146 0.0108 0.0069
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0157 0.0139 0.0698
Loa Loa (eye worm) loechrig isoform VII 0.1516 0.3827 0.3827
Echinococcus granulosus AMPK beta subunit 0.084 0.1991 0.3446
Loa Loa (eye worm) hypothetical protein 0.0288 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0134 0.0074 0.0074
Schistosoma mansoni ephrin receptor 0.038 0.0744 0.1929
Trypanosoma brucei 5'-AMP-activated protein kinase subunit beta 0.084 0.1991 1
Echinococcus granulosus ephrin type A receptor 4 A 0.038 0.0744 0.1209
Brugia malayi loechrig isoform VII 0.1516 0.3827 0.3801
Brugia malayi protein-tyrosine kinase 0.0271 0.0447 0.0407
Treponema pallidum Mg2+ transport protein (mgtE) 0.0157 0.0139 1
Brugia malayi protein C17H12.11 0.0773 0.1809 0.1775
Echinococcus granulosus tyrosine protein kinase HCK 0.0228 0.033 0.0467
Echinococcus granulosus roundabout 2 0.0146 0.0108 0.0069
Trypanosoma brucei SNF1-related protein kinases, putative 0.0298 0.0521 0.2616
Echinococcus multilocularis 5' AMP activated protein kinase subunit beta 1 0.0451 0.0935 0.1551
Echinococcus granulosus roundabout 2 0.0408 0.0819 0.1343
Loa Loa (eye worm) hypothetical protein 0.0395 0.0785 0.0785
Echinococcus multilocularis activin receptor type 0.2187 0.5647 1
Echinococcus granulosus H:Cl exchange transporter 7 0.0157 0.0139 0.0124
Echinococcus granulosus peroxidasin 0.0134 0.0074 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Chlamydia trachomatis CBS domain-containing protein 0.0157 0.0139 0.5
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0134 0.0074 0.0192
Schistosoma mansoni serine/threonine protein kinase 0.0298 0.0521 0.1351
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0146 0.0108 0.0069
Leishmania major hypothetical protein, conserved 0.084 0.1991 1
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0157 0.0139 0.0698
Loa Loa (eye worm) hypothetical protein 0.0157 0.0139 0.0139
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0157 0.0139 0.0124
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0313 0.0561 0.0881
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0157 0.0139 0.0698
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0132 0.007 0.0181
Loa Loa (eye worm) hypothetical protein 0.017 0.0172 0.0172
Echinococcus granulosus TGF beta receptor type 1 0.1092 0.2675 0.4671
Schistosoma mansoni protein kinase 0.0953 0.2298 0.5958
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0262 0.0422 0.0632
Loa Loa (eye worm) hypothetical protein 0.0773 0.1809 0.1809
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.1359 0.3399 0.597
Echinococcus multilocularis AMPK beta subunit 0.084 0.1991 0.3446
Onchocerca volvulus 0.3407 0.8959 0.9688
Schistosoma mansoni tyrosine kinase 0.0313 0.0561 0.1454
Brugia malayi hypothetical protein 0.0773 0.1809 0.1775
Trypanosoma cruzi 5'-AMP-activated protein kinase subunit beta, putative 0.084 0.1991 1
Loa Loa (eye worm) LjBmp2/4b 0.2544 0.6618 0.6618
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0157 0.0139 0.0698
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.2175 0.5616 0.5616
Brugia malayi ancient conserved domain protein 2 0.0157 0.0139 0.0098
Giardia lamblia Kinase, CAMK CAMKL 0.0298 0.0521 0.1036
Mycobacterium leprae conserved hypothetical protein 0.0157 0.0139 0.5
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0298 0.0521 0.2616
Echinococcus granulosus lachesin 0.0134 0.0074 0.0008
Brugia malayi Immunoglobulin I-set domain containing protein 0.0134 0.0074 0.0033
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0262 0.0422 0.1094
Schistosoma mansoni serine/threonine protein kinase 0.1527 0.3858 1
Echinococcus multilocularis roundabout 2 0.0408 0.0819 0.1343
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.0108 0.0067
Brugia malayi Transforming growth factor beta like domain containing protein 0.2544 0.6618 0.6604
Onchocerca volvulus Tyrosine kinase homolog 0.3512 0.9245 1
Brugia malayi Protein kinase domain containing protein 0.2175 0.5616 0.5597
Trypanosoma cruzi chloride channel protein, putative 0.0157 0.0139 0.0698
Schistosoma mansoni nephrin 0.0146 0.0108 0.028
Brugia malayi chloride channel protein 7 0.0157 0.0139 0.0098
Schistosoma mansoni septate junction protein 0.0134 0.0074 0.0192
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0146 0.0108 0.0069
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.0108 0.0067
Treponema pallidum hemolysin (tlyC) 0.0157 0.0139 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0132 0.007 0.0028
Brugia malayi Immunoglobulin I-set domain containing protein 0.0134 0.0074 0.0033
Echinococcus granulosus tyrosine protein kinase otk 0.0134 0.0074 0.0008
Toxoplasma gondii histone kinase SNF1, putative 0.0298 0.0521 0.493
Echinococcus granulosus tyrosine protein kinase Src42A 0.0224 0.032 0.0448
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0298 0.0521 0.0809
Schistosoma mansoni chloride channel protein 0.0157 0.0139 0.036
Trypanosoma cruzi GMP reductase 0.0157 0.0139 0.0698
Brugia malayi ancient conserved domain protein 4 0.0157 0.0139 0.0098
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0157 0.0139 0.036
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0157 0.0139 0.5
Schistosoma mansoni protein kinase 0.1092 0.2675 0.6933
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0146 0.0108 0.0069
Schistosoma mansoni tyrosine kinase 0.0132 0.007 0.0181
Echinococcus granulosus Immunoglobulin 0.0262 0.0422 0.0632
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0157 0.0139 0.5
Loa Loa (eye worm) hypothetical protein 0.0262 0.0422 0.0422
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0313 0.0561 0.0881
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0319 0.0576 0.0908
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0156 0.0136 0.0136
Brugia malayi Immunoglobulin I-set domain containing protein 0.0274 0.0456 0.0416
Echinococcus multilocularis tyrosine protein kinase Srms 0.0271 0.0447 0.0676
Brugia malayi Transforming growth factor beta like domain containing protein 0.0319 0.0576 0.0537
Echinococcus granulosus TGF-beta receptor type-1 0.1092 0.2675 0.4671
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0313 0.0561 0.0881
Toxoplasma gondii 5'-AMP-activated protein kinase subunit beta-1 family protein, putative 0.0496 0.1057 1
Wolbachia endosymbiont of Brugia malayi hemolysin 0.0157 0.0139 0.5
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0157 0.0139 0.0698
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0298 0.0521 0.2616
Echinococcus granulosus serine:threonine kinase SAD 1 0.0298 0.0521 0.0809
Loa Loa (eye worm) hypothetical protein 0.0134 0.0074 0.0074
Toxoplasma gondii CBS family protein 0.0157 0.0139 0.1315
Brugia malayi SRC-1 0.0313 0.0561 0.0521
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0313 0.0561 0.0881
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0313 0.0561 0.0881
Schistosoma mansoni tyrosine kinase 0.0313 0.0561 0.1454
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0157 0.0139 0.5
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0319 0.0576 0.0908
Loa Loa (eye worm) hypothetical protein 0.0134 0.0074 0.0074
Mycobacterium ulcerans hypothetical protein 0.0157 0.0139 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Brugia malayi Prion-like- 0.0134 0.0074 0.0033
Echinococcus granulosus twitchin 0.0331 0.0609 0.0967
Brugia malayi hypothetical protein 0.0274 0.0456 0.0416
Loa Loa (eye worm) hypothetical protein 0.0157 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0274 0.0456 0.0456
Schistosoma mansoni tyrosine kinase 0.0132 0.007 0.0181
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0157 0.0139 0.0098
Echinococcus multilocularis roundabout 2 0.0146 0.0108 0.0069
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0157 0.0139 0.0698
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0337 0.0625 0.0996
Trypanosoma cruzi GMP reductase 0.0157 0.0139 0.0698
Loa Loa (eye worm) hypothetical protein 0.0288 0.0493 0.0493
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0157 0.0139 0.1315
Loa Loa (eye worm) SRC-1 0.0313 0.0561 0.0561
Brugia malayi 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein 0.084 0.1991 0.1958
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.1527 0.3858 0.3858
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0134 0.0074 0.0074
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0157 0.0139 0.5
Loa Loa (eye worm) hypothetical protein 0.0274 0.0456 0.0456
Schistosoma mansoni serine/threonine protein kinase 0.0298 0.0521 0.1351
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0146 0.0108 0.0069
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0521 0.5
Brugia malayi 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein 0.084 0.1991 0.1958
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0157 0.0139 0.5
Schistosoma mansoni chloride channel protein 0.0157 0.0139 0.036
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0134 0.0074 0.0008
Loa Loa (eye worm) TK/EPH protein kinase 0.0472 0.0992 0.0992
Schistosoma mansoni nephrin 0.0333 0.0615 0.1595
Echinococcus granulosus activin receptor type 0.2187 0.5647 1
Mycobacterium ulcerans cystathionine beta-synthase 0.0157 0.0139 0.5
Trypanosoma cruzi chloride channel protein, putative 0.0157 0.0139 0.0698
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.1516 0.3827 0.6736
Leishmania major chloride channel protein, putative 0.0157 0.0139 0.0698
Schistosoma mansoni serine/threonine protein kinase 0.0521 0.1127 0.2921
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0157 0.0139 0.0124
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0157 0.0139 0.0124
Echinococcus multilocularis tyrosine protein kinase Blk 0.0271 0.0447 0.0676
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0313 0.0561 0.0881
Entamoeba histolytica serine/threonine protein kinase, putative 0.0298 0.0521 1
Loa Loa (eye worm) bone morphogenic protein 6 0.0319 0.0576 0.0576
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0134 0.0074 0.0074
Trypanosoma cruzi SNF1-related protein kinase regulatory subunit beta, putative 0.084 0.1991 1
Echinococcus multilocularis roundabout 2 0.0146 0.0108 0.0069
Schistosoma mansoni septate junction protein 0.0134 0.0074 0.0192

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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